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Id Subject Object Predicate Lexical cue
T5104 0-3 DT denotes The
T5105 4-15 NN denotes performance
T5106 56-58 VBZ denotes is
T5107 16-18 IN denotes of
T5108 19-22 NN denotes D2R
T5109 26-30 NNS denotes mice
T5110 22-23 SYM denotes -
T5111 23-24 HYPH denotes /
T5112 24-25 SYM denotes -
T5113 31-37 IN denotes during
T5114 38-46 NN denotes reversal
T5115 47-55 NN denotes learning
T5116 59-68 JJ denotes deficient
T5117 69-78 VBG denotes revealing
T5118 79-80 DT denotes a
T5119 81-85 NN denotes role
T5120 86-89 IN denotes for
T5121 90-98 NN denotes dopamine
T5122 99-102 NN denotes D2R
T5123 103-111 VBN denotes mediated
T5124 102-103 HYPH denotes -
T5125 112-121 NN denotes signaling
T5126 122-124 IN denotes in
T5127 125-130 NNS denotes tasks
T5128 131-140 VBG denotes requiring
T5129 141-151 JJ denotes behavioral
T5130 152-163 NN denotes flexibility
T5131 163-398 sentence denotes Perseverative behavioral patterns characterized the D2R-/- mice relative to D2R+/+ mice during reversal learning sessions (Figure 4), manifested during early reversal trials (Figure 6) and persisted across several sessions (Figure 7).
T5132 164-177 JJ denotes Perseverative
T5133 189-197 NNS denotes patterns
T5134 178-188 JJ denotes behavioral
T5135 198-211 VBD denotes characterized
T5136 212-215 DT denotes the
T5137 223-227 NNS denotes mice
T5138 216-219 NN denotes D2R
T5139 219-220 SYM denotes -
T5140 220-221 HYPH denotes /
T5141 221-222 SYM denotes -
T5142 228-236 JJ denotes relative
T5143 237-239 IN denotes to
T5144 240-243 NN denotes D2R
T5145 247-251 NNS denotes mice
T5146 243-244 SYM denotes +
T5147 244-245 HYPH denotes /
T5148 245-246 SYM denotes +
T5149 252-258 IN denotes during
T5150 259-267 NN denotes reversal
T5151 277-285 NNS denotes sessions
T5152 268-276 NN denotes learning
T5153 286-287 -LRB- denotes (
T5154 287-293 NN denotes Figure
T5155 294-295 CD denotes 4
T5156 295-296 -RRB- denotes )
T5157 296-298 , denotes ,
T5158 298-308 VBD denotes manifested
T5159 309-315 IN denotes during
T5160 316-321 JJ denotes early
T5161 331-337 NNS denotes trials
T5162 322-330 NN denotes reversal
T5163 338-339 -LRB- denotes (
T5164 339-345 NN denotes Figure
T5165 346-347 CD denotes 6
T5166 347-348 -RRB- denotes )
T5167 349-352 CC denotes and
T5168 353-362 VBD denotes persisted
T5169 363-369 IN denotes across
T5170 370-377 JJ denotes several
T5171 378-386 NNS denotes sessions
T5172 387-388 -LRB- denotes (
T5173 388-394 NN denotes Figure
T5174 395-396 CD denotes 7
T5175 396-397 -RRB- denotes )
T5176 397-398 . denotes .
T5177 398-704 sentence denotes These findings are significant because D2R-/- mice respond to food reinforcers and ultimately form and maintain odor-driven S+/S- relationships (a putative D1R-mediated behavior [6]) just as D2R+/+ mice (both groups achieved ≥ 80% discrimination accuracy, the dopamine D1Rs in our mice were not targeted).
T5178 399-404 DT denotes These
T5179 405-413 NNS denotes findings
T5180 414-417 VBP denotes are
T5181 418-429 JJ denotes significant
T5182 430-437 IN denotes because
T5183 450-457 VBP denotes respond
T5184 438-441 NN denotes D2R
T5185 445-449 NNS denotes mice
T5186 441-442 SYM denotes -
T5187 442-443 HYPH denotes /
T5188 443-444 SYM denotes -
T5189 458-460 IN denotes to
T5190 461-465 NN denotes food
T5191 466-477 NNS denotes reinforcers
T5192 478-481 CC denotes and
T5193 482-492 RB denotes ultimately
T5194 493-497 VBP denotes form
T5195 498-501 CC denotes and
T5196 502-510 VBP denotes maintain
T5197 511-515 NN denotes odor
T5198 516-522 VBN denotes driven
T5199 515-516 HYPH denotes -
T5200 529-542 NNS denotes relationships
T5201 523-524 NN denotes S
T5202 524-525 SYM denotes +
T5203 525-526 HYPH denotes /
T5204 526-527 NN denotes S
T5205 527-528 SYM denotes -
T5206 543-544 -LRB- denotes (
T5207 568-576 NN denotes behavior
T5208 544-545 DT denotes a
T5209 546-554 JJ denotes putative
T5210 555-558 NN denotes D1R
T5211 559-567 VBN denotes mediated
T5212 558-559 HYPH denotes -
T5213 577-578 -LRB- denotes [
T5214 578-579 CD denotes 6
T5215 579-580 -RRB- denotes ]
T5216 580-581 -RRB- denotes )
T5217 582-586 RB denotes just
T5218 587-589 IN denotes as
T5219 590-593 NN denotes D2R
T5220 597-601 NNS denotes mice
T5221 593-594 SYM denotes +
T5222 594-595 HYPH denotes /
T5223 595-596 SYM denotes +
T5224 602-603 -LRB- denotes (
T5225 694-702 VBN denotes targeted
T5226 603-607 DT denotes both
T5227 608-614 NNS denotes groups
T5228 615-623 VBD denotes achieved
T5229 624-625 SYM denotes ≥
T5230 626-628 CD denotes 80
T5231 628-629 NN denotes %
T5232 645-653 NN denotes accuracy
T5233 630-644 NN denotes discrimination
T5234 653-655 , denotes ,
T5235 655-658 DT denotes the
T5236 668-672 NNS denotes D1Rs
T5237 659-667 NN denotes dopamine
T5238 673-675 IN denotes in
T5239 676-679 PRP$ denotes our
T5240 680-684 NNS denotes mice
T5241 685-689 VBD denotes were
T5242 690-693 RB denotes not
T5243 702-703 -RRB- denotes )
T5244 703-704 . denotes .
T5245 704-904 sentence denotes A future extension of this study would be to test performance over a fixed number of trials and determine patterns of error rates during acquisition of the discrimination and reversal learning tasks.
T5246 705-706 DT denotes A
T5247 714-723 NN denotes extension
T5248 707-713 JJ denotes future
T5249 744-746 VB denotes be
T5250 724-726 IN denotes of
T5251 727-731 DT denotes this
T5252 732-737 NN denotes study
T5253 738-743 MD denotes would
T5254 747-749 TO denotes to
T5255 750-754 VB denotes test
T5256 755-766 NN denotes performance
T5257 767-771 IN denotes over
T5258 772-773 DT denotes a
T5259 780-786 NN denotes number
T5260 774-779 VBN denotes fixed
T5261 787-789 IN denotes of
T5262 790-796 NNS denotes trials
T5263 797-800 CC denotes and
T5264 801-810 VB denotes determine
T5265 811-819 NNS denotes patterns
T5266 820-822 IN denotes of
T5267 823-828 NN denotes error
T5268 829-834 NNS denotes rates
T5269 835-841 IN denotes during
T5270 842-853 NN denotes acquisition
T5271 854-856 IN denotes of
T5272 857-860 DT denotes the
T5273 898-903 NNS denotes tasks
T5274 861-875 NN denotes discrimination
T5275 876-879 CC denotes and
T5276 880-888 NN denotes reversal
T5277 889-897 NN denotes learning
T5278 903-904 . denotes .
T5279 904-1159 sentence denotes This manipulation would control the number of errors based on trials performed to determine if the apparent difference in absolute number of errors demonstrated by the mutant mice (the putative performance deficit) is simply a reflection of extra trials.
T5280 905-909 DT denotes This
T5281 910-922 NN denotes manipulation
T5282 929-936 VB denotes control
T5283 923-928 MD denotes would
T5284 937-940 DT denotes the
T5285 941-947 NN denotes number
T5286 948-950 IN denotes of
T5287 951-957 NNS denotes errors
T5288 958-963 VBN denotes based
T5289 964-966 IN denotes on
T5290 967-973 NNS denotes trials
T5291 974-983 VBN denotes performed
T5292 984-986 TO denotes to
T5293 987-996 VB denotes determine
T5294 997-999 IN denotes if
T5295 1120-1122 VBZ denotes is
T5296 1000-1003 DT denotes the
T5297 1013-1023 NN denotes difference
T5298 1004-1012 JJ denotes apparent
T5299 1024-1026 IN denotes in
T5300 1027-1035 JJ denotes absolute
T5301 1036-1042 NN denotes number
T5302 1043-1045 IN denotes of
T5303 1046-1052 NNS denotes errors
T5304 1053-1065 VBN denotes demonstrated
T5305 1066-1068 IN denotes by
T5306 1069-1072 DT denotes the
T5307 1080-1084 NNS denotes mice
T5308 1073-1079 JJ denotes mutant
T5309 1085-1086 -LRB- denotes (
T5310 1111-1118 NN denotes deficit
T5311 1086-1089 DT denotes the
T5312 1090-1098 JJ denotes putative
T5313 1099-1110 NN denotes performance
T5314 1118-1119 -RRB- denotes )
T5315 1123-1129 RB denotes simply
T5316 1132-1142 NN denotes reflection
T5317 1130-1131 DT denotes a
T5318 1143-1145 IN denotes of
T5319 1146-1151 JJ denotes extra
T5320 1152-1158 NNS denotes trials
T5321 1158-1159 . denotes .
