Somatic consequences of mild hypercortisolemia may be subtle or subclinical, but over time will be additive and inexorable. Evidence implies that patients may develop complications associated with long-term exposure to hypercortisolemia, such as diabetes mellitus, metabolic disturbances, and obesity [38]. More importantly, patients with SCS caused by hormonally active adrenal tumors may exhibit slow, long-term progression of these symptoms if not surgically treated. A retrospective study involving >100 patients suggested that treating SCS by means of laparoscopic adrenalectomy may improve blood pressure control, weight control, and carbohydrate metabolism [39].