Acknowledgments This work was supported by the NIH (1R01AR062886, R01AR042742, R01AR050511, R01AR062382, 5U01GM092691-04, 1R01AR063759-01A1, and 2R01AR050266), the Arthritis Foundation, a Clinical Scientist Development Award to S.R. from the Doris Duke Foundation, the Japan Society of the Promotion of Science, the Japan Science and Technology Agency, the Ann Arbor Veterans Affairs Hospital, the Canadian Institute of Health Research, the Krembil Foundation, the Arthritis Society, a Vernieuwingsimpuls VIDI Award (project 016.126.354) from the Netherlands Organization for Scientific Research, and the Babcock Memorial Trust.