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recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T18783","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T18782","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T18781","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T18780","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T18779","span":{"begin":226,"end":234},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T20267","span":{"begin":537,"end":544},"obj":"http://www.uniprot.org/uniprot/P28033"},{"id":"T20238","span":{"begin":798,"end":806},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20237","span":{"begin":403,"end":411},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20236","span":{"begin":226,"end":234},"obj":"http://www.uniprot.org/uniprot/P05120"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"GO-BP","denotations":[{"id":"T18843","span":{"begin":888,"end":913},"obj":"http://purl.obolibrary.org/obo/GO_0002418"},{"id":"T18842","span":{"begin":586,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T18841","span":{"begin":577,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0050663"},{"id":"T18840","span":{"begin":481,"end":498},"obj":"http://purl.obolibrary.org/obo/GO_0030010"},{"id":"T18823","span":{"begin":276,"end":288},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T18822","span":{"begin":97,"end":109},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T18806","span":{"begin":777,"end":790},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"GO-CC","denotations":[{"id":"T18853","span":{"begin":895,"end":900},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18852","span":{"begin":608,"end":613},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18851","span":{"begin":481,"end":485},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"sentences","denotations":[{"id":"T18512","span":{"begin":666,"end":931},"obj":"Sentence"},{"id":"T18511","span":{"begin":523,"end":665},"obj":"Sentence"},{"id":"T18510","span":{"begin":387,"end":522},"obj":"Sentence"},{"id":"T18509","span":{"begin":226,"end":386},"obj":"Sentence"},{"id":"T18508","span":{"begin":0,"end":225},"obj":"Sentence"},{"id":"T273","span":{"begin":0,"end":225},"obj":"Sentence"},{"id":"T274","span":{"begin":226,"end":386},"obj":"Sentence"},{"id":"T275","span":{"begin":387,"end":522},"obj":"Sentence"},{"id":"T276","span":{"begin":523,"end":665},"obj":"Sentence"},{"id":"T277","span":{"begin":666,"end":931},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"simple1","denotations":[{"id":"T18920","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T18919","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T18918","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T18917","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T18916","span":{"begin":226,"end":234},"obj":"Protein"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T20199","span":{"begin":765,"end":776},"obj":"Positive_regulation"},{"id":"T20198","span":{"begin":777,"end":790},"obj":"Transcription"},{"id":"T20197","span":{"begin":235,"end":245},"obj":"Gene_expression"},{"id":"T20128","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T20127","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T20126","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T20125","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T20124","span":{"begin":226,"end":234},"obj":"Protein"}],"relations":[{"id":"R14567","pred":"themeOf","subj":"T20124","obj":"T20197"},{"id":"R14568","pred":"themeOf","subj":"T20128","obj":"T20198"},{"id":"R14610","pred":"themeOf","subj":"T20198","obj":"T20199"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T20638","span":{"begin":777,"end":790},"obj":"Transcription"},{"id":"T20637","span":{"begin":765,"end":776},"obj":"Positive_regulation"},{"id":"T20636","span":{"begin":235,"end":245},"obj":"Gene_expression"},{"id":"T20578","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T20577","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T20576","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T20575","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T20574","span":{"begin":226,"end":234},"obj":"Protein"}],"relations":[{"id":"R14776","pred":"themeOf","subj":"T20574","obj":"T20636"},{"id":"R14777","pred":"themeOf","subj":"T20578","obj":"T20638"},{"id":"R14800","pred":"themeOf","subj":"T20638","obj":"T20637"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"DLUT931","denotations":[{"id":"T20418","span":{"begin":765,"end":776},"obj":"Positive_regulation"},{"id":"T20417","span":{"begin":777,"end":790},"obj":"Transcription"},{"id":"T20416","span":{"begin":255,"end":265},"obj":"Binding"},{"id":"T20415","span":{"begin":235,"end":245},"obj":"Gene_expression"},{"id":"T20352","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T20351","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T20350","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T20349","