Enrichment of Specific Types of SNVs in pQTLs and eQTLs
The annotation of all SNVs was performed using SeattleSNP Annotation 129. For each unique annotation (“coding-synonymous,” “intergenic,” “intron,” “missense,” “near-gene-3,” “near-gene-5,” “nonsense,” “splice-3,” “splice-5,” “utr-3,” and “utr-5”), we used a Fisher exact test to test the null hypothesis that the fraction of that annotation type in either recombination-block-filtered eQTLs or pQTLs for overlapping gene models at p < 10−4 was equal to the fraction in all annotated SNVs.