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PMC:3342329 / 1690-7233 JSONTXT

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test3

Id Subject Object Predicate Lexical cue
T1394 5496-5500 Protein denotes CCR5
T1393 5477-5495 Protein denotes chemokine receptor
T1392 5463-5469 Protein denotes IL-1Ra
T1391 5286-5292 Protein denotes IL-1Ra
T1390 5272-5282 Gene_expression denotes expression
T1389 5084-5091 Negative_regulation denotes inhibit
T1388 5061-5069 Protein denotes icIL-1Ra
T1387 5039-5059 Protein denotes Intracellular IL-1Ra
T1386 4982-4991 Negative_regulation denotes deficient
T1385 4975-4981 Protein denotes IL-1Ra
T1384 4962-4971 Positive_regulation denotes prolonged
T1383 4949-4957 Positive_regulation denotes enhanced
T1382 4926-4929 Protein denotes p65
T1381 4902-4915 Localization denotes translocation
T1380 4894-4901 Entity denotes Nuclear
T1379 4851-4855 Protein denotes PU.1
T1378 4790-4802 Binding denotes interactions
T1377 4746-4756 Gene_expression denotes expression
T1376 4734-4740 Protein denotes IL-1Ra
T1375 4720-4730 Regulation denotes regulation
T1374 4671-4678 Regulation denotes effects
T1373 4642-4650 Negative_regulation denotes abrogate
T1372 4632-4638 Protein denotes IL-1Ra
T1371 4522-4528 Protein denotes IL-1Ra
T1370 4490-4492 Protein denotes KC
T1369 4478-4484 Protein denotes GM-CSF
T1368 4472-4476 Protein denotes IL-6
T1367 4461-4470 Protein denotes IL-1alpha
T1366 4309-4313 Protein denotes CCR5
T1365 4177-4181 Protein denotes CCL5
T1364 4120-4124 Protein denotes CCR5
T1363 3439-3448 Negative_regulation denotes deficient
T1362 3399-3409 Gene_expression denotes expression
T1361 3382-3388 Protein denotes GM-CSF
T1360 3376-3380 Protein denotes IL-3
T1359 3370-3374 Protein denotes IL-2
T1358 3356-3365 Positive_regulation denotes essential
T1357 3347-3352 Protein denotes c-Rel
T1356 3314-3323 Negative_regulation denotes deficient
T1355 3308-3313 Protein denotes c-Rel
T1354 2759-2767 Protein denotes cytokine
T1353 2709-2715 Protein denotes IL-1Ra
T1352 2531-2537 Protein denotes IL-1Ra
T1351 2434-2442 Negative_regulation denotes knockout
T1350 2274-2280 Protein denotes IL-1Ra
T1349 2129-2136 Negative_regulation denotes reduced
T1348 2113-2119 Protein denotes IL-1Ra
T1347 1957-1966 Negative_regulation denotes deficient
T1346 1950-1956 Protein denotes IL-1Ra
T1345 1852-1859 Negative_regulation denotes reduced
T1344 1837-1847 Gene_expression denotes expression
T1343 1830-1836 Protein denotes IL-1Ra
T1342 1795-1801 Protein denotes IL-1Ra
T1341 1611-1617 Protein denotes IL-1Ra
T1340 1572-1578 Negative_regulation denotes blocks
T1339 1544-1552 Protein denotes cytokine
T1338 1481-1487 Protein denotes IL-1Ra
T1337 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T1336 1385-1389 Protein denotes CCR5
T1335 1267-1271 Protein denotes CCR5
T1334 1060-1064 Protein denotes CCR5
T1333 1007-1011 Protein denotes CCR5
T1332 862-866 Protein denotes CCR5
T1331 742-746 Protein denotes CCL5
T1330 506-510 Protein denotes CCR5
T1329 328-332 Protein denotes CCR5
T1328 304-326 Protein denotes C-C chemokine receptor
T1327 294-298 Protein denotes CCL5
T1326 262-292 Protein denotes chemokine (C-C motif) ligand 5
T1325 5496-5500 Protein denotes CCR5
T1324 5477-5495 Protein denotes chemokine receptor
T1323 5463-5469 Protein denotes IL-1Ra
T1322 5286-5292 Protein denotes IL-1Ra
T1321 5061-5069 Protein denotes icIL-1Ra
T1320 5039-5059 Protein denotes Intracellular IL-1Ra
T1319 4975-4981 Protein denotes IL-1Ra
T1318 4926-4929 Protein denotes p65
T1317 4851-4855 Protein denotes PU.1
T1316 4734-4740 Protein denotes IL-1Ra
T1315 4632-4638 Protein denotes IL-1Ra
T1314 4522-4528 Protein denotes IL-1Ra
T1313 4490-4492 Protein denotes KC
T1312 4478-4484 Protein denotes GM-CSF
T1311 4472-4476 Protein denotes IL-6
T1310 4461-4470 Protein denotes IL-1alpha
T1309 4309-4313 Protein denotes CCR5
T1308 4177-4181 Protein denotes CCL5
T1307 4120-4124 Protein denotes CCR5
T1306 3382-3388 Protein denotes GM-CSF
T1305 3376-3380 Protein denotes IL-3
T1304 3370-3374 Protein denotes IL-2
T1303 3347-3352 Protein denotes c-Rel
T1302 3308-3313 Protein denotes c-Rel
T1301 2759-2767 Protein denotes cytokine
T1300 2709-2715 Protein denotes IL-1Ra
T1299 2531-2537 Protein denotes IL-1Ra
T1298 2274-2280 Protein denotes IL-1Ra
T1297 2113-2119 Protein denotes IL-1Ra
T1296 1950-1956 Protein denotes IL-1Ra
T1295 1830-1836 Protein denotes IL-1Ra
T1294 1795-1801 Protein denotes IL-1Ra
T1293 1611-1617 Protein denotes IL-1Ra
T1292 1544-1552 Protein denotes cytokine
T1291 1481-1487 Protein denotes IL-1Ra
T1290 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T1289 1385-1389 Protein denotes CCR5
T1288 1267-1271 Protein denotes CCR5
T1287 1060-1064 Protein denotes CCR5
T1286 1007-1011 Protein denotes CCR5
T1285 862-866 Protein denotes CCR5
T1284 742-746 Protein denotes CCL5
T1283 506-510 Protein denotes CCR5
T1282 328-332 Protein denotes CCR5
T1281 304-326 Protein denotes C-C chemokine receptor
T1280 294-298 Protein denotes CCL5
T1279 262-292 Protein denotes chemokine (C-C motif) ligand 5
R771 T1327 T1326 equivalentTo CCL5,chemokine (C-C motif) ligand 5
R772 T1329 T1328 equivalentTo CCR5,C-C chemokine receptor
R773 T1329 T1326 equivalentTo CCR5,chemokine (C-C motif) ligand 5
R774 T1337 T1339 themeOf Interleukin-1 receptor antagonist,cytokine
R775 T1338 T1337 equivalentTo IL-1Ra,Interleukin-1 receptor antagonist
R776 T1343 T1344 themeOf IL-1Ra,expression
R777 T1344 T1345 themeOf expression,reduced
R778 T1346 T1347 themeOf IL-1Ra,deficient
R779 T1355 T1356 themeOf c-Rel,deficient
R780 T1356 T1358 causeOf deficient,essential
R781 T1357 T1358 causeOf c-Rel,essential
R782 T1359 T1362 themeOf IL-2,expression
R783 T1360 T1362 themeOf IL-3,expression
R784 T1361 T1362 themeOf GM-CSF,expression
R785 T1362 T1358 themeOf expression,essential
R786 T1376 T1377 themeOf IL-1Ra,expression
R787 T1377 T1375 themeOf expression,regulation
R788 T1380 T1381 locationOf Nuclear,translocation
R789 T1381 T1384 themeOf translocation,prolonged
R790 T1381 T1383 themeOf translocation,enhanced
R791 T1385 T1386 themeOf IL-1Ra,deficient
R792 T1386 T1384 causeOf deficient,prolonged
R793 T1387 T1389 causeOf Intracellular IL-1Ra,inhibit
R794 T1388 T1387 equivalentTo icIL-1Ra,Intracellular IL-1Ra
R795 T1391 T1390 themeOf IL-1Ra,expression

testone

Id Subject Object Predicate Lexical cue
T1278 5272-5282 Gene_expression denotes expression
T1277 5084-5091 Negative_regulation denotes inhibit
T1276 4982-4991 Negative_regulation denotes deficient
T1275 4949-4957 Positive_regulation denotes enhanced
T1274 4902-4915 Localization denotes translocation
T1273 4894-4901 Entity denotes Nuclear
T1272 4790-4802 Binding denotes interactions
T1271 4746-4756 Gene_expression denotes expression
T1270 4720-4730 Regulation denotes regulation
T1269 4671-4678 Regulation denotes effects
T1268 4642-4650 Negative_regulation denotes abrogate
T1267 4125-4135 Gene_expression denotes expression
T1266 4106-4116 Negative_regulation denotes inhibition
T1265 3439-3448 Negative_regulation denotes deficient
T1264 3399-3409 Gene_expression denotes expression
T1263 3356-3365 Positive_regulation denotes essential
T1262 3314-3323 Negative_regulation denotes deficient
T1261 2434-2442 Negative_regulation denotes knockout
T1260 1957-1966 Negative_regulation denotes deficient
T1259 1852-1859 Negative_regulation denotes reduced
T1258 1837-1847 Gene_expression denotes expression
T1257 1390-1400 Negative_regulation denotes deficiency
T1256 1221-1231 Negative_regulation denotes deficiency
T1255 867-877 Negative_regulation denotes disruption
T1254 724-734 Gene_expression denotes production
T1253 511-521 Gene_expression denotes expression
T1252 170-177 Gene_expression denotes express
T1251 5496-5500 Protein denotes CCR5
T1250 5477-5495 Protein denotes chemokine receptor
T1249 5463-5469 Protein denotes IL-1Ra
T1248 5286-5292 Protein denotes IL-1Ra
T1247 5061-5069 Protein denotes icIL-1Ra
T1246 5039-5059 Protein denotes Intracellular IL-1Ra
T1245 4975-4981 Protein denotes IL-1Ra
T1244 4926-4929 Protein denotes p65
T1243 4851-4855 Protein denotes PU.1
T1242 4734-4740 Protein denotes IL-1Ra
T1241 4632-4638 Protein denotes IL-1Ra
T1240 4522-4528 Protein denotes IL-1Ra
T1239 4490-4492 Protein denotes KC
T1238 4478-4484 Protein denotes GM-CSF
T1237 4472-4476 Protein denotes IL-6
T1236 4461-4470 Protein denotes IL-1alpha
T1235 4309-4313 Protein denotes CCR5
T1234 4177-4181 Protein denotes CCL5
T1233 4120-4124 Protein denotes CCR5
T1232 3382-3388 Protein denotes GM-CSF
T1231 3376-3380 Protein denotes IL-3
T1230 3370-3374 Protein denotes IL-2
T1229 3347-3352 Protein denotes c-Rel
T1228 3308-3313 Protein denotes c-Rel
T1227 2759-2767 Protein denotes cytokine
T1226 2709-2715 Protein denotes IL-1Ra
T1225 2531-2537 Protein denotes IL-1Ra
T1224 2274-2280 Protein denotes IL-1Ra
T1223 2113-2119 Protein denotes IL-1Ra
T1222 1950-1956 Protein denotes IL-1Ra
T1221 1830-1836 Protein denotes IL-1Ra
T1220 1795-1801 Protein denotes IL-1Ra
T1219 1611-1617 Protein denotes IL-1Ra
T1218 1544-1552 Protein denotes cytokine
T1217 1481-1487 Protein denotes IL-1Ra
T1216 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T1215 1385-1389 Protein denotes CCR5
T1214 1267-1271 Protein denotes CCR5
T1213 1060-1064 Protein denotes CCR5
T1212 1007-1011 Protein denotes CCR5
T1211 862-866 Protein denotes CCR5
T1210 742-746 Protein denotes CCL5
T1209 506-510 Protein denotes CCR5
T1208 328-332 Protein denotes CCR5
T1207 304-326 Protein denotes C-C chemokine receptor
T1206 294-298 Protein denotes CCL5
T1205 262-292 Protein denotes chemokine (C-C motif) ligand 5
R741 T1206 T1205 equivalentTo CCL5,chemokine (C-C motif) ligand 5
R742 T1208 T1207 equivalentTo CCR5,C-C chemokine receptor
R743 T1208 T1205 equivalentTo CCR5,chemokine (C-C motif) ligand 5
R744 T1209 T1253 themeOf CCR5,expression
R745 T1210 T1254 themeOf CCL5,production
R746 T1211 T1255 themeOf CCR5,disruption
R747 T1214 T1256 themeOf CCR5,deficiency
R748 T1215 T1257 themeOf CCR5,deficiency
R749 T1217 T1216 equivalentTo IL-1Ra,Interleukin-1 receptor antagonist
R750 T1221 T1258 themeOf IL-1Ra,expression
R751 T1222 T1260 themeOf IL-1Ra,deficient
R752 T1228 T1262 themeOf c-Rel,deficient
R753 T1229 T1263 causeOf c-Rel,essential
R754 T1230 T1264 themeOf IL-2,expression
R755 T1231 T1264 themeOf IL-3,expression
R756 T1232 T1264 themeOf GM-CSF,expression
R757 T1233 T1267 themeOf CCR5,expression
R758 T1242 T1271 themeOf IL-1Ra,expression
R759 T1245 T1276 themeOf IL-1Ra,deficient
R760 T1246 T1277 causeOf Intracellular IL-1Ra,inhibit
R761 T1247 T1246 equivalentTo icIL-1Ra,Intracellular IL-1Ra
R762 T1248 T1278 themeOf IL-1Ra,expression
R763 T1258 T1259 themeOf expression,reduced
R764 T1262 T1263 causeOf deficient,essential
R765 T1264 T1263 themeOf expression,essential
R766 T1267 T1266 themeOf expression,inhibition
R767 T1271 T1270 themeOf expression,regulation
R768 T1273 T1274 locationOf Nuclear,translocation
R769 T1274 T1275 themeOf translocation,enhanced
R770 T1276 T1275 causeOf deficient,enhanced

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T2938 4975-4981 Protein denotes IL-1Ra
T2937 4926-4929 Protein denotes p65
T2936 4851-4855 Protein denotes PU.1
T2935 4734-4740 Protein denotes IL-1Ra
T2934 4632-4638 Protein denotes IL-1Ra
T2933 4522-4528 Protein denotes IL-1Ra
T2932 4490-4492 Protein denotes KC
T2931 4478-4484 Protein denotes GM-CSF
T2930 4472-4476 Protein denotes IL-6
T2929 4461-4470 Protein denotes IL-1alpha
T2928 4309-4313 Protein denotes CCR5
T2927 4177-4181 Protein denotes CCL5
T2926 4120-4124 Protein denotes CCR5
T2925 3382-3388 Protein denotes GM-CSF
T2924 3376-3380 Protein denotes IL-3
T2923 3370-3374 Protein denotes IL-2
T2922 3347-3352 Protein denotes c-Rel
T2921 3308-3313 Protein denotes c-Rel
T2920 2759-2767 Protein denotes cytokine
T2919 2709-2715 Protein denotes IL-1Ra
T2918 2531-2537 Protein denotes IL-1Ra
T2917 2274-2280 Protein denotes IL-1Ra
T2916 2113-2119 Protein denotes IL-1Ra
T2915 1950-1956 Protein denotes IL-1Ra
T2914 1830-1836 Protein denotes IL-1Ra
T2913 1795-1801 Protein denotes IL-1Ra
T2912 1611-1617 Protein denotes IL-1Ra
T2911 1544-1552 Protein denotes cytokine
T2910 1481-1487 Protein denotes IL-1Ra
T2909 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T2908 1385-1389 Protein denotes CCR5
T2907 1267-1271 Protein denotes CCR5
T2906 1060-1064 Protein denotes CCR5
T2905 1007-1011 Protein denotes CCR5
T2904 862-866 Protein denotes CCR5
T2903 742-746 Protein denotes CCL5
T2902 506-510 Protein denotes CCR5
T2901 328-332 Protein denotes CCR5
T2900 304-326 Protein denotes C-C chemokine receptor
T2899 294-298 Protein denotes CCL5
T2898 262-292 Protein denotes chemokine (C-C motif) ligand 5
T2965 5272-5282 Gene_expression denotes expression
T2964 4949-4957 Positive_regulation denotes enhanced
T2963 4902-4915 Localization denotes translocation
T2962 4982-4991 Negative_regulation denotes deficient
T2961 4746-4756 Gene_expression denotes expression
T2960 4720-4730 Regulation denotes regulation
T2959 4106-4116 Negative_regulation denotes inhibition
T2958 4125-4135 Gene_expression denotes expression
T2957 3314-3323 Negative_regulation denotes deficient
T2956 3356-3365 Positive_regulation denotes essential
T2955 3399-3409 Gene_expression denotes expression
T2954 1957-1966 Negative_regulation denotes deficient
T2953 1837-1847 Gene_expression denotes expression
T2952 1852-1859 Negative_regulation denotes reduced
T2951 1390-1400 Negative_regulation denotes deficiency
T2950 1221-1231 Negative_regulation denotes deficiency
T2949 996-1003 Negative_regulation denotes absence
T2948 1065-1075 Negative_regulation denotes inhibitors
T2947 867-877 Negative_regulation denotes disruption
T2946 724-734 Gene_expression denotes production
T2945 511-521 Gene_expression denotes expression
T2944 5496-5500 Protein denotes CCR5
T2943 5477-5495 Protein denotes chemokine receptor
T2942 5463-5469 Protein denotes IL-1Ra
T2941 5286-5292 Protein denotes IL-1Ra
T2940 5061-5069 Protein denotes icIL-1Ra
T2939 5039-5059 Protein denotes Intracellular IL-1Ra
R1875 T2902 T2945 themeOf CCR5,expression
R1881 T2903 T2946 themeOf CCL5,production
R1883 T2904 T2947 themeOf CCR5,disruption
R1886 T2905 T2949 themeOf CCR5,absence
R1888 T2906 T2948 themeOf CCR5,inhibitors
R1891 T2907 T2950 themeOf CCR5,deficiency
R1893 T2908 T2951 themeOf CCR5,deficiency
R1894 T2914 T2953 themeOf IL-1Ra,expression
R1895 T2915 T2954 themeOf IL-1Ra,deficient
R1896 T2921 T2957 themeOf c-Rel,deficient
R1899 T2922 T2956 causeOf c-Rel,essential
R1901 T2922 T2956 causeOf c-Rel,essential
R1902 T2922 T2956 causeOf c-Rel,essential
R1904 T2923 T2956 themeOf IL-2,essential
R1907 T2923 T2955 themeOf IL-2,expression
R1908 T2924 T2956 themeOf IL-3,essential
R1913 T2924 T2955 themeOf IL-3,expression
R1914 T2925 T2956 themeOf GM-CSF,essential
R1915 T2925 T2955 themeOf GM-CSF,expression
R1917 T2926 T2958 themeOf CCR5,expression
R1919 T2935 T2961 themeOf IL-1Ra,expression
R1923 T2937 T2963 themeOf p65,translocation
R1929 T2938 T2962 themeOf IL-1Ra,deficient
R1930 T2941 T2965 themeOf IL-1Ra,expression
R1934 T2953 T2952 themeOf expression,reduced
R1939 T2958 T2959 themeOf expression,inhibition
R1943 T2961 T2960 themeOf expression,regulation
R1944 T2963 T2964 themeOf translocation,enhanced

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T4172 1481-1487 Protein denotes IL-1Ra
T4171 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T4170 1385-1389 Protein denotes CCR5
T4169 1267-1271 Protein denotes CCR5
T4168 1060-1064 Protein denotes CCR5
T4167 1007-1011 Protein denotes CCR5
T4166 862-866 Protein denotes CCR5
T4165 742-746 Protein denotes CCL5
T4164 506-510 Protein denotes CCR5
T4163 328-332 Protein denotes CCR5
T4162 304-326 Protein denotes C-C chemokine receptor
T4161 294-298 Protein denotes CCL5
T4160 262-292 Protein denotes chemokine (C-C motif) ligand 5
T4227 5272-5282 Gene_expression denotes expression
T4226 4982-4991 Negative_regulation denotes deficient
T4225 4949-4957 Positive_regulation denotes enhanced
T4224 4902-4915 Localization denotes translocation
T4223 4720-4730 Regulation denotes regulation
T4222 4746-4756 Gene_expression denotes expression
T4221 4125-4135 Gene_expression denotes expression
T4220 4106-4116 Negative_regulation denotes inhibition
T4219 3314-3323 Negative_regulation denotes deficient
T4218 3356-3365 Positive_regulation denotes essential
T4217 3399-3409 Gene_expression denotes expression
T4216 1957-1966 Negative_regulation denotes deficient
T4215 1852-1859 Negative_regulation denotes reduced
T4214 1837-1847 Gene_expression denotes expression
T4213 1390-1400 Negative_regulation denotes deficiency
T4212 1221-1231 Negative_regulation denotes deficiency
T4211 996-1003 Negative_regulation denotes absence
T4210 1065-1075 Negative_regulation denotes inhibitors
T4209 867-877 Negative_regulation denotes disruption
T4208 724-734 Gene_expression denotes production
T4207 511-521 Gene_expression denotes expression
T4206 5496-5500 Protein denotes CCR5
T4205 5477-5495 Protein denotes chemokine receptor
T4204 5463-5469 Protein denotes IL-1Ra
T4181 2709-2715 Protein denotes IL-1Ra
T4180 2531-2537 Protein denotes IL-1Ra
T4179 2274-2280 Protein denotes IL-1Ra
T4178 2113-2119 Protein denotes IL-1Ra
T4177 1950-1956 Protein denotes IL-1Ra
T4176 1830-1836 Protein denotes IL-1Ra
T4175 1795-1801 Protein denotes IL-1Ra
T4174 1611-1617 Protein denotes IL-1Ra
T4173 1544-1552 Protein denotes cytokine
T4189 4177-4181 Protein denotes CCL5
T4188 4120-4124 Protein denotes CCR5
T4187 3382-3388 Protein denotes GM-CSF
T4186 3376-3380 Protein denotes IL-3
T4185 3370-3374 Protein denotes IL-2
T4184 3347-3352 Protein denotes c-Rel
T4183 3308-3313 Protein denotes c-Rel
T4182 2759-2767 Protein denotes cytokine
T4203 5286-5292 Protein denotes IL-1Ra
T4202 5061-5069 Protein denotes icIL-1Ra
T4201 5039-5059 Protein denotes Intracellular IL-1Ra
T4200 4975-4981 Protein denotes IL-1Ra
T4199 4926-4929 Protein denotes p65
T4198 4851-4855 Protein denotes PU.1
T4197 4734-4740 Protein denotes IL-1Ra
T4196 4632-4638 Protein denotes IL-1Ra
T4195 4522-4528 Protein denotes IL-1Ra
T4194 4490-4492 Protein denotes KC
T4193 4478-4484 Protein denotes GM-CSF
T4192 4472-4476 Protein denotes IL-6
T4191 4461-4470 Protein denotes IL-1alpha
T4190 4309-4313 Protein denotes CCR5
R3010 T4200 T4226 themeOf IL-1Ra,deficient
R3011 T4203 T4227 themeOf IL-1Ra,expression
R3016 T4214 T4215 themeOf expression,reduced
R3018 T4217 T4218 themeOf expression,essential
R3019 T4217 T4218 themeOf expression,essential
R3020 T4217 T4218 themeOf expression,essential
R3022 T4221 T4220 themeOf expression,inhibition
R3023 T4222 T4223 themeOf expression,regulation
R3025 T4224 T4225 themeOf translocation,enhanced
R2982 T4176 T4214 themeOf IL-1Ra,expression
R2967 T4164 T4207 themeOf CCR5,expression
R2968 T4165 T4208 themeOf CCL5,production
R2970 T4166 T4209 themeOf CCR5,disruption
R2971 T4167 T4211 themeOf CCR5,absence
R2972 T4168 T4210 themeOf CCR5,inhibitors
R2974 T4169 T4212 themeOf CCR5,deficiency
R2975 T4170 T4213 themeOf CCR5,deficiency
R2983 T4177 T4216 themeOf IL-1Ra,deficient
R2986 T4183 T4219 themeOf c-Rel,deficient
R2987 T4184 T4218 causeOf c-Rel,essential
R2988 T4184 T4218 causeOf c-Rel,essential
R2989 T4184 T4218 causeOf c-Rel,essential
R2990 T4184 T4218 causeOf c-Rel,essential
R2991 T4184 T4218 causeOf c-Rel,essential
R2992 T4184 T4218 causeOf c-Rel,essential
R2993 T4185 T4218 themeOf IL-2,essential
R2994 T4185 T4217 themeOf IL-2,expression
R2995 T4186 T4218 themeOf IL-3,essential
R2996 T4186 T4217 themeOf IL-3,expression
R2998 T4187 T4218 themeOf GM-CSF,essential
R2999 T4187 T4217 themeOf GM-CSF,expression
R3000 T4188 T4221 themeOf CCR5,expression
R3007 T4197 T4222 themeOf IL-1Ra,expression
R3008 T4199 T4224 themeOf p65,translocation

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T1519 4851-4855 Antecedent denotes PU.1
T1518 4822-4843 Anaphor denotes transcription factors
R836 T1518 T1519 boundBy transcription factors,PU.1

2_test

Id Subject Object Predicate Lexical cue
22567084-19275640-91706998 214-215 19275640 denotes 1
22567084-19446722-91706999 603-604 19446722 denotes 2
22567084-17306330-91707000 617-618 17306330 denotes 3
22567084-17259344-91707001 631-632 17259344 denotes 4
22567084-17935139-91707002 667-668 17935139 denotes 5
22567084-19334035-91707003 714-715 19334035 denotes 6
22567084-19409696-91707004 802-803 19409696 denotes 7
22567084-15501955-91707005 847-848 15501955 denotes 8
22567084-19155524-91707006 974-975 19155524 denotes 9
22567084-12682253-91707007 1051-1053 12682253 denotes 10
22567084-20579875-91707008 1131-1133 20579875 denotes 11
22567084-17259344-91707009 1167-1168 17259344 denotes 4
22567084-17653092-91707010 1188-1190 17653092 denotes 12
22567084-1826616-91707011 1598-1600 1826616 denotes 13
22567084-15042672-91707012 1873-1875 15042672 denotes 14
22567084-12851675-91707013 1886-1888 12851675 denotes 15
22567084-10326864-91707014 1908-1910 10326864 denotes 16
22567084-17283139-91707015 2035-2037 17283139 denotes 17
22567084-14522922-91707016 2173-2175 14522922 denotes 18
22567084-8168095-91707017 2228-2230 8168095 denotes 19
22567084-14597552-91707018 2315-2317 14597552 denotes 20
22567084-17900737-91707019 2356-2358 17900737 denotes 21
22567084-16006751-91707020 2390-2392 16006751 denotes 22
22567084-11346884-91707021 2424-2426 11346884 denotes 23
22567084-12598651-91707022 2503-2505 12598651 denotes 24
22567084-20332438-91707023 2679-2681 20332438 denotes 25
22567084-12001991-91707024 2945-2947 12001991 denotes 26
22567084-15256061-91707025 3087-3089 15256061 denotes 27
22567084-9990849-91707026 3190-3192 9990849 denotes 28
22567084-15313403-91707027 3292-3294 15313403 denotes 29
22567084-8622948-91707028 3428-3430 8622948 denotes 30
22567084-11704834-91707029 3624-3626 11704834 denotes 31
22567084-19469019-91707030 4137-4139 19469019 denotes 32
22567084-19073147-91707031 4237-4239 19073147 denotes 33
22567084-9238507-91707032 4494-4496 9238507 denotes 34
22567084-9727052-91707033 4889-4891 9727052 denotes 35
22567084-16622035-91707034 5034-5036 16622035 denotes 36
22567084-12901852-91707035 5171-5173 12901852 denotes 37
22567084-9646173-91707036 5242-5244 9646173 denotes 38

