Fig. 1  Effects of family history of CRC and GRS on the risk of CRC in Koreans who participated in the KCPS-II (adjusted for age, BMI and smoking status) (A) counted GRS in men and women (B) weighted GRS in men and women. CRC, colorectal cancer; GRS, genetic risk scores; KCPS-II, Korean Cancer Prevention Study-II; BMI, body mass index; OR, odds ratio. aMeans statistically significant.