Conclusions
A conclusive scene of omics network in migraine pathophysiology is still far to be sharpened. We know a lot of genomics, but less of proteomics and metabolomics of migraine. However, there are numerous scientific evidences assigning an increasingly dominant role to external factors, environmental or behavioural, that interact with the pathophysiology of migraine. Although genomics represents the hierarchical basis of migraine mechanism, proteomics and metabolomics mirror its real image. We have to continue to study the connections among omics in order to unsnarl the Ariadne’s tread of migraine.