Figure 1  Plots of Nominal Association between the MHC Variants and PsV and Its Subphenotypes of PsA and PsC
Each diamond represents the –log10(p) of the variants, including SNPs, classical HLA or MICA alleles, and amino acid polymorphisms encoded by the HLA genes or MICA. The dotted horizontal line represents the significance threshold of p = 5.0 × 10−8. The bottom panel shows the physical positions of the HLA genes, MICA, and PSORS1 on chromosome 6 (UCSC Genome Browser hg18). We tested four binary phenotypes: (A) PsV-affected versus control individuals, (B) PsA-affected versus control individuals, (C) PsC-affected versus control individuals, and (D) PsA-affected versus PsC-affected individuals.