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PMC:400732 / 14478-16698 JSONTXT

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Id Subject Object Predicate Lexical cue
T4537 0-4 IN denotes That
T4538 28-40 VBZ denotes orchestrates
T4539 5-8 NN denotes D2R
T4540 9-17 VBN denotes mediated
T4541 8-9 HYPH denotes -
T4542 18-27 NN denotes signaling
T4543 75-77 VBZ denotes is
T4544 41-45 RB denotes just
T4545 52-62 NNS denotes components
T4547 63-65 IN denotes of
T4548 66-74 NN denotes learning
T4549 78-79 DT denotes a
T4550 80-90 NN denotes conclusion
T4551 91-95 WDT denotes that
T4552 96-98 VBZ denotes is
T4553 99-110 RB denotes potentially
T4554 111-117 VBN denotes biased
T4555 118-121 IN denotes due
T4556 122-124 IN denotes to
T4557 125-128 DT denotes the
T4558 129-137 NN denotes practice
T4559 138-140 IN denotes of
T4560 141-149 VBG denotes avoiding
T4561 150-155 NNS denotes doses
T4562 156-158 IN denotes of
T4563 159-164 NNS denotes drugs
T4564 165-169 WDT denotes that
T4565 170-176 VBP denotes induce
T4566 177-186 NN denotes catalepsy
T4567 187-188 -LRB- denotes (
T4568 188-191 CC denotes and
T4569 192-201 RB denotes therefore
T4570 202-211 VBG denotes measuring
T4571 212-216 RB denotes only
T4572 225-233 NN denotes blockade
T4573 217-224 JJ denotes partial
T4574 234-236 IN denotes of
T4575 237-245 NN denotes dopamine
T4576 246-250 NNS denotes D2Rs
T4577 250-251 -RRB- denotes )
T4578 252-255 CC denotes and
T4579 256-262 JJ denotes single
T4580 263-278 NNS denotes administrations
T4581 279-280 -LRB- denotes [
T4582 286-287 CD denotes 3
T4583 280-284 FW denotes e.g.
T4584 285-286 -LRB- denotes [
T4585 287-288 -RRB- denotes ]
T4586 288-289 -RRB- denotes ]
T4587 289-290 . denotes .
T4588 290-434 sentence denotes Quite possibly, the functional role of D2Rs in associative learning might be masked because of this concern about locomotor disruption [2,6,8].
T4589 291-296 RB denotes Quite
T4590 297-305 RB denotes possibly
T4591 368-374 VBN denotes masked
T4592 305-307 , denotes ,
T4593 307-310 DT denotes the
T4594 322-326 NN denotes role
T4595 311-321 JJ denotes functional
T4596 327-329 IN denotes of
T4597 330-334 NNS denotes D2Rs
T4598 335-337 IN denotes in
T4599 338-349 JJ denotes associative
T4600 350-358 NN denotes learning
T4601 359-364 MD denotes might
T4602 365-367 VB denotes be
T4603 375-382 RB denotes because
T4604 383-385 IN denotes of
T4605 386-390 DT denotes this
T4606 391-398 NN denotes concern
T4607 399-404 IN denotes about
T4608 405-414 NN denotes locomotor
T4609 415-425 NN denotes disruption
T4610 426-427 -LRB- denotes [
T4611 431-432 CD denotes 8
T4612 427-428 CD denotes 2
T4613 428-429 , denotes ,
T4614 429-430 CD denotes 6
T4615 430-431 , denotes ,
T4616 432-433 -RRB- denotes ]
T4617 433-434 . denotes .
T4618 434-602 sentence denotes Doses of raclopride as low as 0.5 mg/kg significantly disrupt motor behavior [25], although this peripheral dose is consistently used in learning paradigms [e.g. [6]].
T4619 435-440 NNS denotes Doses
T4620 489-496 VBP denotes disrupt
T4621 441-443 IN denotes of
T4622 444-454 NN denotes raclopride
T4623 455-457 RB denotes as
T4624 465-468 CD denotes 0.5
T4625 458-461 JJ denotes low
T4626 462-464 IN denotes as
T4627 469-471 NNS denotes mg
T4628 471-472 SYM denotes /
T4629 472-474 NN denotes kg
T4630 475-488 RB denotes significantly
T4631 497-502 JJ denotes motor
T4632 503-511 NN denotes behavior
T4633 512-513 -LRB- denotes [
T4634 513-515 CD denotes 25
T4635 515-516 -RRB- denotes ]
T4636 516-518 , denotes ,
T4637 518-526 IN denotes although
T4638 564-568 VBN denotes used
T4639 527-531 DT denotes this
T4640 543-547 NN denotes dose
T4641 532-542 JJ denotes peripheral
T4642 548-550 VBZ denotes is
T4643 551-563 RB denotes consistently
T4644 569-571 IN denotes in
T4645 572-580 VBG denotes learning
T4646 581-590 NNS denotes paradigms
T4647 591-592 -LRB- denotes [
T4648 598-599 CD denotes 6
T4649 592-596 FW denotes e.g.
T4650 597-598 -LRB- denotes [
T4651 599-600 -RRB- denotes ]
T4652 600-601 -RRB- denotes ]
T4653 601-602 . denotes .
T4654 602-716 sentence denotes One might then ask: "How then could the role of D2Rs in associative learning be dissociated from motor behavior?"