T5322 1159-1523 sentence denotes Nonetheless, the inability of D2R-/- mice to disengage from previously established S+/S- contingencies (responding to a discriminative stimulus; Fig. 4) strongly argues that mesolimbic dopamine, and in particular dopamine D2R-mediated signaling, modulates the process of alerting the subject that familiar contingencies are now associated unexpected consequences.
T5323 1160-1171 RB denotes Nonetheless
T5324 1322-1328 VBZ denotes argues
T5325 1171-1173 , denotes ,
T5326 1173-1176 DT denotes the
T5327 1177-1186 NN denotes inability
T5328 1187-1189 IN denotes of
T5329 1190-1193 NN denotes D2R
T5330 1197-1201 NNS denotes mice
T5331 1193-1194 SYM denotes -
T5332 1194-1195 HYPH denotes /
T5333 1195-1196 SYM denotes -
T5334 1202-1204 TO denotes to
T5335 1205-1214 VB denotes disengage
T5336 1215-1219 IN denotes from
T5337 1220-1230 RB denotes previously
T5338 1231-1242 VBN denotes established
T5339 1249-1262 NNS denotes contingencies
T5340 1243-1244 NN denotes S
T5341 1244-1245 SYM denotes +
T5342 1245-1246 HYPH denotes /
T5343 1246-1247 NN denotes S
T5344 1247-1248 HYPH denotes -
T5345 1263-1264 -LRB- denotes (
T5346 1305-1309 NN denotes Fig.
T5347 1264-1274 VBG denotes responding
T5348 1275-1277 IN denotes to
T5349 1278-1279 DT denotes a
T5350 1295-1303 NN denotes stimulus
T5351 1280-1294 JJ denotes discriminative
T5352 1303-1304 : denotes ;
T5353 1310-1311 CD denotes 4
T5354 1311-1312 -RRB- denotes )
T5355 1313-1321 RB denotes strongly
T5356 1329-1333 IN denotes that
T5357 1406-1415 VBZ denotes modulates
T5358 1334-1344 JJ denotes mesolimbic
T5359 1345-1353 NN denotes dopamine
T5360 1353-1355 , denotes ,
T5361 1355-1358 CC denotes and
T5362 1359-1361 IN denotes in
T5363 1395-1404 NN denotes signaling
T5364 1362-1372 JJ denotes particular
T5365 1373-1381 NN denotes dopamine
T5366 1382-1385 NN denotes D2R
T5367 1386-1394 VBN denotes mediated
T5368 1385-1386 HYPH denotes -
T5369 1404-1406 , denotes ,
T5370 1416-1419 DT denotes the
T5371 1420-1427 NN denotes process
T5372 1428-1430 IN denotes of
T5373 1431-1439 VBG denotes alerting
T5374 1440-1443 DT denotes the
T5375 1444-1451 NN denotes subject
T5376 1452-1456 IN denotes that
T5377 1488-1498 VBN denotes associated
T5378 1457-1465 JJ denotes familiar
T5379 1466-1479 NNS denotes contingencies
T5380 1480-1483 VBP denotes are
T5381 1484-1487 RB denotes now
T5382 1499-1509 JJ denotes unexpected
T5383 1510-1522 NNS denotes consequences
T5384 1522-1523 . denotes .
T5385 1523-1680 sentence denotes Schultz and colleagues have demonstrated that dopamine cells display consistent tonic firing patterns during maintenance of associative learning tasks [33].
T5386 1524-1531 NNP denotes Schultz
T5387 1552-1564 VBN denotes demonstrated
T5388 1532-1535 CC denotes and
T5389 1536-1546 NNS denotes colleagues
T5390 1547-1551 VBP denotes have
T5391 1565-1569 IN denotes that
T5392 1585-1592 VBP denotes display
T5393 1570-1578 NN denotes dopamine
T5394 1579-1584 NNS denotes cells
T5395 1593-1603 JJ denotes consistent
T5396 1617-1625 NNS denotes patterns
T5397 1604-1609 JJ denotes tonic
T5398 1610-1616 NN denotes firing
T5399 1626-1632 IN denotes during
T5400 1633-1644 NN denotes maintenance
T5401 1645-1647 IN denotes of
T5402 1648-1659 JJ denotes associative
T5403 1660-1668 NN denotes learning
T5404 1669-1674 NNS denotes tasks
T5405 1675-1676 -LRB- denotes [
T5406 1676-1678 CD denotes 33
T5407 1678-1679 -RRB- denotes ]
T5408 1679-1680 . denotes .
T5409 1680-1832 sentence denotes However, phasic burst activity of dopaminergic cells occurs when discrepancies between predicted and actual reinforcement contingencies transpire [14].
T5410 1681-1688 RB denotes However
T5411 1734-1740 VBZ denotes occurs
T5412 1688-1690 , denotes ,
T5413 1690-1696 JJ denotes phasic
T5414 1703-1711 NN denotes activity
T5415 1697-1702 NN denotes burst
T5416 1712-1714 IN denotes of
T5417 1715-1727 JJ denotes dopaminergic
T5418 1728-1733 NNS denotes cells
T5419 1741-1745 WRB denotes when
T5420 1817-1826 VBP denotes transpire
T5421 1746-1759 NNS denotes discrepancies
T5422 1760-1767 IN denotes between
T5423 1768-1777 JJ denotes predicted
T5424 1803-1816 NNS denotes contingencies
T5425 1778-1781 CC denotes and
T5426 1782-1788 JJ denotes actual
T5427 1789-1802 NN denotes reinforcement
T5428 1827-1828 -LRB- denotes [
T5429 1828-1830 CD denotes 14
T5430 1830-1831 -RRB- denotes ]
T5431 1831-1832 . denotes .
T5432 1832-1969 sentence denotes This robust increase of dopaminergic cell activation in response to unpredicted outcomes has been referred to as an "error" signal [14].
T5433 1833-1837 DT denotes This
T5434 1845-1853 NN denotes increase
T5435 1838-1844 JJ denotes robust
T5436 1931-1939 VBN denotes referred
T5437 1854-1856 IN denotes of
T5438 1857-1869 JJ denotes dopaminergic
T5439 1875-1885 NN denotes activation
T5440 1870-1874 NN denotes cell
T5441 1886-1888 IN denotes in
T5442 1889-1897 NN denotes response
T5443 1898-1900 IN denotes to
T5444 1901-1912 JJ denotes unpredicted
T5445 1913-1921 NNS denotes outcomes
T5446 1922-1925 VBZ denotes has
T5447 1926-1930 VBN denotes been
T5448 1940-1942 IN denotes to
T5449 1943-1945 IN denotes as
T5450 1946-1948 DT denotes an
T5451 1957-1963 NN denotes signal
T5452 1949-1950 `` denotes "
T5453 1950-1955 NN denotes error
T5454 1955-1956 '' denotes "
T5455 1964-1965 -LRB- denotes [
T5456 1965-1967 CD denotes 14
T5457 1967-1968 -RRB- denotes ]
T5458 1968-1969 . denotes .
T5459 1969-2044 sentence denotes To date, the molecular basis of this error signal has not been identified.
T5460 1970-1972 IN denotes To
T5461 2033-2043 VBN denotes identified
T5462 1973-1977 NN denotes date
T5463 1977-1979 , denotes ,
T5464 1979-1982 DT denotes the
T5465 1993-1998 NN denotes basis
T5466 1983-1992 JJ denotes molecular
T5467 1999-2001 IN denotes of
T5468 2002-2006 DT denotes this
T5469 2013-2019 NN denotes signal
T5470 2007-2012 NN denotes error
T5471 2020-2023 VBZ denotes has
T5472 2024-2027 RB denotes not
T5473 2028-2032 VBN denotes been
T5474 2043-2044 . denotes .
T5475 2044-2231 sentence denotes The inability of the D2R-/- mice to desist responding to a previously reinforced stimulus suggests that the dopamine D2R might in fact be the focal point of this error-signaling cascade.
