The authors would like to thank Dr. Abul Abbas at the University of California San Francisco for providing breeding pairs of BALB/c CD154 KO mice. This work was supported by 5K01DA023503 NIDA (PI Cao) and 1P20GM103643 (PI Meng, sub-project PI Cao) from the NIH, the Provost’s Faculty Grant at UNE (PI Cao), and the Dean’s Research Fellowship (Research Fellow Slaiby) from the College of Osteopathic Medicine, UNE.