T4655 603-606 PRP denotes One
T4656 618-621 VB denotes ask
T4657 607-612 MD denotes might
T4658 613-617 RB denotes then
T4659 621-623 : denotes :
T4660 623-624 `` denotes "
T4661 624-627 WRB denotes How
T4662 683-694 VBN denotes dissociated
T4663 628-632 RB denotes then
T4664 633-638 MD denotes could
T4665 639-642 DT denotes the
T4666 643-647 NN denotes role
T4667 648-650 IN denotes of
T4668 651-655 NNS denotes D2Rs
T4669 656-658 IN denotes in
T4670 659-670 JJ denotes associative
T4671 671-679 NN denotes learning
T4672 680-682 VB denotes be
T4673 695-699 IN denotes from
T4674 700-705 JJ denotes motor
T4675 706-714 NN denotes behavior
T4676 714-715 . denotes ?
T4677 715-716 '' denotes "
T4678 716-921 sentence denotes Seminal experiments [26-28] have clearly demonstrated that repeated administration of catalepsy-inducing doses of D2R antagonists in rodents actually leads to a striking behavioral tolerance to catalepsy.
T4679 717-724 JJ denotes Seminal
T4680 725-736 NNS denotes experiments
T4681 758-770 VBN denotes demonstrated
T4682 737-738 -LRB- denotes [
T4683 738-740 CD denotes 26
T4684 740-741 SYM denotes -
T4685 741-743 CD denotes 28
T4686 743-744 -RRB- denotes ]
T4687 745-749 VBP denotes have
T4688 750-757 RB denotes clearly
T4689 771-775 IN denotes that
T4690 867-872 VBZ denotes leads
T4691 776-784 JJ denotes repeated
T4692 785-799 NN denotes administration
T4693 800-802 IN denotes of
T4694 803-812 NN denotes catalepsy
T4695 813-821 VBG denotes inducing
T4696 812-813 HYPH denotes -
T4697 822-827 NNS denotes doses
T4698 828-830 IN denotes of
T4699 831-834 NN denotes D2R
T4700 835-846 NNS denotes antagonists
T4701 847-849 IN denotes in
T4702 850-857 NNS denotes rodents
T4703 858-866 RB denotes actually
T4704 873-875 IN denotes to
T4705 876-877 DT denotes a
T4706 898-907 NN denotes tolerance
T4707 878-886 JJ denotes striking
T4708 887-897 JJ denotes behavioral
T4709 908-910 IN denotes to
T4710 911-920 NN denotes catalepsy
T4711 920-921 . denotes .
T4712 921-997 sentence denotes These doses have been shown to occupy well over 80% of available D2Rs [29].
T4713 922-927 DT denotes These
T4714 928-933 NNS denotes doses
T4715 944-949 VBN denotes shown
T4716 934-938 VBP denotes have
T4717 939-943 VBN denotes been
T4718 950-952 TO denotes to
T4719 953-959 VB denotes occupy
T4720 960-964 RB denotes well
T4721 970-972 CD denotes 80
T4722 965-969 IN denotes over
T4723 972-973 NN denotes %
T4724 974-976 IN denotes of
T4725 977-986 JJ denotes available
T4726 987-991 NNS denotes D2Rs
T4727 992-993 -LRB- denotes [
T4728 993-995 CD denotes 29
T4729 995-996 -RRB- denotes ]
T4730 996-997 . denotes .
T4731 997-1245 sentence denotes Future experiments measuring acquisition of associative learning in rodents that received chronic administration of D2R antagonists and demonstrated behavioral tolerance to their motor disrupting effects would be a logical test of this hypothesis.
T4732 998-1004 JJ denotes Future
T4733 1005-1016 NNS denotes experiments
T4734 1208-1210 VB denotes be
T4735 1017-1026 VBG denotes measuring
T4736 1027-1038 NN denotes acquisition
T4737 1039-1041 IN denotes of
T4738 1042-1053 JJ denotes associative
T4739 1054-1062 NN denotes learning
T4740 1063-1065 IN denotes in
T4741 1066-1073 NNS denotes rodents
T4742 1074-1078 WDT denotes that
T4743 1079-1087 VBD denotes received
T4744 1088-1095 JJ denotes chronic
T4745 1096-1110 NN denotes administration
T4746 1111-1113 IN denotes of
T4747 1114-1117 NN denotes D2R
T4748 1118-1129 NNS denotes antagonists
T4749 1130-1133 CC denotes and
T4750 1134-1146 VBD denotes demonstrated
T4751 1147-1157 JJ denotes behavioral
T4752 1158-1167 NN denotes tolerance
T4753 1168-1170 IN denotes to
T4754 1171-1176 PRP$ denotes their
T4755 1194-1201 NNS denotes effects
T4756 1177-1182 NN denotes motor
T4757 1183-1193 VBG denotes disrupting
T4758 1202-1207 MD denotes would
T4759 1211-1212 DT denotes a
T4760 1221-1225 NN denotes test
T4761 1213-1220 JJ denotes logical
T4762 1226-1228 IN denotes of
T4763 1229-1233 DT denotes this
T4764 1234-1244 NN denotes hypothesis
T4765 1244-1245 . denotes .
T4766 1245-1454 sentence denotes However, the realization that multiple dopamine receptor subtypes would be concurrently targeted with the presently commercially available antagonists, such as D2Rs, D3Rs, and D4Rs would have to be rectified.
