Plots of Stepwise Conditional Association of the Variants in the MHC Region
(A–E) Stepwise analysis of HLA-C, HLA-B, HLA-A, and HLA-DQA1 in PsV-affected versus control individuals.
(F and G) Stepwise analysis of HLA-B in PsA versus PsC individuals. Each diamond represents the –log10(p) of the variants, including SNPs, classical HLA or MICA alleles, and amino acid polymorphisms encoded by the HLA genes or MICA. The dotted horizontal line represents the significance threshold of p = 5.0 × 10−8. The most strongly associated amino acid polymorphisms and HLA classical alleles are labeled when their associations satisfied p < 5.0 × 10−8.