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T20348","span":{"begin":226,"end":234},"obj":"Protein"}],"relations":[{"id":"R14661","pred":"themeOf","subj":"T20348","obj":"T20415"},{"id":"R14662","pred":"themeOf","subj":"T20348","obj":"T20416"},{"id":"R14663","pred":"themeOf","subj":"T20352","obj":"T20417"},{"id":"R14698","pred":"themeOf","subj":"T20417","obj":"T20418"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T21111","span":{"begin":748,"end":811},"obj":"Transcription"},{"id":"T21087","span":{"begin":733,"end":811},"obj":"Regulation"},{"id":"T21079","span":{"begin":601,"end":614},"obj":"Entity"},{"id":"T21039","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T21018","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T20976","span":{"begin":439,"end":503},"obj":"Protein"},{"id":"T20946","span":{"begin":126,"end":158},"obj":"Entity"},{"id":"T20929","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T20921","span":{"begin":400,"end":411},"obj":"Protein"},{"id":"T20916","span":{"begin":765,"end":776},"obj":"Entity"},{"id":"T20913","span":{"begin":226,"end":234},"obj":"Protein"},{"id":"T20954","span":{"begin":791,"end":811},"obj":"Protein"},{"id":"T20948","span":{"begin":126,"end":146},"obj":"Entity"}],"relations":[{"id":"R14945","pred":"themeOf","subj":"T20954","obj":"T21111"},{"id":"R14979","pred":"themeOf","subj":"T21111","obj":"T21087"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T20765","span":{"begin":733,"end":742},"obj":"Positive_regulation"},{"id":"T20764","span":{"begin":777,"end":790},"obj":"Transcription"},{"id":"T20763","span":{"begin":798,"end":811},"obj":"Protein"},{"id":"T20762","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T20761","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T20760","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T20759","span":{"begin":235,"end":245},"obj":"Gene_expression"},{"id":"T20758","span":{"begin":226,"end":234},"obj":"Protein"}],"relations":[{"id":"R14862","pred":"themeOf","subj":"T20758","obj":"T20759"},{"id":"R14863","pred":"causeOf","subj":"T20762","obj":"T20765"},{"id":"R14864","pred":"themeOf","subj":"T20763","obj":"T20764"},{"id":"R14865","pred":"themeOf","subj":"T20764","obj":"T20765"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"testone","denotations":[{"id":"T18278","span":{"begin":777,"end":790},"obj":"Transcription"},{"id":"T18277","span":{"begin":769,"end":776},"obj":"Positive_regulation"},{"id":"T18231","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T18230","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T18229","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T18228","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T18227","span":{"begin":226,"end":234},"obj":"Protein"}],"relations":[{"id":"R13142","pred":"themeOf","subj":"T18231","obj":"T18278"},{"id":"R13156","pred":"themeOf","subj":"T18278","obj":"T18277"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}

{"project":"test3","denotations":[{"id":"T18472","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T18471","span":{"begin":777,"end":790},"obj":"Transcription"},{"id":"T18470","span":{"begin":769,"end":776},"obj":"Positive_regulation"},{"id":"T18469","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T18468","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T18467","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T18466","span":{"begin":235,"end":245},"obj":"Gene_expression"},{"id":"T18465","span":{"begin":226,"end":234},"obj":"Protein"},{"id":"T18348","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T18347","span":{"begin":698,"end":705},"obj":"Protein"},{"id":"T18346","span":{"begin":537,"end":544},"obj":"Protein"},{"id":"T18345","span":{"begin":403,"end":411},"obj":"Protein"},{"id":"T18344","span":{"begin":226,"end":234},"obj":"Protein"}],"relations":[{"id":"R13218","pred":"themeOf","subj":"T18465","obj":"T18466"},{"id":"R13219","pred":"themeOf","subj":"T18471","obj":"T18470"},{"id":"R13220","pred":"themeOf","subj":"T18472","obj":"T18471"}],"text":"In recent years it has become apparent that persistent infection is integrally linked to chronic inflammation and cancer, and immune cells such as macrophages can either promote or attenuate cancer progression [2]; [74]–[76]. SerpinB2 expression has been associated with both inflammation and cancer, and is a favorable or unfavorable prognostic indicator depending on cancer type [77]. The presence of SerpinB2 has been shown to modulate cytokine profiles which can affect immune cell polarization [27]; [28]; [77]; [78]. Interestingly C/EBP-β has also been shown to modulate cytokine secretion from immune cells, thereby modifying their phenotype [27]; [79]–[81]. Our study has demonstrated that C/EBP-β plays an important role in mediating both constitutive and LPS-induced transcription of the SerpinB2 gene, which may have implications for the inflammatory phenotype of infiltrating immune cells in the tumor microenvironment."}