T4767 1246-1253 RB denotes However
T4768 1433-1437 VB denotes have
T4769 1253-1255 , denotes ,
T4770 1255-1258 DT denotes the
T4771 1259-1270 NN denotes realization
T4772 1271-1275 IN denotes that
T4773 1334-1342 VBN denotes targeted
T4774 1276-1284 JJ denotes multiple
T4775 1303-1311 NNS denotes subtypes
T4776 1285-1293 NN denotes dopamine
T4777 1294-1302 NN denotes receptor
T4778 1312-1317 MD denotes would
T4779 1318-1320 VB denotes be
T4780 1321-1333 RB denotes concurrently
T4781 1343-1347 IN denotes with
T4782 1348-1351 DT denotes the
T4783 1385-1396 NNS denotes antagonists
T4784 1352-1361 RB denotes presently
T4785 1375-1384 JJ denotes available
T4786 1362-1374 RB denotes commercially
T4787 1396-1398 , denotes ,
T4788 1398-1402 JJ denotes such
T4789 1403-1405 IN denotes as
T4790 1406-1410 NNS denotes D2Rs
T4791 1410-1412 , denotes ,
T4792 1412-1416 NNS denotes D3Rs
T4793 1416-1418 , denotes ,
T4794 1418-1421 CC denotes and
T4795 1422-1426 NNS denotes D4Rs
T4796 1427-1432 MD denotes would
T4797 1438-1440 TO denotes to
T4798 1444-1453 VBN denotes rectified
T4799 1441-1443 VB denotes be
T4800 1453-1454 . denotes .
T4801 1454-1668 sentence denotes We would argue that the most parsimonious approach at this time is to utilize mice that have been genetically altered such that they are lacking one or both functional alleles of the specific receptor of interest.
T4802 1455-1457 PRP denotes We
T4803 1464-1469 VB denotes argue
T4804 1458-1463 MD denotes would
T4805 1470-1474 IN denotes that
T4806 1519-1521 VBZ denotes is
T4807 1475-1478 DT denotes the
T4808 1497-1505 NN denotes approach
T4809 1479-1483 RBS denotes most
T4810 1484-1496 JJ denotes parsimonious
T4811 1506-1508 IN denotes at
T4812 1509-1513 DT denotes this
T4813 1514-1518 NN denotes time
T4814 1522-1524 TO denotes to
T4815 1525-1532 VB denotes utilize
T4816 1533-1537 NNS denotes mice
T4817 1538-1542 WDT denotes that
T4818 1565-1572 VBN denotes altered
T4819 1543-1547 VBP denotes have
T4820 1548-1552 VBN denotes been
T4821 1553-1564 RB denotes genetically
T4822 1573-1577 JJ denotes such
T4823 1592-1599 VBG denotes lacking
T4824 1578-1582 IN denotes that
T4825 1583-1587 PRP denotes they
T4826 1588-1591 VBP denotes are
T4827 1600-1603 CD denotes one
T4828 1623-1630 NNS denotes alleles
T4829 1604-1606 CC denotes or
T4830 1607-1611 DT denotes both
T4831 1612-1622 JJ denotes functional
T4832 1631-1633 IN denotes of
T4833 1634-1637 DT denotes the
T4834 1647-1655 NN denotes receptor
T4835 1638-1646 JJ denotes specific
T4836 1656-1658 IN denotes of
T4837 1659-1667 NN denotes interest
T4838 1667-1668 . denotes .
T4839 1668-2220 sentence denotes While they do have their limitations (e.g. developmental compensation and strain effects in mouse lines not backcrossed adequately to a parental strain for a minimum of 10 generations), use of our inbred (N20 generation) animals in the present study (where no differences in locomotor behavior were detected between D2R-/- and D2R+/+ mice; Figs. 1 &2) revealed a previously unappreciated role of D2R-mediated signaling in associative learning and attention that could not be measured with the currently available, acutely administered D2R antagonists.
T4840 1669-1674 IN denotes While
T4841 1683-1687 VB denotes have
T4842 1675-1679 PRP denotes they
T4843 1680-1682 VBP denotes do
T4844 2021-2029 VBD denotes revealed
T4845 1688-1693 PRP$ denotes their
T4846 1694-1705 NNS denotes limitations
T4847 1706-1707 -LRB- denotes (
T4848 1726-1738 NN denotes compensation
T4849 1707-1711 FW denotes e.g.
T4850 1712-1725 JJ denotes developmental
T4851 1739-1742 CC denotes and
T4852 1743-1749 NN denotes strain
T4853 1750-1757 NNS denotes effects
T4854 1758-1760 IN denotes in
T4855 1761-1766 NN denotes mouse
T4856 1767-1772 NNS denotes lines
T4857 1773-1776 RB denotes not
T4858 1777-1788 VBN denotes backcrossed
T4859 1789-1799 RB denotes adequately
T4860 1800-1802 IN denotes to
T4861 1803-1804 DT denotes a
T4862 1814-1820 NN denotes strain
T4863 1805-1813 JJ denotes parental
T4864 1821-1824 IN denotes for
T4865 1825-1826 DT denotes a
T4866 1827-1834 NN denotes minimum
T4867 1835-1837 IN denotes of
T4868 1838-1840 CD denotes 10
T4869 1841-1852 NNS denotes generations
T4870 1852-1853 -RRB- denotes )
T4871 1853-1855 , denotes ,
T4872 1855-1858 NN denotes use
T4873 1859-1861 IN denotes of
T4874 1862-1865 PRP$ denotes our
T4875 1890-1897 NNS denotes animals
T4876 1866-1872 JJ denotes inbred
T4877 1873-1874 -LRB- denotes (
T4878 1878-1888 NN denotes generation
T4879 1874-1877 NN denotes N20
T4880 1888-1889 -RRB- denotes )
T4881 1898-1900 IN denotes in
T4882 1901-1904 DT denotes the
T4883 1913-1918 NN denotes study
T4884 1905-1912 JJ denotes present
T4885 1919-1920 -LRB- denotes (
T4886 1920-1925 WRB denotes where
T4887 1968-1976 VBN denotes detected
T4888 1926-1928 DT denotes no
T4889 1929-1940 NNS denotes differences
T4890 1941-1943 IN denotes in
T4891 1944-1953 NN denotes locomotor
T4892 1954-1962 NN denotes behavior
T4893 1963-1967 VBD denotes were
T4894 1977-1984 IN denotes between
T4895 1985-1988 NN denotes D2R
T4896 2003-2007 NNS denotes mice
T4897 1988-1989 SYM denotes -
T4898 1989-1990 HYPH denotes /
T4899 1990-1991 SYM denotes -
T4900 1992-1995 CC denotes and
T4901 1996-1999 NN denotes D2R
T4902 1999-2000 SYM denotes +
T4903 2000-2001 HYPH denotes /
T4904 2001-2002 SYM denotes +
T4905 2007-2008 : denotes ;
T4906 2009-2014 NNS denotes Figs.