T5476 2045-2048 DT denotes The
T5477 2049-2058 NN denotes inability
T5478 2135-2143 VBZ denotes suggests
T5479 2059-2061 IN denotes of
T5480 2062-2065 DT denotes the
T5481 2073-2077 NNS denotes mice
T5482 2066-2069 NN denotes D2R
T5483 2069-2070 SYM denotes -
T5484 2070-2071 HYPH denotes /
T5485 2071-2072 SYM denotes -
T5486 2078-2080 TO denotes to
T5487 2081-2087 VB denotes desist
T5488 2088-2098 VBG denotes responding
T5489 2099-2101 IN denotes to
T5490 2102-2103 DT denotes a
T5491 2126-2134 NN denotes stimulus
T5492 2104-2114 RB denotes previously
T5493 2115-2125 VBN denotes reinforced
T5494 2144-2148 IN denotes that
T5495 2180-2182 VB denotes be
T5496 2149-2152 DT denotes the
T5497 2162-2165 NN denotes D2R
T5498 2153-2161 NN denotes dopamine
T5499 2166-2171 MD denotes might
T5500 2172-2174 IN denotes in
T5501 2175-2179 NN denotes fact
T5502 2183-2186 DT denotes the
T5503 2193-2198 NN denotes point
T5504 2187-2192 JJ denotes focal
T5505 2199-2201 IN denotes of
T5506 2202-2206 DT denotes this
T5507 2223-2230 NN denotes cascade
T5508 2207-2212 NN denotes error
T5509 2213-2222 VBG denotes signaling
T5510 2212-2213 HYPH denotes -
T5511 2230-2231 . denotes .
T5512 2231-2374 sentence denotes Electrophysiological data further support the hypothesis that signaling mediated by dopamine D2Rs tunes D1R-mediated mesocorticolimbic output.
T5513 2232-2252 JJ denotes Electrophysiological
T5514 2253-2257 NNS denotes data
T5515 2266-2273 VBP denotes support
T5516 2258-2265 RB denotes further
T5517 2274-2277 DT denotes the
T5518 2278-2288 NN denotes hypothesis
T5519 2289-2293 IN denotes that
T5520 2330-2335 VBZ denotes tunes
T5521 2294-2303 NN denotes signaling
T5522 2304-2312 VBN denotes mediated
T5523 2313-2315 IN denotes by
T5524 2316-2324 NN denotes dopamine
T5525 2325-2329 NNS denotes D2Rs
T5526 2336-2339 NN denotes D1R
T5527 2340-2348 VBN denotes mediated
T5528 2339-2340 HYPH denotes -
T5529 2367-2373 NN denotes output
T5530 2349-2366 JJ denotes mesocorticolimbic
T5531 2373-2374 . denotes .
T5532 2374-2573 sentence denotes Calabresi et al. [34] demonstrated that tetanic stimulation of dorsal striatum slices prepared from D2R-/- mice is associated with enhanced EPSP and as a result increased striatal synaptic efficacy.
T5533 2375-2384 NNP denotes Calabresi
T5534 2397-2409 VBD denotes demonstrated
T5535 2385-2387 FW denotes et
T5536 2388-2391 FW denotes al.
T5537 2392-2393 -LRB- denotes [
T5538 2393-2395 CD denotes 34
T5539 2395-2396 -RRB- denotes ]
T5540 2410-2414 IN denotes that
T5541 2490-2500 VBN denotes associated
T5542 2415-2422 JJ denotes tetanic
T5543 2423-2434 NN denotes stimulation
T5544 2435-2437 IN denotes of
T5545 2438-2444 JJ denotes dorsal
T5546 2454-2460 NNS denotes slices
T5547 2445-2453 NN denotes striatum
T5548 2461-2469 VBN denotes prepared
T5549 2470-2474 IN denotes from
T5550 2475-2478 NN denotes D2R
T5551 2482-2486 NNS denotes mice
T5552 2478-2479 SYM denotes -
T5553 2479-2480 HYPH denotes /
T5554 2480-2481 SYM denotes -
T5555 2487-2489 VBZ denotes is
T5556 2501-2505 IN denotes with
T5557 2506-2514 VBN denotes enhanced
T5558 2515-2519 NN denotes EPSP
T5559 2520-2523 CC denotes and
T5560 2524-2526 IN denotes as
T5561 2564-2572 NN denotes efficacy
T5562 2527-2528 DT denotes a
T5563 2529-2535 NN denotes result
T5564 2536-2545 VBN denotes increased
T5565 2546-2554 JJ denotes striatal
T5566 2555-2563 JJ denotes synaptic
T5567 2572-2573 . denotes .
T5568 2573-2753 sentence denotes In contrast, stimulation of dorsal striatum slices from wild-type mice resulted in IPSP activity, long-term depression, and decreased neuronal activity of striatal efferents [34].
T5569 2574-2576 IN denotes In
T5570 2645-2653 VBD denotes resulted
T5571 2577-2585 NN denotes contrast
T5572 2585-2587 , denotes ,
T5573 2587-2598 NN denotes stimulation
T5574 2599-2601 IN denotes of
T5575 2602-2608 JJ denotes dorsal
T5576 2618-2624 NNS denotes slices
T5577 2609-2617 NN denotes striatum
T5578 2625-2629 IN denotes from
T5579 2630-2634 JJ denotes wild
T5580 2635-2639 NN denotes type
T5581 2634-2635 HYPH denotes -
T5582 2640-2644 NNS denotes mice
T5583 2654-2656 IN denotes in
T5584 2657-2661 NN denotes IPSP
T5585 2662-2670 NN denotes activity
T5586 2670-2672 , denotes ,
T5587 2672-2676 JJ denotes long
T5588 2677-2681 NN denotes term
T5589 2676-2677 HYPH denotes -
T5590 2682-2692 NN denotes depression
T5591 2692-2694 , denotes ,
T5592 2694-2697 CC denotes and
T5593 2698-2707 VBN denotes decreased
T5594 2717-2725 NN denotes activity
T5595 2708-2716 JJ denotes neuronal
T5596 2726-2728 IN denotes of
T5597 2729-2737 JJ denotes striatal
T5598 2738-2747 NNS denotes efferents
T5599 2748-2749 -LRB- denotes [
T5600 2749-2751 CD denotes 34
T5601 2751-2752 -RRB- denotes ]
T5602 2752-2753 . denotes .
T5603 2753-2927 sentence denotes Carlsson and colleagues [35] have speculated that dopamine D2R stimulation in the striatum serves to "brake" or diminish excitatory corticostriatal signaling and plasticity.
T5604 2754-2762 NNP denotes Carlsson
T5605 2788-2798 VBN denotes speculated
T5606 2763-2766 CC denotes and
T5607 2767-2777 NNS denotes colleagues
T5608 2778-2779 -LRB- denotes [
T5609 2779-2781 CD denotes 35
T5610 2781-2782 -RRB- denotes ]
T5611 2783-2787 VBP denotes have
T5612 2799-2803 IN denotes that
T5613 2845-2851 VBZ denotes serves
T5614 2804-2812 NN denotes dopamine
T5615 2813-2816 NN denotes D2R
T5616 2817-2828 NN denotes stimulation
T5617 2829-2831 IN denotes in
T5618 2832-2835 DT denotes the
T5619 2836-2844 NN denotes striatum
T5620 2852-2854 TO denotes to
T5621 2856-2861 VB denotes brake
T5622 2855-2856 `` denotes "
T5623 2861-2862 '' denotes "
T5624 2863-2865 CC denotes or
T5625 2866-2874 VB denotes diminish
T5626 2875-2885 JJ denotes excitatory
T5627 2902-2911 NN denotes signaling
T5628 2886-2901 JJ denotes corticostriatal
T5629 2912-2915 CC denotes and
T5630 2916-2926 NN denotes plasticity
T5631 2926-2927 . denotes .
T5632 2927-3187 sentence denotes Indeed, perseverative behavior is associated with over activity of the dorsal striatum in rodents [36] and over activity of the caudate in patients with ADHD [37] and a strong inverse correlation of D2R binding with compulsive behavior has been reported [22].
T5633 2928-2934 RB denotes Indeed
T5634 2962-2972 VBN denotes associated
T5635 2934-2936 , denotes ,
T5636 2936-2949 JJ denotes perseverative
T5637 2950-2958 NN denotes behavior
T5638 2959-2961 VBZ denotes is
T5639 2973-2977 IN denotes with
T5640 2978-2982 JJ denotes over
T5641 2983-2991 NN denotes activity
T5642 2992-2994 IN denotes of
T5643 2995-2998 DT denotes the
T5644 3006-3014 NN denotes striatum
T5645 2999-3005 JJ denotes dorsal
T5646 3015-3017 IN denotes in
T5647 3018-3025 NNS denotes rodents
T5648 3026-3027 -LRB- denotes [
T5649 3027-3029 CD denotes 36
T5650 3029-3030 -RRB- denotes ]
T5651 3031-3034 CC denotes and
T5652 3035-3039 JJ denotes over
T5653 3040-3048 NN denotes activity
T5654 3049-3051 IN denotes of
T5655 3052-3055 DT denotes the
T5656 3056-3063 NN denotes caudate
T5657 3064-3066 IN denotes in
T5658 3067-3075 NNS denotes patients
T5659 3076-3080 IN denotes with
T5660 3081-3085 NN denotes ADHD
T5661 3086-3087 -LRB- denotes [
T5662 3087-3089 CD denotes 37
T5663 3089-3090 -RRB- denotes ]
T5664 3091-3094 CC denotes and
T5665 3095-3096 DT denotes a
T5666 3112-3123 NN denotes correlation
T5667 3097-3103 JJ denotes strong
T5668 3104-3111 JJ denotes inverse
T5669 3173-3181 VBN denotes reported
T5670 3124-3126 IN denotes of
T5671 3127-3130 NN denotes D2R
T5672 3131-3138 NN denotes binding
T5673 3139-3143 IN denotes with
T5674 3144-3154 JJ denotes compulsive
T5675 3155-3163 NN denotes behavior
T5676 3164-3167 VBZ denotes has
T5677 3168-3172 VBN denotes been
T5678 3182-3183 -LRB- denotes [
T5679 3183-3185 CD denotes 22
T5680 3185-3186 -RRB- denotes ]
T5681 3186-3187 . denotes .