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T1906 794-800 NN denotes cancer
T2527 4395-4397 IN denotes in
T2526 4387-4394 JJ denotes present
T2525 4383-4386 VB denotes are
T2524 4377-4382 NN denotes sites
T2523 4369-4376 NN denotes binding
T2522 4362-4368 NN denotes factor
T2521 4348-4361 NN denotes transcription
T2520 4342-4347 NN denotes NF-κB
T2519 4329-4340 NN denotes development
T2518 4323-4328 NN denotes tumor
T2517 4314-4322 VB denotes mediated
T2516 4309-4313 NN denotes CCR5
T2515 4306-4308 IN denotes in
T2514 4297-4305 VB denotes involved
T2513 4294-4296 VB denotes be
T2512 4288-4293 MD denotes could
T2511 4282-4287 NN denotes NF-κB
T2510 4279-4281 IN denotes of
T2509 4268-4278 NN denotes inhibition
T2508 4263-4267 IN denotes that
T2507 4254-4262 JJ denotes possible
T2506 4251-4253 VB denotes is
T2505 4248-4250 PRP denotes it
T2504 4246-4247 -COMMA- denotes ,
T2503 4242-4246 RB denotes Thus
T2502 4239-4240 -RRB- denotes ]
T2501 4237-4239 CD denotes 33
T2500 4236-4237 -LRB- denotes [
T2499 4225-4235 NN denotes metastasis
T2498 4220-4224 NN denotes lung
T2497 4216-4219 CC denotes and
T2496 4214-4215 -RRB- denotes )
T2495 4213-4214 CD denotes 5
T2494 4212-4213 -LRB- denotes (
T2493 4203-4211 NN denotes motility
T2492 4196-4202 NN denotes cancer
T2491 4191-4195 JJ denotes oral
T2490 4177-4190 JJ denotes CCL5-mediated
T2489 4167-4176 VB denotes increases
T2488 4162-4166 RB denotes also
T2487 4156-4161 NN denotes NF-κB
T2486 4153-4155 IN denotes of
T2485 4142-4152 NN denotes Activation
T2484 4139-4140 -RRB- denotes ]
T2483 4137-4139 CD denotes 32
T2482 4136-4137 -LRB- denotes [
T2481 4125-4135 NN denotes expression
T2480 4120-4124 NN denotes CCR5
T2479 4117-4119 IN denotes of
T2478 4106-4116 NN denotes inhibition
T2477 4103-4105 IN denotes by
T2476 4094-4102 NN denotes lymphoma
T2475 4085-4093 NN denotes effusion
T2474 4077-4084 JJ denotes primary
T2473 4074-4076 IN denotes of
T2472 4068-4073 NN denotes death
T2471 4063-4067 NN denotes cell
T2470 4055-4062 VB denotes induces
T2469 4053-4054 -RRB- denotes )
T2468 4048-4053 NN denotes DHMEQ
T2467 4047-4048 -LRB- denotes (
T2466 4015-4046 NN denotes dehydroxymethyl-epoxyquinomicin
T2465 4012-4014 IN denotes by
T2464 4006-4011 NN denotes NF-κB
T2463 4003-4005 IN denotes of
T2462 3992-4002 NN denotes inhibition
T2461 3987-3991 IN denotes that
T2460 3978-3986 VB denotes reported
T2459 3974-3977 VB denotes was
T2458 3971-3973 PRP denotes It
T2457 3959-3969 NN denotes metastasis
T2456 3955-3958 CC denotes and
T2455 3948-3954 NN denotes growth
T2454 3942-3947 NN denotes tumor
T2453 3929-3941 JJ denotes CCR-mediated
T2452 3926-3928 IN denotes of
T2451 3915-3925 NN denotes regulation
T2450 3911-3914 DT denotes the
T2449 3908-3910 IN denotes in
T2448 3898-3907 JJ denotes important
T2447 3895-3897 VB denotes is
T2446 3889-3894 NN denotes NF-κB
T2445 3886-3888 IN denotes of
T2444 3875-3885 NN denotes Activation
T2443 3862-3873 NN denotes lymphokines
T2442 3854-3861 NN denotes killing
T2441 3848-3853 NN denotes tumor
T2440 3845-3847 IN denotes of
T2439 3834-3844 NN denotes production
T2438 3830-3833 DT denotes the
T2437 3819-3829 VB denotes increasing
T2436 3817-3818 -RRB- denotes )
T2435 3816-3817 CD denotes 3
T2434 3815-3816 -LRB- denotes (
T2433 3812-3814 CC denotes or
T2432 3799-3811 NN denotes infiltration
T2431 3787-3798 NN denotes lymphocytes
T2430 3779-3786 NN denotes killing
T2429 3773-3778 NN denotes tumor
T2428 3761-3772 VB denotes stimulating
T2427 3759-3760 -RRB- denotes )
T2426 3758-3759 CD denotes 2
T2425 3757-3758 -LRB- denotes (
T2424 3755-3756 -COMMA- denotes ,
T2423 3750-3755 NN denotes death
T2422 3745-3749 NN denotes cell
T2421 3738-3744 NN denotes cancer
T2420 3728-3737 JJ denotes apoptotic
T2419 3718-3727 VB denotes affecting
T2418 3709-3717 RB denotes directly
T2417 3707-3708 -RRB- denotes )
T2416 3706-3707 LS denotes 1
T2415 3705-3706 -LRB- denotes (
T2414 3702-3704 IN denotes by
T2413 3695-3701 NN denotes growth
T2412 3690-3694 NN denotes cell
T2411 3683-3689 NN denotes cancer
T2410 3675-3682 VB denotes prevent
T2409 3672-3674 TO denotes to
T2408 3663-3671 VB denotes targeted
T2407 3653-3662 RB denotes specially
T2406 3650-3652 VB denotes be
T2405 3646-3649 MD denotes can
T2404 3640-3645 NN denotes NF-κB
T2403 3638-3639 -COMMA- denotes ,
T2402 3629-3638 RB denotes Therefore
T2401 3626-3627 -RRB- denotes ]
T2400 3624-3626 CD denotes 31
T2399 3623-3624 -LRB- denotes [
T2398 3618-3622 NN denotes host
T2397 3614-3617 DT denotes the
T2396 3611-3613 IN denotes in
T2395 3601-3610 NN denotes responses
T2394 3594-3600 JJ denotes immune
T2393 3586-3593 JJ denotes humoral
T2392 3582-3585 CC denotes and
T2391 3575-3581 JJ denotes innate
T2390 3570-3574 CC denotes both
T2389 3560-3569 VB denotes affecting
T2388 3548-3559 NN denotes macrophages
T2387 3544-3547 CC denotes and
T2386 3538-3543 NN denotes cells
T2385 3536-3537 NN denotes T
T2384 3533-3535 IN denotes in
T2383 3525-3532 NN denotes factors
T2382 3518-3524 NN denotes growth
T2381 3514-3517 CC denotes and
T2380 3504-3513 NN denotes cytokines
T2379 3496-3503 JJ denotes various
T2378 3493-3495 IN denotes of
T2377 3482-3492 NN denotes deficiency
T2376 3466-3481 JJ denotes tissue-specific
T2375 3464-3465 DT denotes a
T2374 3459-3463 VB denotes have
T2373 3454-3458 RB denotes also
T2372 3449-3453 NN denotes mice
T2371 3433-3448 JJ denotes C-Rel-deficient
T2370 3430-3431 -RRB- denotes ]
T2369 3428-3430 CD denotes 30
T2368 3427-3428 -LRB- denotes [
T2367 3415-3426 NN denotes lymphocytes
T2366 3413-3414 NN denotes T
T2365 3410-3412 IN denotes in
T2364 3399-3409 NN denotes expression
T2363 3394-3398 NN denotes IFNγ
T2362 3390-3393 CC denotes and
T2361 3388-3389 -COMMA- denotes ,
T2360 3382-3388 NN denotes GM-CSF
T2359 3380-3381 -COMMA- denotes ,
T2358 3376-3380 NN denotes IL-3
T2357 3374-3375 -COMMA- denotes ,
T2356 3370-3374 NN denotes IL-2
T2355 3366-3369 IN denotes for
T2354 3356-3365 JJ denotes essential
T2353 3353-3355 VB denotes is
T2352 3347-3352 NN denotes c-Rel
T2351 3342-3346 IN denotes that
T2350 3329-3341 VB denotes demonstrated
T2349 3324-3328 NN denotes mice
T2348 3308-3323 JJ denotes c-Rel-deficient
T2347 3305-3307 IN denotes on
T2346 3297-3304 NN denotes Studies
T2345 3294-3295 -RRB- denotes ]
T2344 3292-3294 CD denotes 29
T2343 3291-3292 -LRB- denotes [
T2342 3282-3290 RB denotes normally
T2341 3273-3281 VB denotes function
T2340 3270-3272 TO denotes to
T2339 3263-3269 NN denotes system
T2338 3256-3262 JJ denotes immune
T2337 3252-3255 DT denotes the
T2336 3248-3251 IN denotes for
T2335 3239-3247 VB denotes required
T2334 3236-3238 VB denotes is
T2333 3233-3235 PRP denotes it
T2332 3231-3232 -COMMA- denotes ,
T2331 3225-3231 NN denotes growth
T2330 3219-3224 NN denotes tumor
T2329 3210-3218 VB denotes promotes
T2328 3204-3209 NN denotes NF-κB
T2327 3195-3203 IN denotes Although
T2326 3192-3193 -RRB- denotes ]
T2325 3190-3192 CD denotes 28
T2324 3189-3190 -LRB- denotes [
T2323 3178-3188 NN denotes expression
T2322 3173-3177 NN denotes gene
T2321 3163-3172 JJ denotes apoptotic
T2320 3154-3162 VB denotes regulate
T2319 3149-3153 RB denotes down
T2318 3142-3148 CC denotes and/or
T2317 3136-3141 NN denotes genes
T2316 3121-3135 JJ denotes anti-apoptotic
T2315 3109-3120 VB denotes up-regulate
T2314 3106-3108 TO denotes to
T2313 3100-3105 VB denotes found
T2312 3096-3099 VB denotes was
T2158 2228-2230 CD denotes 19
T2157 2227-2228 -LRB- denotes [
T2156 2220-2226 NN denotes growth
T2155 2214-2219 NN denotes tumor
T2154 2206-2213 JJ denotes hepatic
T2153 2198-2205 VB denotes reduced
T2717 5496-5509 JJ denotes CCR5-mediated
T2716 5487-5495 NN denotes receptor
T2715 5477-5486 NN denotes chemokine
T2714 5473-5476 DT denotes the
T2713 5470-5472 IN denotes in
T2712 5463-5469 NN denotes IL-1Ra
T2711 5459-5462 CC denotes and
T2710 5453-5458 NN denotes NF-κB
T2709 5450-5452 IN denotes of
T2708 5444-5449 NN denotes roles
T2707 5440-5443 DT denotes the
T2706 5431-5439 VB denotes evaluate
T2705 5428-5430 TO denotes to
T2704 5424-5427 VB denotes was
T2703 5418-5423 NN denotes study
T2702 5413-5417 DT denotes this
T2701 5410-5412 IN denotes of
T2700 5406-5409 NN denotes aim
T2699 5402-5405 DT denotes the
T2698 5400-5401 -COMMA- denotes ,
T2697 5396-5400 RB denotes Thus
T2696 5389-5394 NN denotes versa
T2695 5384-5388 NN denotes vice
T2694 5381-5383 CC denotes or
T2693 5375-5380 NN denotes NF-κB
T2692 5367-5374 NN denotes factors
T2691 5353-5366 NN denotes transcription
T2690 5350-5352 IN denotes of
T2689 5339-5349 NN denotes activation
T2688 5329-5338 JJ denotes autocrine
T2687 5325-5328 DT denotes the
T2686 5322-5324 IN denotes in
T2685 5317-5321 NN denotes role
T2684 5307-5316 JJ denotes important
T2683 5304-5306 DT denotes an
T2682 5299-5303 VB denotes play
T2681 5293-5298 MD denotes could
T2680 5286-5292 NN denotes IL-1Ra
T2679 5283-5285 IN denotes of
T2678 5272-5282 NN denotes expression
T2677 5268-5271 DT denotes the
T2676 5263-5267 IN denotes that
T2675 5250-5262 VB denotes hypothesized
T2674 5247-5249 PRP denotes we
T2673 5245-5246 -COMMA- denotes ,
T2672 5244-5245 -RRB- denotes ]
T2671 5242-5244 CD denotes 38
T2670 5241-5242 -LRB- denotes [
T2669 5230-5240 NN denotes activation
T2668 5224-5229 NN denotes NF-κB
T2667 5221-5223 IN denotes of
T2666 5213-5220 NN denotes inducer
T2665 5210-5212 DT denotes an
T2664 5207-5209 VB denotes be
T2663 5204-5206 TO denotes to
T2662 5198-5203 VB denotes shown
T2661 5193-5197 VB denotes been
T2660 5189-5192 VB denotes has
T2659 5184-5188 NN denotes IL-1
T2658 5176-5183 IN denotes Because
T2657 5173-5174 -RRB- denotes ]
T2656 5171-5173 CD denotes 37
T2655 5170-5171 -LRB- denotes [
T2654 5160-5169 NN denotes responses
T2653 5147-5159 JJ denotes inflammatory
T2652 5144-5146 IN denotes in
T2651 5135-5143 NN denotes pathways
T2650 5122-5134 NN denotes transduction
T2649 5115-5121 NN denotes signal
T2648 5109-5114 NN denotes NF-κB
T2647 5100-5108 VB denotes blocking
T2646 5097-5099 IN denotes by
T2645 5092-5096 NN denotes IL-1
T2644 5084-5091 VB denotes inhibit
T2643 5081-5083 TO denotes to
T2642 5075-5080 VB denotes found
T2641 5071-5074 VB denotes was
T2640 5069-5070 -RRB- denotes )
T2639 5061-5069 NN denotes icIL-1Ra
T2638 5060-5061 -LRB- denotes (
T2637 5053-5059 NN denotes IL-1Ra
T2636 5039-5052 JJ denotes Intracellular
T2635 5036-5037 -RRB- denotes ]
T2634 5034-5036 CD denotes 36
T2633 5033-5034 -LRB- denotes [
T2632 5028-5032 NN denotes mice
T2631 5023-5027 NN denotes type
T2630 5018-5022 JJ denotes wild
T2629 5015-5017 IN denotes in
T2628 5010-5014 DT denotes that
T2627 5007-5009 TO denotes to
T2626 4998-5006 VB denotes compared
T2625 4996-4997 -COMMA- denotes ,
T2624 4992-4996 NN denotes mice
T2623 4975-4991 JJ denotes IL-1Ra-deficient
T2622 4972-4974 IN denotes in
T2621 4962-4971 VB denotes prolonged
T2620 4958-4961 CC denotes and
T2619 4949-4957 VB denotes enhanced
T2618 4935-4948 RB denotes significantly
T2617 4931-4934 VB denotes was
T2616 4929-4930 -RRB- denotes )
T2615 4926-4929 NN denotes p65
T2614 4925-4926 -LRB- denotes (
T2613 4919-4924 NN denotes NF-κB
T2612 4916-4918 IN denotes of
T2611 4902-4915 NN denotes translocation
T2610 4894-4901 JJ denotes Nuclear
T2609 4891-4892 -RRB- denotes ]
T2608 4889-4891 CD denotes 35
T2607 4888-4889 -LRB- denotes [
T2606 4883-4887 NN denotes site
T2605 4875-4882 NN denotes binding
T2604 4867-4874 NN denotes protein
T2603 4845-4866 JJ denotes NF-κB/PU.1/GA-binding
T2602 4843-4844 -COLON- denotes ;
T2601 4836-4843 NN denotes factors
T2600 4822-4835 NN denotes transcription
T2599 4812-4821 JJ denotes different
T2598 4806-4811 CD denotes three
T2597 4803-4805 IN denotes of
T2596 4790-4802 NN denotes interactions
T2595 4786-4789 DT denotes the
T2594 4776-4785 VB denotes involving
T2593 4770-4775 NN denotes event
T2592 4762-4769 JJ denotes complex
T2591 4760-4761 DT denotes a
T2590 4757-4759 VB denotes is
T2589 4746-4756 NN denotes expression
T2588 4741-4745 NN denotes gene
T2587 4734-4740 NN denotes IL-1Ra
T2586 4731-4733 IN denotes of
T2585 4720-4730 NN denotes regulation
T2584 4716-4719 DT denotes the
T2583 4711-4715 IN denotes that
T2582 4701-4710 VB denotes suggested
T2581 4697-4700 FW denotes al.
T2580 4694-4696 FW denotes et
T2579 4688-4693 NNP denotes Smith
T2578 4682-4686 NN denotes IL-1
T2577 4679-4681 IN denotes of
T2576 4671-4678 NN denotes effects
T2575 4655-4670 JJ denotes proinflammatory
T2574 4651-4654 DT denotes the
T2573 4642-4650 VB denotes abrogate
T2572 4639-4641 TO denotes to
T2571 4632-4638 NN denotes IL-1Ra
T2570 4629-4631 IN denotes of
T2569 4621-4628 NN denotes ability
T2568 4617-4620 DT denotes the
T2567 4604-4616 VB denotes demonstrated
T2566 4599-4603 VB denotes have
T2565 4591-4598 NN denotes studies
T2564 4583-4590 JJ denotes Several
T2563 4573-4581 NN denotes response
T2562 4560-4572 JJ denotes inflammatory
T2561 4556-4559 DT denotes the
T2560 4553-4555 IN denotes of
T2559 4543-4552 NN denotes regulator
T2558 4534-4542 JJ denotes negative
T2557 4532-4533 DT denotes a
T2556 4529-4531 VB denotes is
T2555 4522-4528 NN denotes IL-1Ra
T2554 4518-4521 DT denotes the
T2553 4516-4517 -COMMA- denotes ,
T2552 4512-4516 NN denotes hand
T2551 4506-4511 JJ denotes other
T2550 4502-4505 DT denotes the
T2549 4499-4501 IN denotes On
T2548 4496-4497 -RRB- denotes ]
T2547 4494-4496 CD denotes 34
T2546 4493-4494 -LRB- denotes [
T2545 4490-4492 NNP denotes KC
T2544 4486-4489 CC denotes and
T2543 4484-4485 -COMMA- denotes ,
T2542 4478-4484 NN denotes GM-CSF
T2541 4476-4477 -COMMA- denotes ,
T2540 4472-4476 NN denotes IL-6
T2539 4470-4471 -COMMA- denotes ,
T2538 4461-4470 NN denotes IL-1alpha
T2537 4458-4460 IN denotes as
T2536 4453-4457 JJ denotes such
T2535 4451-4452 -COMMA- denotes ,
T2534 4446-4451 NN denotes genes
T2533 4437-4445 NN denotes cytokine
T2532 4421-4436 JJ denotes proinflammatory
T2531 4418-4420 IN denotes of
T2530 4411-4417 NN denotes region
T2529 4402-4410 NN denotes promoter
T2528 4398-4401 DT denotes the
T2152 2193-2197 RB denotes also
T2151 2184-2192 NN denotes blockade
T2150 2178-2183 NN denotes IL-1R
T2149 2175-2176 -RRB- denotes ]
T2148 2173-2175 CD denotes 18
T2147 2172-2173 -LRB- denotes [
T2146 2160-2171 NN denotes development
T2145 2151-2159 NN denotes melanoma
T2144 2141-2150 VB denotes inhibited
T2143 2137-2140 CC denotes and
T2142 2129-2136 VB denotes reduced
T2141 2125-2128 VB denotes was
T2140 2120-2124 NN denotes gene
T2139 2113-2119 NN denotes IL-1Ra
T2138 2108-2112 IN denotes with
T2137 2097-2107 VB denotes transduced
T2136 2092-2096 VB denotes were
T2135 2087-2091 WDT denotes that
T2134 2081-2086 NN denotes cells
T2133 2072-2080 NN denotes melanoma
T2132 2068-2071 DT denotes the
T2131 2065-2067 IN denotes of
T2130 2051-2064 NN denotes proliferation
T2129 2049-2050 -COMMA- denotes ,
T2128 2040-2049 RB denotes Meanwhile
T2127 2037-2038 -RRB- denotes ]
T2126 2035-2037 CD denotes 17
T2125 2034-2035 -LRB- denotes [
T2124 2022-2033 NN denotes carcinogens
T2123 2019-2021 TO denotes to
T2122 2010-2018 NN denotes exposure
T2121 2000-2009 VB denotes following
T2120 1993-1999 NN denotes tumors
T2119 1982-1992 JJ denotes aggressive
T2118 1972-1981 VB denotes developed
T2117 1967-1971 NN denotes mice
T2116 1957-1966 JJ denotes deficient
T2115 1950-1956 NN denotes IL-1Ra
T2114 1939-1949 JJ denotes endogenous
T2113 1934-1938 IN denotes that
T2112 1925-1933 VB denotes reported
T2111 1920-1924 RB denotes also
T2110 1916-1919 VB denotes was
T2109 1913-1915 PRP denotes It
T2108 1910-1911 -RRB- denotes ]
T2107 1908-1910 CD denotes 16
T2106 1907-1908 -LRB- denotes [
T2105 1900-1906 NN denotes cancer
T2104 1895-1899 NN denotes skin
T2103 1891-1894 CC denotes and
T2102 1889-1890 -COMMA- denotes ,
T2101 1888-1889 -RRB- denotes ]
T2100 1886-1888 CD denotes 15
T2099 1885-1886 -LRB- denotes [
T2098 1878-1884 NN denotes breast
T2097 1876-1877 -COMMA- denotes ,
T2096 1875-1876 -RRB- denotes ]
T2095 1873-1875 CD denotes 14
T2094 1872-1873 -LRB- denotes [
T2093 1863-1871 NN denotes prostate
T2092 1860-1862 IN denotes in
T2091 1852-1859 VB denotes reduced
T2090 1848-1851 VB denotes was
T2089 1837-1847 NN denotes expression
T2088 1830-1836 NN denotes IL-1Ra
T2087 1817-1828 NN denotes progression
T2086 1811-1816 NN denotes tumor
T2085 1805-1810 VB denotes block
T2084 1802-1804 TO denotes to
T2083 1795-1801 NN denotes IL-1Ra
T2082 1792-1794 IN denotes of
T2081 1784-1791 NN denotes ability
T2080 1780-1783 DT denotes the
T2079 1771-1779 VB denotes examined
T2078 1766-1770 VB denotes have
T2077 1758-1765 NN denotes studies
T2076 1749-1757 JJ denotes numerous
T2075 1747-1748 -COMMA- denotes ,
T2074 1735-1747 NN denotes chemotherapy
T2073 1732-1734 IN denotes of
T2072 1723-1731 NN denotes activity
T2071 1719-1722 DT denotes the
T2070 1709-1718 VB denotes enhancing
T2069 1706-1708 IN denotes by
T2068 1702-1705 CC denotes and
T2067 1692-1701 NN denotes responses
T2066 1685-1691 JJ denotes immune
T2065 1675-1684 JJ denotes antitumor
T2064 1665-1674 VB denotes promoting
T2063 1662-1664 IN denotes by
T2062 1650-1661 NN denotes progression
T2061 1644-1649 NN denotes tumor
T2060 1636-1643 VB denotes inhibit
T2059 1633-1635 TO denotes to
T2058 1627-1632 VB denotes shown
T2057 1622-1626 VB denotes been
T2056 1618-1621 VB denotes has
T2055 1611-1617 NN denotes IL-1Ra
T2054 1603-1610 IN denotes Because
T2053 1600-1601 -RRB- denotes ]
T2052 1598-1600 CD denotes 13
T2051 1597-1598 -LRB- denotes [
T2050 1588-1596 NN denotes receptor
T2049 1583-1587 NN denotes IL-1
T2048 1579-1582 DT denotes the
T2047 1572-1578 VB denotes blocks
T2046 1558-1571 RB denotes competitively
T2045 1553-1557 WDT denotes that
T2044 1544-1552 NN denotes cytokine
T2043 1534-1543 VB denotes occurring
T2042 1524-1533 RB denotes naturally
T2041 1522-1523 DT denotes a
T2040 1519-1521 VB denotes is
T2039 1517-1518 -COMMA- denotes ,
T2038 1511-1517 NN denotes family
T2037 1506-1510 NN denotes IL-1
T2036 1502-1505 DT denotes the
T2035 1499-1501 IN denotes of
T2034 1492-1498 NN denotes member
T2033 1490-1491 DT denotes a
T2032 1488-1489 -COMMA- denotes ,
T2031 1487-1488 -RRB- denotes )
T2030 1481-1487 NN denotes IL-1Ra
T2029 1480-1481 -LRB- denotes (
T2028 1469-1479 NN denotes antagonist
T2027 1460-1468 NN denotes receptor
T2026 1446-1459 NN denotes Interleukin-1
T2025 1433-1444 NN denotes development
T2024 1427-1432 NN denotes tumor
T2023 1424-1426 IN denotes of
T2022 1413-1423 NN denotes inhibition
T2021 1409-1412 DT denotes the
T2020 1406-1408 IN denotes in
T2019 1401-1405 VB denotes acts
T2018 1390-1400 NN denotes deficiency
T2017 1385-1389 NN denotes CCR5
T2016 1381-1384 WRB denotes how
T2015 1372-1380 VB denotes describe
T2014 1369-1371 TO denotes to
T2013 1360-1368 VB denotes required
T2012 1356-1359 VB denotes are
T2011 1348-1355 NN denotes studies
T2010 1343-1347 JJ denotes more
T2009 1341-1342 -COMMA- denotes ,
T2008 1334-1341 RB denotes However
T2007 1321-1332 NN denotes progression
T2006 1314-1320 NN denotes cancer
T2005 1311-1313 IN denotes in
T2004 1302-1310 NN denotes receptor
T2003 1290-1301 JJ denotes suppressive
T2002 1288-1289 DT denotes a
T2001 1285-1287 IN denotes as
T2000 1276-1284 VB denotes function
T1999 1272-1275 MD denotes may
T1998 1267-1271 NN denotes CCR5
T1997 1258-1266 NN denotes receptor
T1996 1248-1257 NN denotes chemokine
T1995 1235-1247 JJ denotes inflammatory
T1994 1232-1234 IN denotes of
T1993 1221-1231 NN denotes deficiency
T1992 1217-1220 DT denotes the
T1991 1212-1216 IN denotes that
T1990 1204-1211 VB denotes suggest
T1989 1199-1203 NN denotes data
T1988 1193-1198 DT denotes These
T1987 1190-1191 -RRB- denotes ]
T1986 1188-1190 CD denotes 12
T1985 1187-1188 -LRB- denotes [
T1984 1180-1186 NN denotes cancer
T1983 1175-1179 NN denotes lung
T1982 1171-1174 CC denotes and
T1981 1169-1170 -COMMA- denotes ,
T1980 1168-1169 -RRB- denotes ]
T1979 1167-1168 CD denotes 4
T1978 1166-1167 -LRB- denotes [
T1977 1160-1165 NN denotes cells
T1976 1151-1159 NN denotes hepatoma
T1975 1149-1150 -COMMA- denotes ,
T1974 1143-1149 NN denotes cancer
T1973 1136-1142 NN denotes breast
T1972 1134-1135 -COMMA- denotes ,
T1971 1133-1134 -RRB- denotes ]
T1970 1131-1133 CD denotes 11
T1969 1130-1131 -LRB- denotes [
T1968 1123-1129 NN denotes cancer
T1967 1114-1122 NN denotes prostate
T1966 1111-1113 IN denotes as
T1965 1106-1110 JJ denotes such
T1964 1104-1105 -COMMA- denotes ,
T1963 1098-1104 NN denotes growth
T1962 1093-1097 NN denotes cell
T1961 1086-1092 NN denotes cancer
T1960 1076-1085 VB denotes prevented
T1959 1065-1075 NN denotes inhibitors
T1958 1060-1064 NN denotes CCR5
T1957 1056-1059 CC denotes and
T1956 1054-1055 -COMMA- denotes ,
T1955 1053-1054 -RRB- denotes ]
T1954 1051-1053 CD denotes 10
T1953 1050-1051 -LRB- denotes [
T1952 1043-1049 NN denotes growth
T1951 1037-1042 NN denotes tumor
T1950 1034-1036 IN denotes of
T1949 1028-1033 NN denotes delay
T1948 1024-1027 DT denotes the
T1947 1012-1023 VB denotes potentiates
T1946 1007-1011 NN denotes CCR5
T1945 1004-1006 IN denotes of
T1944 996-1003 NN denotes absence
T1943 991-995 NN denotes host
T1935 955-965 JJ denotes pancreatic
T1934 952-954 IN denotes of
T1933 941-951 NN denotes metastasis
T1932 937-940 CC denotes and
T1931 930-936 NN denotes growth
T1930 924-929 NN denotes tumor
T2721 5531-5542 NN denotes development
T2720 5525-5530 NN denotes tumor
T2719 5522-5524 IN denotes of
T2718 5510-5521 NN denotes suppression
T2311 3092-3095 CC denotes and
T2310 3090-3091 -COMMA- denotes ,
T2309 3089-3090 -RRB- denotes ]
T2308 3087-3089 CD denotes 27
T2307 3086-3087 -LRB- denotes [
T2306 3077-3085 NN denotes melanoma
T2305 3073-3076 CC denotes and
T2304 3065-3072 NN denotes cancers
T2303 3056-3064 NN denotes prostate
T2302 3054-3055 -COMMA- denotes ,
T2301 3047-3054 NN denotes cancers
T2300 3041-3046 NN denotes colon
T2299 3031-3040 VB denotes including
T2298 3023-3030 NN denotes cancers
T2297 3020-3022 IN denotes of
T2296 3013-3019 NN denotes number
T2295 3007-3012 JJ denotes great
T2294 3005-3006 DT denotes a
T2293 3002-3004 IN denotes in
T2292 2992-3001 VB denotes described
T2291 2987-2991 VB denotes been
T2290 2983-2986 VB denotes has
T2289 2977-2982 NN denotes NF-κB
T2288 2974-2976 IN denotes of
T2287 2963-2973 NN denotes activation
T2286 2950-2962 JJ denotes Constitutive
T2285 2947-2948 -RRB- denotes ]
T2284 2945-2947 CD denotes 26
T2283 2944-2945 -LRB- denotes [
T2282 2932-2943 NN denotes development
T2281 2925-2931 NN denotes cancer
T2280 2920-2924 IN denotes with
T2279 2909-2919 VB denotes associated
T2278 2901-2908 RB denotes closely
T2277 2898-2900 VB denotes is
T2276 2894-2897 CC denotes and
T2275 2892-2893 -COMMA- denotes ,
T2274 2880-2892 NN denotes inflammation
T2273 2876-2879 CC denotes and
T2272 2862-2875 NN denotes proliferation
T2271 2857-2861 NN denotes cell
T2270 2854-2856 IN denotes of
T2269 2844-2853 NN denotes induction
T2268 2840-2843 DT denotes the
T2267 2837-2839 IN denotes as
T2266 2832-2836 RB denotes well
T2265 2829-2831 RB denotes as
T2264 2827-2828 -COMMA- denotes ,
T2263 2818-2827 NN denotes apoptosis
T2262 2815-2817 IN denotes of
T2261 2803-2814 NN denotes suppression
T2260 2799-2802 DT denotes the
T2259 2796-2798 IN denotes in
T2258 2791-2795 NN denotes role
T2257 2783-2790 JJ denotes crucial
T2256 2781-2782 DT denotes a
T2255 2775-2780 VB denotes plays
T2254 2769-2774 NN denotes NF-κB
T2253 2759-2767 NN denotes cytokine
T2252 2747-2758 VB denotes suppressing
T2251 2740-2746 NN denotes growth
T2250 2734-2739 NN denotes tumor
T2249 2732-2733 DT denotes a
T2248 2729-2731 IN denotes as
T2247 2719-2728 JJ denotes important
T2246 2716-2718 VB denotes is
T2245 2709-2715 NN denotes IL-1Ra
T2244 2704-2708 IN denotes that
T2243 2695-2703 VB denotes indicate
T2242 2690-2694 NN denotes data
T2241 2684-2689 DT denotes These
T2240 2681-2682 -RRB- denotes ]
T2239 2679-2681 CD denotes 25
T2238 2678-2679 -LRB- denotes [
T2237 2673-2677 FW denotes vivo
T2236 2670-2672 FW denotes in
T2235 2664-2669 NN denotes cells
T2234 2655-2663 NN denotes melanoma
T2233 2651-2654 NN denotes B16
T2232 2643-2650 IN denotes against
T2231 2634-2642 NN denotes activity
T2230 2624-2633 JJ denotes antitumor
T2229 2612-2623 JJ denotes significant
T2228 2607-2611 RB denotes more
T2227 2594-2606 VB denotes demonstrated
T2226 2592-2593 -COMMA- denotes ,
T2225 2580-2592 NN denotes chemotherapy
T2224 2570-2579 NN denotes docetaxel
T2223 2566-2569 CC denotes and
T2222 2553-2565 NN denotes temozolomide
T2221 2548-2552 IN denotes with
T2220 2539-2547 VB denotes combined
T2219 2537-2538 -COMMA- denotes ,
T2218 2531-2537 NN denotes IL-1Ra
T2217 2526-2530 IN denotes that
T2216 2520-2525 VB denotes found
T2215 2515-2519 RB denotes also
T2214 2511-2514 VB denotes was
T2213 2508-2510 PRP denotes It
T2212 2505-2506 -RRB- denotes ]
T2211 2503-2505 CD denotes 24
T2210 2502-2503 -LRB- denotes [
T2209 2495-2501 NN denotes tumors
T2208 2489-2494 JJ denotes solid
T2207 2481-2488 VB denotes develop
T2206 2478-2480 TO denotes to
T2205 2471-2477 VB denotes failed
T2204 2462-2470 NN denotes melanoma
T2203 2457-2461 IN denotes with
T2202 2448-2456 VB denotes injected
T2201 2443-2447 NN denotes mice
T2200 2434-2442 NN denotes knockout
T2199 2429-2433 NN denotes IL-1
T2198 2426-2427 -RRB- denotes ]
T2197 2424-2426 CD denotes 23
T2196 2423-2424 -LRB- denotes [
T2195 2411-2422 NN denotes development
T2194 2404-2410 NN denotes cancer
T2193 2399-2403 NN denotes skin
T2192 2395-2398 CC denotes and
T2191 2393-2394 -COMMA- denotes ,
T2190 2392-2393 -RRB- denotes ]
T2189 2390-2392 CD denotes 22
T2188 2389-2390 -LRB- denotes [
T2187 2382-2388 NN denotes growth
T2186 2367-2381 NN denotes adenocarcinoma
T2185 2361-2366 NN denotes colon
T2184 2359-2360 -COMMA- denotes ,
T2183 2358-2359 -RRB- denotes ]
T2182 2356-2358 CD denotes 21
T2181 2355-2356 -LRB- denotes [
T2180 2344-2354 NN denotes metastasis
T2179 2340-2343 CC denotes and
T2178 2333-2339 NN denotes growth
T2177 2324-2332 NN denotes melanoma
T2176 2320-2323 NN denotes B16
T2175 2318-2319 -COMMA- denotes ,
T2174 2317-2318 -RRB- denotes ]
T2173 2315-2317 CD denotes 20
T2172 2314-2315 -LRB- denotes [
T2171 2302-2313 NN denotes development
T2170 2289-2301 NN denotes fibrosarcoma
T2169 2281-2288 VB denotes reduces
T2168 2274-2280 NN denotes IL-1Ra
T2167 2269-2273 IN denotes that
T2166 2260-2268 VB denotes reported
T2165 2255-2259 VB denotes been
T2164 2250-2254 RB denotes also
T2163 2246-2249 VB denotes has
T2162 2243-2245 PRP denotes it
T2161 2241-2242 -COMMA- denotes ,
T2160 2233-2241 RB denotes Moreover
T2159 2230-2231 -RRB- denotes ]
T1929 911-923 JJ denotes experimental
T1928 903-910 VB denotes inhibit
T1927 900-902 TO denotes to
T1926 887-899 VB denotes demonstrated
T1925 882-886 VB denotes been
T1924 878-881 VB denotes has
T1923 867-877 NN denotes disruption
T1922 862-866 NN denotes CCR5
T1921 860-861 -COMMA- denotes ,
T1920 851-860 RB denotes Meanwhile
T1919 848-849 -RRB- denotes ]
T1918 847-848 CD denotes 8
T1917 846-847 -LRB- denotes [
T1916 836-845 NN denotes prognosis
T1915 831-835 JJ denotes poor
T1914 826-830 IN denotes with
T1913 815-825 VB denotes correlates
T1912 810-814 RB denotes also
T1911 806-809 CC denotes and
T1910 804-805 -COMMA- denotes ,
T1909 803-804 -RRB- denotes ]
T1908 802-803 CD denotes 7
T1907 801-802 -LRB- denotes [
T1905 787-793 NN denotes breast
T1904 784-786 IN denotes of
T1903 772-783 NN denotes progression
T1902 768-771 DT denotes the
T1901 765-767 IN denotes in
T1900 755-764 JJ denotes important
T1899 750-754 RB denotes also
T1898 747-749 VB denotes is
T1897 742-746 NN denotes CCL5
T1896 738-741 DT denotes the
T1895 735-737 IN denotes of
T1894 724-734 NN denotes production
T1893 718-723 JJ denotes Local
T1892 715-716 -RRB- denotes ]
T1891 714-715 CD denotes 6
T1890 713-714 -LRB- denotes [
T1889 707-712 NN denotes cells
T1888 700-706 NN denotes cancer
T1887 691-699 NN denotes prostate
T1886 687-690 CC denotes and
T1885 682-686 JJ denotes oral
T1884 679-681 IN denotes as
T1883 674-678 RB denotes well
T1882 671-673 RB denotes as
T1881 669-670 -COMMA- denotes ,
T1880 668-669 -RRB- denotes ]
T1879 667-668 CD denotes 5
T1878 666-667 -LRB- denotes [
T1877 657-665 NN denotes lymphoma
T1876 649-656 NN denotes Hodgkin
T1875 647-648 -COMMA- denotes ,
T1874 635-647 NN denotes glioblastoma
T1873 633-634 -COMMA- denotes ,
T1872 632-633 -RRB- denotes ]
T1871 631-632 CD denotes 4
T1870 630-631 -LRB- denotes [
T1869 621-629 NN denotes hepatoma
T1868 619-620 -COMMA- denotes ,
T1867 618-619 -RRB- denotes ]
T1866 617-618 CD denotes 3
T1865 616-617 -LRB- denotes [
T1864 607-615 NN denotes melanoma
T1863 605-606 -COMMA- denotes ,
T1862 604-605 -RRB- denotes ]
T1861 603-604 CD denotes 2
T1860 602-603 -LRB- denotes [
T1859 595-601 NN denotes cancer
T1858 584-594 JJ denotes colorectal
T1857 581-583 IN denotes of
T1856 569-580 NN denotes development
T1855 555-568 JJ denotes nonmetastatic
T1854 550-554 IN denotes with
T1853 539-549 VB denotes associated
T1852 525-538 RB denotes significantly
T1851 522-524 VB denotes is
T1850 511-521 NN denotes expression
T1849 506-510 NN denotes CCR5
T1848 499-505 JJ denotes strong
T1847 495-498 CC denotes and
T1846 482-494 JJ denotes Intermediate
T1845 473-480 NN denotes cancers
T1844 465-472 JJ denotes several
T1843 462-464 IN denotes of
T1842 451-461 NN denotes metastasis
T1841 447-450 CC denotes and
T1840 433-446 NN denotes proliferation
T1839 429-432 DT denotes the
T1838 426-428 IN denotes in
T1837 417-425 VB denotes involved
T1836 403-416 RB denotes significantly
T1835 400-402 VB denotes be
T1834 396-399 MD denotes may
T1833 394-395 -COMMA- denotes ,
T1832 389-394 NN denotes cells
T1831 376-388 JJ denotes inflammatory
T1830 372-375 IN denotes for
T1829 364-371 NN denotes factors
T1828 352-363 JJ denotes chemotactic
T1827 345-351 JJ denotes potent
T1826 341-344 VB denotes are
T1825 335-340 WDT denotes which
T1824 333-334 -COMMA- denotes ,
T1823 332-333 -RRB- denotes )
T1822 328-332 NN denotes CCR5
T1821 327-328 -LRB- denotes (
T1820 318-326 NN denotes receptor
T1819 308-317 NN denotes chemokine
T1818 304-307 NN denotes C-C
T1817 300-303 CC denotes and
T1816 298-299 -RRB- denotes )
T1815 294-298 NN denotes CCL5
T1814 293-294 -LRB- denotes (
T1813 291-292 CD denotes 5
T1812 284-290 NN denotes ligand
T1811 282-283 -RRB- denotes )
T1810 277-282 NN denotes motif
T1809 273-276 NN denotes C-C
T1808 272-273 -LRB- denotes (
T1807 262-271 NN denotes chemokine
T1806 258-261 DT denotes the
T1805 253-257 IN denotes that
T1804 243-252 VB denotes indicates
T1803 234-242 NN denotes evidence
T1802 222-233 VB denotes accumulated
T1801 218-221 DT denotes The
T1800 215-216 -RRB- denotes ]
T1799 214-215 CD denotes 1
T1798 213-214 -LRB- denotes [
T1797 203-212 NN denotes receptors
T1796 193-202 NN denotes chemokine
T1795 189-192 CC denotes and
T1794 178-188 NN denotes chemokines
T1793 170-177 VB denotes express
T1792 164-169 NN denotes cells
T1791 157-163 NN denotes cancer
T1790 154-156 IN denotes of
T1789 148-153 NN denotes types
T1788 143-147 JJ denotes Many
T1787 129-141 NN denotes inflammation
T1786 126-128 IN denotes by
T1785 119-125 NN denotes growth
T1784 114-118 NN denotes cell
T1783 107-113 NN denotes cancer
T1782 100-106 VB denotes induce
T1781 97-99 TO denotes to
T1780 89-96 NN denotes ability
T1779 82-88 JJ denotes potent
T1778 76-81 PRP-DOLLAR- denotes their
T1777 72-75 IN denotes for
T1776 66-71 VB denotes known
T1775 61-65 RB denotes best
T1774 57-60 VB denotes are
T1773 52-56 WDT denotes that
T1772 42-51 NN denotes molecules
T1771 34-41 JJ denotes soluble
T1770 28-33 JJ denotes small
T1769 24-27 VB denotes are
T1768 13-23 NN denotes Chemokines
T1942 989-990 -COMMA- denotes ,
T1941 981-989 NN denotes addition
T1940 978-980 IN denotes In
T1939 975-976 -RRB- denotes ]
T1938 974-975 CD denotes 9
T1937 973-974 -LRB- denotes [
T1936 966-972 NN denotes cancer
R838 T1768 T1769 arg1Of Chemokines,are
R839 T1772 T1769 arg2Of molecules,are
R840 T1772 T1770 arg1Of molecules,small
R841 T1772 T1771 arg1Of molecules,soluble
R842 T1772 T1773 arg1Of molecules,that
R843 T1772 T1774 arg1Of molecules,are
R844 T1772 T1776 arg2Of molecules,known
R845 T1776 T1774 arg2Of known,are
R846 T1776 T1775 arg1Of known,best
R847 T1776 T1777 arg1Of known,for
R848 T1780 T1777 arg2Of ability,for
R849 T1780 T1778 arg1Of ability,their
R850 T1780 T1779 arg1Of ability,potent
R851 T1780 T1781 modOf ability,to
R852 T1782 T1781 arg1Of induce,to
R853 T1782 T1786 arg1Of induce,by
R854 T1785 T1782 arg2Of growth,induce
R855 T1785 T1783 arg1Of growth,cancer
R856 T1785 T1784 arg1Of growth,cell
R857 T1787 T1786 arg2Of inflammation,by
R858 T1789 T1788 arg1Of types,Many
R859 T1789 T1790 arg1Of types,of
R860 T1789 T1793 arg1Of types,express
R861 T1792 T1790 arg2Of cells,of
R862 T1792 T1791 arg1Of cells,cancer
R863 T1793 T1798 arg1Of express,[
R864 T1794 T1795 arg1Of chemokines,and
R865 T1795 T1793 arg2Of and,express
R866 T1797 T1795 arg2Of receptors,and
R867 T1797 T1796 arg1Of receptors,chemokine
R868 T1799 T1798 arg2Of 1,[
R869 T1800 T1798 arg3Of ],[
R870 T1803 T1801 arg1Of evidence,The
R871 T1803 T1802 arg2Of evidence,accumulated
R872 T1803 T1804 arg1Of evidence,indicates
R873 T1810 T1808 arg2Of motif,(
R874 T1810 T1809 arg1Of motif,C-C
R875 T1811 T1808 arg3Of ),(
R876 T1812 T1806 arg1Of ligand,the
R877 T1812 T1807 arg1Of ligand,chemokine
R878 T1812 T1808 arg1Of ligand,(
R879 T1812 T1813 arg1Of ligand,5
R880 T1812 T1814 arg1Of ligand,(
R881 T1812 T1817 arg1Of ligand,and
R882 T1815 T1814 arg2Of CCL5,(
R883 T1816 T1814 arg3Of ),(
R884 T1817 T1834 arg1Of and,may
R885 T1817 T1835 arg1Of and,be
R886 T1817 T1837 arg2Of and,involved
R887 T1820 T1817 arg2Of receptor,and
R888 T1820 T1818 arg1Of receptor,C-C
R889 T1820 T1819 arg1Of receptor,chemokine
R890 T1820 T1821 arg1Of receptor,(
R891 T1820 T1824 arg1Of receptor,","
R892 T1820 T1825 arg1Of receptor,which
R893 T1820 T1826 arg1Of receptor,are
R894 T1822 T1821 arg2Of CCR5,(
R895 T1823 T1821 arg3Of ),(
R896 T1829 T1826 arg2Of factors,are
R897 T1829 T1827 arg1Of factors,potent
R898 T1829 T1828 arg1Of factors,chemotactic
R899 T1829 T1830 arg1Of factors,for
R900 T1832 T1830 arg2Of cells,for
R901 T1832 T1831 arg1Of cells,inflammatory
R902 T1837 T1804 arg2Of involved,indicates
R903 T1837 T1805 arg1Of involved,that
R904 T1837 T1833 arg1Of involved,","
R905 T1837 T1834 arg2Of involved,may
