Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis
Interplay of Akt and JNK in Necroptosis Control

Abstract
Necroptosis is a regulated form of necrotic cell death that has been implicated in the pathogenesis of various diseases including intestinal inflammation and systemic inflammatory response syndrome (SIRS). In this work, we investigated the signaling mechanisms controlled by the necroptosis mediator receptor interacting protein-1 (RIP1) kinase. We show that Akt kinase activity is critical for necroptosis in L929 cells and plays a key role in TNFα product