T4907 2015-2016 CD denotes 1
T4908 2017-2018 CC denotes &
T4909 2018-2019 CD denotes 2
T4910 2019-2020 -RRB- denotes )
T4911 2030-2031 DT denotes a
T4912 2057-2061 NN denotes role
T4913 2032-2042 RB denotes previously
T4914 2043-2056 JJ denotes unappreciated
T4915 2062-2064 IN denotes of
T4916 2065-2068 NN denotes D2R
T4917 2069-2077 VBN denotes mediated
T4918 2068-2069 HYPH denotes -
T4919 2078-2087 NN denotes signaling
T4920 2088-2090 IN denotes in
T4921 2091-2102 JJ denotes associative
T4922 2103-2111 NN denotes learning
T4923 2112-2115 CC denotes and
T4924 2116-2125 NN denotes attention
T4925 2126-2130 WDT denotes that
T4926 2144-2152 VBN denotes measured
T4927 2131-2136 MD denotes could
T4928 2137-2140 RB denotes not
T4929 2141-2143 VB denotes be
T4930 2153-2157 IN denotes with
T4931 2158-2161 DT denotes the
T4932 2208-2219 NNS denotes antagonists
T4933 2162-2171 RB denotes currently
T4934 2172-2181 JJ denotes available
T4935 2181-2183 , denotes ,
T4936 2183-2190 RB denotes acutely
T4937 2191-2203 VBN denotes administered
T4938 2204-2207 NN denotes D2R
T4939 2219-2220 . denotes .
T4546 46-51 JJ denotes motor
R2631 T4537 T4538 mark That,orchestrates
R2632 T4538 T4543 csubj orchestrates,is
R2633 T4539 T4540 npadvmod D2R,mediated
R2634 T4540 T4542 amod mediated,signaling
R2635 T4541 T4540 punct -,mediated
R2636 T4542 T4538 nsubj signaling,orchestrates
R2637 T4544 T4545 advmod just,components
R2638 T4545 T4538 dobj components,orchestrates
R2639 T4546 T4545 amod motor,components
R2640 T4547 T4545 prep of,components
R2641 T4548 T4547 pobj learning,of
R2642 T4549 T4550 det a,conclusion
R2643 T4550 T4543 attr conclusion,is
R2644 T4551 T4552 dep that,is
R2645 T4552 T4550 relcl is,conclusion
R2646 T4553 T4552 advmod potentially,is
R2647 T4554 T4552 acomp biased,is
R2648 T4555 T4552 prep due,is
R2649 T4556 T4555 pcomp to,due
R2650 T4557 T4558 det the,practice
R2651 T4558 T4555 pobj practice,due
R2652 T4559 T4558 prep of,practice
R2653 T4560 T4559 pobj avoiding,of
R2654 T4561 T4560 dobj doses,avoiding
R2655 T4562 T4561 prep of,doses
R2656 T4563 T4562 pobj drugs,of
R2657 T4564 T4565 dep that,induce
R2658 T4565 T4561 relcl induce,doses
R2659 T4566 T4565 dobj catalepsy,induce
R2660 T4567 T4560 punct (,avoiding
R2661 T4568 T4560 cc and,avoiding
R2662 T4569 T4570 advmod therefore,measuring
R2663 T4570 T4560 conj measuring,avoiding
R2664 T4571 T4572 advmod only,blockade
R2665 T4572 T4570 dobj blockade,measuring
R2666 T4573 T4572 amod partial,blockade
R2667 T4574 T4572 prep of,blockade
R2668 T4575 T4576 compound dopamine,D2Rs
R2669 T4576 T4574 pobj D2Rs,of
R2670 T4577 T4560 punct ),avoiding
R2671 T4578 T4560 cc and,avoiding
R2672 T4579 T4580 amod single,administrations
R2673 T4580 T4560 conj administrations,avoiding
R2674 T4581 T4582 punct [,3
R2675 T4582 T4543 parataxis 3,is
R2676 T4583 T4582 advmod e.g.,3
R2677 T4584 T4582 punct [,3
R2678 T4585 T4582 punct ],3
R2679 T4586 T4582 punct ],3
R2680 T4587 T4543 punct .,is
R2681 T4589 T4590 advmod Quite,possibly
R2682 T4590 T4591 advmod possibly,masked
R2683 T4592 T4591 punct ", ",masked
R2684 T4593 T4594 det the,role
R2685 T4594 T4591 nsubjpass role,masked
R2686 T4595 T4594 amod functional,role
R2687 T4596 T4594 prep of,role
R2688 T4597 T4596 pobj D2Rs,of
R2689 T4598 T4594 prep in,role
R2690 T4599 T4600 amod associative,learning
R2691 T4600 T4598 pobj learning,in
R2692 T4601 T4591 aux might,masked
R2693 T4602 T4591 auxpass be,masked
R2694 T4603 T4604 advmod because,of
R2695 T4604 T4591 prep of,masked
R2696 T4605 T4606 det this,concern
R2697 T4606 T4604 pobj concern,of
R2698 T4607 T4606 prep about,concern
R2699 T4608 T4609 compound locomotor,disruption
R2700 T4609 T4607 pobj disruption,about
R2701 T4610 T4611 punct [,8
R2702 T4611 T4591 parataxis 8,masked
R2703 T4612 T4611 nummod 2,8
R2704 T4613 T4611 punct ",",8
R2705 T4614 T4611 nummod 6,8
R2706 T4615 T4611 punct ",",8
R2707 T4616 T4611 punct ],8
