2.6  Statistical analysis
The following statistical analyses were performed on R (version 2.15.1) with respective packages and a p-value of <0.05 was considered as significant. Expression analysis of mRNA and miRNA was done using the DESeq package [44], which uses the read counts as input. Meta-analysis of mRNA expression and microarray expression data downloaded from Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/) were performed by the MetaDE R package [45]. Fisher exact test was used and a p-value of <0.05 was set as the cutoff.