R906 T1837 T1835 arg2Of involved,be
R907 T1837 T1836 arg1Of involved,significantly
R908 T1837 T1838 arg1Of involved,in
R909 T1840 T1841 arg1Of proliferation,and
R910 T1841 T1838 arg2Of and,in
R911 T1841 T1839 arg1Of and,the
R912 T1841 T1843 arg1Of and,of
R913 T1842 T1841 arg2Of metastasis,and
R914 T1845 T1843 arg2Of cancers,of
R915 T1845 T1844 arg1Of cancers,several
R916 T1846 T1847 arg1Of Intermediate,and
R917 T1848 T1847 arg2Of strong,and
R918 T1850 T1846 arg1Of expression,Intermediate
R919 T1850 T1848 arg1Of expression,strong
R920 T1850 T1849 arg1Of expression,CCR5
R921 T1850 T1851 arg1Of expression,is
R922 T1850 T1853 arg2Of expression,associated
R923 T1853 T1851 arg2Of associated,is
R924 T1853 T1852 arg1Of associated,significantly
R925 T1853 T1854 arg1Of associated,with
R926 T1853 T1890 arg1Of associated,[
R927 T1856 T1855 arg1Of development,nonmetastatic
R928 T1856 T1857 arg1Of development,of
R929 T1856 T1884 arg1Of development,as
R930 T1859 T1858 arg1Of cancer,colorectal
R931 T1859 T1860 arg1Of cancer,[
R932 T1859 T1863 arg1Of cancer,","
R933 T1861 T1860 arg2Of 2,[
R934 T1862 T1860 arg3Of ],[
R935 T1863 T1868 arg1Of ",",","
R936 T1864 T1863 arg2Of melanoma,","
R937 T1864 T1865 arg1Of melanoma,[
R938 T1866 T1865 arg2Of 3,[
R939 T1867 T1865 arg3Of ],[
R940 T1868 T1873 arg1Of ",",","
R941 T1869 T1868 arg2Of hepatoma,","
R942 T1869 T1870 arg1Of hepatoma,[
R943 T1871 T1870 arg2Of 4,[
R944 T1872 T1870 arg3Of ],[
R945 T1873 T1875 arg1Of ",",","
R946 T1874 T1873 arg2Of glioblastoma,","
R947 T1875 T1857 arg2Of ",",of
R948 T1877 T1875 arg2Of lymphoma,","
R949 T1877 T1876 arg1Of lymphoma,Hodgkin
R950 T1877 T1878 arg1Of lymphoma,[
R951 T1879 T1878 arg2Of 5,[
R952 T1880 T1878 arg3Of ],[
R953 T1884 T1854 arg2Of as,with
R954 T1884 T1881 arg1Of as,","
R955 T1884 T1882 arg1Of as,as
R956 T1884 T1883 arg1Of as,well
R957 T1889 T1884 arg2Of cells,as
R958 T1889 T1885 arg1Of cells,oral
R959 T1889 T1886 arg1Of cells,and
R960 T1889 T1887 arg1Of cells,prostate
R961 T1889 T1888 arg1Of cells,cancer
R962 T1891 T1890 arg2Of 6,[
R963 T1892 T1890 arg3Of ],[
R964 T1894 T1893 arg1Of production,Local
R965 T1894 T1895 arg1Of production,of
R966 T1894 T1898 arg1Of production,is
R967 T1894 T1900 arg1Of production,important
R968 T1894 T1913 arg1Of production,correlates
R969 T1897 T1895 arg2Of CCL5,of
R970 T1897 T1896 arg1Of CCL5,the
R971 T1898 T1899 arg1Of is,also
R972 T1898 T1911 arg1Of is,and
R973 T1900 T1898 arg2Of important,is
R974 T1900 T1901 arg1Of important,in
R975 T1903 T1901 arg2Of progression,in
R976 T1903 T1902 arg1Of progression,the
R977 T1903 T1904 arg1Of progression,of
R978 T1906 T1904 arg2Of cancer,of
R979 T1906 T1905 arg1Of cancer,breast
R980 T1906 T1907 arg1Of cancer,[
R981 T1908 T1907 arg2Of 7,[
R982 T1909 T1907 arg3Of ],[
R983 T1911 T1910 arg1Of and,","
R984 T1913 T1911 arg2Of correlates,and
R985 T1913 T1912 arg1Of correlates,also
R986 T1913 T1914 arg1Of correlates,with
R987 T1913 T1917 arg1Of correlates,[
R988 T1916 T1914 arg2Of prognosis,with
R989 T1916 T1915 arg1Of prognosis,poor
R990 T1918 T1917 arg2Of 8,[
R991 T1919 T1917 arg3Of ],[
R992 T1923 T1922 arg1Of disruption,CCR5
R993 T1923 T1924 arg1Of disruption,has
R994 T1923 T1925 arg1Of disruption,been
R995 T1923 T1926 arg2Of disruption,demonstrated
R996 T1923 T1928 arg1Of disruption,inhibit
R997 T1926 T1920 arg1Of demonstrated,Meanwhile
R998 T1926 T1921 arg1Of demonstrated,","
R999 T1926 T1924 arg2Of demonstrated,has
R1000 T1926 T1925 arg2Of demonstrated,been
R1001 T1928 T1926 arg3Of inhibit,demonstrated
R1002 T1928 T1927 arg1Of inhibit,to
R1003 T1928 T1937 arg1Of inhibit,[
R1004 T1931 T1929 arg1Of growth,experimental
R1005 T1931 T1930 arg1Of growth,tumor
R1006 T1931 T1932 arg1Of growth,and
R1007 T1932 T1928 arg2Of and,inhibit
R1008 T1933 T1932 arg2Of metastasis,and
R1009 T1933 T1934 arg1Of metastasis,of
R1010 T1936 T1934 arg2Of cancer,of
R1011 T1936 T1935 arg1Of cancer,pancreatic
R1012 T1938 T1937 arg2Of 9,[
R1013 T1939 T1937 arg3Of ],[
R1014 T1941 T1940 arg2Of addition,In
R1015 T1944 T1943 arg1Of absence,host
R1016 T1944 T1945 arg1Of absence,of
R1017 T1944 T1947 arg1Of absence,potentiates
R1018 T1946 T1945 arg2Of CCR5,of
R1019 T1947 T1957 arg1Of potentiates,and
R1020 T1949 T1947 arg2Of delay,potentiates
R1021 T1949 T1948 arg1Of delay,the
R1022 T1949 T1950 arg1Of delay,of
R1023 T1952 T1950 arg2Of growth,of
R1024 T1952 T1951 arg1Of growth,tumor
R1025 T1952 T1953 arg1Of growth,[
R1026 T1954 T1953 arg2Of 10,[
R1027 T1955 T1953 arg3Of ],[
R1028 T1957 T1940 arg1Of and,In
R1029 T1957 T1942 arg1Of and,","
R1030 T1957 T1956 arg1Of and,","
R1031 T1959 T1958 arg1Of inhibitors,CCR5
R1032 T1959 T1960 arg1Of inhibitors,prevented
R1033 T1960 T1957 arg2Of prevented,and
R1034 T1963 T1960 arg2Of growth,prevented
R1035 T1963 T1961 arg1Of growth,cancer
R1036 T1963 T1962 arg1Of growth,cell
R1037 T1963 T1964 arg1Of growth,","
R1038 T1963 T1966 arg1Of growth,as
R1039 T1966 T1965 arg1Of as,such
R1040 T1968 T1967 arg1Of cancer,prostate
R1041 T1968 T1969 arg1Of cancer,[
R1042 T1968 T1972 arg1Of cancer,","
R1043 T1970 T1969 arg2Of 11,[
R1044 T1971 T1969 arg3Of ],[
R1045 T1972 T1975 arg1Of ",",","
R1046 T1974 T1972 arg2Of cancer,","
R1047 T1974 T1973 arg1Of cancer,breast
R1048 T1975 T1982 arg1Of ",",and
R1049 T1977 T1975 arg2Of cells,","
R1050 T1977 T1976 arg1Of cells,hepatoma
R1051 T1977 T1978 arg1Of cells,[
R1052 T1979 T1978 arg2Of 4,[
R1053 T1980 T1978 arg3Of ],[
R1054 T1982 T1966 arg2Of and,as
R1055 T1982 T1981 arg1Of and,","
R1056 T1984 T1982 arg2Of cancer,and
R1057 T1984 T1983 arg1Of cancer,lung
R1058 T1984 T1985 arg1Of cancer,[
R1059 T1986 T1985 arg2Of 12,[
R1060 T1987 T1985 arg3Of ],[
R1061 T1989 T1988 arg1Of data,These
R1062 T1989 T1990 arg1Of data,suggest
R1063 T1993 T1992 arg1Of deficiency,the
R1064 T1993 T1994 arg1Of deficiency,of
R1065 T1993 T1999 arg1Of deficiency,may
R1066 T1993 T2000 arg1Of deficiency,function
R1067 T1998 T1994 arg2Of CCR5,of
R1068 T1998 T1995 arg1Of CCR5,inflammatory
R1069 T1998 T1996 arg1Of CCR5,chemokine
R1070 T1998 T1997 arg1Of CCR5,receptor
R1071 T2000 T1990 arg2Of function,suggest
R1072 T2000 T1991 arg1Of function,that
R1073 T2000 T1999 arg2Of function,may
R1074 T2000 T2001 arg1Of function,as
R1075 T2004 T2001 arg2Of receptor,as
R1076 T2004 T2002 arg1Of receptor,a
R1077 T2004 T2003 arg1Of receptor,suppressive
R1078 T2004 T2005 arg1Of receptor,in
R1079 T2007 T2005 arg2Of progression,in
R1080 T2007 T2006 arg1Of progression,cancer
R1081 T2011 T2010 arg1Of studies,more
R1082 T2011 T2012 arg1Of studies,are
R1083 T2011 T2013 arg2Of studies,required
R1084 T2013 T2008 arg1Of required,However
R1085 T2013 T2009 arg1Of required,","
R1086 T2013 T2012 arg2Of required,are
R1087 T2015 T2013 arg3Of describe,required
R1088 T2015 T2014 arg1Of describe,to
R1089 T2016 T2015 arg2Of how,describe
R1090 T2018 T2017 arg1Of deficiency,CCR5
R1091 T2018 T2019 arg1Of deficiency,acts
R1092 T2019 T2016 arg1Of acts,how
R1093 T2019 T2020 arg1Of acts,in
R1094 T2022 T2020 arg2Of inhibition,in
R1095 T2022 T2021 arg1Of inhibition,the
R1096 T2022 T2023 arg1Of inhibition,of
R1097 T2025 T2023 arg2Of development,of
R1098 T2025 T2024 arg1Of development,tumor
R1099 T2028 T2026 arg1Of antagonist,Interleukin-1
R1100 T2028 T2027 arg1Of antagonist,receptor
R1101 T2028 T2029 arg1Of antagonist,(
R1102 T2028 T2032 arg1Of antagonist,","
R1103 T2028 T2040 arg1Of antagonist,is
R1104 T2030 T2029 arg2Of IL-1Ra,(
R1105 T2031 T2029 arg3Of ),(
R1106 T2034 T2032 arg2Of member,","
R1107 T2034 T2033 arg1Of member,a
R1108 T2034 T2035 arg1Of member,of
R1109 T2038 T2035 arg2Of family,of
R1110 T2038 T2036 arg1Of family,the
R1111 T2038 T2037 arg1Of family,IL-1
R1112 T2040 T2039 arg1Of is,","
R1113 T2043 T2042 arg1Of occurring,naturally
R1114 T2044 T2040 arg2Of cytokine,is
R1115 T2044 T2041 arg1Of cytokine,a
R1116 T2044 T2043 arg1Of cytokine,occurring
R1117 T2044 T2045 arg1Of cytokine,that
R1118 T2044 T2047 arg1Of cytokine,blocks
R1119 T2047 T2046 arg1Of blocks,competitively
R1120 T2047 T2051 arg1Of blocks,[
R1121 T2050 T2047 arg2Of receptor,blocks
R1122 T2050 T2048 arg1Of receptor,the
R1123 T2050 T2049 arg1Of receptor,IL-1
R1124 T2052 T2051 arg2Of 13,[
R1125 T2053 T2051 arg3Of ],[
R1126 T2055 T2056 arg1Of IL-1Ra,has
R1127 T2055 T2057 arg1Of IL-1Ra,been
R1128 T2055 T2058 arg2Of IL-1Ra,shown
R1129 T2055 T2060 arg1Of IL-1Ra,inhibit
R1130 T2055 T2064 arg1Of IL-1Ra,promoting
R1131 T2055 T2070 arg1Of IL-1Ra,enhancing
R1132 T2058 T2054 arg2Of shown,Because
R1133 T2058 T2056 arg2Of shown,has
R1134 T2058 T2057 arg2Of shown,been
R1135 T2060 T2058 arg3Of inhibit,shown
R1136 T2060 T2059 arg1Of inhibit,to
R1137 T2060 T2063 arg1Of inhibit,by
R1138 T2060 T2069 arg1Of inhibit,by
R1139 T2062 T2060 arg2Of progression,inhibit
R1140 T2062 T2061 arg1Of progression,tumor
R1141 T2063 T2068 arg1Of by,and
R1142 T2064 T2063 arg2Of promoting,by
R1143 T2067 T2064 arg2Of responses,promoting
R1144 T2067 T2065 arg1Of responses,antitumor
R1145 T2067 T2066 arg1Of responses,immune
R1146 T2069 T2068 arg2Of by,and
R1147 T2070 T2069 arg2Of enhancing,by
R1148 T2072 T2070 arg2Of activity,enhancing
R1149 T2072 T2071 arg1Of activity,the
R1150 T2072 T2073 arg1Of activity,of
R1151 T2074 T2073 arg2Of chemotherapy,of
R1152 T2077 T2076 arg1Of studies,numerous
R1153 T2077 T2078 arg1Of studies,have
R1154 T2077 T2079 arg1Of studies,examined
R1155 T2079 T2054 arg1Of examined,Because
R1156 T2079 T2075 arg1Of examined,","
R1157 T2079 T2078 arg2Of examined,have
R1158 T2081 T2079 arg2Of ability,examined
R1159 T2081 T2080 arg1Of ability,the
R1160 T2081 T2082 arg1Of ability,of
R1161 T2081 T2084 modOf ability,to
R1162 T2083 T2082 arg2Of IL-1Ra,of
R1163 T2085 T2084 arg1Of block,to
R1164 T2087 T2085 arg2Of progression,block
R1165 T2087 T2086 arg1Of progression,tumor
R1166 T2089 T2088 arg1Of expression,IL-1Ra
R1167 T2089 T2090 arg1Of expression,was
R1168 T2089 T2091 arg2Of expression,reduced
R1169 T2091 T2090 arg2Of reduced,was
R1170 T2091 T2092 arg1Of reduced,in
R1171 T2093 T2094 arg1Of prostate,[
R1172 T2093 T2097 arg1Of prostate,","
R1173 T2095 T2094 arg2Of 14,[
R1174 T2096 T2094 arg3Of ],[
R1175 T2097 T2103 arg1Of ",",and
R1176 T2098 T2097 arg2Of breast,","
R1177 T2098 T2099 arg1Of breast,[
R1178 T2100 T2099 arg2Of 15,[
R1179 T2101 T2099 arg3Of ],[
R1180 T2103 T2092 arg2Of and,in
R1181 T2103 T2102 arg1Of and,","
R1182 T2105 T2103 arg2Of cancer,and
R1183 T2105 T2104 arg1Of cancer,skin
R1184 T2105 T2106 arg1Of cancer,[
R1185 T2107 T2106 arg2Of 16,[
R1186 T2108 T2106 arg3Of ],[
R1187 T2109 T2110 arg1Of It,was
R1188 T2109 T2112 arg2Of It,reported
R1189 T2112 T2110 arg2Of reported,was
R1190 T2112 T2111 arg1Of reported,also
R1191 T2117 T2114 arg1Of mice,endogenous
R1192 T2117 T2115 arg1Of mice,IL-1Ra
R1193 T2117 T2116 arg1Of mice,deficient
R1194 T2117 T2118 arg1Of mice,developed
R1195 T2118 T2112 arg3Of developed,reported
R1196 T2118 T2113 arg1Of developed,that
R1197 T2118 T2121 arg1Of developed,following
R1198 T2120 T2118 arg2Of tumors,developed
R1199 T2120 T2119 arg1Of tumors,aggressive
R1200 T2122 T2121 arg2Of exposure,following
R1201 T2122 T2123 arg1Of exposure,to
R1202 T2124 T2123 arg2Of carcinogens,to
R1203 T2124 T2125 arg1Of carcinogens,[
R1204 T2126 T2125 arg2Of 17,[
R1205 T2127 T2125 arg3Of ],[
R1206 T2130 T2131 arg1Of proliferation,of
R1207 T2130 T2141 arg1Of proliferation,was
R1208 T2130 T2142 arg2Of proliferation,reduced
R1209 T2130 T2144 arg1Of proliferation,inhibited
R1210 T2134 T2131 arg2Of cells,of
R1211 T2134 T2132 arg1Of cells,the
R1212 T2134 T2133 arg1Of cells,melanoma
R1213 T2134 T2135 arg1Of cells,that
R1214 T2134 T2136 arg1Of cells,were
R1215 T2134 T2137 arg2Of cells,transduced
R1216 T2137 T2136 arg2Of transduced,were
R1217 T2137 T2138 arg1Of transduced,with
R1218 T2140 T2138 arg2Of gene,with
R1219 T2140 T2139 arg1Of gene,IL-1Ra
R1220 T2142 T2141 arg2Of reduced,was
R1221 T2142 T2143 arg1Of reduced,and
R1222 T2143 T2128 arg1Of and,Meanwhile
R1223 T2143 T2129 arg1Of and,","
R1224 T2143 T2147 arg1Of and,[
R1225 T2144 T2143 arg2Of inhibited,and
R1226 T2146 T2144 arg2Of development,inhibited
R1227 T2146 T2145 arg1Of development,melanoma
R1228 T2148 T2147 arg2Of 18,[
R1229 T2149 T2147 arg3Of ],[
R1230 T2151 T2150 arg1Of blockade,IL-1R
R1231 T2151 T2153 arg1Of blockade,reduced
R1232 T2153 T2152 arg1Of reduced,also
R1233 T2156 T2153 arg2Of growth,reduced
R1234 T2156 T2154 arg1Of growth,hepatic
R1235 T2156 T2155 arg1Of growth,tumor
R1236 T2156 T2157 arg1Of growth,[
R1237 T2158 T2157 arg2Of 19,[
R1238 T2159 T2157 arg3Of ],[
R1239 T2162 T2163 arg1Of it,has
R1240 T2162 T2165 arg1Of it,been
R1241 T2162 T2166 arg2Of it,reported
R1242 T2166 T2160 arg1Of reported,Moreover
R1243 T2166 T2161 arg1Of reported,","
R1244 T2166 T2163 arg2Of reported,has
R1245 T2166 T2164 arg1Of reported,also
R1246 T2166 T2165 arg2Of reported,been
R1247 T2168 T2169 arg1Of IL-1Ra,reduces
R1248 T2169 T2166 arg3Of reduces,reported
R1249 T2169 T2167 arg1Of reduces,that
R1250 T2169 T2196 arg1Of reduces,[
R1251 T2171 T2172 arg1Of development,[
R1252 T2171 T2175 arg1Of development,","
R1253 T2173 T2172 arg2Of 20,[
R1254 T2174 T2172 arg3Of ],[
R1255 T2177 T2175 arg2Of melanoma,","
R1256 T2177 T2176 arg1Of melanoma,B16
R1257 T2178 T2179 arg1Of growth,and
R1258 T2179 T2170 arg1Of and,fibrosarcoma
R1259 T2179 T2171 arg1Of and,development
R1260 T2179 T2177 arg1Of and,melanoma
R1261 T2179 T2181 arg1Of and,[
R1262 T2179 T2184 arg1Of and,","
R1263 T2180 T2179 arg2Of metastasis,and
R1264 T2182 T2181 arg2Of 21,[
R1265 T2183 T2181 arg3Of ],[
R1266 T2184 T2192 arg1Of ",",and
R1267 T2187 T2184 arg2Of growth,","
R1268 T2187 T2185 arg1Of growth,colon
R1269 T2187 T2186 arg1Of growth,adenocarcinoma
R1270 T2187 T2188 arg1Of growth,[
R1271 T2189 T2188 arg2Of 22,[
R1272 T2190 T2188 arg3Of ],[
R1273 T2192 T2169 arg2Of and,reduces
R1274 T2192 T2191 arg1Of and,","
R1275 T2195 T2192 arg2Of development,and
R1276 T2195 T2193 arg1Of development,skin
R1277 T2195 T2194 arg1Of development,cancer
R1278 T2197 T2196 arg2Of 23,[
R1279 T2198 T2196 arg3Of ],[
R1280 T2201 T2199 arg1Of mice,IL-1
R1281 T2201 T2200 arg1Of mice,knockout
R1282 T2201 T2202 arg2Of mice,injected
R1283 T2201 T2205 arg1Of mice,failed
R1284 T2201 T2207 arg1Of mice,develop
R1285 T2202 T2203 arg1Of injected,with
R1286 T2204 T2203 arg2Of melanoma,with
R1287 T2207 T2205 arg2Of develop,failed
R1288 T2207 T2206 arg1Of develop,to
R1289 T2209 T2207 arg2Of tumors,develop
R1290 T2209 T2208 arg1Of tumors,solid
R1291 T2209 T2210 arg1Of tumors,[
R1292 T2211 T2210 arg2Of 24,[
R1293 T2212 T2210 arg3Of ],[
R1294 T2213 T2214 arg1Of It,was
R1295 T2213 T2216 arg2Of It,found
R1296 T2216 T2214 arg2Of found,was
R1297 T2216 T2215 arg1Of found,also
R1298 T2218 T2219 arg1Of IL-1Ra,","
R1299 T2218 T2220 arg2Of IL-1Ra,combined
R1300 T2218 T2223 arg1Of IL-1Ra,and
R1301 T2220 T2221 arg1Of combined,with
R1302 T2222 T2221 arg2Of temozolomide,with
R1303 T2223 T2227 arg1Of and,demonstrated
R1304 T2225 T2223 arg2Of chemotherapy,and
R1305 T2225 T2224 arg1Of chemotherapy,docetaxel
R1306 T2227 T2216 arg3Of demonstrated,found
R1307 T2227 T2217 arg1Of demonstrated,that
R1308 T2227 T2226 arg1Of demonstrated,","
R1309 T2227 T2232 arg1Of demonstrated,against
R1310 T2227 T2238 arg1Of demonstrated,[
R1311 T2229 T2228 arg1Of significant,more
R1312 T2231 T2227 arg2Of activity,demonstrated
R1313 T2231 T2229 arg1Of activity,significant
R1314 T2231 T2230 arg1Of activity,antitumor
R1315 T2235 T2232 arg2Of cells,against
R1316 T2235 T2233 arg1Of cells,B16
R1317 T2235 T2234 arg1Of cells,melanoma
R1318 T2235 T2237 arg1Of cells,vivo
R1319 T2237 T2236 arg1Of vivo,in
R1320 T2239 T2238 arg2Of 25,[
R1321 T2240 T2238 arg3Of ],[
R1322 T2242 T2241 arg1Of data,These
R1323 T2242 T2243 arg1Of data,indicate
R1324 T2245 T2246 arg1Of IL-1Ra,is
R1325 T2245 T2247 arg1Of IL-1Ra,important
R1326 T2246 T2243 arg2Of is,indicate
R1327 T2246 T2244 arg1Of is,that
R1328 T2247 T2246 arg2Of important,is
R1329 T2247 T2248 arg1Of important,as
R1330 T2253 T2248 arg2Of cytokine,as
R1331 T2253 T2249 arg1Of cytokine,a
R1332 T2253 T2250 arg1Of cytokine,tumor
R1333 T2253 T2251 arg1Of cytokine,growth
R1334 T2253 T2252 arg1Of cytokine,suppressing
R1335 T2254 T2255 arg1Of NF-κB,plays
R1336 T2254 T2277 arg1Of NF-κB,is
R1337 T2254 T2279 arg2Of NF-κB,associated
R1338 T2255 T2259 arg1Of plays,in
R1339 T2255 T2276 arg1Of plays,and
R1340 T2258 T2255 arg2Of role,plays
R1341 T2258 T2256 arg1Of role,a
R1342 T2258 T2257 arg1Of role,crucial
R1343 T2261 T2260 arg1Of suppression,the
R1344 T2261 T2262 arg1Of suppression,of
R1345 T2261 T2267 arg1Of suppression,as
R1346 T2263 T2262 arg2Of apoptosis,of
R1347 T2267 T2259 arg2Of as,in
R1348 T2267 T2264 arg1Of as,","
R1349 T2267 T2265 arg1Of as,as
R1350 T2267 T2266 arg1Of as,well
R1351 T2269 T2267 arg2Of induction,as
R1352 T2269 T2268 arg1Of induction,the
R1353 T2269 T2270 arg1Of induction,of
R1354 T2272 T2273 arg1Of proliferation,and
R1355 T2273 T2270 arg2Of and,of
R1356 T2273 T2271 arg1Of and,cell
R1357 T2274 T2273 arg2Of inflammation,and
R1358 T2276 T2275 arg1Of and,","
R1359 T2279 T2276 arg2Of associated,and
R1360 T2279 T2277 arg2Of associated,is
R1361 T2279 T2278 arg1Of associated,closely
R1362 T2279 T2280 arg1Of associated,with
R1363 T2279 T2283 arg1Of associated,[
R1364 T2282 T2280 arg2Of development,with
R1365 T2282 T2281 arg1Of development,cancer
R1366 T2284 T2283 arg2Of 26,[
R1367 T2285 T2283 arg3Of ],[
R1368 T2287 T2286 arg1Of activation,Constitutive
R1369 T2287 T2288 arg1Of activation,of
R1370 T2287 T2290 arg1Of activation,has
R1371 T2287 T2291 arg1Of activation,been
R1372 T2287 T2292 arg2Of activation,described
R1373 T2287 T2312 arg1Of activation,was
R1374 T2287 T2313 arg2Of activation,found
R1375 T2287 T2315 arg1Of activation,up-regulate
R1376 T2287 T2320 arg1Of activation,regulate
R1377 T2289 T2288 arg2Of NF-κB,of
R1378 T2292 T2290 arg2Of described,has
R1379 T2292 T2291 arg2Of described,been
R1380 T2292 T2293 arg1Of described,in
R1381 T2292 T2311 arg1Of described,and
R1382 T2296 T2293 arg2Of number,in
R1383 T2296 T2294 arg1Of number,a
R1384 T2296 T2295 arg1Of number,great
R1385 T2296 T2297 arg1Of number,of
R1386 T2298 T2297 arg2Of cancers,of
R1387 T2298 T2299 arg1Of cancers,including
R1388 T2301 T2300 arg1Of cancers,colon
R1389 T2301 T2302 arg1Of cancers,","
R1390 T2302 T2305 arg1Of ",",and
R1391 T2304 T2302 arg2Of cancers,","
R1392 T2304 T2303 arg1Of cancers,prostate
R1393 T2305 T2299 arg2Of and,including
R1394 T2306 T2305 arg2Of melanoma,and
R1395 T2306 T2307 arg1Of melanoma,[
R1396 T2308 T2307 arg2Of 27,[
R1397 T2309 T2307 arg3Of ],[
R1398 T2311 T2310 arg1Of and,","
R1399 T2311 T2324 arg1Of and,[
R1400 T2313 T2312 arg2Of found,was
R1401 T2323 T2320 arg2Of expression,regulate
R1402 T2323 T2321 arg1Of expression,apoptotic
R1403 T2323 T2322 arg1Of expression,gene
R1404 T2313 T2318 arg1Of found,and/or
R1405 T2315 T2313 arg3Of up-regulate,found
R1406 T2325 T2324 arg2Of 28,[
R1407 T2326 T2324 arg3Of ],[
R1408 T2328 T2329 arg1Of NF-κB,promotes
R1409 T2315 T2314 arg1Of up-regulate,to
R1410 T2329 T2327 arg2Of promotes,Although
R1411 T2317 T2315 arg2Of genes,up-regulate
R1412 T2331 T2329 arg2Of growth,promotes
R1413 T2331 T2330 arg1Of growth,tumor
R1414 T2333 T2334 arg1Of it,is
R1415 T2333 T2335 arg2Of it,required
R1416 T2317 T2316 arg1Of genes,anti-apoptotic
R1417 T2318 T2311 arg2Of and/or,and
R1418 T2335 T2327 arg1Of required,Although
R1419 T2335 T2332 arg1Of required,","
R1420 T2335 T2334 arg2Of required,is
R1421 T2335 T2336 arg1Of required,for
R1422 T2320 T2318 arg2Of regulate,and/or
R1423 T2339 T2336 arg2Of system,for
R1424 T2339 T2337 arg1Of system,the
R1425 T2339 T2338 arg1Of system,immune
R1426 T2339 T2340 modOf system,to
R1427 T2320 T2319 arg1Of regulate,down
R1428 T2423 T2419 arg2Of death,affecting
R1429 T2341 T2340 arg1Of function,to
R1430 T2341 T2342 arg1Of function,normally
R1431 T2341 T2343 arg1Of function,[
R1432 T2344 T2343 arg2Of 29,[
R1433 T2345 T2343 arg3Of ],[
R1434 T2346 T2347 arg1Of Studies,on
R1435 T2346 T2350 arg1Of Studies,demonstrated
R1436 T2349 T2347 arg2Of mice,on
R1437 T2349 T2348 arg1Of mice,c-Rel-deficient
R1438 T2423 T2420 arg1Of death,apoptotic
R1439 T2423 T2421 arg1Of death,cancer
R1440 T2423 T2422 arg1Of death,cell
R1441 T2423 T2424 arg1Of death,","
R1442 T2423 T2425 arg1Of death,(
R1443 T2352 T2353 arg1Of c-Rel,is
R1444 T2352 T2354 arg1Of c-Rel,essential
R1445 T2353 T2350 arg2Of is,demonstrated
R1446 T2353 T2351 arg1Of is,that
R1447 T2353 T2368 arg1Of is,[
R1448 T2354 T2353 arg2Of essential,is
R1449 T2354 T2355 arg1Of essential,for
R1450 T2356 T2357 arg1Of IL-2,","
R1451 T2357 T2359 arg1Of ",",","
R1452 T2358 T2357 arg2Of IL-3,","
R1453 T2359 T2362 arg1Of ",",and
R1454 T2423 T2428 arg1Of death,stimulating
R1455 T2360 T2359 arg2Of GM-CSF,","
R1456 T2423 T2433 arg1Of death,or
R1457 T2423 T2434 arg1Of death,(
R1458 T2362 T2355 arg2Of and,for
R1459 T2362 T2361 arg1Of and,","
R1460 T2362 T2365 arg1Of and,in
R1461 T2423 T2437 arg1Of death,increasing
R1462 T2364 T2362 arg2Of expression,and
R1463 T2364 T2363 arg1Of expression,IFNγ
R1464 T2426 T2425 arg2Of 2,(
R1465 T2367 T2365 arg2Of lymphocytes,in
R1466 T2367 T2366 arg1Of lymphocytes,T
R1467 T2369 T2368 arg2Of 30,[
R1468 T2370 T2368 arg3Of ],[
R1469 T2427 T2425 arg3Of ),(
R1470 T2372 T2371 arg1Of mice,C-Rel-deficient
R1471 T2372 T2374 arg1Of mice,have
R1472 T2432 T2428 arg2Of infiltration,stimulating
R1473 T2374 T2373 arg1Of have,also
R1474 T2374 T2384 arg1Of have,in
R1475 T2377 T2374 arg2Of deficiency,have
R1476 T2377 T2375 arg1Of deficiency,a
R1477 T2377 T2376 arg1Of deficiency,tissue-specific
R1478 T2377 T2378 arg1Of deficiency,of
R1479 T2380 T2379 arg1Of cytokines,various
R1480 T2380 T2381 arg1Of cytokines,and
R1481 T2381 T2378 arg2Of and,of
R1482 T2432 T2429 arg1Of infiltration,tumor
R1483 T2383 T2381 arg2Of factors,and
R1484 T2383 T2382 arg1Of factors,growth
R1485 T2432 T2430 arg1Of infiltration,killing
R1486 T2432 T2431 arg1Of infiltration,lymphocytes
R1487 T2435 T2434 arg2Of 3,(
R1488 T2386 T2385 arg1Of cells,T
R1489 T2386 T2387 arg1Of cells,and
R1490 T2387 T2384 arg2Of and,in
R1491 T2387 T2389 arg1Of and,affecting
R1492 T2388 T2387 arg2Of macrophages,and
R1493 T2389 T2396 arg1Of affecting,in
R1494 T2389 T2399 arg1Of affecting,[
R1495 T2391 T2392 arg1Of innate,and
R1496 T2436 T2434 arg3Of ),(
R1497 T2392 T2390 arg1Of and,both
R1498 T2393 T2392 arg2Of humoral,and
R1499 T2395 T2389 arg2Of responses,affecting
R1500 T2395 T2391 arg1Of responses,innate
R1501 T2395 T2393 arg1Of responses,humoral
R1502 T2395 T2394 arg1Of responses,immune
R1503 T2398 T2396 arg2Of host,in
R1504 T2398 T2397 arg1Of host,the
R1505 T2439 T2437 arg2Of production,increasing
R1506 T2400 T2399 arg2Of 31,[
R1507 T2401 T2399 arg3Of ],[
R1508 T2439 T2438 arg1Of production,the
R1509 T2404 T2405 arg1Of NF-κB,can
R1510 T2404 T2406 arg1Of NF-κB,be
R1511 T2404 T2408 arg2Of NF-κB,targeted
R1512 T2404 T2410 arg1Of NF-κB,prevent
R1513 T2439 T2440 arg1Of production,of
R1514 T2443 T2440 arg2Of lymphokines,of
R1515 T2404 T2419 arg1Of NF-κB,affecting
R1516 T2443 T2441 arg1Of lymphokines,tumor
R1517 T2408 T2402 arg1Of targeted,Therefore
R1518 T2408 T2403 arg1Of targeted,","
R1519 T2408 T2405 arg2Of targeted,can
R1520 T2408 T2406 arg2Of targeted,be
R1521 T2408 T2407 arg1Of targeted,specially
R1522 T2410 T2408 arg3Of prevent,targeted
R1523 T2410 T2409 arg1Of prevent,to
R1524 T2410 T2414 arg1Of prevent,by
R1525 T2443 T2442 arg1Of lymphokines,killing
R1526 T2444 T2445 arg1Of Activation,of
R1527 T2413 T2410 arg2Of growth,prevent
R1528 T2413 T2411 arg1Of growth,cancer
R1529 T2413 T2412 arg1Of growth,cell
R1530 T2444 T2447 arg1Of Activation,is
R1531 T2444 T2448 arg1Of Activation,important
R1532 T2416 T2415 arg1Of 1,(
R1533 T2416 T2417 arg1Of 1,)
R1534 T2446 T2445 arg2Of NF-κB,of
R1535 T2419 T2414 arg2Of affecting,by
R1536 T2419 T2416 arg1Of affecting,1
R1537 T2419 T2418 arg1Of affecting,directly
R1538 T2448 T2447 arg2Of important,is
R1539 T2448 T2449 arg1Of important,in
R1540 T2451 T2449 arg2Of regulation,in
R1541 T2451 T2450 arg1Of regulation,the
R1542 T2451 T2452 arg1Of regulation,of
R1543 T2455 T2456 arg1Of growth,and
R1544 T2519 T2515 arg2Of development,in
R1545 T2519 T2516 arg1Of development,CCR5
R1546 T2519 T2517 arg2Of development,mediated
R1547 T2519 T2518 arg1Of development,tumor
R1548 T2524 T2520 arg1Of sites,NF-κB
R1549 T2524 T2521 arg1Of sites,transcription
R1550 T2524 T2522 arg1Of sites,factor
R1551 T2524 T2523 arg1Of sites,binding
R1552 T2524 T2525 arg1Of sites,are
R1553 T2524 T2526 arg1Of sites,present
R1554 T2456 T2452 arg2Of and,of
R1555 T2526 T2525 arg2Of present,are
R1556 T2526 T2527 arg1Of present,in
R1557 T2456 T2453 arg1Of and,CCR-mediated
R1558 T2456 T2454 arg1Of and,tumor
R1559 T2530 T2527 arg2Of region,in
R1560 T2530 T2528 arg1Of region,the
R1561 T2530 T2529 arg1Of region,promoter
R1562 T2530 T2531 arg1Of region,of
R1563 T2457 T2456 arg2Of metastasis,and
R1564 T2534 T2531 arg2Of genes,of
R1565 T2534 T2532 arg1Of genes,proinflammatory
R1566 T2534 T2533 arg1Of genes,cytokine
R1567 T2534 T2535 arg1Of genes,","
R1568 T2534 T2537 arg1Of genes,as
R1569 T2458 T2459 arg1Of It,was
R1570 T2537 T2536 arg1Of as,such
R1571 T2538 T2539 arg1Of IL-1alpha,","
R1572 T2458 T2460 arg2Of It,reported
R1573 T2539 T2541 arg1Of ",",","
R1574 T2540 T2539 arg2Of IL-6,","
R1575 T2460 T2459 arg2Of reported,was
R1576 T2541 T2544 arg1Of ",",and
R1577 T2542 T2541 arg2Of GM-CSF,","
R1578 T2544 T2537 arg2Of and,as
R1579 T2544 T2543 arg1Of and,","
R1580 T2545 T2544 arg2Of KC,and
R1581 T2545 T2546 arg1Of KC,[
R1582 T2462 T2463 arg1Of inhibition,of
R1583 T2547 T2546 arg2Of 34,[
R1584 T2548 T2546 arg3Of ],[
R1585 T2462 T2465 arg1Of inhibition,by
R1586 T2462 T2470 arg1Of inhibition,induces
R1587 T2464 T2463 arg2Of NF-κB,of
R1588 T2552 T2549 arg2Of hand,On
R1589 T2552 T2550 arg1Of hand,the
R1590 T2552 T2551 arg1Of hand,other
R1591 T2555 T2554 arg1Of IL-1Ra,the
R1592 T2555 T2556 arg1Of IL-1Ra,is
R1593 T2556 T2549 arg1Of is,On
R1594 T2556 T2553 arg1Of is,","
R1595 T2466 T2465 arg2Of dehydroxymethyl-epoxyquinomicin,by
R1596 T2559 T2556 arg2Of regulator,is
R1597 T2559 T2557 arg1Of regulator,a
R1598 T2559 T2558 arg1Of regulator,negative
R1599 T2559 T2560 arg1Of regulator,of
R1600 T2563 T2560 arg2Of response,of
R1601 T2563 T2561 arg1Of response,the
R1602 T2466 T2467 arg1Of dehydroxymethyl-epoxyquinomicin,(
R1603 T2468 T2467 arg2Of DHMEQ,(
R1604 T2563 T2562 arg1Of response,inflammatory
R1605 T2565 T2564 arg1Of studies,Several
R1606 T2565 T2566 arg1Of studies,have
R1607 T2565 T2567 arg1Of studies,demonstrated
R1608 T2567 T2566 arg2Of demonstrated,have
R1609 T2469 T2467 arg3Of ),(
R1610 T2569 T2567 arg2Of ability,demonstrated
R1611 T2569 T2568 arg1Of ability,the
R1612 T2569 T2570 arg1Of ability,of
R1613 T2569 T2572 modOf ability,to
R1614 T2470 T2460 arg3Of induces,reported
R1615 T2571 T2570 arg2Of IL-1Ra,of
R1616 T2470 T2461 arg1Of induces,that
R1617 T2573 T2572 arg1Of abrogate,to
R1618 T2470 T2477 arg1Of induces,by
R1619 T2470 T2482 arg1Of induces,[
R1620 T2576 T2573 arg2Of effects,abrogate
R1621 T2576 T2574 arg1Of effects,the
R1622 T2576 T2575 arg1Of effects,proinflammatory
R1623 T2576 T2577 arg1Of effects,of
R1624 T2472 T2470 arg2Of death,induces
R1625 T2578 T2577 arg2Of IL-1,of
R1626 T2579 T2581 arg1Of Smith,al.
R1627 T2579 T2582 arg1Of Smith,suggested
R1628 T2581 T2580 arg1Of al.,et
R1629 T2472 T2471 arg1Of death,cell
R1630 T2472 T2473 arg1Of death,of
R1631 T2476 T2473 arg2Of lymphoma,of
R1632 T2585 T2584 arg1Of regulation,the
R1633 T2585 T2586 arg1Of regulation,of
R1634 T2585 T2590 arg1Of regulation,is
R1635 T2589 T2586 arg2Of expression,of
R1636 T2589 T2587 arg1Of expression,IL-1Ra
R1637 T2589 T2588 arg1Of expression,gene
R1638 T2590 T2582 arg2Of is,suggested
R1639 T2590 T2583 arg1Of is,that
R1640 T2590 T2607 arg1Of is,[
R1641 T2476 T2474 arg1Of lymphoma,primary
R1642 T2476 T2475 arg1Of lymphoma,effusion
R1643 T2593 T2590 arg2Of event,is
R1644 T2593 T2591 arg1Of event,a
R1645 T2593 T2592 arg1Of event,complex
R1646 T2593 T2594 arg1Of event,involving
R1647 T2593 T2602 arg1Of event,;
R1648 T2478 T2477 arg2Of inhibition,by
R1649 T2596 T2594 arg2Of interactions,involving
R1650 T2596 T2595 arg1Of interactions,the
R1651 T2596 T2597 arg1Of interactions,of
R1652 T2601 T2597 arg2Of factors,of
R1653 T2601 T2598 arg1Of factors,three
R1654 T2601 T2599 arg1Of factors,different
R1655 T2601 T2600 arg1Of factors,transcription
R1656 T2478 T2479 arg1Of inhibition,of
R1657 T2481 T2479 arg2Of expression,of
R1658 T2606 T2602 arg2Of site,;
R1659 T2606 T2603 arg1Of site,NF-κB/PU.1/GA-binding
R1660 T2606 T2604 arg1Of site,protein
R1661 T2606 T2605 arg1Of site,binding
R1662 T2608 T2607 arg2Of 35,[
R1663 T2609 T2607 arg3Of ],[
R1664 T2481 T2480 arg1Of expression,CCR5
R1665 T2611 T2610 arg1Of translocation,Nuclear
R1666 T2611 T2612 arg1Of translocation,of
R1667 T2611 T2617 arg1Of translocation,was
R1668 T2611 T2619 arg2Of translocation,enhanced
R1669 T2611 T2621 arg2Of translocation,prolonged
R1670 T2613 T2612 arg2Of NF-κB,of
R1671 T2613 T2614 arg1Of NF-κB,(
R1672 T2483 T2482 arg2Of 32,[
R1673 T2484 T2482 arg3Of ],[
R1674 T2615 T2614 arg2Of p65,(
R1675 T2485 T2486 arg1Of Activation,of
R1676 T2616 T2614 arg3Of ),(
R1677 T2485 T2489 arg1Of Activation,increases
R1678 T2619 T2620 arg1Of enhanced,and
R1679 T2487 T2486 arg2Of NF-κB,of
R1680 T2620 T2617 arg2Of and,was
R1681 T2620 T2618 arg1Of and,significantly
R1682 T2620 T2622 arg1Of and,in
R1683 T2620 T2625 arg1Of and,","
R1684 T2620 T2626 arg1Of and,compared
R1685 T2621 T2620 arg2Of prolonged,and
R1686 T2624 T2622 arg2Of mice,in
R1687 T2624 T2623 arg1Of mice,IL-1Ra-deficient
R1688 T2489 T2488 arg1Of increases,also
R1689 T2627 T2626 arg2Of to,compared
R1690 T2628 T2627 arg2Of that,to
R1691 T2628 T2629 arg1Of that,in
R1692 T2493 T2490 arg1Of motility,CCL5-mediated
R1693 T2632 T2629 arg2Of mice,in
R1694 T2632 T2630 arg1Of mice,wild
R1695 T2632 T2631 arg1Of mice,type
R1696 T2632 T2633 arg1Of mice,[
R1697 T2634 T2633 arg2Of 36,[
R1698 T2635 T2633 arg3Of ],[
R1699 T2637 T2636 arg1Of IL-1Ra,Intracellular
R1700 T2637 T2638 arg1Of IL-1Ra,(
R1701 T2637 T2641 arg1Of IL-1Ra,was
R1702 T2637 T2642 arg2Of IL-1Ra,found
R1703 T2637 T2644 arg1Of IL-1Ra,inhibit
R1704 T2637 T2647 arg1Of IL-1Ra,blocking
R1705 T2493 T2491 arg1Of motility,oral
R1706 T2639 T2638 arg2Of icIL-1Ra,(
R1707 T2493 T2492 arg1Of motility,cancer
R1708 T2640 T2638 arg3Of ),(
R1709 T2493 T2494 arg1Of motility,(
R1710 T2642 T2641 arg2Of found,was
R1711 T2493 T2497 arg1Of motility,and
R1712 T2495 T2494 arg2Of 5,(
R1713 T2644 T2642 arg3Of inhibit,found
R1714 T2644 T2643 arg1Of inhibit,to
R1715 T2644 T2646 arg1Of inhibit,by
R1716 T2645 T2644 arg2Of IL-1,inhibit
R1717 T2647 T2646 arg2Of blocking,by
R1718 T2496 T2494 arg3Of ),(
R1719 T2651 T2647 arg2Of pathways,blocking
R1720 T2651 T2648 arg1Of pathways,NF-κB
R1721 T2651 T2649 arg1Of pathways,signal
R1722 T2651 T2650 arg1Of pathways,transduction
R1723 T2651 T2652 arg1Of pathways,in
R1724 T2497 T2489 arg2Of and,increases
R1725 T2654 T2652 arg2Of responses,in
R1726 T2654 T2653 arg1Of responses,inflammatory
R1727 T2654 T2655 arg1Of responses,[
R1728 T2499 T2497 arg2Of metastasis,and
R1729 T2656 T2655 arg2Of 37,[
R1730 T2657 T2655 arg3Of ],[
R1731 T2659 T2660 arg1Of IL-1,has
R1732 T2659 T2661 arg1Of IL-1,been
R1733 T2659 T2662 arg2Of IL-1,shown
R1734 T2659 T2664 arg1Of IL-1,be
R1735 T2499 T2498 arg1Of metastasis,lung
R1736 T2662 T2658 arg2Of shown,Because
R1737 T2662 T2660 arg2Of shown,has
R1738 T2662 T2661 arg2Of shown,been
R1739 T2499 T2500 arg1Of metastasis,[
R1740 T2664 T2662 arg3Of be,shown
R1741 T2664 T2663 arg1Of be,to
R1742 T2501 T2500 arg2Of 33,[
R1743 T2666 T2664 arg2Of inducer,be
R1744 T2666 T2665 arg1Of inducer,an
R1745 T2666 T2667 arg1Of inducer,of
R1746 T2669 T2667 arg2Of activation,of
R1747 T2669 T2668 arg1Of activation,NF-κB
R1748 T2669 T2670 arg1Of activation,[
R1749 T2502 T2500 arg3Of ],[
R1750 T2671 T2670 arg2Of 38,[
R1751 T2672 T2670 arg3Of ],[
R1752 T2674 T2675 arg1Of we,hypothesized
R1753 T2675 T2658 arg1Of hypothesized,Because
R1754 T2675 T2673 arg1Of hypothesized,","
R1755 T2506 T2503 arg1Of is,Thus
R1756 T2678 T2677 arg1Of expression,the
R1757 T2678 T2679 arg1Of expression,of
R1758 T2678 T2681 arg1Of expression,could
R1759 T2678 T2682 arg1Of expression,play
R1760 T2680 T2679 arg2Of IL-1Ra,of
R1761 T2682 T2675 arg2Of play,hypothesized
R1762 T2682 T2676 arg1Of play,that
R1763 T2682 T2681 arg2Of play,could
R1764 T2682 T2686 arg1Of play,in
R1765 T2685 T2682 arg2Of role,play
R1766 T2685 T2683 arg1Of role,an
R1767 T2685 T2684 arg1Of role,important
R1768 T2506 T2504 arg1Of is,","
R1769 T2507 T2506 arg2Of possible,is
R1770 T2689 T2686 arg2Of activation,in
R1771 T2689 T2687 arg1Of activation,the
R1772 T2689 T2688 arg1Of activation,autocrine
R1773 T2689 T2690 arg1Of activation,of
R1774 T2509 T2510 arg1Of inhibition,of
R1775 T2692 T2691 arg1Of factors,transcription
R1776 T2693 T2694 arg1Of NF-κB,or
R1777 T2694 T2690 arg2Of or,of
R1778 T2694 T2692 arg1Of or,factors
R1779 T2509 T2512 arg1Of inhibition,could
R1780 T2509 T2513 arg1Of inhibition,be
R1781 T2696 T2694 arg2Of versa,or
R1782 T2696 T2695 arg1Of versa,vice
R1783 T2509 T2514 arg2Of inhibition,involved
R1784 T2511 T2510 arg2Of NF-κB,of
R1785 T2700 T2699 arg1Of aim,the
R1786 T2700 T2701 arg1Of aim,of
R1787 T2700 T2704 arg1Of aim,was
R1788 T2703 T2701 arg2Of study,of
R1789 T2703 T2702 arg1Of study,this
R1790 T2704 T2697 arg1Of was,Thus
R1791 T2704 T2698 arg1Of was,","
R1792 T2514 T2505 arg1Of involved,it
R1793 T2706 T2704 arg2Of evaluate,was
R1794 T2706 T2705 arg1Of evaluate,to
R1795 T2708 T2706 arg2Of roles,evaluate
R1796 T2708 T2707 arg1Of roles,the
R1797 T2708 T2709 arg1Of roles,of
R1798 T2708 T2713 arg1Of roles,in
R1799 T2514 T2506 arg1Of involved,is
R1800 T2710 T2711 arg1Of NF-κB,and
R1801 T2514 T2507 arg1Of involved,possible
R1802 T2514 T2508 arg1Of involved,that
R1803 T2514 T2512 arg2Of involved,could
R1804 T2514 T2513 arg2Of involved,be
R1805 T2514 T2515 arg1Of involved,in
R1807 T2711 T2709 arg2Of and,of
R1808 T2712 T2711 arg2Of IL-1Ra,and
R1809 T2718 T2713 arg2Of suppression,in
R1810 T2718 T2714 arg1Of suppression,the
R1811 T2718 T2715 arg1Of suppression,chemokine
R1812 T2718 T2716 arg1Of suppression,receptor
R1813 T2718 T2717 arg1Of suppression,CCR5-mediated
R1814 T2718 T2719 arg1Of suppression,of
R1815 T2721 T2719 arg2Of development,of
R1816 T2721 T2720 arg1Of development,tumor