T5682 3187-3374 sentence denotes Importantly, our data indicate that the poor performances displayed by the D2R-/- mice are manifestations of reversal learning deficits and not gross motivational or sensory impairments.
T5683 3188-3199 RB denotes Importantly
T5684 3210-3218 VBP denotes indicate
T5685 3199-3201 , denotes ,
T5686 3201-3204 PRP$ denotes our
T5687 3205-3209 NNS denotes data
T5688 3219-3223 IN denotes that
T5689 3275-3278 VBP denotes are
T5690 3224-3227 DT denotes the
T5691 3233-3245 NNS denotes performances
T5692 3228-3232 JJ denotes poor
T5693 3246-3255 VBN denotes displayed
T5694 3256-3258 IN denotes by
T5695 3259-3262 DT denotes the
T5696 3270-3274 NNS denotes mice
T5697 3263-3266 NN denotes D2R
T5698 3266-3267 SYM denotes -
T5699 3267-3268 HYPH denotes /
T5700 3268-3269 SYM denotes -
T5701 3279-3293 NNS denotes manifestations
T5702 3294-3296 IN denotes of
T5703 3297-3305 NN denotes reversal
T5704 3306-3314 NN denotes learning
T5705 3315-3323 NNS denotes deficits
T5706 3324-3327 CC denotes and
T5707 3328-3331 RB denotes not
T5708 3332-3337 JJ denotes gross
T5709 3362-3373 NNS denotes impairments
T5710 3338-3350 JJ denotes motivational
T5711 3351-3353 CC denotes or
T5712 3354-3361 JJ denotes sensory
T5713 3373-3374 . denotes .
T5714 3374-3553 sentence denotes We therefore argue that D2Rs participate in signaling or alerting the organism of learning contingency changes during reversal learning and sculpt ongoing goal-directed behavior.
T5715 3375-3377 PRP denotes We
T5716 3388-3393 VBP denotes argue
T5717 3378-3387 RB denotes therefore
T5718 3394-3398 IN denotes that
T5719 3404-3415 VBP denotes participate
T5720 3399-3403 NNS denotes D2Rs
T5721 3416-3418 IN denotes in
T5722 3419-3428 VBG denotes signaling
T5723 3429-3431 CC denotes or
T5724 3432-3440 VBG denotes alerting
T5725 3441-3444 DT denotes the
T5726 3445-3453 NN denotes organism
T5727 3454-3456 IN denotes of
T5728 3457-3465 NN denotes learning
T5729 3466-3477 NN denotes contingency
T5730 3478-3485 NNS denotes changes
T5731 3486-3492 IN denotes during
T5732 3493-3501 NN denotes reversal
T5733 3502-3510 NN denotes learning
T5734 3511-3514 CC denotes and
T5735 3515-3521 VBP denotes sculpt
T5736 3522-3529 JJ denotes ongoing
T5737 3544-3552 NN denotes behavior
T5738 3530-3534 NN denotes goal
T5739 3535-3543 VBN denotes directed
T5740 3534-3535 HYPH denotes -
T5741 3552-3553 . denotes .
R3151 T5181 T5180 acomp significant,are
R3152 T5182 T5183 mark because,respond
R3154 T5183 T5180 advcl respond,are
R3155 T5184 T5185 nmod D2R,mice
R3156 T5185 T5183 nsubj mice,respond
R3158 T5186 T5184 punct -,D2R
R3159 T5187 T5184 punct /,D2R
R3160 T5188 T5184 punct -,D2R
R3162 T5189 T5183 prep to,respond
R3163 T5190 T5191 compound food,reinforcers
R3165 T5191 T5189 pobj reinforcers,to
R3166 T5192 T5183 cc and,respond
R3167 T5193 T5194 advmod ultimately,form
R3169 T5194 T5183 conj form,respond
R3170 T5195 T5194 cc and,form
R3171 T5196 T5194 conj maintain,form
R3172 T5197 T5198 npadvmod odor,driven
R3173 T5198 T5200 amod driven,relationships
R3174 T5199 T5198 punct -,driven
R3176 T5200 T5196 dobj relationships,maintain
R3177 T5201 T5200 nmod S,relationships
R3178 T5202 T5201 punct +,S
R3180 T5203 T5201 punct /,S
R3182 T5204 T5201 appos S,S
R3183 T5205 T5204 punct -,S
R3184 T5206 T5207 punct (,behavior
R3185 T5207 T5200 appos behavior,relationships
R3187 T5208 T5207 det a,behavior
R3188 T5209 T5207 amod putative,behavior
R3190 T5210 T5211 npadvmod D1R,mediated
R3191 T5211 T5207 amod mediated,behavior
R3192 T5212 T5211 punct -,mediated
R3194 T5213 T5214 punct [,6
R3195 T5214 T5196 parataxis 6,maintain
R3196 T5215 T5214 punct ],6
R3198 T5216 T5196 punct ),maintain
R3199 T5217 T5218 advmod just,as
R3200 T5218 T5183 prep as,respond
R3202 T5219 T5220 nmod D2R,mice
R3203 T5220 T5218 pobj mice,as
R3204 T5221 T5219 punct +,D2R
R3206 T5222 T5219 punct /,D2R
R3207 T5223 T5219 punct +,D2R
R3208 T5224 T5225 punct (,targeted
R3211 T5225 T5220 parataxis targeted,mice
R3212 T5226 T5227 det both,groups
R3214 T5227 T5228 nsubj groups,achieved
R3215 T5228 T5225 ccomp achieved,targeted
R3216 T5229 T5230 punct ≥,80
R3218 T5230 T5231 nummod 80,%
R3219 T5231 T5232 compound %,accuracy
R3220 T5232 T5228 dobj accuracy,achieved
R3222 T5233 T5232 compound discrimination,accuracy
R3223 T5234 T5225 punct ", ",targeted
R3224 T5235 T5236 det the,D1Rs
R3225 T5236 T5225 nsubjpass D1Rs,targeted
R3226 T5237 T5236 compound dopamine,D1Rs
R3227 T5238 T5236 prep in,D1Rs
R3228 T5104 T5105 det The,performance
R3229 T5239 T5240 poss our,mice
R3230 T5240 T5238 pobj mice,in
R3231 T5241 T5225 auxpass were,targeted
R3232 T5242 T5225 neg not,targeted
R3233 T5105 T5106 nsubj performance,is
R3234 T5243 T5225 punct ),targeted
R3235 T5244 T5180 punct .,are
R3236 T5107 T5105 prep of,performance
R3237 T5246 T5247 det A,extension
R3238 T5247 T5249 nsubj extension,be
R3239 T5108 T5109 nmod D2R,mice
R3240 T5248 T5247 amod future,extension
R3241 T5250 T5247 prep of,extension
R3242 T5109 T5107 pobj mice,of
R3243 T5251 T5252 det this,study
R3244 T5252 T5250 pobj study,of
R3245 T5110 T5108 punct -,D2R
R3246 T5253 T5249 aux would,be
R3247 T5254 T5255 aux to,test
R3248 T5255 T5249 xcomp test,be
R3249 T5111 T5108 punct /,D2R
R3250 T5256 T5255 dobj performance,test
R3251 T5257 T5256 prep over,performance
R3252 T5258 T5259 det a,number
R3253 T5112 T5108 punct -,D2R
R3254 T5259 T5257 pobj number,over
R3255 T5260 T5259 amod fixed,number
R3256 T5261 T5259 prep of,number
R3257 T5113 T5105 prep during,performance
R3258 T5262 T5261 pobj trials,of
R3259 T5263 T5255 cc and,test
R3260 T5264 T5255 conj determine,test
R3261 T5114 T5115 compound reversal,learning
R3262 T5265 T5264 dobj patterns,determine
R3263 T5266 T5265 prep of,patterns
R3264 T5267 T5268 compound error,rates
R3265 T5115 T5113 pobj learning,during
R3266 T5268 T5266 pobj rates,of
R3267 T5269 T5264 prep during,determine
R3268 T5270 T5269 pobj acquisition,during
R3269 T5116 T5106 acomp deficient,is
R3270 T5271 T5270 prep of,acquisition
R3271 T5272 T5273 det the,tasks
R3272 T5117 T5106 advcl revealing,is
R3273 T5273 T5271 pobj tasks,of
R3274 T5274 T5273 nmod discrimination,tasks
R3275 T5275 T5274 cc and,discrimination
R3276 T5276 T5274 conj reversal,discrimination
R3277 T5277 T5273 compound learning,tasks
R3278 T5278 T5249 punct .,be
R3279 T5280 T5281 det This,manipulation
R3280 T5281 T5282 nsubj manipulation,control
R3281 T5283 T5282 aux would,control
R3282 T5284 T5285 det the,number
R3283 T5118 T5119 det a,role
R3284 T5285 T5282 dobj number,control
R3285 T5119 T5117 dobj role,revealing
R3286 T5120 T5119 prep for,role
R3287 T5121 T5122 compound dopamine,D2R
R3288 T5286 T5285 prep of,number
R3289 T5287 T5286 pobj errors,of
R3290 T5122 T5123 npadvmod D2R,mediated
R3291 T5288 T5282 prep based,control
R3292 T5289 T5288 prep on,based
R3293 T5290 T5289 pobj trials,on
R3294 T5123 T5125 amod mediated,signaling
