Table 2 Mammal-specific GO term enrichment of the four gene classes. Class GO code GO name 1 2 3 4 5 6 7 8 9 10 11 12 TS GO:0016324 Apical plasma membrane * – – – – – * * * – – – TS GO:0005516 Calmodulin binding * – – * – – – * * – – – TS GO:0006812 Cation transport * – – * – – – * * – – – TS GO:0005856 Cytoskeleton * – – * – – – * * – – – TS GO:0005829 Cytosol * – – – – – * * * – – – TS GO:0005783 Endoplasmic reticulum – – * * – – – * * – – – TS GO:0005887 Integral to plasma membrane * – – – * – * * * – * – TS GO:0023034 Intracellular signaling pathway * – – * – – – * * – – – TS GO:0005216 Ion channel activity * – * * – – – * * – * – TS GO:0008237 Metallopeptidase activity * – – – – – * * * – – – TS GO:0042803 Protein homodimerization activity * – – * – – – * * – – – T GO:0005576 Extracellular region – * * * * * * – * – – – S GO:0030326 Embryonic limb morphogenesis * – – * – – – * * – * – S GO:0009954 Proximal/distal pattern formation * – – * – – – * * * * – S GO:0030528 Transcription regulator activity * – * * * * * * * – * – N GO:0009952 Anterior/posterior pattern formation * * * * * * * * * * – – N GO:0048706 Embryonic skeletal system development – * * – – * * – – * – – N GO:0048704 Embryonic skeletal system morphogenesis – – * * – * * – * – * – N GO:0005576 Extracellular region * * * – * * * * * * – – N GO:0005179 Hormone activity * * * – – * * – – * – – N GO:0030528 Transcription regulator activity * – * * * * * * * – * – Notes: The species codes are the same as what listed in Table 1. The asterisks indicate enrichment of GO terms.