Compound Trial Patients (N) Treatment duration Outcome
Pasireotide Boscaro et al. [40] 29 15 days 5/29 patients (17 %) achieved UFC ≤ ULN; 22/29 patients (76 %) experienced reduction in mean UFC
Colao et al. [43] 162 12 months 33/162 patients (20 %) achieved UFC ≤ ULN within 6 months without increase from randomized dose; the majority of patients experienced reduction in UFC at month 6, sustained through month 12
Cabergoline Lila et al. [52] 18 5 months 5 patients (28 %) achieved MNSC <5 μg/dL or low-dose dexamethasone-suppressed serum cortisol <1.8 μg/dL
Pivonello et al. [48, 53] 20 3–24 months After 3 months, 15 patients (75 %) achieved UFC ≤ ULN or ≥25 % reduction from baseline; 8 patients (40 %) maintained UFC ≤ ULN at 24 months
Retinoic acid Pecori Girald et al. [59] 7 6–12 months 3/7 patients (43 %) achieved UFC ≤ ULN; 5/7 patients (71 %) experienced reduction in UFC