R3295 T5291 T5290 acl performed,trials
R3296 T5292 T5293 aux to,determine
R3297 T5293 T5282 advcl determine,control
R3298 T5124 T5123 punct -,mediated
R3299 T5294 T5295 mark if,is
R3300 T5295 T5293 ccomp is,determine
R3301 T5296 T5297 det the,difference
R3302 T5125 T5120 pobj signaling,for
R3303 T5297 T5295 nsubj difference,is
R3304 T5298 T5297 amod apparent,difference
R3305 T5299 T5297 prep in,difference
R3306 T5126 T5119 prep in,role
R3307 T5300 T5301 amod absolute,number
R3308 T5301 T5299 pobj number,in
R3309 T5302 T5301 prep of,number
R3310 T5127 T5126 pobj tasks,in
R3311 T5303 T5302 pobj errors,of
R3312 T5304 T5297 acl demonstrated,difference
R3313 T5305 T5304 agent by,demonstrated
R3314 T5128 T5127 acl requiring,tasks
R3315 T5306 T5307 det the,mice
R3316 T5307 T5305 pobj mice,by
R3317 T5308 T5307 amod mutant,mice
R3318 T5129 T5130 amod behavioral,flexibility
R3319 T5309 T5310 punct (,deficit
R3320 T5310 T5297 appos deficit,difference
R3321 T5311 T5310 det the,deficit
R3322 T5130 T5128 dobj flexibility,requiring
R3323 T5312 T5310 amod putative,deficit
R3324 T5313 T5310 compound performance,deficit
R3325 T5314 T5310 punct ),deficit
R3326 T5315 T5316 advmod simply,reflection
R3327 T5316 T5295 attr reflection,is
R3328 T5317 T5316 det a,reflection
R3329 T5132 T5133 amod Perseverative,patterns
R3330 T5318 T5316 prep of,reflection
R3331 T5319 T5320 amod extra,trials
R3332 T5320 T5318 pobj trials,of
R3333 T5321 T5282 punct .,control
R3334 T5133 T5135 nsubj patterns,characterized
R3335 T5323 T5324 advmod Nonetheless,argues
R3336 T5134 T5133 amod behavioral,patterns
R3337 T5136 T5137 det the,mice
R3338 T5325 T5324 punct ", ",argues
R3339 T5326 T5327 det the,inability
R3340 T5137 T5135 dobj mice,characterized
R3341 T5327 T5324 nsubj inability,argues
R3342 T5138 T5137 nmod D2R,mice
R3343 T5328 T5327 prep of,inability
R3344 T5329 T5330 nmod D2R,mice
R3345 T5330 T5328 pobj mice,of
R3346 T5331 T5329 punct -,D2R
R3347 T5139 T5138 punct -,D2R
R3348 T5332 T5329 punct /,D2R
R3349 T5333 T5329 punct -,D2R
R3350 T5140 T5138 punct /,D2R
R3351 T5334 T5335 aux to,disengage
R3352 T5335 T5327 acl disengage,inability
R3353 T5336 T5335 prep from,disengage
R3354 T5141 T5138 punct -,D2R
R3355 T5337 T5338 advmod previously,established
R3356 T5338 T5339 amod established,contingencies
R3357 T5142 T5137 amod relative,mice
R3358 T5339 T5336 pobj contingencies,from
R3359 T5340 T5339 nmod S,contingencies
R3360 T5341 T5340 punct +,S
R3361 T5342 T5340 punct /,S
R3362 T5143 T5142 prep to,relative
R3363 T5343 T5340 appos S,S
R3364 T5344 T5343 punct -,S
R3365 T5144 T5145 nmod D2R,mice
R3366 T5345 T5346 punct (,Fig.
R3367 T5346 T5327 parataxis Fig.,inability
R3368 T5347 T5346 advcl responding,Fig.
R3369 T5145 T5143 pobj mice,to
R3370 T5348 T5347 prep to,responding
R3371 T5349 T5350 det a,stimulus
R3372 T5350 T5348 pobj stimulus,to
R3373 T5146 T5144 punct +,D2R
R3375 T5352 T5346 punct ;,Fig.
R3376 T5353 T5346 nummod 4,Fig.
R3377 T5147 T5144 punct /,D2R
R3378 T5354 T5346 punct ),Fig.
R3379 T5355 T5324 advmod strongly,argues
R3380 T5356 T5357 mark that,modulates
R3381 T5357 T5324 ccomp modulates,argues
R3384 T5148 T5144 punct +,D2R
R3385 T5360 T5359 punct ", ",dopamine
R3386 T5361 T5359 cc and,dopamine
R3387 T5362 T5363 prep in,signaling
R3388 T5149 T5135 prep during,characterized
R3389 T5363 T5359 conj signaling,dopamine
R3390 T5364 T5362 amod particular,in
R3391 T5365 T5366 compound dopamine,D2R
R3392 T5150 T5151 compound reversal,sessions
R3393 T5366 T5367 npadvmod D2R,mediated
R3394 T5151 T5149 pobj sessions,during
R3395 T5367 T5363 amod mediated,signaling
R3396 T5368 T5367 punct -,mediated
R3397 T5369 T5357 punct ", ",modulates
R3398 T5152 T5151 compound learning,sessions
R3399 T5370 T5371 det the,process
R3400 T5371 T5357 dobj process,modulates
R3401 T5372 T5371 prep of,process
R3402 T5153 T5154 punct (,Figure
R3403 T5373 T5372 pcomp alerting,of
R3404 T5374 T5375 det the,subject
R3405 T5154 T5135 parataxis Figure,characterized
R3406 T5155 T5154 nummod 4,Figure
R3407 T5375 T5373 dobj subject,alerting
R3408 T5156 T5154 punct ),Figure
R3409 T5376 T5377 mark that,associated
R3410 T5377 T5373 ccomp associated,alerting
R3411 T5157 T5135 punct ", ",characterized
R3412 T5378 T5379 amod familiar,contingencies
R3413 T5379 T5377 nsubjpass contingencies,associated
R3414 T5380 T5377 auxpass are,associated
R3415 T5158 T5135 conj manifested,characterized
R3416 T5381 T5377 advmod now,associated
R3417 T5382 T5383 amod unexpected,consequences
R3418 T5383 T5377 dep consequences,associated
R3419 T5159 T5158 prep during,manifested
R3420 T5384 T5324 punct .,argues
R3421 T5386 T5387 nsubj Schultz,demonstrated
R3422 T5160 T5161 amod early,trials
R3423 T5388 T5386 cc and,Schultz
R3424 T5161 T5159 pobj trials,during
R3425 T5389 T5386 conj colleagues,Schultz
R3426 T5390 T5387 aux have,demonstrated
R3427 T5391 T5392 mark that,display
R3428 T5162 T5161 compound reversal,trials
R3429 T5163 T5164 punct (,Figure
R3430 T5164 T5159 parataxis Figure,during
R3431 T5392 T5387 ccomp display,demonstrated
R3432 T5393 T5394 compound dopamine,cells
R3433 T5394 T5392 nsubj cells,display
R3434 T5165 T5164 nummod 6,Figure
R3435 T5395 T5396 amod consistent,patterns
R3436 T5396 T5392 dobj patterns,display
R3437 T5397 T5398 amod tonic,firing
R3438 T5166 T5164 punct ),Figure
R3439 T5398 T5396 compound firing,patterns
R3440 T5399 T5392 prep during,display
R3441 T5400 T5399 pobj maintenance,during
R3442 T5167 T5158 cc and,manifested
R3443 T5401 T5400 prep of,maintenance
R3444 T5402 T5403 amod associative,learning
R3445 T5403 T5404 compound learning,tasks
R3446 T5168 T5158 conj persisted,manifested
R3447 T5404 T5401 pobj tasks,of
R3448 T5405 T5406 punct [,33
R3449 T5406 T5387 parataxis 33,demonstrated
R3450 T5169 T5168 prep across,persisted
R3451 T5407 T5406 punct ],33
R3452 T5170 T5171 amod several,sessions
R3453 T5171 T5169 pobj sessions,across
R3454 T5408 T5387 punct .,demonstrated
R3455 T5172 T5173 punct (,Figure
R3456 T5410 T5411 advmod However,occurs
R3457 T5173 T5168 parataxis Figure,persisted
R3458 T5412 T5411 punct ", ",occurs
R3459 T5413 T5414 amod phasic,activity
R3460 T5414 T5411 nsubj activity,occurs
R3461 T5174 T5173 nummod 7,Figure
R3462 T5415 T5414 compound burst,activity
R3463 T5416 T5414 prep of,activity
R3464 T5417 T5418 amod dopaminergic,cells
R3465 T5175 T5173 punct ),Figure
R3466 T5418 T5416 pobj cells,of
R3467 T5176 T5135 punct .,characterized
R3468 T5419 T5420 advmod when,transpire
R3469 T5420 T5411 advcl transpire,occurs
R3470 T5421 T5420 nsubj discrepancies,transpire
R3471 T5178 T5179 det These,findings
R3472 T5422 T5421 prep between,discrepancies
R3473 T5423 T5424 amod predicted,contingencies
R3474 T5424 T5422 pobj contingencies,between
R3475 T5425 T5423 cc and,predicted
R3476 T5179 T5180 nsubj findings,are
R3477 T5426 T5423 conj actual,predicted