R2708 T4617 T4591 punct .,masked
R2709 T4619 T4620 nsubj Doses,disrupt
R2710 T4621 T4619 prep of,Doses
R2711 T4622 T4621 pobj raclopride,of
R2712 T4623 T4624 advmod as,0.5
R2713 T4624 T4627 nummod 0.5,mg
R2714 T4625 T4624 amod low,0.5
R2715 T4626 T4624 quantmod as,0.5
R2716 T4627 T4619 appos mg,Doses
R2717 T4628 T4629 punct /,kg
R2718 T4629 T4627 prep kg,mg
R2719 T4630 T4620 advmod significantly,disrupt
R2720 T4631 T4632 amod motor,behavior
R2721 T4632 T4620 dobj behavior,disrupt
R2722 T4633 T4634 punct [,25
R2723 T4634 T4620 parataxis 25,disrupt
R2724 T4635 T4634 punct ],25
R2725 T4636 T4620 punct ", ",disrupt
R2726 T4637 T4638 mark although,used
R2727 T4638 T4620 advcl used,disrupt
R2728 T4639 T4640 det this,dose
R2729 T4640 T4638 nsubjpass dose,used
R2730 T4641 T4640 amod peripheral,dose
R2731 T4642 T4638 auxpass is,used
R2732 T4643 T4638 advmod consistently,used
R2733 T4644 T4638 prep in,used
R2734 T4645 T4646 amod learning,paradigms
R2735 T4646 T4644 pobj paradigms,in
R2736 T4647 T4648 punct [,6
R2737 T4648 T4638 parataxis 6,used
R2738 T4649 T4648 advmod e.g.,6
R2739 T4650 T4648 punct [,6
R2740 T4651 T4648 punct ],6
R2741 T4652 T4648 punct ],6
R2742 T4653 T4620 punct .,disrupt
R2743 T4655 T4656 nsubj One,ask
R2744 T4657 T4656 aux might,ask
R2745 T4658 T4656 advmod then,ask
R2746 T4659 T4656 punct : ,ask
R2747 T4660 T4656 punct """",ask
R2748 T4661 T4662 advmod How,dissociated
R2749 T4662 T4656 ccomp dissociated,ask
R2750 T4663 T4662 advmod then,dissociated
R2751 T4664 T4662 aux could,dissociated
R2752 T4665 T4666 det the,role
R2753 T4666 T4662 nsubjpass role,dissociated
R2754 T4667 T4666 prep of,role
R2755 T4668 T4667 pobj D2Rs,of
R2756 T4669 T4666 prep in,role
R2757 T4670 T4671 amod associative,learning
R2758 T4671 T4669 pobj learning,in
R2759 T4672 T4662 auxpass be,dissociated
R2760 T4673 T4662 prep from,dissociated
R2761 T4674 T4675 amod motor,behavior
R2762 T4675 T4673 pobj behavior,from
R2763 T4676 T4656 punct ?,ask
R2764 T4677 T4656 punct """",ask
R2765 T4679 T4680 amod Seminal,experiments
R2766 T4680 T4681 nsubj experiments,demonstrated
R2767 T4682 T4683 punct [,26
R2768 T4683 T4680 parataxis 26,experiments
R2769 T4684 T4685 punct -,28
R2770 T4685 T4683 prep 28,26
R2771 T4686 T4683 punct ],26
R2772 T4687 T4681 aux have,demonstrated
R2773 T4688 T4681 advmod clearly,demonstrated
R2774 T4689 T4690 mark that,leads
R2775 T4690 T4681 ccomp leads,demonstrated
R2776 T4691 T4692 amod repeated,administration
R2777 T4692 T4690 nsubj administration,leads
R2778 T4693 T4692 prep of,administration
R2779 T4694 T4695 npadvmod catalepsy,inducing
R2780 T4695 T4697 amod inducing,doses
R2781 T4696 T4695 punct -,inducing
R2782 T4697 T4693 pobj doses,of
R2783 T4698 T4697 prep of,doses
R2784 T4699 T4700 compound D2R,antagonists
R2785 T4700 T4698 pobj antagonists,of
R2786 T4701 T4692 prep in,administration
R2787 T4702 T4701 pobj rodents,in
R2788 T4703 T4690 advmod actually,leads
R2789 T4704 T4690 prep to,leads
R2790 T4705 T4706 det a,tolerance
R2791 T4706 T4704 pobj tolerance,to
R2792 T4707 T4706 amod striking,tolerance
R2793 T4708 T4706 amod behavioral,tolerance
R2794 T4709 T4706 prep to,tolerance
R2795 T4710 T4709 pobj catalepsy,to
R2796 T4711 T4681 punct .,demonstrated
R2797 T4713 T4714 det These,doses
R2798 T4714 T4715 nsubjpass doses,shown
R2799 T4716 T4715 aux have,shown
R2800 T4717 T4715 auxpass been,shown
R2801 T4718 T4719 aux to,occupy
R2802 T4719 T4715 xcomp occupy,shown
R2803 T4720 T4721 advmod well,80
R2804 T4721 T4723 nummod 80,%
R2805 T4722 T4721 quantmod over,80
R2806 T4723 T4719 dobj %,occupy
R2807 T4724 T4723 prep of,%
R2808 T4725 T4726 amod available,D2Rs
R2809 T4726 T4724 pobj D2Rs,of
R2810 T4727 T4728 punct [,29
R2811 T4728 T4715 parataxis 29,shown
R2812 T4729 T4728 punct ],29
R2813 T4730 T4715 punct .,shown
R2814 T4732 T4733 amod Future,experiments
R2815 T4733 T4734 nsubj experiments,be
