Table 1  Features described from the CA125 amino acid sequence based on the data of O’Brien [18,21], Yin [17], Maeda [22] and Berman [23]; Amino acid (aa) number (numbering derived from [18]) indicates the position of those residues as they appear within the respective domain. bp: base pairs.
Domain  Carboxy Domain  Repeat Domain  Amino Domain
Features
Exons  9  5  9
Nucleotides (bp)  14,000  Single: 1900Cumulative: Unknown  50,950
Amino Acids (aa)  284  Single: 156Cumulative: >9360  12,068
Molecular Characteristics  Stop CodonPoly A SignalPotential Transmembrane Region (aa 230–252)Potential Cytoplasmic Region (aa 256–260)Potential ProteolyticCleavage Sites (aa 171–181 [18] and aa 35/36 [22])  SEA domainCysteine loop (aa 59,79) [23]Conserved Methionine (aa 24)Serine/Threonine/Proline Rich  Serine/Threonine Rich(Abundant O-glycosylation Potential, N-glycosylation Potential)