R3478 T5427 T5424 compound reinforcement,contingencies
R3479 T5498 T5497 compound dopamine,D2R
R3480 T5428 T5429 punct [,14
R3481 T5429 T5411 parataxis 14,occurs
R3482 T5430 T5429 punct ],14
R3483 T5431 T5411 punct .,occurs
R3484 T5433 T5434 det This,increase
R3485 T5499 T5495 aux might,be
R3486 T5434 T5436 nsubjpass increase,referred
R3487 T5435 T5434 amod robust,increase
R3488 T5500 T5495 prep in,be
R3489 T5437 T5434 prep of,increase
R3490 T5438 T5439 amod dopaminergic,activation
R3491 T5439 T5437 pobj activation,of
R3492 T5501 T5500 pobj fact,in
R3493 T5440 T5439 compound cell,activation
R3494 T5441 T5434 prep in,increase
R3495 T5442 T5441 pobj response,in
R3496 T5502 T5503 det the,point
R3497 T5443 T5442 prep to,response
R3498 T5444 T5445 amod unpredicted,outcomes
R3499 T5445 T5443 pobj outcomes,to
R3500 T5503 T5495 attr point,be
R3501 T5446 T5436 aux has,referred
R3502 T5447 T5436 auxpass been,referred
R3503 T5448 T5436 prep to,referred
R3504 T5504 T5503 amod focal,point
R3505 T5449 T5436 prep as,referred
R3506 T5450 T5451 det an,signal
R3507 T5505 T5503 prep of,point
R3508 T5451 T5449 pobj signal,as
R3509 T5452 T5451 punct """",signal
R3510 T5453 T5451 nmod error,signal
R3511 T5506 T5507 det this,cascade
R3512 T5454 T5451 punct """",signal
R3513 T5455 T5456 punct [,14
R3514 T5456 T5436 parataxis 14,referred
R3515 T5507 T5505 pobj cascade,of
R3516 T5457 T5456 punct ],14
R3517 T5458 T5436 punct .,referred
R3518 T5508 T5509 npadvmod error,signaling
R3519 T5460 T5461 prep To,identified
R3520 T5509 T5507 amod signaling,cascade
R3521 T5462 T5460 pobj date,To
R3522 T5463 T5461 punct ", ",identified
R3523 T5464 T5465 det the,basis
R3524 T5510 T5509 punct -,signaling
R3525 T5465 T5461 nsubjpass basis,identified
R3526 T5466 T5465 amod molecular,basis
R3527 T5467 T5465 prep of,basis
R3528 T5511 T5478 punct .,suggests
R3529 T5468 T5469 det this,signal
R3530 T5469 T5467 pobj signal,of
R3531 T5513 T5514 amod Electrophysiological,data
R3532 T5470 T5469 compound error,signal
R3533 T5471 T5461 aux has,identified
R3534 T5472 T5461 neg not,identified
R3535 T5473 T5461 auxpass been,identified
R3536 T5474 T5461 punct .,identified
R3537 T5476 T5477 det The,inability
R3538 T5514 T5515 nsubj data,support
R3539 T5477 T5478 nsubj inability,suggests
R3540 T5479 T5477 prep of,inability
R3541 T5516 T5515 advmod further,support
R3542 T5480 T5481 det the,mice
R3543 T5481 T5479 pobj mice,of
R3544 T5482 T5481 nmod D2R,mice
R3545 T5483 T5482 punct -,D2R
R3546 T5517 T5518 det the,hypothesis
R3547 T5484 T5482 punct /,D2R
R3548 T5485 T5482 punct -,D2R
R3549 T5518 T5515 dobj hypothesis,support
R3550 T5486 T5487 aux to,desist
R3551 T5487 T5477 acl desist,inability
R3552 T5488 T5487 xcomp responding,desist
R3553 T5519 T5520 mark that,tunes
R3554 T5489 T5488 prep to,responding
R3555 T5490 T5491 det a,stimulus
R3556 T5491 T5489 pobj stimulus,to
R3557 T5520 T5518 acl tunes,hypothesis
R3558 T5492 T5493 advmod previously,reinforced
R3559 T5493 T5491 amod reinforced,stimulus
R3560 T5494 T5495 mark that,be
R3561 T5521 T5520 nsubj signaling,tunes
R3562 T5522 T5521 acl mediated,signaling
R3563 T5495 T5478 ccomp be,suggests
R3564 T5523 T5522 agent by,mediated
R3565 T5496 T5497 det the,D2R
R3566 T5497 T5495 nsubj D2R,be
R3567 T5524 T5525 compound dopamine,D2Rs
R3568 T5525 T5523 pobj D2Rs,by
R3569 T5526 T5527 npadvmod D1R,mediated
R3570 T5527 T5529 amod mediated,output
R3571 T5604 T5605 nsubj Carlsson,speculated
R3572 T5528 T5527 punct -,mediated
R3573 T5606 T5604 cc and,Carlsson
R3574 T5607 T5604 conj colleagues,Carlsson
R3575 T5529 T5520 dobj output,tunes
R3576 T5608 T5609 punct [,35
R3577 T5609 T5607 parataxis 35,colleagues
R3578 T5610 T5609 punct ],35
R3579 T5530 T5529 amod mesocorticolimbic,output
R3580 T5611 T5605 aux have,speculated
R3581 T5612 T5613 mark that,serves
R3582 T5613 T5605 ccomp serves,speculated
R3583 T5531 T5515 punct .,support
R3584 T5614 T5615 compound dopamine,D2R
R3585 T5615 T5616 compound D2R,stimulation
R3586 T5616 T5613 nsubj stimulation,serves
R3587 T5617 T5616 prep in,stimulation
R3588 T5618 T5619 det the,striatum
R3589 T5619 T5617 pobj striatum,in
R3590 T5533 T5534 nsubj Calabresi,demonstrated
R3591 T5620 T5621 aux to,brake
R3592 T5621 T5613 xcomp brake,serves
R3593 T5622 T5621 punct """",brake
R3594 T5623 T5621 punct """",brake
R3595 T5535 T5536 advmod et,al.
R3596 T5624 T5621 cc or,brake
R3597 T5625 T5621 conj diminish,brake
R3598 T5626 T5627 amod excitatory,signaling
R3599 T5627 T5625 dobj signaling,diminish
R3600 T5536 T5533 advmod al.,Calabresi
R3601 T5628 T5627 amod corticostriatal,signaling
R3602 T5629 T5627 cc and,signaling
R3603 T5630 T5627 conj plasticity,signaling
R3604 T5537 T5538 punct [,34
R3605 T5631 T5605 punct .,speculated
R3606 T5538 T5533 parataxis 34,Calabresi
R3607 T5633 T5634 advmod Indeed,associated
R3608 T5635 T5634 punct ", ",associated
R3609 T5539 T5538 punct ],34
R3610 T5636 T5637 amod perseverative,behavior
R3611 T5637 T5634 nsubjpass behavior,associated
R3612 T5638 T5634 auxpass is,associated
R3613 T5540 T5541 mark that,associated
R3614 T5639 T5634 prep with,associated
R3615 T5640 T5641 amod over,activity
R3616 T5541 T5534 ccomp associated,demonstrated
R3617 T5641 T5639 pobj activity,with
R3618 T5642 T5641 prep of,activity
R3619 T5542 T5543 amod tetanic,stimulation
R3620 T5643 T5644 det the,striatum
R3621 T5644 T5642 pobj striatum,of
R3622 T5645 T5644 amod dorsal,striatum
R3623 T5543 T5541 nsubjpass stimulation,associated
R3624 T5646 T5641 prep in,activity
R3625 T5647 T5646 pobj rodents,in
R3626 T5544 T5543 prep of,stimulation
R3627 T5648 T5649 punct [,36
R3628 T5649 T5641 parataxis 36,activity
R3629 T5650 T5649 punct ],36
R3630 T5545 T5546 amod dorsal,slices
R3631 T5651 T5641 cc and,activity
R3632 T5652 T5653 amod over,activity
R3633 T5653 T5641 conj activity,activity
R3634 T5546 T5544 pobj slices,of
R3635 T5654 T5653 prep of,activity
R3636 T5655 T5656 det the,caudate
R3637 T5547 T5546 compound striatum,slices
R3638 T5656 T5654 pobj caudate,of
R3639 T5657 T5653 prep in,activity
R3640 T5658 T5657 pobj patients,in
R3641 T5659 T5658 prep with,patients
R3642 T5660 T5659 pobj ADHD,with
R3643 T5661 T5662 punct [,37
R3644 T5548 T5546 acl prepared,slices
R3645 T5662 T5653 parataxis 37,activity
R3646 T5663 T5662 punct ],37
R3647 T5664 T5634 cc and,associated
R3648 T5549 T5548 prep from,prepared
R3649 T5665 T5666 det a,correlation
R3650 T5666 T5669 nsubjpass correlation,reported
R3651 T5667 T5666 amod strong,correlation
R3652 T5550 T5551 nmod D2R,mice
R3653 T5668 T5666 amod inverse,correlation
R3654 T5551 T5549 pobj mice,from
R3655 T5552 T5550 punct -,D2R
R3658 T5553 T5550 punct /,D2R
R3662 T5554 T5550 punct -,D2R
R3665 T5555 T5541 auxpass is,associated
R3668 T5556 T5541 prep with,associated
R3669 T5678 T5679 punct [,22
R3670 T5679 T5669 parataxis 22,reported
R3671 T5557 T5558 amod enhanced,EPSP
R3672 T5680 T5679 punct ],22
R3673 T5681 T5669 punct .,reported