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T1558 4851-4855 Protein denotes PU.1
T1557 4734-4740 Protein denotes IL-1Ra
T1556 4632-4638 Protein denotes IL-1Ra
T1555 4522-4528 Protein denotes IL-1Ra
T1554 4490-4492 Protein denotes KC
T1553 4478-4484 Protein denotes GM-CSF
T1552 4472-4476 Protein denotes IL-6
T1551 4461-4470 Protein denotes IL-1alpha
T1550 4309-4313 Protein denotes CCR5
T1549 4177-4181 Protein denotes CCL5
T1548 4120-4124 Protein denotes CCR5
T1547 3382-3388 Protein denotes GM-CSF
T1546 3376-3380 Protein denotes IL-3
T1545 3370-3374 Protein denotes IL-2
T1544 3347-3352 Protein denotes c-Rel
T1543 3308-3313 Protein denotes c-Rel
T1542 2759-2767 Protein denotes cytokine
T1541 2709-2715 Protein denotes IL-1Ra
T1540 2531-2537 Protein denotes IL-1Ra
T1539 2274-2280 Protein denotes IL-1Ra
T1538 2113-2119 Protein denotes IL-1Ra
T1537 1950-1956 Protein denotes IL-1Ra
T1534 1611-1617 Protein denotes IL-1Ra
T1533 1544-1552 Protein denotes cytokine
T1532 1481-1487 Protein denotes IL-1Ra
T1531 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T1530 1385-1389 Protein denotes CCR5
T1529 1267-1271 Protein denotes CCR5
T1528 1060-1064 Protein denotes CCR5
T1527 1007-1011 Protein denotes CCR5
T1526 862-866 Protein denotes CCR5
T1525 742-746 Protein denotes CCL5
T1524 506-510 Protein denotes CCR5
T1523 328-332 Protein denotes CCR5
T1522 304-326 Protein denotes C-C chemokine receptor
T1521 294-298 Protein denotes CCL5
T1520 262-292 Protein denotes chemokine (C-C motif) ligand 5
T1536 1830-1836 Protein denotes IL-1Ra
T1535 1795-1801 Protein denotes IL-1Ra
T1566 5496-5500 Protein denotes CCR5
T1565 5477-5495 Protein denotes chemokine receptor
T1564 5463-5469 Protein denotes IL-1Ra
T1563 5286-5292 Protein denotes IL-1Ra
T1562 5061-5069 Protein denotes icIL-1Ra
T1561 5039-5059 Protein denotes Intracellular IL-1Ra
T1560 4975-4981 Protein denotes IL-1Ra
T1559 4926-4929 Protein denotes p65

