10.1371/journal.pone.0068938.g001 Figure 1 Reported time-to-onset for short-versus long-term treatments for angioedema and hepatitis, respectively. Drugs with expected long-term treatments (panels B and D) generally presented with longer RTTO than drugs with expected short-term treatment (panels A and C). In fact, the patterns of RTTO of angioedema for long-term treatments were very similar to the patterns of RTTO of hepatitis for short-term treatments (panels B and C). 1