While D2R antagonists have been used in the context of rodent associative learning paradigms, their lack of receptor subtype specificity [13] and motor-disrupting effects [6,8] have prevented a rigorous examination of the actual role this dopamine receptor subtype plays in associative and reversal learning in the context of an operant behavior. Past experiments seeking to explore the possible involvement of dopamine D2Rs in associative learning have utilized low to moderate doses of drugs [2,5,6] and site-specific administration [7,9] in order to avoid the confounding effect that locomotor disruption associated with acute D2R blockade can have on learning performance in rodents. Besides their lack of receptor subtype specificity, an acute exposure to commercially available D2 receptor antagonists fails to completely block signaling mediated solely by D2Rs. Moreover, acute dosing does not recapitulate the marked learning deficits produced in rodents [15,16] by chronic exposure to dopamine D2R antagonists [6,7].