The primary objective of this study was to estimate the prevalence and burden attributed to each of anxiety, depression and the headache disorders of public-health importance (migraine, TTH and medication-overuse headache [MOH]) in Nepal. The secondary objective was to identify the factors associated with each: demographic, life-style, comorbidities and health-care resource-utilization. The purpose was to support health policy through needs assessments, and provide evidence for health-care resource allocation in Nepal.