R3674 T5558 T5556 pobj EPSP,with
R3675 T5683 T5684 advmod Importantly,indicate
R3676 T5559 T5558 cc and,EPSP
R3677 T5685 T5684 punct ", ",indicate
R3678 T5686 T5687 poss our,data
R3679 T5560 T5561 prep as,efficacy
R3680 T5687 T5684 nsubj data,indicate
R3681 T5688 T5689 mark that,are
R3682 T5561 T5558 conj efficacy,EPSP
R3683 T5689 T5684 ccomp are,indicate
R3684 T5690 T5691 det the,performances
R3685 T5691 T5689 nsubj performances,are
R3686 T5562 T5563 det a,result
R3687 T5692 T5691 amod poor,performances
R3688 T5693 T5691 acl displayed,performances
R3689 T5694 T5693 agent by,displayed
R3690 T5695 T5696 det the,mice
R3691 T5696 T5694 pobj mice,by
R3692 T5563 T5560 pobj result,as
R3693 T5697 T5696 nmod D2R,mice
R3694 T5698 T5697 punct -,D2R
R3695 T5564 T5561 amod increased,efficacy
R3696 T5699 T5697 punct /,D2R
R3697 T5700 T5697 punct -,D2R
R3698 T5701 T5689 attr manifestations,are
R3699 T5565 T5561 amod striatal,efficacy
R3700 T5702 T5701 prep of,manifestations
R3701 T5703 T5704 compound reversal,learning
R3702 T5704 T5705 compound learning,deficits
R3703 T5566 T5561 amod synaptic,efficacy
R3704 T5705 T5702 pobj deficits,of
R3705 T5706 T5701 cc and,manifestations
R3706 T5707 T5706 neg not,and
R3707 T5567 T5534 punct .,demonstrated
R3708 T5708 T5709 amod gross,impairments
R3709 T5709 T5701 conj impairments,manifestations
R3710 T5569 T5570 prep In,resulted
R3711 T5571 T5569 pobj contrast,In
R3714 T5572 T5570 punct ", ",resulted
R3715 T5712 T5710 conj sensory,motivational
R3717 T5573 T5570 nsubj stimulation,resulted
R3718 T5715 T5716 nsubj We,argue
R3719 T5574 T5573 prep of,stimulation
R3720 T5717 T5716 advmod therefore,argue
R3721 T5718 T5719 mark that,participate
R3722 T5719 T5716 ccomp participate,argue
R3723 T5575 T5576 amod dorsal,slices
R3724 T5720 T5719 nsubj D2Rs,participate
R3725 T5721 T5719 prep in,participate
R3726 T5576 T5574 pobj slices,of
R3727 T5722 T5721 pcomp signaling,in
R3728 T5723 T5722 cc or,signaling
R3729 T5724 T5722 conj alerting,signaling
R3730 T5577 T5576 compound striatum,slices
R3731 T5725 T5726 det the,organism
R3732 T5726 T5724 dobj organism,alerting
R3733 T5727 T5726 prep of,organism
R3734 T5578 T5573 prep from,stimulation
R3735 T5728 T5729 compound learning,contingency
R3736 T5729 T5730 compound contingency,changes
R3737 T5730 T5727 pobj changes,of
R3738 T5579 T5580 amod wild,type
R3739 T5731 T5724 prep during,alerting
R3740 T5732 T5733 compound reversal,learning
R3741 T5580 T5582 compound type,mice
R3742 T5733 T5731 pobj learning,during
R3743 T5734 T5719 cc and,participate
R3744 T5735 T5719 conj sculpt,participate
R3745 T5736 T5737 amod ongoing,behavior
R3746 T5737 T5735 dobj behavior,sculpt
R3747 T5738 T5739 npadvmod goal,directed
R3748 T5581 T5580 punct -,type
R3749 T5739 T5737 amod directed,behavior
R3750 T5740 T5739 punct -,directed
R3751 T5741 T5716 punct .,argue
R3752 T5582 T5578 pobj mice,from
R3753 T5583 T5570 prep in,resulted
R3754 T5584 T5585 compound IPSP,activity
R3755 T5585 T5583 pobj activity,in
R3756 T5586 T5585 punct ", ",activity
R3757 T5587 T5588 amod long,term
R3758 T5588 T5590 compound term,depression
R3759 T5589 T5588 punct -,term
R3760 T5590 T5585 conj depression,activity
R3761 T5591 T5590 punct ", ",depression
R3762 T5592 T5590 cc and,depression
R3763 T5593 T5594 amod decreased,activity
R3764 T5594 T5590 conj activity,depression
R3765 T5595 T5594 amod neuronal,activity
R3766 T5596 T5594 prep of,activity
R3767 T5597 T5598 amod striatal,efferents
R3768 T5598 T5596 pobj efferents,of
R3769 T5599 T5600 punct [,34
R3770 T5600 T5570 parataxis 34,resulted
R3771 T5601 T5600 punct ],34
R3772 T5602 T5570 punct .,resulted
R3383 T5359 T5357 nsubj dopamine,modulates
R3712 T5710 T5709 amod motivational,impairments
R3713 T5711 T5710 cc or,motivational
R3716 T5713 T5684 punct .,indicate
R3374 T5351 T5350 amod discriminative,stimulus
R3382 T5358 T5359 amod mesolimbic,dopamine
R3656 T5669 T5634 conj reported,associated
R3657 T5670 T5666 prep of,correlation
R3659 T5671 T5672 compound D2R,binding
R3660 T5672 T5670 pobj binding,of
R3661 T5673 T5666 prep with,correlation
R3663 T5674 T5675 amod compulsive,behavior
R3664 T5675 T5673 pobj behavior,with
R3666 T5676 T5669 aux has,reported
R3667 T5677 T5669 auxpass been,reported

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3914 19-22 PR_EXT:000001177 denotes D2R
T3915 22-23 SO_EXT:sequence_nullness_or_absence denotes -
T3916 24-25 SO_EXT:sequence_nullness_or_absence denotes -
T3917 26-30 NCBITaxon:10088 denotes mice
T3918 47-55 GO:0007612 denotes learning
T3919 90-98 CHEBI:18243 denotes dopamine
T3920 90-102 PR_EXT:000001177 denotes dopamine D2R
T3921 112-121 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3922 141-151 GO_PATO_EXT:biological_behavior denotes behavioral
T3923 178-188 GO_PATO_EXT:biological_behavior denotes behavioral
T3924 216-219 PR_EXT:000001177 denotes D2R
T3925 219-220 SO_EXT:sequence_nullness_or_absence denotes -
T3926 221-222 SO_EXT:sequence_nullness_or_absence denotes -
T3927 223-227 NCBITaxon:10088 denotes mice
T3928 240-243 PR_EXT:000001177 denotes D2R
T3929 243-244 SO_EXT:normal_or_wild_type_or_present denotes +
T3930 245-246 SO_EXT:normal_or_wild_type_or_present denotes +
T3931 247-251 NCBITaxon:10088 denotes mice
T3932 268-276 GO:0007612 denotes learning
T3933 438-441 PR_EXT:000001177 denotes D2R
T3934 441-442 SO_EXT:sequence_nullness_or_absence denotes -
T3935 443-444 SO_EXT:sequence_nullness_or_absence denotes -
T3936 445-449 NCBITaxon:10088 denotes mice
T3937 450-457 GO_EXT:reaction_or_response denotes respond
T3938 461-465 CHEBI_EXT:33290 denotes food
T3939 555-558 PR_EXT:000001175 denotes D1R
T3940 568-576 GO_PATO_EXT:biological_behavior denotes behavior
T3941 590-593 PR_EXT:000001177 denotes D2R
T3942 593-594 SO_EXT:normal_or_wild_type_or_present denotes +
T3943 595-596 SO_EXT:normal_or_wild_type_or_present denotes +
T3944 597-601 NCBITaxon:10088 denotes mice
T3945 659-667 CHEBI:18243 denotes dopamine
T3946 659-672 PR_EXT:000001175 denotes dopamine D1Rs
T3954 1197-1201 NCBITaxon:10088 denotes mice
T3955 1264-1274 GO_EXT:reaction_or_response denotes responding
T3956 1345-1353 CHEBI:18243 denotes dopamine
T3957 1373-1381 CHEBI:18243 denotes dopamine
T3958 1373-1385 PR_EXT:000001177 denotes dopamine D2R
T3959 1395-1404 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3960 1406-1415 GO:0065007 denotes modulates
T3961 1570-1578 CHEBI:18243 denotes dopamine
T3962 1570-1584 CL:0000700 denotes dopamine cells
T3963 1579-1584 CL_GO_EXT:cell denotes cells
T3964 1648-1668 GO:0008306 denotes associative learning
T3965 1715-1727 CHEBI:18243 denotes dopaminergic
T3966 1715-1733 CL:0000700 denotes dopaminergic cells
T3967 1728-1733 CL_GO_EXT:cell denotes cells
T3968 1857-1869 CHEBI:18243 denotes dopaminergic
T3969 1857-1874 CL:0000700 denotes dopaminergic cell
T3970 1870-1874 CL_GO_EXT:cell denotes cell
