NAcb-DBS Modulated Challenge-Induced Neuronal Activation Patterns in HAB Mice
An overview of c-Fos expression in the analyzed brain areas and P-values are given in Table 2. Repeated NAcb-DBS modulated stress-induced neuronal activity in four out of seven investigated areas. In comparison with their NAcb-sham controls, in NAcb-DBS-treated HAB mice the numbers of c-Fos-positive cells were significantly enhanced in the lateral OFC, lateral habenula, and dentate gyrus of the HPC, while c-Fos induction was reduced in the prelimbic cortex only (Figure 5).