R2816 T4735 T4733 acl measuring,experiments
R2817 T4736 T4735 dobj acquisition,measuring
R2818 T4737 T4736 prep of,acquisition
R2819 T4738 T4739 amod associative,learning
R2820 T4739 T4737 pobj learning,of
R2821 T4740 T4735 prep in,measuring
R2822 T4741 T4740 pobj rodents,in
R2823 T4742 T4743 dep that,received
R2824 T4743 T4741 relcl received,rodents
R2825 T4744 T4745 amod chronic,administration
R2826 T4745 T4743 dobj administration,received
R2827 T4746 T4745 prep of,administration
R2828 T4747 T4748 compound D2R,antagonists
R2829 T4748 T4746 pobj antagonists,of
R2830 T4749 T4743 cc and,received
R2831 T4750 T4743 conj demonstrated,received
R2832 T4751 T4752 amod behavioral,tolerance
R2833 T4752 T4750 dobj tolerance,demonstrated
R2834 T4753 T4752 prep to,tolerance
R2835 T4754 T4755 poss their,effects
R2836 T4755 T4753 pobj effects,to
R2837 T4756 T4755 nmod motor,effects
R2838 T4757 T4755 amod disrupting,effects
R2839 T4758 T4734 aux would,be
R2840 T4759 T4760 det a,test
R2841 T4760 T4734 attr test,be
R2842 T4761 T4760 amod logical,test
R2843 T4762 T4760 prep of,test
R2844 T4763 T4764 det this,hypothesis
R2845 T4764 T4762 pobj hypothesis,of
R2846 T4765 T4734 punct .,be
R2847 T4767 T4768 advmod However,have
R2848 T4769 T4768 punct ", ",have
R2849 T4770 T4771 det the,realization
R2850 T4771 T4768 nsubj realization,have
R2851 T4772 T4773 mark that,targeted
R2852 T4773 T4771 acl targeted,realization
R2853 T4774 T4775 amod multiple,subtypes
R2854 T4775 T4773 nsubjpass subtypes,targeted
R2855 T4776 T4777 compound dopamine,receptor
R2856 T4777 T4775 compound receptor,subtypes
R2857 T4778 T4773 aux would,targeted
R2858 T4863 T4862 amod parental,strain
R2859 T4779 T4773 auxpass be,targeted
R2860 T4864 T4858 prep for,backcrossed
R2861 T4780 T4773 advmod concurrently,targeted
R2862 T4865 T4866 det a,minimum
R2863 T4866 T4864 pobj minimum,for
R2864 T4867 T4866 prep of,minimum
R2865 T4781 T4773 prep with,targeted
R2866 T4868 T4869 nummod 10,generations
R2867 T4869 T4867 pobj generations,of
R2868 T4782 T4783 det the,antagonists
R2869 T4870 T4848 punct ),compensation
R2870 T4871 T4844 punct ", ",revealed
R2871 T4872 T4844 nsubj use,revealed
R2872 T4783 T4781 pobj antagonists,with
R2873 T4873 T4872 prep of,use
R2874 T4874 T4875 poss our,animals
R2875 T4875 T4873 pobj animals,of
R2876 T4784 T4785 advmod presently,available
R2877 T4876 T4875 amod inbred,animals
R2878 T4877 T4878 punct (,generation
R2879 T4785 T4783 amod available,antagonists
R2880 T4878 T4875 parataxis generation,animals
R2881 T4879 T4878 compound N20,generation
R2882 T4880 T4878 punct ),generation
R2883 T4786 T4785 advmod commercially,available
R2884 T4881 T4872 prep in,use
R2885 T4882 T4883 det the,study
R2886 T4883 T4881 pobj study,in
R2887 T4787 T4783 punct ", ",antagonists
R2888 T4884 T4883 amod present,study
R2889 T4885 T4883 punct (,study
R2890 T4886 T4887 advmod where,detected
R2891 T4788 T4789 amod such,as
R2892 T4887 T4883 relcl detected,study
R2893 T4888 T4889 det no,differences
R2894 T4789 T4783 prep as,antagonists
R2895 T4889 T4887 nsubjpass differences,detected
R2896 T4890 T4889 prep in,differences
R2897 T4891 T4892 compound locomotor,behavior
R2898 T4790 T4789 pobj D2Rs,as
R2899 T4892 T4890 pobj behavior,in
R2900 T4791 T4790 punct ", ",D2Rs
R2901 T4893 T4887 auxpass were,detected
R2902 T4894 T4887 prep between,detected
R2903 T4895 T4896 nmod D2R,mice
R2904 T4792 T4790 conj D3Rs,D2Rs
R2905 T4896 T4894 pobj mice,between
R2906 T4793 T4792 punct ", ",D3Rs
R2907 T4897 T4895 punct -,D2R
R2908 T4898 T4895 punct /,D2R
R2909 T4794 T4792 cc and,D3Rs
R2910 T4899 T4895 punct -,D2R
R2911 T4900 T4895 cc and,D2R
R2912 T4901 T4895 conj D2R,D2R
R2913 T4902 T4901 punct +,D2R
R2914 T4903 T4901 punct /,D2R
R2915 T4795 T4792 conj D4Rs,D3Rs
R2916 T4904 T4901 punct +,D2R
R2917 T4905 T4906 punct ;,Figs.
R2918 T4906 T4872 parataxis Figs.,use
R2919 T4796 T4768 aux would,have
R2920 T4907 T4906 nummod 1,Figs.