T3971 1870-1885 GO:0001775 denotes cell activation
T3972 1889-1897 GO_EXT:reaction_or_response denotes response
T3973 1983-1992 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T3974 2066-2069 PR_EXT:000001177 denotes D2R
T3975 2069-2070 SO_EXT:sequence_nullness_or_absence denotes -
T3976 2071-2072 SO_EXT:sequence_nullness_or_absence denotes -
T3977 2073-2077 NCBITaxon:10088 denotes mice
T3978 2088-2098 GO_EXT:reaction_or_response denotes responding
T3979 2153-2161 CHEBI:18243 denotes dopamine
T3980 2153-2165 PR_EXT:000001177 denotes dopamine D2R
T3981 2213-2230 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling cascade
T3982 2294-2303 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3983 2316-2324 CHEBI:18243 denotes dopamine
T3984 2316-2329 PR_EXT:000001177 denotes dopamine D2Rs
T3985 2336-2339 PR_EXT:000001175 denotes D1R
T3986 2438-2453 UBERON:0005382 denotes dorsal striatum
T3987 2475-2478 PR_EXT:000001177 denotes D2R
T3988 2478-2479 SO_EXT:sequence_nullness_or_absence denotes -
T3989 2480-2481 SO_EXT:sequence_nullness_or_absence denotes -
T3990 2482-2486 NCBITaxon:10088 denotes mice
T3991 2546-2554 UBERON:0002435 denotes striatal
T3992 2555-2563 GO:0045202 denotes synaptic
T3993 2602-2617 UBERON:0005382 denotes dorsal striatum
T3994 2630-2639 SO_EXT:wild_type_entity_or_quality denotes wild-type
T3995 2640-2644 NCBITaxon:10088 denotes mice
T3996 2708-2716 CL:0000540 denotes neuronal
T3997 2729-2737 UBERON:0002435 denotes striatal
T3998 2738-2747 UBERON:0006798 denotes efferents
T3999 2804-2812 CHEBI:18243 denotes dopamine
T4000 2804-2816 PR_EXT:000001177 denotes dopamine D2R
T4001 2836-2844 UBERON:0002435 denotes striatum
T4002 2902-2911 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T4003 2950-2958 GO_PATO_EXT:biological_behavior denotes behavior
T4004 2999-3014 UBERON:0005382 denotes dorsal striatum
T4005 3018-3025 NCBITaxon:9989 denotes rodents
T4006 3056-3063 UBERON:0001873 denotes caudate
T4007 3127-3130 PR_EXT:000001177 denotes D2R
T4008 3131-3138 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T4009 3155-3163 GO_PATO_EXT:biological_behavior denotes behavior
T4010 3263-3266 PR_EXT:000001177 denotes D2R
T4011 3266-3267 SO_EXT:sequence_nullness_or_absence denotes -
T4012 3268-3269 SO_EXT:sequence_nullness_or_absence denotes -
T4013 3270-3274 NCBITaxon:10088 denotes mice
T4014 3306-3314 GO:0007612 denotes learning
T4015 3354-3361 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T4016 3399-3403 PR_EXT:000001177 denotes D2Rs
T4017 3419-3428 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T4018 3445-3453 NCBITaxon:1 denotes organism
T4019 3457-3465 GO:0007612 denotes learning
T4020 3502-3510 GO:0007612 denotes learning
T4021 3535-3543 GO_EXT:biological_direction_or_guidance denotes directed
T4022 3544-3552 GO_PATO_EXT:biological_behavior denotes behavior
T3947 680-684 NCBITaxon:10088 denotes mice
T3948 889-897 GO:0007612 denotes learning
T3949 1073-1079 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3950 1080-1084 NCBITaxon:10088 denotes mice
T3951 1190-1193 PR_EXT:000001177 denotes D2R
T3952 1193-1194 SO_EXT:sequence_nullness_or_absence denotes -
T3953 1195-1196 SO_EXT:sequence_nullness_or_absence denotes -

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3670 19-22 PR:000001177 denotes D2R
T3671 26-30 NCBITaxon:10088 denotes mice
T3672 47-55 GO:0007612 denotes learning
T3673 90-98 CHEBI:18243 denotes dopamine
T3674 90-102 PR:000001177 denotes dopamine D2R
T3675 216-219 PR:000001177 denotes D2R
T3676 223-227 NCBITaxon:10088 denotes mice
T3677 240-243 PR:000001177 denotes D2R
T3678 247-251 NCBITaxon:10088 denotes mice
T3679 268-276 GO:0007612 denotes learning
T3680 438-441 PR:000001177 denotes D2R
T3681 445-449 NCBITaxon:10088 denotes mice
T3682 461-465 CHEBI:33290 denotes food
T3683 555-558 PR:000001175 denotes D1R
T3684 590-593 PR:000001177 denotes D2R
T3685 597-601 NCBITaxon:10088 denotes mice
T3686 659-667 CHEBI:18243 denotes dopamine
T3687 659-672 PR:000001175 denotes dopamine D1Rs
T3688 680-684 NCBITaxon:10088 denotes mice
T3689 889-897 GO:0007612 denotes learning
T3690 1080-1084 NCBITaxon:10088 denotes mice
T3691 1190-1193 PR:000001177 denotes D2R
T3692 1197-1201 NCBITaxon:10088 denotes mice
T3693 1345-1353 CHEBI:18243 denotes dopamine
T3694 1373-1381 CHEBI:18243 denotes dopamine
T3695 1373-1385 PR:000001177 denotes dopamine D2R
T3696 1406-1415 GO:0065007 denotes modulates
T3697 1570-1578 CHEBI:18243 denotes dopamine
T3698 1570-1584 CL:0000700 denotes dopamine cells
T3699 1648-1668 GO:0008306 denotes associative learning
T3700 1715-1727 CHEBI:18243 denotes dopaminergic
T3701 1715-1733 CL:0000700 denotes dopaminergic cells
T3702 1857-1869 CHEBI:18243 denotes dopaminergic
T3703 1857-1874 CL:0000700 denotes dopaminergic cell
T3704 1870-1885 GO:0001775 denotes cell activation
T3705 2066-2069 PR:000001177 denotes D2R
T3706 2073-2077 NCBITaxon:10088 denotes mice
T3707 2153-2161 CHEBI:18243 denotes dopamine
T3708 2153-2165 PR:000001177 denotes dopamine D2R
T3709 2316-2324 CHEBI:18243 denotes dopamine
T3710 2316-2329 PR:000001177 denotes dopamine D2Rs
T3711 2336-2339 PR:000001175 denotes D1R
T3712 2438-2453 UBERON:0005382 denotes dorsal striatum
T3713 2475-2478 PR:000001177 denotes D2R
T3714 2482-2486 NCBITaxon:10088 denotes mice
T3715 2546-2554 UBERON:0002435 denotes striatal
T3728 3127-3130 PR:000001177 denotes D2R
T3729 3263-3266 PR:000001177 denotes D2R
T3730 3270-3274 NCBITaxon:10088 denotes mice
T3731 3306-3314 GO:0007612 denotes learning
T3732 3399-3403 PR:000001177 denotes D2Rs
T3733 3445-3453 NCBITaxon:1 denotes organism
T3716 2555-2563 GO:0045202 denotes synaptic
T3717 2602-2617 UBERON:0005382 denotes dorsal striatum
T3718 2640-2644 NCBITaxon:10088 denotes mice
T3719 2708-2716 CL:0000540 denotes neuronal
T3720 2729-2737 UBERON:0002435 denotes striatal
T3721 2738-2747 UBERON:0006798 denotes efferents
T3722 2804-2812 CHEBI:18243 denotes dopamine
T3723 2804-2816 PR:000001177 denotes dopamine D2R
T3724 2836-2844 UBERON:0002435 denotes striatum
T3725 2999-3014 UBERON:0005382 denotes dorsal striatum
T3726 3018-3025 NCBITaxon:9989 denotes rodents
T3727 3056-3063 UBERON:0001873 denotes caudate
T3734 3457-3465 GO:0007612 denotes learning
T3735 3502-3510 GO:0007612 denotes learning

2_test

Id Subject Object Predicate Lexical cue
15061865-12629161-12857752 578-579 12629161 denotes 6
15061865-12649484-12857753 1676-1678 12649484 denotes 33
15061865-11257908-12857754 1828-1830 11257908 denotes 14
15061865-11257908-12857755 1965-1967 11257908 denotes 14
15061865-9169514-12857756 2393-2395 9169514 denotes 34
15061865-9169514-12857757 2749-2751 9169514 denotes 34
15061865-11264457-12857758 2779-2781 11264457 denotes 35
15061865-11144344-12857759 3027-3029 11144344 denotes 36
15061865-10742158-12857760 3087-3089 10742158 denotes 37
15061865-10484959-12857761 3183-3185 10484959 denotes 22