Complementary and alternative medicine Increasing attention is being paid worldwide to more traditional medical systems, including Ayurveda, yoga, naturopathy, Unani medicine, Siddha, and homeopathy.30 Use of CAM therapies in various illnesses is on the rise.31 Perron et al found that barriers to conventional treatment have contributed to the increased use of CAM in mentally ill patients.31 Another study found that use of CAM was unaffected by the perceived effectiveness of conventional treatment or compliance with medication among persons with bipolar disorder.32 There are now more than 120 CAM treatments available (Table 1), all of which involve body, mind, and spiritual concepts. This classification of various therapies, and designated by mind, body, or spirit, is perceived as strict compartmentalization, but many of the therapies mentioned have double or triple designations in terms of our theoretical understanding of diagnosis, treatment, and causal mechanisms. Another reason for increasing use of CAM is the positive findings of studies in patients with major depression.33 Many clinical trials of CAM are presently under way worldwide, and are expected to yield positive results in patients with major depression and other mood disorders.