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T2757 4926-4929 http://www.uniprot.org/uniprot/P21579 denotes p65
T2756 4926-4929 http://www.uniprot.org/uniprot/Q04206 denotes p65
T2755 4851-4855 http://www.uniprot.org/uniprot/P17947 denotes PU.1
T2754 4472-4476 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T2753 4481-4484 http://www.uniprot.org/uniprot/P04141 denotes CSF
T2752 3385-3388 http://www.uniprot.org/uniprot/P04141 denotes CSF
T2751 3382-3388 http://www.uniprot.org/uniprot/P04141 denotes GM-CSF
T2750 3370-3374 http://www.uniprot.org/uniprot/P60568 denotes IL-2
T2749 3347-3352 http://www.uniprot.org/uniprot/Q04864 denotes c-Rel
T2748 3308-3313 http://www.uniprot.org/uniprot/Q04864 denotes c-Rel
T2747 5463-5469 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2746 5286-5292 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2745 5053-5059 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2744 4975-4981 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2743 4734-4740 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2742 4632-4638 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2741 4522-4528 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2740 2709-2715 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2739 2531-2537 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2738 2274-2280 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2737 2113-2119 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2736 1950-1956 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2735 1830-1836 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2734 1795-1801 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2733 1611-1617 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2732 1481-1487 http://www.uniprot.org/uniprot/P18510 denotes IL-1Ra
T2731 5496-5500 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2730 4309-4313 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2729 4120-4124 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2728 1385-1389 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2727 1267-1271 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2726 1060-1064 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2725 1007-1011 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2724 862-866 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2723 506-510 http://www.uniprot.org/uniprot/P51681 denotes CCR5
T2722 328-332 http://www.uniprot.org/uniprot/P51681 denotes CCR5

