Figure 3  Lumbar spinal cord IFNγ production in both WT and CD4 KO mice post-L5Tx.WT BALB/c and BALB/c CD4 KO mice were subjected to either L5Tx or sham surgery. Lumbar spinal cords were collected at selected times post-surgery and then processed for IFNγ ELISA. Changes in lumbar spinal cord levels of IFNγ in WT (n = 9–15) and CD4 KO mice (n = 4–16) are shown here. All data are presented as mean ± SEM. No significant differences between L5Tx and sham treatments were detected within either WT or CD4 KO mice via one-way ANOVA. Two-way ANOVA with “time” and “genotype” as factors was further performed with all data (regardless of surgery). * indicates p < 0.05 between WT and CD4 KO mice at the indicated time point (regardless of surgery). “D” = Day, “WT” = WT mice, “KO” = CD4 KO mice, Tx = L5Tx, and Sh = sham.