R2921 T4908 T4906 cc &,Figs.
R2922 T4797 T4798 aux to,rectified
R2923 T4909 T4906 conj 2,Figs.
R2924 T4910 T4906 punct ),Figs.
R2925 T4911 T4912 det a,role
R2926 T4798 T4768 xcomp rectified,have
R2927 T4912 T4844 dobj role,revealed
R2928 T4913 T4914 advmod previously,unappreciated
R2929 T4914 T4912 amod unappreciated,role
R2930 T4799 T4798 auxpass be,rectified
R2931 T4915 T4912 prep of,role
R2932 T4916 T4917 npadvmod D2R,mediated
R2933 T4800 T4768 punct .,have
R2934 T4917 T4919 amod mediated,signaling
R2935 T4918 T4917 punct -,mediated
R2936 T4919 T4915 pobj signaling,of
R2937 T4802 T4803 nsubj We,argue
R2938 T4920 T4912 prep in,role
R2939 T4921 T4922 amod associative,learning
R2940 T4922 T4920 pobj learning,in
R2941 T4923 T4922 cc and,learning
R2942 T4804 T4803 aux would,argue
R2943 T4924 T4922 conj attention,learning
R2944 T4925 T4926 dep that,measured
R2945 T4926 T4912 relcl measured,role
R2946 T4805 T4806 mark that,is
R2947 T4927 T4926 aux could,measured
R2948 T4928 T4926 neg not,measured
R2949 T4929 T4926 auxpass be,measured
R2950 T4806 T4803 ccomp is,argue
R2951 T4930 T4926 prep with,measured
R2952 T4931 T4932 det the,antagonists
R2953 T4807 T4808 det the,approach
R2954 T4932 T4930 pobj antagonists,with
R2955 T4933 T4934 advmod currently,available
R2956 T4934 T4932 amod available,antagonists
R2957 T4808 T4806 nsubj approach,is
R2958 T4935 T4932 punct ", ",antagonists
R2959 T4936 T4937 advmod acutely,administered
R2960 T4809 T4810 advmod most,parsimonious
R2961 T4937 T4932 amod administered,antagonists
R2962 T4938 T4932 compound D2R,antagonists
R2963 T4939 T4844 punct .,revealed
R2966 T4810 T4808 amod parsimonious,approach
R2969 T4811 T4808 prep at,approach
R2972 T4812 T4813 det this,time
R2976 T4813 T4811 pobj time,at
R2979 T4814 T4815 aux to,utilize
R2983 T4815 T4806 xcomp utilize,is
R2987 T4816 T4815 dobj mice,utilize
R2990 T4817 T4818 dep that,altered
R2994 T4818 T4816 relcl altered,mice
R2997 T4819 T4818 aux have,altered
R3001 T4820 T4818 auxpass been,altered
R3002 T4821 T4818 advmod genetically,altered
R3003 T4822 T4823 amod such,lacking
R3004 T4823 T4818 advcl lacking,altered
R3006 T4824 T4823 mark that,lacking
R3009 T4825 T4823 nsubj they,lacking
R3011 T4826 T4823 aux are,lacking
R3013 T4827 T4828 nummod one,alleles
R3021 T4828 T4823 dobj alleles,lacking
R3023 T4829 T4827 cc or,one
R3026 T4830 T4827 conj both,one
R3030 T4831 T4828 amod functional,alleles
R3034 T4832 T4828 prep of,alleles
R3036 T4833 T4834 det the,receptor
R3037 T4834 T4832 pobj receptor,of
R3039 T4835 T4834 amod specific,receptor
R3041 T4836 T4834 prep of,receptor
R3044 T4837 T4836 pobj interest,of
R3048 T4838 T4803 punct .,argue
R3051 T4840 T4841 mark While,have
R3056 T4841 T4844 advcl have,revealed
R3058 T4842 T4841 nsubj they,have
R3062 T4843 T4841 aux do,have
R3064 T4845 T4846 poss their,limitations
R3071 T4846 T4841 dobj limitations,have
R3075 T4847 T4848 punct (,compensation
R3079 T4848 T4846 appos compensation,limitations
R3083 T4849 T4848 advmod e.g.,compensation
R3086 T4850 T4848 amod developmental,compensation
R3087 T4851 T4848 cc and,compensation
R3089 T4852 T4853 compound strain,effects
R3093 T4853 T4848 conj effects,compensation
R3097 T4854 T4848 prep in,compensation
R3101 T4855 T4856 compound mouse,lines
R3105 T4856 T4854 pobj lines,in
R3109 T4857 T4858 neg not,backcrossed
R3111 T4858 T4856 acl backcrossed,lines
R3115 T4859 T4858 advmod adequately,backcrossed
R3122 T4860 T4858 prep to,backcrossed
R3125 T4861 T4862 det a,strain
R3127 T4862 T4860 pobj strain,to

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3823 5-8 PR_EXT:000001177 denotes D2R
T3824 18-27 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3825 46-51 GO_EXT:biological_movement_or_translocation_process denotes motor
T3826 66-74 GO:0007612 denotes learning
T3827 159-164 CHEBI_EXT:23888 denotes drugs
T3828 237-245 CHEBI:18243 denotes dopamine
T3829 237-250 PR_EXT:000001177 denotes dopamine D2Rs
T3830 330-334 PR_EXT:000001177 denotes D2Rs
T3831 338-358 GO:0008306 denotes associative learning
T3832 405-414 GO:0040011 denotes locomotor
T3833 497-502 GO_EXT:biological_movement_or_translocation_process denotes motor
T3834 503-511 GO_PATO_EXT:biological_behavior denotes behavior
T3835 572-580 GO:0007612 denotes learning
T3836 651-655 PR_EXT:000001177 denotes D2Rs