UBERON-AE

Id Subject Object Predicate Lexical cue
T1403 3466-3472 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T1402 3256-3269 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T1401 3041-3046 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T1400 2361-2366 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T1399 4220-4224 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T1398 1175-1179 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T1397 1878-1884 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T1396 1136-1142 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T1395 787-793 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

GO-BP

Id Subject Object Predicate Lexical cue
T1636 5339-5374 http://purl.obolibrary.org/obo/GO_1901485 denotes activation of transcription factors
T1635 5339-5374 http://purl.obolibrary.org/obo/GO_0032793 denotes activation of transcription factors
T1634 5339-5374 http://purl.obolibrary.org/obo/GO_0051091 denotes activation of transcription factors
T1633 5122-5134 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T1632 5115-5143 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathways
T1631 5115-5143 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathways
T1630 5115-5143 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathways
T1629 5115-5143 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathways
T1599 1685-1701 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T1598 1446-1479 http://purl.obolibrary.org/obo/GO_0005152 denotes Interleukin-1 receptor antagonist
T1597 2178-2183 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T1596 1583-1596 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T1595 1446-1468 http://purl.obolibrary.org/obo/GO_0004908 denotes Interleukin-1 receptor
T1594 724-746 http://purl.obolibrary.org/obo/GO_0071609 denotes production of the CCL5
T1593 5531-5542 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1592 4329-4340 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1591 2932-2943 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1590 2411-2422 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1589 2302-2313 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1588 2160-2171 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1587 1433-1444 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1586 569-580 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1585 5147-5169 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T1584 4560-4581 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T1583 2880-2892 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1582 129-141 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1581 3948-3954 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1580 3695-3701 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1579 3518-3524 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1578 3225-3231 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1577 2740-2746 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1576 2382-2388 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1575 2333-2339 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1574 2220-2226 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1573 1098-1104 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1572 1043-1049 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1571 930-936 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1570 119-125 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1569 3690-3701 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T1568 1093-1104 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T1567 114-125 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T1628 5115-5134 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T1627 5115-5121 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T1626 5109-5134 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signal transduction
T1625 4856-4858 http://purl.obolibrary.org/obo/GO_0033968 denotes GA
T1624 5353-5366 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1623 4822-4835 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1622 4348-4361 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1621 3929-3932 http://purl.obolibrary.org/obo/GO_0043880 denotes CCR
T1620 4720-4730 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1619 3915-3925 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1618 4068-4073 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T1617 3750-3755 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T1616 4063-4073 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T1615 3745-3755 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T1614 3601-3622 http://purl.obolibrary.org/obo/GO_0075136 denotes responses in the host
T1613 3594-3622 http://purl.obolibrary.org/obo/GO_0052572 denotes immune responses in the host
T1612 3586-3610 http://purl.obolibrary.org/obo/GO_0002921 denotes humoral immune responses
T1611 3586-3610 http://purl.obolibrary.org/obo/GO_0002920 denotes humoral immune responses
T1610 3586-3610 http://purl.obolibrary.org/obo/GO_0006959 denotes humoral immune responses
T1609 3586-3610 http://purl.obolibrary.org/obo/GO_0002922 denotes humoral immune responses
T1608 4741-4756 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T1607 3173-3188 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T1606 5339-5380 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of transcription factors NF-κB
T1605 5224-5240 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T1604 2963-2982 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T1603 2857-2875 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T1602 2818-2827 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1601 2818-2827 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1600 3594-3610 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses

GO-MF

Id Subject Object Predicate Lexical cue
T1673 5339-5374 http://purl.obolibrary.org/obo/GO_0033613 denotes activation of transcription factors
T1672 4859-4874 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T1671 4856-4858 http://purl.obolibrary.org/obo/GO_0033968 denotes GA
T1670 4472-4476 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1669 3929-3932 http://purl.obolibrary.org/obo/GO_0043880 denotes CCR
T1668 3376-3380 http://purl.obolibrary.org/obo/GO_0005135 denotes IL-3
T1667 3370-3374 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T1666 2424-2431 http://purl.obolibrary.org/obo/GO_0045519 denotes 23]. IL
T1665 2173-2180 http://purl.obolibrary.org/obo/GO_0045515 denotes 18]. IL
T1664 1446-1479 http://purl.obolibrary.org/obo/GO_0005152 denotes Interleukin-1 receptor antagonist
T1663 5184-5188 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1662 5092-5096 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1661 4682-4686 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1660 2429-2433 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1659 1583-1587 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1658 1506-1510 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1657 1446-1468 http://purl.obolibrary.org/obo/GO_0005149 denotes Interleukin-1 receptor
T1656 2178-2183 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T1655 1583-1596 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T1654 1446-1468 http://purl.obolibrary.org/obo/GO_0004908 denotes Interleukin-1 receptor
T1653 5477-5500 http://purl.obolibrary.org/obo/GO_0031730 denotes chemokine receptor CCR5
T1652 1248-1271 http://purl.obolibrary.org/obo/GO_0031730 denotes chemokine receptor CCR5
T1651 308-332 http://purl.obolibrary.org/obo/GO_0031730 denotes chemokine receptor (CCR5
T1650 4875-4882 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1649 4859-4866 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1648 4369-4376 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1647 284-290 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand

GO-CC

Id Subject Object Predicate Lexical cue
T1646 5039-5052 http://purl.obolibrary.org/obo/GO_0005622 denotes Intracellular
T1645 1583-1596 http://purl.obolibrary.org/obo/GO_0045323 denotes IL-1 receptor
T1644 3618-3622 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1643 991-995 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1642 4063-4067 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1641 3745-3749 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1640 3690-3694 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1639 2857-2861 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1638 1093-1097 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1637 114-118 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

sentences

Id Subject Object Predicate Lexical cue
T1425 3195-3296 Sentence denotes Although NF-κB promotes tumor growth, it is required for the immune system to function normally [29].
T1424 2950-3194 Sentence denotes Constitutive activation of NF-κB has been described in a great number of cancers including colon cancers, prostate cancers and melanoma [27], and was found to up-regulate anti-apoptotic genes and/or down regulate apoptotic gene expression [28].
T1423 2769-2949 Sentence denotes NF-κB plays a crucial role in the suppression of apoptosis, as well as the induction of cell proliferation and inflammation, and is closely associated with cancer development [26].
T1422 2684-2768 Sentence denotes These data indicate that IL-1Ra is important as a tumor growth suppressing cytokine.
T1421 2508-2683 Sentence denotes It was also found that IL-1Ra, combined with temozolomide and docetaxel chemotherapy, demonstrated more significant antitumor activity against B16 melanoma cells in vivo [25].
T1420 2429-2507 Sentence denotes IL-1 knockout mice injected with melanoma failed to develop solid tumors [24].
T1419 2233-2428 Sentence denotes Moreover, it has also been reported that IL-1Ra reduces fibrosarcoma development [20], B16 melanoma growth and metastasis [21], colon adenocarcinoma growth [22], and skin cancer development [23].
T1418 2178-2232 Sentence denotes IL-1R blockade also reduced hepatic tumor growth [19].
T1417 2040-2177 Sentence denotes Meanwhile, proliferation of the melanoma cells that were transduced with IL-1Ra gene was reduced and inhibited melanoma development [18].
T1416 1913-2039 Sentence denotes It was also reported that endogenous IL-1Ra deficient mice developed aggressive tumors following exposure to carcinogens [17].
T1415 1830-1912 Sentence denotes IL-1Ra expression was reduced in prostate [14], breast [15], and skin cancer [16].
T1414 1603-1829 Sentence denotes Because IL-1Ra has been shown to inhibit tumor progression by promoting antitumor immune responses and by enhancing the activity of chemotherapy, numerous studies have examined the ability of IL-1Ra to block tumor progression.
T1413 1446-1602 Sentence denotes Interleukin-1 receptor antagonist (IL-1Ra), a member of the IL-1 family, is a naturally occurring cytokine that competitively blocks the IL-1 receptor [13].
T1412 1334-1445 Sentence denotes However, more studies are required to describe how CCR5 deficiency acts in the inhibition of tumor development.
T1411 1193-1333 Sentence denotes These data suggest that the deficiency of inflammatory chemokine receptor CCR5 may function as a suppressive receptor in cancer progression.
T1410 978-1192 Sentence denotes In addition, host absence of CCR5 potentiates the delay of tumor growth [10], and CCR5 inhibitors prevented cancer cell growth, such as prostate cancer [11], breast cancer, hepatoma cells [4], and lung cancer [12].
T1409 851-977 Sentence denotes Meanwhile, CCR5 disruption has been demonstrated to inhibit experimental tumor growth and metastasis of pancreatic cancer [9].
T1408 718-850 Sentence denotes Local production of the CCL5 is also important in the progression of breast cancer [7], and also correlates with poor prognosis [8].
T1407 482-717 Sentence denotes Intermediate and strong CCR5 expression is significantly associated with nonmetastatic development of colorectal cancer [2], melanoma [3], hepatoma [4], glioblastoma, Hodgkin lymphoma [5], as well as oral and prostate cancer cells [6].
T1406 218-481 Sentence denotes The accumulated evidence indicates that the chemokine (C-C motif) ligand 5 (CCL5) and C-C chemokine receptor (CCR5), which are potent chemotactic factors for inflammatory cells, may be significantly involved in the proliferation and metastasis of several cancers.
T1405 143-217 Sentence denotes Many types of cancer cells express chemokines and chemokine receptors [1].
T1404 13-142 Sentence denotes Chemokines are small soluble molecules that are best known for their potent ability to induce cancer cell growth by inflammation.
T1430 3971-4141 Sentence denotes It was reported that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ) induces cell death of primary effusion lymphoma by inhibition of CCR5 expression [32].
T1429 3875-3970 Sentence denotes Activation of NF-κB is important in the regulation of CCR-mediated tumor growth and metastasis.
T1428 3629-3874 Sentence denotes Therefore, NF-κB can be specially targeted to prevent cancer cell growth by (1) directly affecting apoptotic cancer cell death, (2) stimulating tumor killing lymphocytes infiltration or (3) increasing the production of tumor killing lymphokines.
T1427 3433-3628 Sentence denotes C-Rel-deficient mice also have a tissue-specific deficiency of various cytokines and growth factors in T cells and macrophages affecting both innate and humoral immune responses in the host [31].
T1426 3297-3432 Sentence denotes Studies on c-Rel-deficient mice demonstrated that c-Rel is essential for IL-2, IL-3, GM-CSF, and IFNγ expression in T lymphocytes [30].
T1440 5396-5543 Sentence denotes Thus, the aim of this study was to evaluate the roles of NF-κB and IL-1Ra in the chemokine receptor CCR5-mediated suppression of tumor development.
T1439 5176-5395 Sentence denotes Because IL-1 has been shown to be an inducer of NF-κB activation [38], we hypothesized that the expression of IL-1Ra could play an important role in the autocrine activation of transcription factors NF-κB or vice versa.
T1438 5039-5175 Sentence denotes Intracellular IL-1Ra (icIL-1Ra) was found to inhibit IL-1 by blocking NF-κB signal transduction pathways in inflammatory responses [37].
T1437 4894-5038 Sentence denotes Nuclear translocation of NF-κB (p65) was significantly enhanced and prolonged in IL-1Ra-deficient mice, compared to that in wild type mice [36].
T1436 4688-4893 Sentence denotes Smith et al. suggested that the regulation of IL-1Ra gene expression is a complex event involving the interactions of three different transcription factors; NF-κB/PU.1/GA-binding protein binding site [35].
T1435 4583-4687 Sentence denotes Several studies have demonstrated the ability of IL-1Ra to abrogate the proinflammatory effects of IL-1.
T1434 4499-4582 Sentence denotes On the other hand, the IL-1Ra is a negative regulator of the inflammatory response.
T1433 4342-4498 Sentence denotes NF-κB transcription factor binding sites are present in the promoter region of proinflammatory cytokine genes, such as IL-1alpha, IL-6, GM-CSF, and KC [34].
T1432 4242-4341 Sentence denotes Thus, it is possible that inhibition of NF-κB could be involved in CCR5 mediated tumor development.
T1431 4142-4241 Sentence denotes Activation of NF-κB also increases CCL5-mediated oral cancer motility (5) and lung metastasis [33].
T12 0-12 Sentence denotes Introduction
T13 13-142 Sentence denotes Chemokines are small soluble molecules that are best known for their potent ability to induce cancer cell growth by inflammation.
T14 143-217 Sentence denotes Many types of cancer cells express chemokines and chemokine receptors [1].
T15 218-481 Sentence denotes The accumulated evidence indicates that the chemokine (C-C motif) ligand 5 (CCL5) and C-C chemokine receptor (CCR5), which are potent chemotactic factors for inflammatory cells, may be significantly involved in the proliferation and metastasis of several cancers.
T16 482-717 Sentence denotes Intermediate and strong CCR5 expression is significantly associated with nonmetastatic development of colorectal cancer [2], melanoma [3], hepatoma [4], glioblastoma, Hodgkin lymphoma [5], as well as oral and prostate cancer cells [6].
T17 718-850 Sentence denotes Local production of the CCL5 is also important in the progression of breast cancer [7], and also correlates with poor prognosis [8].
T18 851-977 Sentence denotes Meanwhile, CCR5 disruption has been demonstrated to inhibit experimental tumor growth and metastasis of pancreatic cancer [9].
T19 978-1192 Sentence denotes In addition, host absence of CCR5 potentiates the delay of tumor growth [10], and CCR5 inhibitors prevented cancer cell growth, such as prostate cancer [11], breast cancer, hepatoma cells [4], and lung cancer [12].
T20 1193-1333 Sentence denotes These data suggest that the deficiency of inflammatory chemokine receptor CCR5 may function as a suppressive receptor in cancer progression.
T21 1334-1445 Sentence denotes However, more studies are required to describe how CCR5 deficiency acts in the inhibition of tumor development.
T22 1446-1602 Sentence denotes Interleukin-1 receptor antagonist (IL-1Ra), a member of the IL-1 family, is a naturally occurring cytokine that competitively blocks the IL-1 receptor [13].
T23 1603-1829 Sentence denotes Because IL-1Ra has been shown to inhibit tumor progression by promoting antitumor immune responses and by enhancing the activity of chemotherapy, numerous studies have examined the ability of IL-1Ra to block tumor progression.
T24 1830-1912 Sentence denotes IL-1Ra expression was reduced in prostate [14], breast [15], and skin cancer [16].
T25 1913-2039 Sentence denotes It was also reported that endogenous IL-1Ra deficient mice developed aggressive tumors following exposure to carcinogens [17].
T26 2040-2177 Sentence denotes Meanwhile, proliferation of the melanoma cells that were transduced with IL-1Ra gene was reduced and inhibited melanoma development [18].
T27 2178-2232 Sentence denotes IL-1R blockade also reduced hepatic tumor growth [19].
T28 2233-2428 Sentence denotes Moreover, it has also been reported that IL-1Ra reduces fibrosarcoma development [20], B16 melanoma growth and metastasis [21], colon adenocarcinoma growth [22], and skin cancer development [23].
T29 2429-2507 Sentence denotes IL-1 knockout mice injected with melanoma failed to develop solid tumors [24].
T30 2508-2683 Sentence denotes It was also found that IL-1Ra, combined with temozolomide and docetaxel chemotherapy, demonstrated more significant antitumor activity against B16 melanoma cells in vivo [25].
T31 2684-2768 Sentence denotes These data indicate that IL-1Ra is important as a tumor growth suppressing cytokine.
T32 2769-2949 Sentence denotes NF-κB plays a crucial role in the suppression of apoptosis, as well as the induction of cell proliferation and inflammation, and is closely associated with cancer development [26].
T33 2950-3194 Sentence denotes Constitutive activation of NF-κB has been described in a great number of cancers including colon cancers, prostate cancers and melanoma [27], and was found to up-regulate anti-apoptotic genes and/or down regulate apoptotic gene expression [28].
T34 3195-3296 Sentence denotes Although NF-κB promotes tumor growth, it is required for the immune system to function normally [29].
T35 3297-3432 Sentence denotes Studies on c-Rel-deficient mice demonstrated that c-Rel is essential for IL-2, IL-3, GM-CSF, and IFNγ expression in T lymphocytes [30].
T36 3433-3628 Sentence denotes C-Rel-deficient mice also have a tissue-specific deficiency of various cytokines and growth factors in T cells and macrophages affecting both innate and humoral immune responses in the host [31].
T37 3629-3874 Sentence denotes Therefore, NF-κB can be specially targeted to prevent cancer cell growth by (1) directly affecting apoptotic cancer cell death, (2) stimulating tumor killing lymphocytes infiltration or (3) increasing the production of tumor killing lymphokines.
T38 3875-3970 Sentence denotes Activation of NF-κB is important in the regulation of CCR-mediated tumor growth and metastasis.
T39 3971-4141 Sentence denotes It was reported that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ) induces cell death of primary effusion lymphoma by inhibition of CCR5 expression [32].
T40 4142-4241 Sentence denotes Activation of NF-κB also increases CCL5-mediated oral cancer motility (5) and lung metastasis [33].
T41 4242-4341 Sentence denotes Thus, it is possible that inhibition of NF-κB could be involved in CCR5 mediated tumor development.
T42 4342-4498 Sentence denotes NF-κB transcription factor binding sites are present in the promoter region of proinflammatory cytokine genes, such as IL-1alpha, IL-6, GM-CSF, and KC [34].
T43 4499-4582 Sentence denotes On the other hand, the IL-1Ra is a negative regulator of the inflammatory response.
T44 4583-4687 Sentence denotes Several studies have demonstrated the ability of IL-1Ra to abrogate the proinflammatory effects of IL-1.
T45 4688-4893 Sentence denotes Smith et al. suggested that the regulation of IL-1Ra gene expression is a complex event involving the interactions of three different transcription factors; NF-κB/PU.1/GA-binding protein binding site [35].
T46 4894-5038 Sentence denotes Nuclear translocation of NF-κB (p65) was significantly enhanced and prolonged in IL-1Ra-deficient mice, compared to that in wild type mice [36].
T47 5039-5175 Sentence denotes Intracellular IL-1Ra (icIL-1Ra) was found to inhibit IL-1 by blocking NF-κB signal transduction pathways in inflammatory responses [37].
T48 5176-5395 Sentence denotes Because IL-1 has been shown to be an inducer of NF-κB activation [38], we hypothesized that the expression of IL-1Ra could play an important role in the autocrine activation of transcription factors NF-κB or vice versa.
T49 5396-5543 Sentence denotes Thus, the aim of this study was to evaluate the roles of NF-κB and IL-1Ra in the chemokine receptor CCR5-mediated suppression of tumor development.

simple1

Id Subject Object Predicate Lexical cue
T1720 5496-5500 Protein denotes CCR5
T1688 1611-1617 Protein denotes IL-1Ra
T1687 1544-1552 Protein denotes cytokine
T1686 1481-1487 Protein denotes IL-1Ra
T1685 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T1684 1385-1389 Protein denotes CCR5
T1683 1267-1271 Protein denotes CCR5
T1682 1060-1064 Protein denotes CCR5
T1681 1007-1011 Protein denotes CCR5
T1680 862-866 Protein denotes CCR5
T1679 742-746 Protein denotes CCL5
T1678 506-510 Protein denotes CCR5
T1677 328-332 Protein denotes CCR5
T1676 304-326 Protein denotes C-C chemokine receptor
T1675 294-298 Protein denotes CCL5
T1674 262-292 Protein denotes chemokine (C-C motif) ligand 5
T1719 5477-5495 Protein denotes chemokine receptor
T1718 5463-5469 Protein denotes IL-1Ra
T1717 5286-5292 Protein denotes IL-1Ra
T1716 5061-5069 Protein denotes icIL-1Ra
T1715 5039-5059 Protein denotes Intracellular IL-1Ra
T1714 4975-4981 Protein denotes IL-1Ra
T1713 4926-4929 Protein denotes p65
T1712 4851-4855 Protein denotes PU.1
T1711 4734-4740 Protein denotes IL-1Ra
T1710 4632-4638 Protein denotes IL-1Ra
T1709 4522-4528 Protein denotes IL-1Ra
T1708 4490-4492 Protein denotes KC
T1707 4478-4484 Protein denotes GM-CSF
T1706 4472-4476 Protein denotes IL-6
T1705 4461-4470 Protein denotes IL-1alpha
T1704 4309-4313 Protein denotes CCR5
T1703 4177-4181 Protein denotes CCL5
T1702 4120-4124 Protein denotes CCR5
T1701 3382-3388 Protein denotes GM-CSF
T1700 3376-3380 Protein denotes IL-3
T1699 3370-3374 Protein denotes IL-2
T1698 3347-3352 Protein denotes c-Rel
T1697 3308-3313 Protein denotes c-Rel
T1696 2759-2767 Protein denotes cytokine
T1695 2709-2715 Protein denotes IL-1Ra
T1694 2531-2537 Protein denotes IL-1Ra
T1693 2274-2280 Protein denotes IL-1Ra
T1692 2113-2119 Protein denotes IL-1Ra
T1691 1950-1956 Protein denotes IL-1Ra
T1690 1830-1836 Protein denotes IL-1Ra
T1689 1795-1801 Protein denotes IL-1Ra

DLUT931

Id Subject Object Predicate Lexical cue
T2833 5501-5509 Positive_regulation denotes mediated
T2832 5317-5321 Regulation denotes role
T2831 5272-5282 Gene_expression denotes expression
T2830 5084-5091 Negative_regulation denotes inhibit
T2829 4982-4991 Negative_regulation denotes deficient
T2828 4949-4957 Positive_regulation denotes enhanced
T2827 4902-4915 Localization denotes translocation
T2826 4720-4730 Regulation denotes regulation
T2825 4875-4882 Binding denotes binding
T2824 4856-4866 Binding denotes GA-binding
T2823 4746-4756 Gene_expression denotes expression
T2822 4642-4650 Negative_regulation denotes abrogate
T2821 4055-4062 Positive_regulation denotes induces
T2820 4106-4116 Negative_regulation denotes inhibition
T2819 4125-4135 Gene_expression denotes expression
T2818 3399-3409 Gene_expression denotes expression
T2817 3356-3365 Positive_regulation denotes essential
T2816 3314-3323 Negative_regulation denotes deficient
T2815 1957-1966 Negative_regulation denotes deficient
T2814 1852-1859 Negative_regulation denotes reduced
T2813 1837-1847 Gene_expression denotes expression
T2812 1636-1643 Negative_regulation denotes inhibit
T2811 1390-1400 Negative_regulation denotes deficiency
T2810 1221-1231 Negative_regulation denotes deficiency
T2809 1065-1075 Negative_regulation denotes inhibitors
T2808 996-1003 Negative_regulation denotes absence
T2807 867-877 Negative_regulation denotes disruption
T2806 724-734 Gene_expression denotes production
T2805 511-521 Gene_expression denotes expression
T2804 5496-5500 Protein denotes CCR5
T2803 5477-5495 Protein denotes chemokine receptor
T2802 5463-5469 Protein denotes IL-1Ra
T2801 5286-5292 Protein denotes IL-1Ra
T2800 5061-5069 Protein denotes icIL-1Ra
T2799 5039-5059 Protein denotes Intracellular IL-1Ra
T2798 4975-4981 Protein denotes IL-1Ra
T2797 4926-4929 Protein denotes p65
T2796 4851-4855 Protein denotes PU.1
T2795 4734-4740 Protein denotes IL-1Ra
T2794 4632-4638 Protein denotes IL-1Ra
T2793 4522-4528 Protein denotes IL-1Ra
T2792 4490-4492 Protein denotes KC
T2791 4478-4484 Protein denotes GM-CSF
T2790 4472-4476 Protein denotes IL-6
T2789 4461-4470 Protein denotes IL-1alpha
T2788 4309-4313 Protein denotes CCR5
T2787 4177-4181 Protein denotes CCL5
T2786 4120-4124 Protein denotes CCR5
T2785 3382-3388 Protein denotes GM-CSF
T2784 3376-3380 Protein denotes IL-3
T2783 3370-3374 Protein denotes IL-2
T2782 3347-3352 Protein denotes c-Rel
T2781 3308-3313 Protein denotes c-Rel
T2780 2759-2767 Protein denotes cytokine
T2779 2709-2715 Protein denotes IL-1Ra
T2778 2531-2537 Protein denotes IL-1Ra
T2777 2274-2280 Protein denotes IL-1Ra
T2776 2113-2119 Protein denotes IL-1Ra
T2775 1950-1956 Protein denotes IL-1Ra
T2774 1830-1836 Protein denotes IL-1Ra
T2773 1795-1801 Protein denotes IL-1Ra
T2772 1611-1617 Protein denotes IL-1Ra
T2771 1544-1552 Protein denotes cytokine
T2770 1481-1487 Protein denotes IL-1Ra
T2769 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T2768 1385-1389 Protein denotes CCR5
T2767 1267-1271 Protein denotes CCR5
T2766 1060-1064 Protein denotes CCR5
T2765 1007-1011 Protein denotes CCR5
T2764 862-866 Protein denotes CCR5
T2763 742-746 Protein denotes CCL5
T2762 506-510 Protein denotes CCR5
T2761 328-332 Protein denotes CCR5
T2760 304-326 Protein denotes C-C chemokine receptor
T2759 294-298 Protein denotes CCL5
T2758 262-292 Protein denotes chemokine (C-C motif) ligand 5
R1806 T2794 T2822 themeOf IL-1Ra,abrogate
R1817 T2762 T2805 themeOf CCR5,expression
R1818 T2763 T2806 themeOf CCL5,production
R1819 T2764 T2807 themeOf CCR5,disruption
R1820 T2765 T2808 themeOf CCR5,absence
R1821 T2766 T2809 themeOf CCR5,inhibitors
R1822 T2767 T2810 themeOf CCR5,deficiency
R1823 T2768 T2811 themeOf CCR5,deficiency
R1824 T2772 T2812 themeOf IL-1Ra,inhibit
R1825 T2774 T2813 themeOf IL-1Ra,expression
R1826 T2775 T2815 themeOf IL-1Ra,deficient
R1827 T2795 T2823 themeOf IL-1Ra,expression
R1828 T2796 T2824 themeOf PU.1,GA-binding
R1829 T2781 T2816 themeOf c-Rel,deficient
R1830 T2796 T2825 themeOf PU.1,binding
R1831 T2797 T2827 themeOf p65,translocation
R1832 T2798 T2829 themeOf IL-1Ra,deficient
R1833 T2782 T2817 causeOf c-Rel,essential
R1834 T2782 T2817 causeOf c-Rel,essential
R1835 T2782 T2817 causeOf c-Rel,essential
R1836 T2799 T2830 themeOf Intracellular IL-1Ra,inhibit
R1837 T2783 T2817 themeOf IL-2,essential
R1838 T2783 T2818 themeOf IL-2,expression
R1839 T2784 T2817 themeOf IL-3,essential
R1840 T2784 T2818 themeOf IL-3,expression
R1841 T2801 T2831 themeOf IL-1Ra,expression
R1842 T2785 T2817 causeOf GM-CSF,essential
R1843 T2785 T2817 causeOf GM-CSF,essential
R1844 T2785 T2818 themeOf GM-CSF,expression
R1845 T2785 T2817 causeOf GM-CSF,essential
R1846 T2785 T2817 causeOf GM-CSF,essential
R1847 T2785 T2817 causeOf GM-CSF,essential
R1848 T2786 T2819 themeOf CCR5,expression
R1849 T2803 T2833 themeOf chemokine receptor,mediated
R1850 T2804 T2833 causeOf CCR5,mediated
R1851 T2813 T2814 themeOf expression,reduced
R1855 T2818 T2817 themeOf expression,essential
R1858 T2818 T2817 themeOf expression,essential
R1859 T2818 T2817 themeOf expression,essential
R1860 T2818 T2817 themeOf expression,essential
R1861 T2818 T2817 themeOf expression,essential
R1862 T2818 T2817 themeOf expression,essential
R1863 T2819 T2820 themeOf expression,inhibition
R1865 T2820 T2821 themeOf inhibition,induces
R1867 T2823 T2826 themeOf expression,regulation
R1870 T2827 T2828 themeOf translocation,enhanced
R1872 T2831 T2832 themeOf expression,role

