We replicated previous observations, such as a de novo deletion intersecting PTCHD1AS in a male (adding to the evidence that both PTCHD1 and PTCHD1AS contribute to ASD risk14) and de novo events involving the miRNA miR137 (MIM 614304) in 1p21.2–p21.3 in two subjects. Microdeletions of miR137 have been reported in ASD,39 ID,40 and schizophrenia.41 Examples of ASD candidate genes identified by small de novo CNVs include SETD5, DTNA (MIM 601239), and LSAMP (MIM 603241) (Supplemental Data section “Highlighted Genes,” Figures S9, S10, and S14).