T3837 659-679 GO:0008306 denotes associative learning
T3838 700-705 GO_EXT:biological_movement_or_translocation_process denotes motor
T3839 706-714 GO_PATO_EXT:biological_behavior denotes behavior
T3840 831-834 PR_EXT:000001177 denotes D2R
T3841 835-846 CHEBI_GO_EXT:antagonist denotes antagonists
T3842 850-857 NCBITaxon:9989 denotes rodents
T3843 887-897 GO_PATO_EXT:biological_behavior denotes behavioral
T3844 987-991 PR_EXT:000001177 denotes D2Rs
T3845 1042-1062 GO:0008306 denotes associative learning
T3846 1066-1073 NCBITaxon:9989 denotes rodents
T3847 1114-1117 PR_EXT:000001177 denotes D2R
T3848 1118-1129 CHEBI_GO_EXT:antagonist denotes antagonists
T3849 1147-1157 GO_PATO_EXT:biological_behavior denotes behavioral
T3850 1177-1182 GO_EXT:biological_movement_or_translocation_process denotes motor
T3851 1285-1293 CHEBI:18243 denotes dopamine
T3852 1285-1302 GO_EXT:0004952 denotes dopamine receptor
T3853 1385-1396 CHEBI_GO_EXT:antagonist denotes antagonists
T3854 1406-1410 PR_EXT:000001177 denotes D2Rs
T3855 1412-1416 PR_EXT:000001178 denotes D3Rs
T3856 1422-1426 PR_EXT:000001179 denotes D4Rs
T3857 1533-1537 NCBITaxon:10088 denotes mice
T3858 1553-1564 SO_EXT:0000704 denotes genetically
T3859 1565-1572 SO_EXT:sequence_alteration_process denotes altered
T3860 1623-1630 SO_EXT:0001023 denotes alleles
T3861 1647-1655 GO_EXT:0004872 denotes receptor
T3862 1761-1766 NCBITaxon:10088 denotes mouse
T3863 1890-1897 NCBITaxon:33208 denotes animals
T3864 1944-1962 GO:0007626 denotes locomotor behavior
T3865 1985-1988 PR_EXT:000001177 denotes D2R
T3866 1988-1989 SO_EXT:sequence_nullness_or_absence denotes -
T3867 1990-1991 SO_EXT:sequence_nullness_or_absence denotes -
T3868 1996-1999 PR_EXT:000001177 denotes D2R
T3869 1999-2000 SO_EXT:normal_or_wild_type_or_present denotes +
T3870 2001-2002 SO_EXT:normal_or_wild_type_or_present denotes +
T3871 2003-2007 NCBITaxon:10088 denotes mice
T3872 2065-2068 PR_EXT:000001177 denotes D2R
T3873 2078-2087 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3874 2091-2111 GO:0008306 denotes associative learning
T3875 2204-2207 PR_EXT:000001177 denotes D2R
T3876 2208-2219 CHEBI_GO_EXT:antagonist denotes antagonists

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3609 5-8 PR:000001177 denotes D2R
T3610 66-74 GO:0007612 denotes learning
T3611 159-164 CHEBI:23888 denotes drugs
T3612 237-245 CHEBI:18243 denotes dopamine
T3613 237-250 PR:000001177 denotes dopamine D2Rs
T3614 330-334 PR:000001177 denotes D2Rs
T3615 338-358 GO:0008306 denotes associative learning
T3616 405-414 GO:0040011 denotes locomotor
T3617 572-580 GO:0007612 denotes learning
T3618 651-655 PR:000001177 denotes D2Rs
T3619 659-679 GO:0008306 denotes associative learning
T3620 831-834 PR:000001177 denotes D2R
T3621 850-857 NCBITaxon:9989 denotes rodents
T3622 987-991 PR:000001177 denotes D2Rs
T3623 1042-1062 GO:0008306 denotes associative learning
T3624 1066-1073 NCBITaxon:9989 denotes rodents
T3625 1114-1117 PR:000001177 denotes D2R
T3626 1285-1293 CHEBI:18243 denotes dopamine
T3627 1406-1410 PR:000001177 denotes D2Rs
T3628 1412-1416 PR:000001178 denotes D3Rs
T3629 1422-1426 PR:000001179 denotes D4Rs
T3630 1533-1537 NCBITaxon:10088 denotes mice
T3631 1553-1564 SO:0000704 denotes genetically
T3632 1623-1630 SO:0001023 denotes alleles
T3633 1761-1766 NCBITaxon:10088 denotes mouse
T3634 1890-1897 NCBITaxon:33208 denotes animals
T3635 1944-1962 GO:0007626 denotes locomotor behavior
T3636 1985-1988 PR:000001177 denotes D2R
T3637 1996-1999 PR:000001177 denotes D2R
T3638 2003-2007 NCBITaxon:10088 denotes mice
T3639 2065-2068 PR:000001177 denotes D2R
T3640 2091-2111 GO:0008306 denotes associative learning
T3641 2204-2207 PR:000001177 denotes D2R

2_test

Id Subject Object Predicate Lexical cue
15061865-9329075-12857741 286-287 9329075 denotes 3
15061865-12445713-12857742 427-428 12445713 denotes 2
15061865-12629161-12857743 429-430 12629161 denotes 6
15061865-12445722-12857744 431-432 12445722 denotes 8
15061865-3615345-12857745 513-515 3615345 denotes 25
15061865-12629161-12857746 598-599 12629161 denotes 6
15061865-7197320-12857747 738-740 7197320 denotes 26
15061865-556989-12857747 738-740 556989 denotes 26
15061865-4277740-12857747 738-740 4277740 denotes 26
15061865-11229973-12857748 993-995 11229973 denotes 29