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T4362 862-877 Negative_regulation denotes CCR5 disruption
T4361 4268-4287 Negative_regulation denotes inhibition of NF-κB
T4360 3830-3873 Gene_expression denotes the production of tumor killing lymphokines
T4359 5221-5245 Positive_regulation denotes of NF-κB activation [38]
T4358 5100-5114 Negative_regulation denotes blocking NF-κB
T4357 4142-4161 Positive_regulation denotes Activation of NF-κB
T4356 4894-4981 Positive_regulation denotes Nuclear translocation of NF-κB (p65) was significantly enhanced and prolonged in IL-1Ra
T4355 4731-4756 Gene_expression denotes of IL-1Ra gene expression
T4354 1522-1601 Negative_regulation denotes a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
T4353 482-521 Gene_expression denotes Intermediate and strong CCR5 expression
T4352 4716-4756 Regulation denotes the regulation of IL-1Ra gene expression
T4351 1830-1847 Gene_expression denotes IL-1Ra expression
T4350 3815-3873 Positive_regulation denotes (3) increasing the production of tumor killing lymphokines
T4349 4894-4981 Regulation denotes Nuclear translocation of NF-κB (p65) was significantly enhanced and prolonged in IL-1Ra
T4348 5268-5292 Gene_expression denotes the expression of IL-1Ra
T4347 4106-4140 Negative_regulation denotes inhibition of CCR5 expression [32]
T4346 4306-4340 Regulation denotes in CCR5 mediated tumor development
T4345 1830-1911 Negative_regulation denotes IL-1Ra expression was reduced in prostate [14], breast [15], and skin cancer [16]
T4344 3875-3894 Positive_regulation denotes Activation of NF-κB
T4343 4117-4135 Gene_expression denotes of CCR5 expression
T4342 3394-3409 Gene_expression denotes IFNγ expression
T4341 5084-5096 Negative_regulation denotes inhibit IL-1
T4340 718-746 Gene_expression denotes Local production of the CCL5
T4339 3987-4054 Negative_regulation denotes that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ)
T4338 1151-1169 Entity denotes hepatoma cells [4]
T4337 2769-2774 Protein denotes NF-κB
T4336 3886-3894 Protein denotes of NF-κB
T4335 3496-3513 Protein denotes various cytokines
T4334 4012-4054 Entity denotes by dehydroxymethyl-epoxyquinomicin (DHMEQ)
T4333 862-866 Protein denotes CCR5
T4332 13-23 Protein denotes Chemokines
T4331 3728-3798 Entity denotes apoptotic cancer cell death, (2) stimulating tumor killing lymphocytes
T4330 4306-4340 Protein denotes in CCR5 mediated tumor development
T4329 5061-5069 Protein denotes icIL-1Ra
T4328 1579-1601 Protein denotes the IL-1 receptor [13]
T4327 1611-1617 Protein denotes IL-1Ra
T4326 4629-4638 Protein denotes of IL-1Ra
T4325 4845-4892 Entity denotes NF-κB/PU.1/GA-binding protein binding site [35]
T4324 1232-1257 Protein denotes of inflammatory chemokine
T4323 3548-3559 Entity denotes macrophages
T4322 1060-1075 Entity denotes CCR5 inhibitors
T4321 4803-4843 Protein denotes of three different transcription factors
T4320 4003-4011 Protein denotes of NF-κB
T4319 2178-2192 Protein denotes IL-1R blockade
T4318 193-202 Protein denotes chemokine
T4317 4461-4470 Protein denotes IL-1alpha
T4316 2320-2339 Entity denotes B16 melanoma growth
T4315 4916-4930 Protein denotes of NF-κB (p65)
T4314 4398-4452 Entity denotes the promoter region of proinflammatory cytokine genes,
T4313 4153-4161 Protein denotes of NF-κB
T4312 1583-1587 Protein denotes IL-1
T4311 154-169 Entity denotes of cancer cells
T4310 5477-5509 Protein denotes chemokine receptor CCR5-mediated
T4309 1481-1487 Protein denotes IL-1Ra
T4308 4975-4981 Protein denotes IL-1Ra
T4307 2709-2715 Protein denotes IL-1Ra
T4306 1499-1517 Protein denotes of the IL-1 family
T4305 4926-4929 Protein denotes p65
T4304 4418-4452 Protein denotes of proinflammatory cytokine genes,
T4303 4177-4190 Protein denotes CCL5-mediated
T4302 28-141 Entity denotes small soluble molecules that are best known for their potent ability to induce cancer cell growth by inflammation
T4301 2429-2433 Protein denotes IL-1
T4300 4279-4287 Protein denotes of NF-κB
T4299 258-299 Protein denotes the chemokine (C-C motif) ligand 5 (CCL5)
T4298 1522-1601 Protein denotes a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
T4297 3640-3645 Protein denotes NF-κB
T4296 5224-5229 Protein denotes NF-κB
T4295 3121-3141 Protein denotes anti-apoptotic genes
T4294 193-212 Protein denotes chemokine receptors
T4293 1950-1956 Protein denotes IL-1Ra
T4292 1385-1400 Protein denotes CCR5 deficiency
T4291 2651-2682 Entity denotes B16 melanoma cells in vivo [25]
T4290 2531-2538 Protein denotes IL-1Ra,
T4289 4734-4740 Protein denotes IL-1Ra
T4288 4120-4124 Protein denotes CCR5
T4287 3204-3209 Protein denotes NF-κB
T4286 5184-5188 Protein denotes IL-1
T4285 1004-1011 Protein denotes of CCR5
T4284 2950-2982 Protein denotes Constitutive activation of NF-κB
T4283 3433-3453 Protein denotes C-Rel-deficient mice
T4282 1288-1310 Protein denotes a suppressive receptor
T4281 506-510 Protein denotes CCR5
T4280 2269-2280 Protein denotes that IL-1Ra
T4279 3394-3398 Protein denotes IFNγ
T4278 1934-1971 Protein denotes that endogenous IL-1Ra deficient mice
T4277 5477-5486 Protein denotes chemokine
T4276 4518-4528 Protein denotes the IL-1Ra
T4275 3347-3352 Protein denotes c-Rel
T4274 2022-2038 Entity denotes carcinogens [17]
T4273 4490-4492 Protein denotes KC
T4272 3382-3388 Protein denotes GM-CSF
T4271 4478-4484 Protein denotes GM-CSF
T4270 3370-3374 Protein denotes IL-2
T4269 5109-5114 Protein denotes NF-κB
T4268 3536-3543 Entity denotes T cells
T4267 4342-4382 Entity denotes NF-κB transcription factor binding sites
T4266 4992-4996 Protein denotes mice
T4265 691-716 Entity denotes prostate cancer cells [6]
T4264 178-188 Protein denotes chemokines
T4263 304-334 Protein denotes C-C chemokine receptor (CCR5),
T4262 5463-5469 Protein denotes IL-1Ra
T4261 2570-2579 Entity denotes docetaxel
T4260 1060-1064 Protein denotes CCR5
T4259 1446-1518 Protein denotes Interleukin-1 receptor antagonist (IL-1Ra), a member of the IL-1 family,
T4258 4682-4686 Protein denotes IL-1
T4257 5453-5458 Protein denotes NF-κB
T4256 1217-1271 Protein denotes the deficiency of inflammatory chemokine receptor CCR5
T4255 1792-1801 Protein denotes of IL-1Ra
T4254 2113-2124 Protein denotes IL-1Ra gene
T4253 1469-1488 Entity denotes antagonist (IL-1Ra)
T4252 328-332 Protein denotes CCR5
T4251 3305-3313 Protein denotes on c-Rel
T4250 3413-3431 Entity denotes T lymphocytes [30]
T4249 5283-5292 Protein denotes of IL-1Ra
T4248 735-746 Protein denotes of the CCL5
T4247 4342-4347 Protein denotes NF-κB
T4246 4472-4476 Protein denotes IL-6
T4245 2429-2470 Protein denotes IL-1 knockout mice injected with melanoma
T4244 2553-2565 Entity denotes temozolomide
T4243 3845-3873 Protein denotes of tumor killing lymphokines
T4242 2113-2119 Protein denotes IL-1Ra
T4241 4437-4445 Protein denotes cytokine
T4240 5375-5380 Protein denotes NF-κB
T4239 3815-3873 Entity denotes (3) increasing the production of tumor killing lymphokines
T4238 376-394 Entity denotes inflammatory cells
T4237 5039-5070 Protein denotes Intracellular IL-1Ra (icIL-1Ra)
T4236 5477-5509 Protein denotes chemokine receptor CCR5-mediated
T4235 1830-1836 Protein denotes IL-1Ra
T4234 2759-2767 Protein denotes cytokine
T4233 3376-3380 Protein denotes IL-3
T4232 2065-2124 Entity denotes of the melanoma cells that were transduced with IL-1Ra gene
T4231 5092-5096 Protein denotes IL-1
T4230 1258-1266 Protein denotes receptor
T4229 5018-5037 Protein denotes wild type mice [36]
T4228 294-298 Protein denotes CCL5
R3033 T4231 T4341 themeOf IL-1,inhibit IL-1
R3036 T4235 T4351 themeOf IL-1Ra,IL-1Ra expression
R3038 T4239 T4350 causeOf (3) increasing the production of tumor killing lymphokines,(3) increasing the production of tumor killing lymphokines
R3041 T4243 T4360 themeOf of tumor killing lymphokines,the production of tumor killing lymphokines
R3044 T4248 T4340 themeOf of the CCL5,Local production of the CCL5
R3045 T4249 T4348 themeOf of IL-1Ra,the expression of IL-1Ra
R3051 T4279 T4342 themeOf IFNγ,IFNγ expression
R3052 T4269 T4358 themeOf NF-κB,blocking NF-κB
R3053 T4281 T4353 themeOf CCR5,Intermediate and strong CCR5 expression
R3054 T4288 T4343 themeOf CCR5,of CCR5 expression
R3055 T4289 T4355 themeOf IL-1Ra,of IL-1Ra gene expression
R3056 T4296 T4359 themeOf NF-κB,of NF-κB activation [38]
R3057 T4298 T4354 causeOf a naturally occurring cytokine that competitively blocks the IL-1 receptor [13],a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
R3058 T4300 T4361 themeOf of NF-κB,inhibition of NF-κB
R3059 T4313 T4357 themeOf of NF-κB,Activation of NF-κB
R3060 T4320 T4339 themeOf of NF-κB,that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ)
R3061 T4328 T4354 themeOf the IL-1 receptor [13],a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
R3062 T4330 T4346 themeOf in CCR5 mediated tumor development,in CCR5 mediated tumor development
R3063 T4333 T4362 themeOf CCR5,CCR5 disruption
R3064 T4334 T4339 causeOf by dehydroxymethyl-epoxyquinomicin (DHMEQ),that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ)
R3065 T4336 T4344 themeOf of NF-κB,Activation of NF-κB
R3066 T4343 T4347 themeOf of CCR5 expression,inhibition of CCR5 expression [32]
R3067 T4351 T4345 themeOf IL-1Ra expression,"IL-1Ra expression was reduced in prostate [14], breast [15], and skin cancer [16]"
R3068 T4355 T4352 themeOf of IL-1Ra gene expression,the regulation of IL-1Ra gene expression
R3069 T4360 T4350 themeOf the production of tumor killing lymphokines,(3) increasing the production of tumor killing lymphokines

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T3958 4437-4445 NN denotes cytokine
T3957 4421-4436 JJ denotes proinflammatory
T3956 4418-4420 IN denotes of
T3955 4411-4417 NN denotes region
T3954 4402-4410 NN denotes promoter
T3953 4398-4401 DT denotes the
T3952 4395-4397 IN denotes in
T3951 4387-4394 JJ denotes present
T3950 4383-4386 VBP denotes are
T3903 4125-4135 NN denotes expression
T3852 3799-3811 NN denotes infiltration
T3851 3787-3798 NNS denotes lymphocytes
T3850 3779-3786 VBG denotes killing
T3849 3773-3778 NN denotes tumor
T3848 3761-3772 VBG denotes stimulating
T3847 3759-3760 -RRB- denotes )
T3846 3758-3759 LS denotes 2
T3845 3757-3758 -LRB- denotes (
T3844 3755-3756 , denotes ,
T3843 3750-3755 NN denotes death
T3842 3745-3749 NN denotes cell
T3796 3482-3492 NN denotes deficiency
T3795 3466-3481 JJ denotes tissue-specific
T3794 3464-3465 DT denotes a
T3793 3459-3463 VBP denotes have
T3792 3454-3458 RB denotes also
T3791 3449-3453 NNS denotes mice
T3790 3433-3448 JJ denotes C-Rel-deficient
T3789 3431-3432 . denotes .
T3788 3430-3431 NNP denotes ]
T3787 3428-3430 CD denotes 30
T3786 3427-3428 NNP denotes [
T3785 3415-3426 NNS denotes lymphocytes
T3784 3413-3414 NNP denotes T
T3783 3410-3412 IN denotes in
T3782 3399-3409 NN denotes expression
T3781 3394-3398 NNP denotes IFNγ
T3780 3390-3393 CC denotes and
T3779 3388-3389 , denotes ,
T3778 3382-3388 NNP denotes GM-CSF
T3777 3380-3381 , denotes ,
T3776 3376-3380 NNP denotes IL-3
T3744 3195-3203 IN denotes Although
T3743 3193-3194 . denotes .
T3742 3192-3193 NNP denotes ]
T3741 3190-3192 CD denotes 28
T3740 3189-3190 NNP denotes [
T3739 3178-3188 NN denotes expression
T4159 5542-5543 . denotes .
T4158 5531-5542 NN denotes development
T4157 5525-5530 NN denotes tumor
T4156 5522-5524 IN denotes of
T4155 5510-5521 NN denotes suppression
T4154 5496-5509 JJ denotes CCR5-mediated
T4153 5487-5495 NN denotes receptor
T4152 5477-5486 NN denotes chemokine
T4151 5473-5476 DT denotes the
T4150 5470-5472 IN denotes in
T4149 5463-5469 NN denotes IL-1Ra
T4148 5459-5462 CC denotes and
T4147 5453-5458 NN denotes NF-κB
T4146 5450-5452 IN denotes of
T4145 5444-5449 NNS denotes roles
T4144 5440-5443 DT denotes the
T4143 5431-5439 VB denotes evaluate
T4142 5428-5430 TO denotes to
T4141 5424-5427 VBD denotes was
T4140 5418-5423 NN denotes study
T4139 5413-5417 DT denotes this
T4138 5410-5412 IN denotes of
T4137 5406-5409 NN denotes aim
T4136 5402-5405 DT denotes the
T4135 5400-5401 , denotes ,
T4134 5396-5400 RB denotes Thus
T4133 5394-5395 . denotes .
T4132 5389-5394 RB denotes versa
T4131 5384-5388 NN denotes vice
T4130 5381-5383 CC denotes or
T4129 5375-5380 VBP denotes NF-κB
T4128 5367-5374 NNS denotes factors
T4127 5353-5366 NN denotes transcription
T4126 5350-5352 IN denotes of
T4125 5339-5349 NN denotes activation
T4124 5329-5338 NN denotes autocrine
T4123 5325-5328 DT denotes the
T4122 5322-5324 IN denotes in
T4121 5317-5321 NN denotes role
T4120 5307-5316 JJ denotes important
T4119 5304-5306 DT denotes an
T4118 5299-5303 VB denotes play
T4117 5293-5298 MD denotes could
T4116 5286-5292 NN denotes IL-1Ra
T4115 5283-5285 IN denotes of
T4114 5272-5282 NN denotes expression
T4113 5268-5271 DT denotes the
T4112 5263-5267 IN denotes that
T4111 5250-5262 VBD denotes hypothesized
T4110 5247-5249 PRP denotes we
T4109 5245-5246 , denotes ,
T4108 5244-5245 NNP denotes ]
T4107 5242-5244 CD denotes 38
T4106 5241-5242 NNP denotes [
T4105 5230-5240 NN denotes activation
T4104 5224-5229 JJ denotes NF-κB
T4103 5221-5223 IN denotes of
T4102 5213-5220 NN denotes inducer
T4101 5210-5212 DT denotes an
T4100 5207-5209 VB denotes be
T4099 5204-5206 TO denotes to
T4098 5198-5203 VBN denotes shown
T4097 5193-5197 VBN denotes been
T4096 5189-5192 VBZ denotes has
T4095 5184-5188 NN denotes IL-1
T4094 5176-5183 IN denotes Because
T4093 5174-5175 . denotes .
T4092 5173-5174 NNP denotes ]
T4091 5171-5173 CD denotes 37
T4090 5170-5171 NNP denotes [
T4089 5160-5169 NNS denotes responses
T4088 5147-5159 JJ denotes inflammatory
T4087 5144-5146 IN denotes in
T4086 5135-5143 NNS denotes pathways
T4085 5122-5134 NN denotes transduction
T4084 5115-5121 NN denotes signal
T4083 5109-5114 JJ denotes NF-κB
T4082 5100-5108 VBG denotes blocking
T4081 5097-5099 IN denotes by
T4080 5092-5096 NN denotes IL-1
T4079 5084-5091 VB denotes inhibit
T4078 5081-5083 TO denotes to
T4077 5075-5080 VBN denotes found
T4076 5071-5074 VBD denotes was
T4075 5069-5070 -RRB- denotes )
T4074 5061-5069 NN denotes icIL-1Ra
T4073 5060-5061 -LRB- denotes (
T4072 5053-5059 NN denotes IL-1Ra
T4071 5039-5052 JJ denotes Intracellular
T4070 5037-5038 . denotes .
T4069 5036-5037 NNP denotes ]
T4068 5034-5036 CD denotes 36
T4067 5033-5034 NNP denotes [
T4066 5028-5032 NNS denotes mice
T4065 5023-5027 NN denotes type
T4064 5018-5022 JJ denotes wild
T4063 5015-5017 IN denotes in
T4062 5010-5014 DT denotes that
T4061 5007-5009 TO denotes to
T4060 4998-5006 VBN denotes compared
T4059 4996-4997 , denotes ,
T4058 4992-4996 NNS denotes mice
T4057 4975-4991 JJ denotes IL-1Ra-deficient
T4056 4972-4974 IN denotes in
T4055 4962-4971 VBN denotes prolonged
T4054 4958-4961 CC denotes and
T4053 4949-4957 VBN denotes enhanced
T4052 4935-4948 RB denotes significantly
T4051 4931-4934 VBD denotes was
T4050 4929-4930 -RRB- denotes )
T4049 4926-4929 NNS denotes p65
T4048 4925-4926 -LRB- denotes (
T4047 4919-4924 NNP denotes NF-κB
T4046 4916-4918 IN denotes of
T4045 4902-4915 NN denotes translocation
T4044 4894-4901 NNP denotes Nuclear
T4043 4892-4893 . denotes .
T4042 4891-4892 NNP denotes ]
T4041 4889-4891 CD denotes 35
T4040 4888-4889 NNP denotes [
T4039 4883-4887 NN denotes site
T4038 4875-4882 JJ denotes binding
T4037 4867-4874 NN denotes protein
T4036 4856-4866 JJ denotes GA-binding
T4035 4855-4856 CD denotes /
T4034 4853-4855 CD denotes .1
T4033 4851-4853 NNP denotes PU
T4032 4850-4851 NNP denotes /
T4031 4845-4850 NNP denotes NF-κB
T4030 4843-4844 : denotes ;
T4029 4836-4843 NNS denotes factors
T4028 4822-4835 NN denotes transcription
T4027 4812-4821 JJ denotes different
T4026 4806-4811 CD denotes three
T4025 4803-4805 IN denotes of
T4024 4790-4802 NNS denotes interactions
T4023 4786-4789 DT denotes the
T4022 4776-4785 VBG denotes involving
T4021 4770-4775 NN denotes event
T4020 4762-4769 JJ denotes complex
T4019 4760-4761 DT denotes a
T4018 4757-4759 VBZ denotes is
T4017 4746-4756 NN denotes expression
T4016 4741-4745 NN denotes gene
T4015 4734-4740 NN denotes IL-1Ra
T4014 4731-4733 IN denotes of
T4013 4720-4730 NN denotes regulation
T4012 4716-4719 DT denotes the
T4011 4711-4715 IN denotes that
T4010 4701-4710 VBD denotes suggested
T4009 4697-4700 FW denotes al.
T4008 4694-4696 FW denotes et
T4007 4688-4693 NNP denotes Smith
T4006 4686-4687 . denotes .
T3738 3173-3177 NN denotes gene
T3737 3163-3172 JJ denotes apoptotic
T3736 3154-3162 VB denotes regulate
T3735 3149-3153 RB denotes down
T3734 3142-3148 CC denotes and/or
T3733 3136-3141 NNS denotes genes
T3732 3121-3135 JJ denotes anti-apoptotic
T3731 3109-3120 VB denotes up-regulate
T3730 3106-3108 TO denotes to
T3729 3100-3105 VBN denotes found
T3728 3096-3099 VBD denotes was
T3727 3092-3095 CC denotes and
T3726 3090-3091 , denotes ,
T3725 3089-3090 NNP denotes ]
T3724 3087-3089 CD denotes 27
T3723 3086-3087 NNP denotes [
T3722 3077-3085 NN denotes melanoma
T3721 3073-3076 CC denotes and
T3720 3065-3072 NNS denotes cancers
T3719 3056-3064 NN denotes prostate
T3718 3054-3055 , denotes ,
T3717 3047-3054 NNS denotes cancers
T3716 3041-3046 NN denotes colon
T3715 3031-3040 VBG denotes including
T3714 3023-3030 NNS denotes cancers
T3713 3020-3022 IN denotes of
T3712 3013-3019 NN denotes number
T3711 3007-3012 JJ denotes great
T3710 3005-3006 DT denotes a
T3709 3002-3004 IN denotes in
T3708 2992-3001 VBN denotes described
T3707 2987-2991 VBN denotes been
T3706 2983-2986 VBZ denotes has
T3705 2977-2982 NNP denotes NF-κB
T3704 2974-2976 IN denotes of
T3703 2963-2973 NN denotes activation
T3702 2950-2962 JJ denotes Constitutive
T3701 2948-2949 . denotes .
T3700 2947-2948 NNP denotes ]
T3660 2716-2718 VBZ denotes is
T3659 2709-2715 NN denotes IL-1Ra
T3658 2704-2708 IN denotes that
T3657 2695-2703 VBP denotes indicate
T3656 2690-2694 NNS denotes data
T3655 2684-2689 DT denotes These
T3654 2682-2683 . denotes .
T3653 2681-2682 NNP denotes ]
T3652 2679-2681 CD denotes 25
T3651 2678-2679 NNP denotes [
T3650 2673-2677 NN denotes vivo
T3649 2670-2672 IN denotes in
T3648 2664-2669 NNS denotes cells
T3647 2655-2663 NN denotes melanoma
T3646 2651-2654 NNP denotes B16
T3602 2393-2394 , denotes ,
T3601 2392-2393 NNP denotes ]
T3600 2390-2392 CD denotes 22
T3599 2389-2390 NNP denotes [
T3598 2382-2388 NN denotes growth
T3597 2367-2381 NN denotes adenocarcinoma
T3596 2361-2366 NN denotes colon
T3595 2359-2360 , denotes ,
T3594 2358-2359 NNP denotes ]
T3593 2356-2358 CD denotes 21
T3592 2355-2356 NNP denotes [
T3591 2344-2354 NN denotes metastasis
T3590 2340-2343 CC denotes and
T3589 2333-2339 NN denotes growth
T3588 2324-2332 NN denotes melanoma
T3587 2320-2323 NNP denotes B16
T3586 2318-2319 , denotes ,
T3585 2317-2318 NNP denotes ]
T3584 2315-2317 CD denotes 20
T3583 2314-2315 NNP denotes [
T3582 2302-2313 NN denotes development
T3581 2289-2301 NN denotes fibrosarcoma
T3580 2281-2288 VBZ denotes reduces
T3579 2274-2280 JJ denotes IL-1Ra
T3578 2269-2273 IN denotes that
T3577 2260-2268 VBN denotes reported
T3576 2255-2259 VBN denotes been
T3575 2250-2254 RB denotes also
T3574 2246-2249 VBZ denotes has
T3573 2243-2245 PRP denotes it
T3572 2241-2242 , denotes ,
T3571 2233-2241 RB denotes Moreover
T3570 2231-2232 . denotes .
T3569 2230-2231 NNP denotes ]
T3568 2228-2230 CD denotes 19
T3567 2227-2228 NNP denotes [
T3566 2220-2226 NN denotes growth
T3565 2214-2219 NN denotes tumor
T3564 2206-2213 JJ denotes hepatic
T3563 2198-2205 VBD denotes reduced
T3562 2193-2197 RB denotes also
T3561 2184-2192 NN denotes blockade
T3560 2178-2183 NN denotes IL-1R
T3559 2176-2177 . denotes .
T3558 2175-2176 NNP denotes ]
T3557 2173-2175 CD denotes 18
T3556 2172-2173 NNP denotes [
T3555 2160-2171 NN denotes development
T3554 2151-2159 NN denotes melanoma
T3553 2141-2150 VBN denotes inhibited
T3552 2137-2140 CC denotes and
T3551 2129-2136 VBN denotes reduced
T3550 2125-2128 VBD denotes was
T3549 2120-2124 NN denotes gene
T3548 2113-2119 JJ denotes IL-1Ra
T3547 2108-2112 IN denotes with
T3546 2097-2107 VBN denotes transduced
T3545 2092-2096 VBD denotes were
T3544 2087-2091 WDT denotes that
T3543 2081-2086 NNS denotes cells
T3542 2072-2080 NN denotes melanoma
T3541 2068-2071 DT denotes the
T3540 2065-2067 IN denotes of
T3539 2051-2064 NN denotes proliferation
T3538 2049-2050 , denotes ,
T3537 2040-2049 RB denotes Meanwhile
T3536 2038-2039 . denotes .
T3535 2037-2038 NNP denotes ]
T3534 2035-2037 CD denotes 17
T3533 2034-2035 NNP denotes [
T3532 2022-2033 NNS denotes carcinogens
T3531 2019-2021 TO denotes to
T3530 2010-2018 NN denotes exposure
T3529 2000-2009 VBG denotes following
T3517 1913-1915 PRP denotes It
T3516 1911-1912 . denotes .
T3515 1910-1911 NNP denotes ]
T3514 1908-1910 CD denotes 16
T3513 1907-1908 NNP denotes [
T3512 1900-1906 NN denotes cancer
T3775 3374-3375 , denotes ,
T3774 3370-3374 NNP denotes IL-2
T3773 3366-3369 IN denotes for
T3772 3356-3365 JJ denotes essential
T3771 3353-3355 VBZ denotes is
T3770 3347-3352 NNP denotes c-Rel
T3769 3342-3346 IN denotes that
T3768 3329-3341 VBD denotes demonstrated
T3767 3324-3328 NNS denotes mice
T3766 3308-3323 JJ denotes c-Rel-deficient
T3765 3305-3307 IN denotes on
T3764 3297-3304 NNS denotes Studies
T3763 3295-3296 . denotes .
T3762 3294-3295 NN denotes ]
T3761 3292-3294 CD denotes 29
T3760 3291-3292 JJ denotes [
T3759 3282-3290 RB denotes normally
T3758 3273-3281 VB denotes function
T3757 3270-3272 TO denotes to
T3756 3263-3269 NN denotes system
T3755 3256-3262 JJ denotes immune
T3754 3252-3255 DT denotes the
T3753 3248-3251 IN denotes for
T3752 3239-3247 VBN denotes required
T3751 3236-3238 VBZ denotes is
T3750 3233-3235 PRP denotes it
T3749 3231-3232 , denotes ,
T3748 3225-3231 NN denotes growth
T3747 3219-3224 NN denotes tumor
T3746 3210-3218 VBZ denotes promotes
T3745 3204-3209 JJ denotes NF-κB
T3511 1895-1899 NN denotes skin
T3510 1891-1894 CC denotes and
T3509 1889-1890 , denotes ,
T3508 1888-1889 NNP denotes ]
T3507 1886-1888 CD denotes 15
T3506 1885-1886 NNP denotes [
T3505 1878-1884 NN denotes breast
T3504 1876-1877 , denotes ,
T3503 1875-1876 NNP denotes ]
T3502 1873-1875 CD denotes 14
T3501 1872-1873 NNP denotes [
T3500 1863-1871 NN denotes prostate
T3499 1860-1862 IN denotes in
T3498 1852-1859 VBN denotes reduced
T3497 1848-1851 VBD denotes was
T3496 1837-1847 NN denotes expression
T3495 1830-1836 NN denotes IL-1Ra
T3494 1828-1829 . denotes .
T3493 1817-1828 NN denotes progression
T3492 1811-1816 NN denotes tumor
T3491 1805-1810 VB denotes block
T3490 1802-1804 TO denotes to
T3489 1795-1801 NN denotes IL-1Ra
T3488 1792-1794 IN denotes of
T3487 1784-1791 NN denotes ability
T3486 1780-1783 DT denotes the
T3485 1771-1779 VBN denotes examined
T3484 1766-1770 VBP denotes have
T3483 1758-1765 NNS denotes studies
T3482 1749-1757 JJ denotes numerous
T3481 1747-1748 , denotes ,
T3480 1735-1747 JJ denotes chemotherapy
T3479 1732-1734 IN denotes of
T3478 1723-1731 NN denotes activity
T3477 1719-1722 DT denotes the
T3476 1709-1718 VBG denotes enhancing
T3475 1706-1708 IN denotes by
T3474 1702-1705 CC denotes and
T3473 1692-1701 NNS denotes responses
T3472 1685-1691 JJ denotes immune
T3471 1675-1684 JJ denotes antitumor
T3470 1665-1674 VBG denotes promoting
T3469 1662-1664 IN denotes by
T3468 1650-1661 NN denotes progression
T3467 1644-1649 NN denotes tumor
T3466 1636-1643 VB denotes inhibit
T3465 1633-1635 TO denotes to
T3464 1627-1632 VBN denotes shown
T3463 1622-1626 VBN denotes been
T3462 1618-1621 VBZ denotes has
T3461 1611-1617 NN denotes IL-1Ra
T3460 1603-1610 IN denotes Because
T3459 1601-1602 . denotes .
T3458 1600-1601 NNP denotes ]
T3457 1598-1600 CD denotes 13
T3456 1597-1598 NNP denotes [
T3455 1588-1596 NN denotes receptor
T3454 1583-1587 NN denotes IL-1
T3453 1579-1582 DT denotes the
T3452 1572-1578 VBZ denotes blocks
T3451 1558-1571 RB denotes competitively
T3450 1553-1557 WDT denotes that
T3449 1544-1552 NN denotes cytokine
T3448 1534-1543 VBG denotes occurring
T3447 1524-1533 RB denotes naturally
T3446 1522-1523 DT denotes a
T3445 1519-1521 VBZ denotes is
T3444 1517-1518 , denotes ,
T3443 1511-1517 NN denotes family
T3442 1506-1510 NNP denotes IL-1
T3441 1502-1505 DT denotes the
T3440 1499-1501 IN denotes of
T3439 1492-1498 NN denotes member
T3438 1490-1491 DT denotes a
T3437 1488-1489 , denotes ,
T3436 1487-1488 -RRB- denotes )
T3435 1481-1487 NN denotes IL-1Ra
T3434 1480-1481 -LRB- denotes (
T3433 1469-1479 NN denotes antagonist
T3432 1460-1468 NN denotes receptor
T3431 1446-1459 NN denotes Interleukin-1
T3430 1444-1445 . denotes .
T3429 1433-1444 NN denotes development
T3428 1427-1432 NN denotes tumor
T3427 1424-1426 IN denotes of
T3426 1413-1423 NN denotes inhibition
T3425 1409-1412 DT denotes the
T3424 1406-1408 IN denotes in
T3423 1401-1405 NNS denotes acts
T3422 1390-1400 NN denotes deficiency
T3421 1385-1389 JJ denotes CCR5
T3420 1381-1384 WRB denotes how
T3419 1372-1380 VB denotes describe
T3418 1369-1371 TO denotes to
T3417 1360-1368 VBN denotes required
T3416 1356-1359 VBP denotes are
T3415 1348-1355 NNS denotes studies
T3414 1343-1347 JJR denotes more
T3413 1341-1342 , denotes ,
T3412 1334-1341 RB denotes However
T3411 1332-1333 . denotes .
T3410 1321-1332 NN denotes progression
T3409 1314-1320 NN denotes cancer
T3372 1131-1133 CD denotes 11
T3371 1130-1131 NNP denotes [
T3370 1123-1129 NN denotes cancer
T3369 1114-1122 NN denotes prostate
T3368 1111-1113 IN denotes as
T3367 1106-1110 JJ denotes such
T3366 1104-1105 , denotes ,
T3365 1098-1104 NN denotes growth
T3364 1093-1097 NN denotes cell
T3363 1086-1092 NN denotes cancer
T3362 1076-1085 VBD denotes prevented
T3361 1065-1075 NNS denotes inhibitors
T3360 1060-1064 NNP denotes CCR5
T3359 1056-1059 CC denotes and
T3358 1054-1055 , denotes ,
T3357 1053-1054 NNP denotes ]
T3356 1051-1053 CD denotes 10
T3355 1050-1051 NNP denotes [
T3354 1043-1049 NN denotes growth
T3353 1037-1042 NN denotes tumor
T3352 1034-1036 IN denotes of
T3351 1028-1033 NN denotes delay
T3350 1024-1027 DT denotes the
T3349 1012-1023 NNS denotes potentiates
T3310 804-805 , denotes ,
T3309 803-804 NNP denotes ]
T3308 802-803 CD denotes 7
T3307 801-802 NN denotes [
T3306 794-800 NN denotes cancer
T3305 787-793 NN denotes breast
T3304 784-786 IN denotes of
T3303 772-783 NN denotes progression
T3302 768-771 DT denotes the
T3231 394-395 , denotes ,
T3230 389-394 NNS denotes cells
T3229 376-388 JJ denotes inflammatory
T3228 372-375 IN denotes for
T3227 364-371 NNS denotes factors
T3226 352-363 NN denotes chemotactic
T3528 1993-1999 NNS denotes tumors
T3527 1982-1992 JJ denotes aggressive
T3526 1972-1981 VBD denotes developed
T3525 1967-1971 NNS denotes mice
T3524 1957-1966 NN denotes deficient
T3523 1950-1956 NN denotes IL-1Ra
T3522 1939-1949 JJ denotes endogenous
T3521 1934-1938 IN denotes that
T3520 1925-1933 VBN denotes reported
T3519 1920-1924 RB denotes also
T3518 1916-1919 VBD denotes was
T3225 345-351 JJ denotes potent
T3224 341-344 VBP denotes are
T3223 335-340 WDT denotes which
T3222 333-334 , denotes ,
T3221 332-333 -RRB- denotes )
T3220 328-332 NNS denotes CCR5
T3219 327-328 -LRB- denotes (
T3218 318-326 NN denotes receptor
T3217 308-317 NN denotes chemokine
T3216 304-307 NNP denotes C-C
T3215 300-303 CC denotes and
T3214 298-299 -RRB- denotes )
T3213 294-298 NNS denotes CCL5
T3212 293-294 -LRB- denotes (
T3211 291-292 CD denotes 5
T3210 284-290 NN denotes ligand
T3209 282-283 -RRB- denotes )
T3208 277-282 NN denotes motif
T3207 273-276 JJ denotes C-C
T3206 272-273 -LRB- denotes (
T3205 262-271 NN denotes chemokine
T3204 258-261 DT denotes the
T3203 253-257 IN denotes that
T3202 243-252 VBZ denotes indicates
T3201 234-242 NN denotes evidence
T3200 222-233 VBN denotes accumulated
T3199 218-221 DT denotes The
T3198 216-217 . denotes .
T3197 215-216 NNP denotes ]
T3196 214-215 CD denotes 1
T3195 213-214 VBP denotes [
T3194 203-212 NNS denotes receptors
T3193 193-202 NN denotes chemokine
T3192 189-192 CC denotes and
T3191 178-188 NNS denotes chemokines
T3190 170-177 VBP denotes express
T3189 164-169 NNS denotes cells
T3188 157-163 NN denotes cancer
T3187 154-156 IN denotes of
T3186 148-153 NNS denotes types
T3185 143-147 JJ denotes Many
T3184 141-142 . denotes .
T3183 129-141 NN denotes inflammation
T3182 126-128 IN denotes by
T3181 119-125 NN denotes growth
T3180 114-118 NN denotes cell
T3179 107-113 NN denotes cancer
T3178 100-106 VB denotes induce
T3177 97-99 TO denotes to
T3176 89-96 NN denotes ability
T3175 82-88 JJ denotes potent
T3174 76-81 PRP$ denotes their
T3173 72-75 IN denotes for
T3172 66-71 VBN denotes known
T3171 61-65 RBS denotes best
T3170 57-60 VBP denotes are
T3169 52-56 WDT denotes that
T3168 42-51 NNS denotes molecules
T3167 34-41 JJ denotes soluble
T3166 28-33 JJ denotes small
T3165 24-27 VBP denotes are
T3164 13-23 NNS denotes Chemokines
T3301 765-767 IN denotes in
T3300 755-764 JJ denotes important
T3299 750-754 RB denotes also
T3298 747-749 VBZ denotes is
T3297 742-746 NNP denotes CCL5
T3296 738-741 DT denotes the
T3295 735-737 IN denotes of
T3294 724-734 NN denotes production
T3293 718-723 JJ denotes Local
T3292 716-717 . denotes .
T3291 715-716 NNP denotes ]
T3290 714-715 CD denotes 6
T3289 713-714 VBP denotes [
T3288 707-712 NNS denotes cells
T3287 700-706 NN denotes cancer
T3286 691-699 NN denotes prostate
T3285 687-690 CC denotes and
T3284 682-686 JJ denotes oral
T3283 679-681 IN denotes as
T3282 674-678 RB denotes well
T3281 671-673 RB denotes as
T3280 669-670 , denotes ,
T3279 668-669 NNP denotes ]
T3278 667-668 CD denotes 5
T3277 666-667 NN denotes [
T3276 657-665 NN denotes lymphoma
T3275 649-656 NNP denotes Hodgkin
T3274 647-648 , denotes ,
T3273 635-647 NN denotes glioblastoma
T3272 633-634 , denotes ,
T3271 632-633 NNP denotes ]
T3270 631-632 CD denotes 4
T3269 630-631 NN denotes [
T3268 621-629 NN denotes hepatoma
T3267 619-620 , denotes ,
T3266 618-619 NNP denotes ]
T3265 617-618 CD denotes 3
T3264 616-617 NN denotes [
T3263 607-615 NN denotes melanoma
T3262 605-606 , denotes ,
T3261 604-605 NNP denotes ]
T3260 603-604 CD denotes 2
T3259 602-603 NN denotes [
T3258 595-601 NN denotes cancer
T3257 584-594 JJ denotes colorectal
T3256 581-583 IN denotes of
T3255 569-580 NN denotes development
T3254 555-568 JJ denotes nonmetastatic
T3253 550-554 IN denotes with
T3252 539-549 VBN denotes associated
T3251 525-538 RB denotes significantly
T3250 522-524 VBZ denotes is
T3249 511-521 NN denotes expression
T3248 506-510 NNS denotes CCR5
T3247 499-505 JJ denotes strong
T3246 495-498 CC denotes and
T3245 482-494 NNP denotes Intermediate
T3244 480-481 . denotes .
T3243 473-480 NNS denotes cancers
T3242 465-472 JJ denotes several
T3241 462-464 IN denotes of
T3240 451-461 NN denotes metastasis
T3239 447-450 CC denotes and
T3238 433-446 NN denotes proliferation
T3237 429-432 DT denotes the
T3236 426-428 IN denotes in
T3235 417-425 VBN denotes involved
T3234 403-416 RB denotes significantly
T3233 400-402 VB denotes be
T3232 396-399 MD denotes may
T3348 1007-1011 CD denotes CCR5
T3347 1004-1006 IN denotes of
T3346 996-1003 NN denotes absence
T3345 991-995 NN denotes host
T3344 989-990 , denotes ,
T3343 981-989 NN denotes addition
T3342 978-980 IN denotes In
T3341 976-977 . denotes .
T3340 975-976 NNP denotes ]
T3339 974-975 CD denotes 9
T3338 973-974 NN denotes [
T3337 966-972 NN denotes cancer
T3336 955-965 JJ denotes pancreatic
T3335 952-954 IN denotes of
T3334 941-951 NN denotes metastasis
T3333 937-940 CC denotes and
T3332 930-936 NN denotes growth
T3331 924-929 NN denotes tumor
T3330 911-923 JJ denotes experimental
T3329 903-910 VB denotes inhibit
T3328 900-902 TO denotes to
T3327 887-899 VBN denotes demonstrated
T3326 882-886 VBN denotes been
T3325 878-881 VBZ denotes has
T3324 867-877 NN denotes disruption
T3323 862-866 NNP denotes CCR5
T3322 860-861 , denotes ,
T3321 851-860 RB denotes Meanwhile
T3320 849-850 . denotes .
T3319 848-849 NNP denotes ]
T3318 847-848 CD denotes 8
T3317 846-847 NN denotes [
T3316 836-845 NN denotes prognosis
T3315 831-835 JJ denotes poor
T3314 826-830 IN denotes with
T3313 815-825 VBZ denotes correlates
T3312 810-814 RB denotes also
T3311 806-809 CC denotes and
T3408 1311-1313 IN denotes in
T3407 1302-1310 NN denotes receptor
T3406 1290-1301 NN denotes suppressive
T3405 1288-1289 DT denotes a
T3404 1285-1287 IN denotes as
T3403 1276-1284 VB denotes function
T3402 1272-1275 MD denotes may
T3401 1267-1271 NNS denotes CCR5
T3400 1258-1266 NN denotes receptor
T3399 1248-1257 NN denotes chemokine
T3398 1235-1247 JJ denotes inflammatory
T3397 1232-1234 IN denotes of
T3396 1221-1231 NN denotes deficiency
T3395 1217-1220 DT denotes the
T3394 1212-1216 IN denotes that
T3393 1204-1211 VBP denotes suggest
T3392 1199-1203 NNS denotes data
T3391 1193-1198 DT denotes These
T3390 1191-1192 . denotes .
T3389 1190-1191 NNP denotes ]
T3388 1188-1190 CD denotes 12
T3387 1187-1188 NNP denotes [
T3386 1180-1186 NN denotes cancer
T3385 1175-1179 NN denotes lung
T3384 1171-1174 CC denotes and
T3383 1169-1170 , denotes ,
T3382 1168-1169 NNP denotes ]
T3381 1167-1168 CD denotes 4
T3380 1166-1167 VBP denotes [
T3379 1160-1165 NNS denotes cells
T3378 1151-1159 NN denotes hepatoma
T3377 1149-1150 , denotes ,
T3376 1143-1149 NN denotes cancer
T3375 1136-1142 NN denotes breast
T3374 1134-1135 , denotes ,
T3373 1133-1134 NNP denotes ]
T3645 2643-2650 IN denotes against
T3644 2634-2642 NN denotes activity
T3643 2624-2633 NN denotes antitumor
T3642 2612-2623 JJ denotes significant
T3641 2607-2611 RBR denotes more
T3640 2594-2606 VBD denotes demonstrated
T3639 2592-2593 , denotes ,
T3638 2580-2592 NN denotes chemotherapy
T3637 2570-2579 NN denotes docetaxel
T3636 2566-2569 CC denotes and
T3635 2553-2565 NN denotes temozolomide
T3634 2548-2552 IN denotes with
T3633 2539-2547 VBN denotes combined
T3632 2537-2538 , denotes ,
T3631 2531-2537 NN denotes IL-1Ra
T3630 2526-2530 IN denotes that
T3629 2520-2525 VBN denotes found
T3628 2515-2519 RB denotes also
T3627 2511-2514 VBD denotes was
T3626 2508-2510 PRP denotes It
T3625 2506-2507 . denotes .
T3624 2505-2506 NNP denotes ]
T3623 2503-2505 CD denotes 24
T3622 2502-2503 NNP denotes [
T3621 2495-2501 NNS denotes tumors
T3620 2489-2494 JJ denotes solid
T3619 2481-2488 VB denotes develop
T3618 2478-2480 TO denotes to
T3617 2471-2477 VBD denotes failed
T3616 2462-2470 NN denotes melanoma
T3615 2457-2461 IN denotes with
T3614 2448-2456 VBN denotes injected
T3613 2443-2447 NNS denotes mice
T3612 2434-2442 NN denotes knockout
T3611 2429-2433 CD denotes IL-1
T3610 2427-2428 . denotes .
T3609 2426-2427 NNP denotes ]
T3608 2424-2426 CD denotes 23
T3607 2423-2424 NNP denotes [
T3606 2411-2422 NN denotes development
T3605 2404-2410 NN denotes cancer
T3604 2399-2403 NN denotes skin
T3603 2395-2398 CC denotes and
T3699 2945-2947 CD denotes 26
T3698 2944-2945 NNP denotes [
T3697 2932-2943 NN denotes development
T3696 2925-2931 NN denotes cancer
T3695 2920-2924 IN denotes with
T3694 2909-2919 VBN denotes associated
T3693 2901-2908 RB denotes closely
T3692 2898-2900 VBZ denotes is
T3691 2894-2897 CC denotes and
T3690 2892-2893 , denotes ,
T3689 2880-2892 NN denotes inflammation
T3688 2876-2879 CC denotes and
T3687 2862-2875 NN denotes proliferation
T3686 2857-2861 NN denotes cell
T3685 2854-2856 IN denotes of
T3684 2844-2853 NN denotes induction
T3683 2840-2843 DT denotes the
T3682 2837-2839 IN denotes as
T3681 2832-2836 RB denotes well
T3680 2829-2831 RB denotes as
T3679 2827-2828 , denotes ,
T3678 2818-2827 NN denotes apoptosis
T3677 2815-2817 IN denotes of
T3676 2803-2814 NN denotes suppression
T3675 2799-2802 DT denotes the
T3674 2796-2798 IN denotes in
T3673 2791-2795 NN denotes role
T3672 2783-2790 JJ denotes crucial
T3671 2781-2782 DT denotes a
T3670 2775-2780 NNS denotes plays
T3669 2769-2774 JJ denotes NF-κB
T3668 2767-2768 . denotes .
T3667 2759-2767 NN denotes cytokine
T3666 2747-2758 VBG denotes suppressing
T3665 2740-2746 NN denotes growth
T3664 2734-2739 NN denotes tumor
T3663 2732-2733 DT denotes a
T3662 2729-2731 IN denotes as
T3661 2719-2728 JJ denotes important
T3797 3493-3495 IN denotes of
T3841 3738-3744 NN denotes cancer
T3840 3728-3737 JJ denotes apoptotic
T3839 3718-3727 VBG denotes affecting
T3838 3709-3717 RB denotes directly
T3837 3707-3708 -RRB- denotes )
T3836 3706-3707 CD denotes 1
T3835 3705-3706 -LRB- denotes (
T3834 3702-3704 IN denotes by
T3833 3695-3701 NN denotes growth
T3832 3690-3694 NN denotes cell
T3831 3683-3689 NN denotes cancer
T3830 3675-3682 VB denotes prevent
T3829 3672-3674 TO denotes to
T3828 3663-3671 VBN denotes targeted
T3827 3653-3662 RB denotes specially
T3826 3650-3652 VB denotes be
T3825 3646-3649 MD denotes can
T3824 3640-3645 NNP denotes NF-κB
T3823 3638-3639 , denotes ,
T3822 3629-3638 RB denotes Therefore
T3821 3627-3628 . denotes .
T3820 3626-3627 NNP denotes ]
T3819 3624-3626 CD denotes 31
T3818 3623-3624 NNP denotes [
T3817 3618-3622 NN denotes host
T3816 3614-3617 DT denotes the
T3815 3611-3613 IN denotes in
T3814 3601-3610 NNS denotes responses
T3813 3594-3600 JJ denotes immune
T3812 3586-3593 JJ denotes humoral
T3811 3582-3585 CC denotes and
T3810 3575-3581 NN denotes innate
T3809 3570-3574 DT denotes both
T3808 3560-3569 VBG denotes affecting
T3807 3548-3559 NNS denotes macrophages
T3806 3544-3547 CC denotes and
T3805 3538-3543 NNS denotes cells
T3804 3536-3537 NNP denotes T
T3803 3533-3535 IN denotes in
T3802 3525-3532 NNS denotes factors
T3801 3518-3524 NN denotes growth
T3800 3514-3517 CC denotes and
T3799 3504-3513 NNS denotes cytokines
T3798 3496-3503 JJ denotes various
T3902 4120-4124 CD denotes CCR5
T3901 4117-4119 IN denotes of
T3900 4106-4116 NN denotes inhibition
T3899 4103-4105 IN denotes by
T3898 4094-4102 NN denotes lymphoma
T3897 4085-4093 NN denotes effusion
T3896 4077-4084 JJ denotes primary
T3895 4074-4076 IN denotes of
T3894 4068-4073 NN denotes death
T3893 4063-4067 NN denotes cell
T3892 4055-4062 VBZ denotes induces
T3891 4053-4054 -RRB- denotes )
T3890 4048-4053 NNP denotes DHMEQ
T3889 4047-4048 -LRB- denotes (
T3888 4015-4046 NN denotes dehydroxymethyl-epoxyquinomicin
T3887 4012-4014 IN denotes by
T3886 4006-4011 NN denotes NF-κB
T3885 4003-4005 IN denotes of
T3884 3992-4002 NN denotes inhibition
T3883 3987-3991 IN denotes that
T3882 3978-3986 VBN denotes reported
T3881 3974-3977 VBD denotes was
T3880 3971-3973 PRP denotes It
T3879 3969-3970 . denotes .
T3878 3959-3969 NN denotes metastasis
T3877 3955-3958 CC denotes and
T3876 3948-3954 NN denotes growth
T3875 3942-3947 NN denotes tumor
T3874 3929-3941 JJ denotes CCR-mediated
T3873 3926-3928 IN denotes of
T3872 3915-3925 NN denotes regulation
T3871 3911-3914 DT denotes the
T3870 3908-3910 IN denotes in
T3869 3898-3907 JJ denotes important
T3868 3895-3897 VBZ denotes is
T3867 3889-3894 NNP denotes NF-κB
T3866 3886-3888 IN denotes of
T3865 3875-3885 NNP denotes Activation
T3864 3873-3874 . denotes .
T3863 3862-3873 NNS denotes lymphokines
T3862 3854-3861 VBG denotes killing
T3861 3848-3853 NN denotes tumor
T3860 3845-3847 IN denotes of
T3859 3834-3844 NN denotes production
T3858 3830-3833 DT denotes the
T3857 3819-3829 VBG denotes increasing
T3856 3817-3818 -RRB- denotes )
T3855 3816-3817 LS denotes 3
T3854 3815-3816 -LRB- denotes (
T3853 3812-3814 CC denotes or
T3949 4377-4382 NNS denotes sites
T3948 4369-4376 JJ denotes binding
T3947 4362-4368 NN denotes factor
T3946 4348-4361 NN denotes transcription
T3945 4342-4347 JJ denotes NF-κB
T3944 4340-4341 . denotes .
T3943 4329-4340 NN denotes development
T3942 4323-4328 NN denotes tumor
T3941 4314-4322 VBD denotes mediated
T3940 4309-4313 NNP denotes CCR5
T3939 4306-4308 IN denotes in
T3938 4297-4305 VBN denotes involved
T3937 4294-4296 VB denotes be
T3936 4288-4293 MD denotes could
T3935 4282-4287 NN denotes NF-κB
T3934 4279-4281 IN denotes of
T3933 4268-4278 NN denotes inhibition
T3932 4263-4267 IN denotes that
T3931 4254-4262 JJ denotes possible
T3930 4251-4253 VBZ denotes is
T3929 4248-4250 PRP denotes it
T3928 4246-4247 , denotes ,
T3927 4242-4246 RB denotes Thus
T3926 4240-4241 . denotes .
T3925 4239-4240 NNP denotes ]
T3924 4237-4239 CD denotes 33
T3923 4236-4237 NNP denotes [
T3922 4225-4235 NN denotes metastasis
T3921 4220-4224 NN denotes lung
T3920 4216-4219 CC denotes and
T3919 4214-4215 -RRB- denotes )
T3918 4213-4214 CD denotes 5
T3917 4212-4213 -LRB- denotes (
T3916 4203-4211 NN denotes motility
T3915 4196-4202 NN denotes cancer
T3914 4191-4195 JJ denotes oral
T3913 4177-4190 JJ denotes CCL5-mediated
T3912 4167-4176 VBZ denotes increases
T3911 4162-4166 RB denotes also
T3910 4156-4161 NNP denotes NF-κB
T3909 4153-4155 IN denotes of
T3908 4142-4152 NNP denotes Activation
T3907 4140-4141 . denotes .
T3906 4139-4140 NNP denotes ]
T3905 4137-4139 CD denotes 32
T3904 4136-4137 NNP denotes [
T3991 4583-4590 JJ denotes Several
T3990 4581-4582 . denotes .
T3989 4573-4581 NN denotes response
T3988 4560-4572 JJ denotes inflammatory
T3987 4556-4559 DT denotes the
T3986 4553-4555 IN denotes of
T3985 4543-4552 NN denotes regulator
T3984 4534-4542 JJ denotes negative
T3983 4532-4533 DT denotes a
T3982 4529-4531 VBZ denotes is
T3981 4522-4528 NN denotes IL-1Ra
T3980 4518-4521 DT denotes the
T3979 4516-4517 , denotes ,
T3978 4512-4516 NN denotes hand
T3977 4506-4511 JJ denotes other
T3976 4502-4505 DT denotes the
T3975 4499-4501 IN denotes On
T3974 4497-4498 . denotes .
T3973 4496-4497 NNP denotes ]
T3972 4494-4496 CD denotes 34
T3971 4493-4494 NNP denotes [
T3970 4490-4492 NNP denotes KC
T3969 4486-4489 CC denotes and
T3968 4484-4485 , denotes ,
T3967 4478-4484 NNP denotes GM-CSF
T3966 4476-4477 , denotes ,
T3965 4472-4476 NNP denotes IL-6
T3964 4470-4471 , denotes ,
T3963 4461-4470 NN denotes IL-1alpha
T3962 4458-4460 IN denotes as
T3961 4453-4457 JJ denotes such
T3960 4451-4452 , denotes ,
T3959 4446-4451 NNS denotes genes
T4005 4682-4686 NN denotes IL-1
T4004 4679-4681 IN denotes of
T4003 4671-4678 NNS denotes effects
T4002 4655-4670 JJ denotes proinflammatory
T4001 4651-4654 DT denotes the
T4000 4642-4650 VB denotes abrogate
T3999 4639-4641 TO denotes to
T3998 4632-4638 NN denotes IL-1Ra
T3997 4629-4631 IN denotes of
T3996 4621-4628 NN denotes ability
T3995 4617-4620 DT denotes the
T3994 4604-4616 VBN denotes demonstrated
T3993 4599-4603 VBP denotes have
T3992 4591-4598 NNS denotes studies
R2007 T3164 T3165 nsubj Chemokines,are
R2010 T3165 T3165 ROOT are,are
R2012 T3166 T3168 amod small,molecules
R2014 T3167 T3168 amod soluble,molecules
R2017 T3168 T3165 attr molecules,are
R2019 T3169 T3172 nsubjpass that,known
R2020 T3170 T3172 auxpass are,known
R2022 T3171 T3172 advmod best,known
R2023 T3172 T3168 relcl known,molecules
R2024 T3173 T3172 prep for,known
R2025 T3174 T3176 poss their,ability
R2026 T3175 T3176 amod potent,ability
R2027 T3214 T3213 punct ),CCL5
R2028 T3176 T3173 pobj ability,for
R2029 T3177 T3178 aux to,induce
R2030 T3178 T3176 acl induce,ability
R2031 T3179 T3180 compound cancer,cell
R2032 T3180 T3181 compound cell,growth
R2033 T3181 T3178 dobj growth,induce
R2034 T3182 T3178 prep by,induce
R2035 T3183 T3182 pobj inflammation,by
R2036 T3184 T3165 punct .,are
R2037 T3185 T3186 amod Many,types
R2038 T3215 T3213 cc and,CCL5
R2039 T3186 T3190 nsubj types,express
R2040 T3187 T3186 prep of,types
R2041 T3188 T3189 compound cancer,cells
R2042 T3216 T3218 compound C-C,receptor
R2043 T3189 T3187 pobj cells,of
R2044 T3190 T3190 ROOT express,express
R2045 T3191 T3190 dobj chemokines,express
R2046 T3192 T3191 cc and,chemokines
R2047 T3217 T3218 compound chemokine,receptor
R2048 T3193 T3194 compound chemokine,receptors
R2049 T3194 T3191 conj receptors,chemokines
R2050 T3195 T3190 conj [,express
R2051 T3196 T3197 nummod 1,]
R2052 T3197 T3195 dobj ],[
R2053 T3198 T3190 punct .,express
R2054 T3199 T3201 det The,evidence
R2055 T3218 T3213 conj receptor,CCL5
R2056 T3200 T3201 amod accumulated,evidence
R2057 T3201 T3202 nsubj evidence,indicates
R2058 T3202 T3202 ROOT indicates,indicates
R2059 T3203 T3235 mark that,involved
R2060 T3219 T3220 punct (,CCR5
R2061 T3204 T3205 det the,chemokine
R2062 T3205 T3235 nsubjpass chemokine,involved
R2063 T3206 T3208 punct (,motif
R2064 T3220 T3218 appos CCR5,receptor
R2065 T3207 T3208 amod C-C,motif
R2066 T3208 T3205 appos motif,chemokine
R2067 T3209 T3205 punct ),chemokine
R2068 T3221 T3220 punct ),CCR5
R2069 T3210 T3213 nmod ligand,CCL5
R2070 T3211 T3210 nummod 5,ligand
R2071 T3212 T3213 punct (,CCL5
R2072 T3213 T3235 nsubjpass CCL5,involved
R2073 T3222 T3218 punct ",",receptor
R2074 T3223 T3224 nsubj which,are
R2075 T3224 T3218 relcl are,receptor
R2076 T3225 T3227 amod potent,factors
R2077 T3226 T3227 compound chemotactic,factors
R2078 T3311 T3309 cc and,]
R2079 T3227 T3224 attr factors,are
R2080 T3312 T3313 advmod also,correlates
R2081 T3313 T3298 conj correlates,is
R2082 T3228 T3227 prep for,factors
R2083 T3314 T3313 prep with,correlates
R2084 T3315 T3316 amod poor,prognosis
R2085 T3316 T3317 compound prognosis,[
R2086 T3317 T3319 nmod [,]
R2087 T3229 T3230 amod inflammatory,cells
R2088 T3318 T3319 nummod 8,]
R2089 T3319 T3314 pobj ],with
R2090 T3230 T3228 pobj cells,for
R2091 T3320 T3313 punct .,correlates
R2092 T3321 T3327 advmod Meanwhile,demonstrated
R2093 T3322 T3327 punct ",",demonstrated
R2094 T3231 T3218 punct ",",receptor
R2095 T3323 T3324 compound CCR5,disruption
R2096 T3324 T3327 nsubjpass disruption,demonstrated
R2097 T3325 T3327 aux has,demonstrated
R2098 T3232 T3235 aux may,involved
R2099 T3233 T3235 auxpass be,involved
R2100 T3326 T3327 auxpass been,demonstrated
R2101 T3234 T3235 advmod significantly,involved
R2102 T3327 T3327 ROOT demonstrated,demonstrated
R2103 T3328 T3329 aux to,inhibit
R2104 T3329 T3327 xcomp inhibit,demonstrated
R2105 T3330 T3332 amod experimental,growth
R2106 T3331 T3332 compound tumor,growth
R2107 T3235 T3202 ccomp involved,indicates
R2108 T3332 T3329 dobj growth,inhibit
R2109 T3333 T3332 cc and,growth
R2110 T3334 T3332 conj metastasis,growth
R2111 T3236 T3235 prep in,involved
R2112 T3335 T3334 prep of,metastasis
R2113 T3336 T3337 compound pancreatic,cancer
R2114 T3337 T3338 compound cancer,[
R2115 T3237 T3238 det the,proliferation
R2116 T3338 T3340 nmod [,]
R2117 T3339 T3338 nummod 9,[
R2118 T3340 T3335 pobj ],of
R2119 T3238 T3236 pobj proliferation,in
R2120 T3341 T3327 punct .,demonstrated
R2121 T3342 T3362 prep In,prevented
R2122 T3343 T3342 pobj addition,In
R2123 T3344 T3362 punct ",",prevented
R2124 T3239 T3238 cc and,proliferation
R2125 T3345 T3346 compound host,absence
R2126 T3346 T3362 nsubj absence,prevented
R2127 T3347 T3346 prep of,absence
R2128 T3348 T3349 nummod CCR5,potentiates
R2129 T3240 T3238 conj metastasis,proliferation
R2130 T3349 T3347 pobj potentiates,of
R2131 T3350 T3351 det the,delay
R2132 T3351 T3346 conj delay,absence
R2133 T3241 T3238 prep of,proliferation
R2134 T3352 T3351 prep of,delay
R2135 T3353 T3354 compound tumor,growth
R2136 T3354 T3352 pobj growth,of
R2137 T3355 T3357 nmod [,]
R2138 T3242 T3243 amod several,cancers
R2139 T3356 T3357 nummod 10,]
R2140 T3357 T3361 nmod ],inhibitors
R2141 T3358 T3357 punct ",",]
R2142 T3243 T3241 pobj cancers,of
R2143 T3359 T3357 cc and,]
R2144 T3360 T3357 conj CCR5,]
R2145 T3361 T3362 nsubj inhibitors,prevented
R2146 T3362 T3362 ROOT prevented,prevented
R2147 T3244 T3202 punct .,indicates
R2148 T3363 T3364 compound cancer,cell
R2149 T3364 T3365 compound cell,growth
R2150 T3365 T3362 dobj growth,prevented
R2151 T3245 T3252 nsubjpass Intermediate,associated
R2152 T3366 T3362 punct ",",prevented
R2153 T3367 T3368 amod such,as
R2154 T3368 T3362 prep as,prevented
R2155 T3369 T3370 compound prostate,cancer
R2156 T3370 T3371 compound cancer,[
R2157 T3371 T3368 pobj [,as
R2158 T3246 T3245 cc and,Intermediate
R2159 T3372 T3373 nummod 11,]
R2160 T3247 T3249 amod strong,expression
R2161 T3248 T3249 compound CCR5,expression
R2162 T3373 T3371 conj ],[
R2163 T3374 T3373 punct ",",]
R2164 T3249 T3245 conj expression,Intermediate
R2165 T3375 T3376 compound breast,cancer
R2166 T3376 T3371 conj cancer,[
R2167 T3250 T3252 auxpass is,associated
R2168 T3377 T3376 punct ",",cancer
R2169 T3378 T3379 compound hepatoma,cells
R2170 T3251 T3252 advmod significantly,associated
R2171 T3379 T3376 conj cells,cancer
R2172 T3380 T3382 nmod [,]
R2173 T3381 T3382 nummod 4,]
R2174 T3252 T3252 ROOT associated,associated
R2175 T3382 T3362 dobj ],prevented
R2176 T3383 T3382 punct ",",]
R2177 T3384 T3382 cc and,]
R2178 T3385 T3386 compound lung,cancer
R2179 T3253 T3252 prep with,associated
R2180 T3386 T3387 compound cancer,[
R2181 T3387 T3382 conj [,]
R2182 T3388 T3389 nummod 12,]
R2183 T3254 T3255 amod nonmetastatic,development
R2184 T3389 T3387 appos ],[
R2185 T3390 T3362 punct .,prevented
R2186 T3391 T3392 det These,data
R2187 T3255 T3253 pobj development,with
R2188 T3392 T3393 nsubj data,suggest
R2189 T3393 T3393 ROOT suggest,suggest
R2190 T3394 T3403 mark that,function
R2191 T3395 T3396 det the,deficiency
R2192 T3256 T3255 prep of,development
R2193 T3396 T3403 nsubj deficiency,function
R2194 T3397 T3396 prep of,deficiency
R2195 T3398 T3401 amod inflammatory,CCR5
R2196 T3257 T3258 compound colorectal,cancer
R2197 T3399 T3400 compound chemokine,receptor
R2198 T3400 T3401 compound receptor,CCR5
R2199 T3258 T3259 compound cancer,[
R2200 T3401 T3397 pobj CCR5,of
R2201 T3402 T3403 aux may,function
R2202 T3403 T3393 ccomp function,suggest
R2203 T3404 T3403 prep as,function
R2204 T3259 T3256 pobj [,of
R2205 T3260 T3261 nummod 2,]
R2206 T3405 T3407 det a,receptor
R2207 T3261 T3269 nmod ],[
R2208 T3262 T3261 punct ",",]
R2209 T3406 T3407 compound suppressive,receptor
R2210 T3407 T3404 pobj receptor,as
R2211 T3408 T3407 prep in,receptor
R2212 T3263 T3264 compound melanoma,[
R2213 T3264 T3261 appos [,]
R2214 T3265 T3264 nummod 3,[
R2215 T3409 T3410 compound cancer,progression
R2216 T3266 T3261 conj ],]
R2217 T3410 T3408 pobj progression,in
R2218 T3411 T3393 punct .,suggest
R2219 T3412 T3417 advmod However,required
R2220 T3267 T3266 punct ",",]
R2221 T3413 T3417 punct ",",required
R2222 T3414 T3415 amod more,studies
R2223 T3268 T3269 compound hepatoma,[
R2224 T3415 T3417 nsubjpass studies,required
R2225 T3416 T3417 auxpass are,required
R2226 T3417 T3417 ROOT required,required
R2227 T3269 T3271 nmod [,]
R2228 T3418 T3419 aux to,describe
R2229 T3419 T3417 xcomp describe,required
R2230 T3420 T3423 advmod how,acts
R2231 T3270 T3271 nummod 4,]
R2232 T3421 T3423 amod CCR5,acts
R2233 T3422 T3423 compound deficiency,acts
R2234 T3423 T3419 dobj acts,describe
R2235 T3271 T3289 nsubj ],[
R2236 T3424 T3423 prep in,acts
R2237 T3425 T3426 det the,inhibition
R2238 T3426 T3424 pobj inhibition,in
R2239 T3427 T3426 prep of,inhibition
R2240 T3272 T3271 punct ",",]
R2241 T3428 T3429 compound tumor,development
R2242 T3429 T3427 pobj development,of
R2243 T3430 T3417 punct .,required
R2244 T3431 T3433 compound Interleukin-1,antagonist
R2245 T3273 T3271 conj glioblastoma,]
R2246 T3432 T3433 compound receptor,antagonist
R2247 T3433 T3445 nsubj antagonist,is
R2248 T3434 T3433 punct (,antagonist
R2249 T3435 T3433 appos IL-1Ra,antagonist
R2250 T3274 T3273 punct ",",glioblastoma
R2251 T3436 T3433 punct ),antagonist
R2252 T3437 T3433 punct ",",antagonist
R2253 T3438 T3439 det a,member
R2254 T3439 T3433 appos member,antagonist
R2255 T3440 T3439 prep of,member
R2256 T3441 T3443 det the,family
R2257 T3442 T3443 amod IL-1,family
R2258 T3275 T3276 compound Hodgkin,lymphoma
R2259 T3443 T3440 pobj family,of
R2260 T3444 T3445 punct ",",is
R2261 T3445 T3445 ROOT is,is
R2262 T3446 T3449 det a,cytokine
R2263 T3276 T3277 compound lymphoma,[
R2264 T3447 T3448 advmod naturally,occurring
R2265 T3448 T3449 amod occurring,cytokine
R2266 T3449 T3445 attr cytokine,is
R2267 T3277 T3273 appos [,glioblastoma
R2268 T3450 T3452 nsubj that,blocks
R2269 T3451 T3452 advmod competitively,blocks
R2270 T3452 T3449 relcl blocks,cytokine
R2271 T3278 T3277 nummod 5,[
R2272 T3453 T3455 det the,receptor
R2273 T3454 T3455 amod IL-1,receptor
R2274 T3455 T3452 dobj receptor,blocks
R2275 T3279 T3277 appos ],[
R2276 T3456 T3458 nmod [,]
R2277 T3457 T3458 nummod 13,]
R2278 T3458 T3449 appos ],cytokine
R2279 T3280 T3277 punct ",",[
R2280 T3459 T3445 punct .,is
R2281 T3460 T3464 mark Because,shown
R2282 T3461 T3464 nsubjpass IL-1Ra,shown
R2283 T3281 T3283 advmod as,as
R2284 T3462 T3464 aux has,shown
R2285 T3463 T3464 auxpass been,shown
R2286 T3464 T3464 ROOT shown,shown
R2287 T3465 T3466 aux to,inhibit
R2288 T3282 T3283 advmod well,as
R2289 T3466 T3464 xcomp inhibit,shown
R2290 T3467 T3468 compound tumor,progression
R2291 T3468 T3466 dobj progression,inhibit
R2292 T3283 T3277 cc as,[
R2293 T3469 T3466 prep by,inhibit
R2294 T3470 T3469 pcomp promoting,by
R2295 T3471 T3473 amod antitumor,responses
R2296 T3284 T3288 amod oral,cells
R2297 T3472 T3473 amod immune,responses
R2298 T3473 T3470 dobj responses,promoting
R2299 T3474 T3469 cc and,by
R2300 T3285 T3284 cc and,oral
R2301 T3475 T3469 conj by,by
R2302 T3476 T3475 pcomp enhancing,by
R2303 T3477 T3478 det the,activity
R2304 T3478 T3476 dobj activity,enhancing
R2305 T3479 T3478 prep of,activity
R2306 T3480 T3483 amod chemotherapy,studies
R2307 T3286 T3284 conj prostate,oral
R2308 T3481 T3483 punct ",",studies
R2309 T3482 T3483 amod numerous,studies
R2310 T3483 T3479 pobj studies,of
R2311 T3287 T3288 compound cancer,cells
R2312 T3288 T3277 conj cells,[
R2313 T3484 T3485 aux have,examined
R2314 T3289 T3252 conj [,associated
R2315 T3290 T3291 nummod 6,]
R2316 T3485 T3464 conj examined,shown
R2317 T3291 T3289 dobj ],[
R2318 T3486 T3487 det the,ability
R2319 T3292 T3289 punct .,[
R2320 T3293 T3294 amod Local,production
R2321 T3294 T3298 nsubj production,is
R2322 T3487 T3485 dobj ability,examined
R2323 T3295 T3294 prep of,production
R2324 T3296 T3297 det the,CCL5
R2325 T3488 T3487 prep of,ability
R2326 T3297 T3295 pobj CCL5,of
R2327 T3298 T3298 ROOT is,is
R2328 T3489 T3488 pobj IL-1Ra,of
R2329 T3299 T3298 advmod also,is
R2330 T3300 T3298 acomp important,is
R2331 T3490 T3491 aux to,block
R2332 T3301 T3298 prep in,is
R2333 T3491 T3487 acl block,ability
R2334 T3302 T3303 det the,progression
R2335 T3303 T3301 pobj progression,in
R2336 T3492 T3493 compound tumor,progression
R2337 T3493 T3491 dobj progression,block
R2338 T3304 T3303 prep of,progression
R2339 T3494 T3464 punct .,shown
R2340 T3495 T3496 compound IL-1Ra,expression
R2341 T3496 T3498 nsubjpass expression,reduced
R2342 T3305 T3306 compound breast,cancer
R2343 T3497 T3498 auxpass was,reduced
R2344 T3498 T3498 ROOT reduced,reduced
R2345 T3499 T3498 prep in,reduced
R2346 T3306 T3304 pobj cancer,of
R2347 T3500 T3499 pobj prostate,in
R2348 T3501 T3503 nmod [,]
R2349 T3307 T3309 nmod [,]
R2350 T3502 T3503 nummod 14,]
R2351 T3503 T3498 npadvmod ],reduced
R2352 T3504 T3503 punct ",",]
R2353 T3505 T3506 compound breast,[
R2354 T3308 T3309 nummod 7,]
R2355 T3309 T3313 nsubj ],correlates
R2356 T3506 T3503 conj [,]
R2357 T3310 T3309 punct ",",]
R2358 T3507 T3508 nummod 15,]
R2359 T3508 T3506 conj ],[
R2360 T3509 T3508 punct ",",]
R2361 T3603 T3601 cc and,]
R2362 T3510 T3508 cc and,]
R2363 T3511 T3512 compound skin,cancer
R2364 T3512 T3513 compound cancer,[
R2365 T3604 T3605 compound skin,cancer
R2366 T3513 T3508 conj [,]
R2367 T3514 T3515 nummod 16,]
R2368 T3515 T3513 appos ],[
R2369 T3516 T3498 punct .,reduced
R2370 T3605 T3606 compound cancer,development
R2371 T3517 T3520 nsubjpass It,reported
R2372 T3518 T3520 auxpass was,reported
R2373 T3519 T3520 advmod also,reported
R2374 T3606 T3580 dobj development,reduces
R2375 T3520 T3520 ROOT reported,reported
R2376 T3521 T3526 mark that,developed
R2377 T3522 T3525 amod endogenous,mice
R2378 T3607 T3609 nmod [,]
R2379 T3523 T3525 compound IL-1Ra,mice
R2380 T3524 T3525 compound deficient,mice
R2381 T3525 T3526 nsubj mice,developed
R2382 T3608 T3609 nummod 23,]
R2383 T3526 T3520 ccomp developed,reported
R2384 T3527 T3528 amod aggressive,tumors
R2385 T3528 T3526 dobj tumors,developed
R2386 T3609 T3580 npadvmod ],reduces
R2387 T3529 T3526 prep following,developed
R2388 T3530 T3529 pobj exposure,following
R2389 T3531 T3530 prep to,exposure
R2390 T3610 T3577 punct .,reported
R2391 T3532 T3531 pobj carcinogens,to
R2392 T3533 T3535 nmod [,]
R2393 T3534 T3533 nummod 17,[
R2394 T3611 T3613 nummod IL-1,mice
R2395 T3535 T3532 appos ],carcinogens
R2396 T3536 T3520 punct .,reported
R2397 T3612 T3613 compound knockout,mice
R2398 T3537 T3551 advmod Meanwhile,reduced
R2399 T3538 T3551 punct ",",reduced
R2400 T3539 T3551 nsubjpass proliferation,reduced
R2401 T3613 T3617 nsubj mice,failed
R2402 T3540 T3539 prep of,proliferation
R2403 T3541 T3543 det the,cells
R2404 T3542 T3543 compound melanoma,cells
R2405 T3543 T3540 pobj cells,of
R2406 T3544 T3546 nsubjpass that,transduced
R2407 T3545 T3546 auxpass were,transduced
R2408 T3614 T3613 acl injected,mice
R2409 T3546 T3543 relcl transduced,cells
R2410 T3547 T3546 prep with,transduced
R2411 T3548 T3549 amod IL-1Ra,gene
R2412 T3615 T3614 prep with,injected
R2413 T3549 T3547 pobj gene,with
R2414 T3550 T3551 auxpass was,reduced
R2415 T3551 T3551 ROOT reduced,reduced
R2416 T3616 T3615 pobj melanoma,with
R2417 T3552 T3551 cc and,reduced
R2418 T3553 T3551 conj inhibited,reduced
R2419 T3554 T3555 compound melanoma,development
R2420 T3555 T3553 dobj development,inhibited
R2421 T3617 T3617 ROOT failed,failed
R2422 T3556 T3558 nmod [,]
R2423 T3557 T3558 nummod 18,]
R2424 T3558 T3555 appos ],development
R2425 T3618 T3619 aux to,develop
R2426 T3559 T3551 punct .,reduced
R2427 T3560 T3561 compound IL-1R,blockade
R2428 T3561 T3563 nsubj blockade,reduced
R2429 T3619 T3617 xcomp develop,failed
R2430 T3620 T3621 amod solid,tumors
R2431 T3562 T3563 advmod also,reduced
R2432 T3621 T3619 dobj tumors,develop
R2433 T3563 T3563 ROOT reduced,reduced
R2434 T3564 T3566 amod hepatic,growth
R2435 T3622 T3624 nsubj [,]
R2436 T3565 T3566 compound tumor,growth
R2437 T3566 T3563 dobj growth,reduced
R2438 T3567 T3569 nmod [,]
R2439 T3623 T3624 nummod 24,]
R2440 T3568 T3569 nummod 19,]
R2441 T3569 T3566 appos ],growth
R2442 T3624 T3617 dep ],failed
R2443 T3570 T3563 punct .,reduced
R2444 T3625 T3617 punct .,failed
R2445 T3571 T3577 advmod Moreover,reported
R2446 T3572 T3577 punct ",",reported
R2447 T3573 T3577 nsubj it,reported
R2448 T3626 T3629 nsubjpass It,found
R2449 T3574 T3577 aux has,reported
R2450 T3575 T3577 advmod also,reported
R2451 T3576 T3577 auxpass been,reported
R2452 T3627 T3629 auxpass was,found
R2453 T3577 T3577 ROOT reported,reported
R2454 T3578 T3580 mark that,reduces
R2455 T3579 T3580 nsubj IL-1Ra,reduces
R2456 T3580 T3577 ccomp reduces,reported
R2457 T3581 T3582 compound fibrosarcoma,development
R2458 T3582 T3580 dobj development,reduces
R2459 T3628 T3629 advmod also,found
R2460 T3583 T3585 nmod [,]
R2461 T3584 T3585 nummod 20,]
R2462 T3585 T3606 nmod ],development
R2463 T3629 T3629 ROOT found,found
R2464 T3586 T3585 punct ",",]
R2465 T3587 T3589 compound B16,growth
R2466 T3588 T3589 compound melanoma,growth
R2467 T3630 T3640 mark that,demonstrated
R2468 T3589 T3585 appos growth,]
R2469 T3590 T3589 cc and,growth
R2470 T3591 T3592 compound metastasis,[
R2471 T3631 T3640 nsubj IL-1Ra,demonstrated
R2472 T3592 T3585 conj [,]
R2473 T3593 T3594 nummod 21,]
R2474 T3594 T3594 ROOT ],]
R2475 T3632 T3631 punct ",",IL-1Ra
R2476 T3595 T3594 punct ",",]
R2477 T3596 T3597 compound colon,adenocarcinoma
R2478 T3597 T3598 compound adenocarcinoma,growth
R2479 T3633 T3631 acl combined,IL-1Ra
R2480 T3598 T3599 compound growth,[
R2481 T3599 T3592 conj [,[
R2482 T3600 T3601 nummod 22,]
R2483 T3634 T3633 prep with,combined
R2484 T3601 T3599 conj ],[
R2485 T3602 T3601 punct ",",]
R2486 T3635 T3634 pobj temozolomide,with
R2487 T3636 T3635 cc and,temozolomide
R2488 T3637 T3635 conj docetaxel,temozolomide
R2489 T3638 T3635 conj chemotherapy,temozolomide
R2490 T3639 T3640 punct ",",demonstrated
R2491 T3661 T3660 acomp important,is
R2492 T3640 T3629 ccomp demonstrated,found
R2493 T3662 T3661 prep as,important
R2494 T3663 T3665 det a,growth
R2495 T3664 T3665 compound tumor,growth
R2496 T3641 T3642 advmod more,significant
R2497 T3665 T3666 npadvmod growth,suppressing
R2498 T3666 T3662 pcomp suppressing,as
R2499 T3667 T3666 dobj cytokine,suppressing
R2500 T3642 T3644 amod significant,activity
R2501 T3668 T3657 punct .,indicate
R2502 T3669 T3670 amod NF-κB,plays
R2503 T3670 T3694 nsubjpass plays,associated
R2504 T3643 T3644 compound antitumor,activity
R2505 T3671 T3673 det a,role
R2506 T3672 T3673 amod crucial,role
R2507 T3673 T3670 dobj role,plays
R2508 T3674 T3673 prep in,role
R2509 T3675 T3676 det the,suppression
R2510 T3676 T3674 pobj suppression,in
R2511 T3677 T3676 prep of,suppression
R2512 T3644 T3640 dobj activity,demonstrated
R2513 T3678 T3677 pobj apoptosis,of
R2514 T3679 T3673 punct ",",role
R2515 T3680 T3682 advmod as,as
R2516 T3681 T3682 advmod well,as
R2517 T3645 T3644 prep against,activity
R2518 T3682 T3673 cc as,role
R2519 T3683 T3684 det the,induction
R2520 T3684 T3673 conj induction,role
R2521 T3646 T3648 compound B16,cells
R2522 T3685 T3684 prep of,induction
R2523 T3686 T3687 compound cell,proliferation
R2524 T3687 T3685 pobj proliferation,of
R2525 T3647 T3648 compound melanoma,cells
R2526 T3688 T3687 cc and,proliferation
R2527 T3689 T3687 conj inflammation,proliferation
R2528 T3690 T3670 punct ",",plays
R2529 T3648 T3645 pobj cells,against
R2530 T3691 T3670 cc and,plays
R2531 T3692 T3694 auxpass is,associated
R2532 T3693 T3694 advmod closely,associated
R2533 T3649 T3648 prep in,cells
R2534 T3694 T3694 ROOT associated,associated
R2535 T3695 T3694 prep with,associated
R2536 T3696 T3697 compound cancer,development
R2537 T3650 T3651 compound vivo,[
R2538 T3697 T3695 pobj development,with
R2539 T3698 T3700 nmod [,]
R2540 T3699 T3700 nummod 26,]
R2541 T3651 T3649 pobj [,in
R2542 T3652 T3653 nummod 25,]
R2543 T3700 T3694 npadvmod ],associated
R2544 T3653 T3651 appos ],[
R2545 T3701 T3694 punct .,associated
R2546 T3702 T3703 amod Constitutive,activation
R2547 T3654 T3629 punct .,found
R2548 T3703 T3708 nsubjpass activation,described
R2549 T3704 T3703 prep of,activation
R2550 T3705 T3704 pobj NF-κB,of
R2551 T3655 T3656 det These,data
R2552 T3706 T3708 aux has,described
R2553 T3707 T3708 auxpass been,described
R2554 T3708 T3708 ROOT described,described
R2555 T3709 T3708 prep in,described
R2556 T3710 T3712 det a,number
R2557 T3711 T3712 amod great,number
R2558 T3656 T3657 nsubj data,indicate
R2559 T3712 T3709 pobj number,in
R2560 T3713 T3712 prep of,number
R2561 T3714 T3713 pobj cancers,of
R2562 T3715 T3714 prep including,cancers
R2563 T3657 T3657 ROOT indicate,indicate
R2564 T3716 T3717 compound colon,cancers
R2565 T3717 T3715 pobj cancers,including
R2566 T3718 T3717 punct ",",cancers
R2567 T3658 T3660 mark that,is
R2568 T3719 T3720 compound prostate,cancers
R2569 T3720 T3717 conj cancers,cancers
R2570 T3721 T3720 cc and,cancers
R2571 T3659 T3660 nsubj IL-1Ra,is
R2572 T3722 T3720 conj melanoma,cancers
R2573 T3723 T3725 nmod [,]
R2574 T3724 T3725 nummod 27,]
R2575 T3660 T3657 ccomp is,indicate
R2576 T3725 T3717 appos ],cancers
R2577 T3726 T3725 punct ",",]
R2578 T3727 T3708 cc and,described
R2579 T3797 T3796 prep of,deficiency
R2580 T3798 T3799 amod various,cytokines
R2581 T3728 T3729 auxpass was,found
R2582 T3729 T3708 conj found,described
R2583 T3799 T3797 pobj cytokines,of
R2584 T3730 T3731 aux to,up-regulate
R2585 T3731 T3729 advcl up-regulate,found
R2586 T3732 T3733 compound anti-apoptotic,genes
R2587 T3800 T3799 cc and,cytokines
R2588 T3733 T3731 dobj genes,up-regulate
R2589 T3734 T3731 cc and/or,up-regulate
R2590 T3735 T3736 advmod down,regulate
R2591 T3801 T3802 compound growth,factors
R2592 T3736 T3731 conj regulate,up-regulate
R2593 T3737 T3739 amod apoptotic,expression
R2594 T3802 T3799 conj factors,cytokines
R2595 T3738 T3739 compound gene,expression
R2596 T3739 T3736 dobj expression,regulate
R2597 T3740 T3742 nmod [,]
R2598 T3803 T3799 prep in,cytokines
R2599 T3741 T3742 nummod 28,]
R2600 T3742 T3739 appos ],expression
R2601 T3804 T3805 compound T,cells
R2602 T3743 T3708 punct .,described
R2603 T3744 T3746 mark Although,promotes
R2604 T3745 T3746 nsubj NF-κB,promotes
R2605 T3746 T3752 advcl promotes,required
R2606 T3747 T3748 compound tumor,growth
R2607 T3748 T3746 dobj growth,promotes
R2608 T3749 T3752 punct ",",required
R2609 T3805 T3803 pobj cells,in
R2610 T3750 T3752 nsubjpass it,required
R2611 T3751 T3752 auxpass is,required
R2612 T3752 T3752 ROOT required,required
R2613 T3753 T3752 prep for,required
R2614 T3806 T3805 cc and,cells
R2615 T3754 T3756 det the,system
R2616 T3755 T3756 amod immune,system
R2617 T3756 T3753 pobj system,for
R2618 T3807 T3805 conj macrophages,cells
R2619 T3757 T3758 aux to,function
R2620 T3758 T3752 advcl function,required
R2621 T3759 T3760 advmod normally,[
R2622 T3760 T3762 amod [,]
R2623 T3808 T3796 acl affecting,deficiency
R2624 T3761 T3762 nummod 29,]
R2625 T3762 T3758 dobj ],function
R2626 T3763 T3752 punct .,required
R2627 T3809 T3810 preconj both,innate
R2628 T3764 T3768 nsubj Studies,demonstrated
R2629 T3765 T3764 prep on,Studies
R2630 T3766 T3767 amod c-Rel-deficient,mice
R2631 T3767 T3765 pobj mice,on
R2632 T3810 T3814 amod innate,responses
R2633 T3768 T3768 ROOT demonstrated,demonstrated
R2634 T3769 T3771 mark that,is
R2635 T3770 T3771 nsubj c-Rel,is
R2636 T3811 T3810 cc and,innate
R2637 T3771 T3768 ccomp is,demonstrated
R2638 T3772 T3771 acomp essential,is
R2639 T3773 T3771 prep for,is
R2640 T3812 T3814 amod humoral,responses
R2641 T3774 T3773 pobj IL-2,for
R2642 T3775 T3774 punct ",",IL-2
R2643 T3776 T3774 conj IL-3,IL-2
R2644 T3777 T3776 punct ",",IL-3
R2645 T3813 T3814 amod immune,responses
R2646 T3778 T3776 conj GM-CSF,IL-3
R2647 T3779 T3778 punct ",",GM-CSF
R2648 T3780 T3778 cc and,GM-CSF
R2649 T3814 T3808 dobj responses,affecting
R2650 T3781 T3782 compound IFNγ,expression
R2651 T3782 T3771 attr expression,is
R2652 T3783 T3782 prep in,expression
R2653 T3815 T3814 prep in,responses
R2654 T3784 T3785 compound T,lymphocytes
R2655 T3785 T3783 pobj lymphocytes,in
R2656 T3786 T3788 nmod [,]
R2657 T3787 T3788 nummod 30,]
R2658 T3788 T3785 appos ],lymphocytes
R2659 T3789 T3768 punct .,demonstrated
R2660 T3816 T3817 det the,host
R2661 T3790 T3791 amod C-Rel-deficient,mice
R2662 T3791 T3793 nsubj mice,have
R2663 T3792 T3793 advmod also,have
R2664 T3817 T3815 pobj host,in
R2665 T3793 T3793 ROOT have,have
R2666 T3794 T3796 det a,deficiency
R2667 T3795 T3796 amod tissue-specific,deficiency
R2668 T3818 T3817 appos [,host
R2669 T3819 T3820 nummod 31,]
R2670 T3796 T3793 dobj deficiency,have
R2671 T3820 T3817 appos ],host
R2672 T3821 T3793 punct .,have
R2673 T3822 T3828 advmod Therefore,targeted
R2674 T3823 T3828 punct ",",targeted
R2675 T3824 T3828 nsubjpass NF-κB,targeted
R2676 T3853 T3852 cc or,infiltration
R2677 T3854 T3855 punct (,3
R2678 T3825 T3828 aux can,targeted
R2679 T3855 T3857 meta 3,increasing
R2680 T3856 T3855 punct ),3
R2681 T3826 T3828 auxpass be,targeted
R2682 T3857 T3848 conj increasing,stimulating
R2683 T3858 T3859 det the,production
R2684 T3859 T3857 dobj production,increasing
R2685 T3827 T3828 advmod specially,targeted
R2686 T3860 T3859 prep of,production
R2687 T3861 T3862 nsubj tumor,killing
R2688 T3862 T3860 pcomp killing,of
R2689 T3828 T3828 ROOT targeted,targeted
R2690 T3863 T3862 dobj lymphokines,killing
R2691 T3864 T3828 punct .,targeted
R2692 T3865 T3868 nsubj Activation,is
R2693 T3866 T3865 prep of,Activation
R2694 T3829 T3830 aux to,prevent
R2695 T3867 T3866 pobj NF-κB,of
R2696 T3868 T3868 ROOT is,is
R2697 T3830 T3828 xcomp prevent,targeted
R2698 T3869 T3868 acomp important,is
R2699 T3870 T3868 prep in,is
R2700 T3871 T3872 det the,regulation
R2701 T3872 T3870 pobj regulation,in
R2702 T3831 T3832 compound cancer,cell
R2703 T3873 T3872 prep of,regulation
R2704 T3874 T3876 amod CCR-mediated,growth
R2705 T3832 T3833 compound cell,growth
R2706 T3875 T3876 compound tumor,growth
R2707 T3876 T3873 pobj growth,of
R2708 T3877 T3876 cc and,growth
R2709 T3878 T3876 conj metastasis,growth
R2710 T3879 T3868 punct .,is
R2711 T3880 T3882 nsubjpass It,reported
R2712 T3833 T3830 dobj growth,prevent
R2713 T3881 T3882 auxpass was,reported
R2714 T3882 T3882 ROOT reported,reported
R2715 T3883 T3892 mark that,induces
R2716 T3834 T3830 prep by,prevent
R2717 T3884 T3892 nsubj inhibition,induces
R2718 T3885 T3884 prep of,inhibition
R2719 T3886 T3885 pobj NF-κB,of
R2720 T3835 T3836 punct (,1
R2721 T3836 T3834 pobj 1,by
R2722 T3887 T3884 prep by,inhibition
R2723 T3837 T3836 punct ),1
R2724 T3838 T3839 advmod directly,affecting
R2725 T3888 T3887 pobj dehydroxymethyl-epoxyquinomicin,by
R2726 T3889 T3890 punct (,DHMEQ
R2727 T3890 T3888 appos DHMEQ,dehydroxymethyl-epoxyquinomicin
R2728 T3839 T3830 advcl affecting,prevent
R2729 T3891 T3884 punct ),inhibition
R2730 T3892 T3882 ccomp induces,reported
R2731 T3893 T3894 compound cell,death
R2732 T3840 T3843 amod apoptotic,death
R2733 T3894 T3892 dobj death,induces
R2734 T3895 T3894 prep of,death
R2735 T3841 T3842 compound cancer,cell
R2736 T3896 T3897 amod primary,effusion
R2737 T3897 T3898 compound effusion,lymphoma
R2738 T3898 T3895 pobj lymphoma,of
R2739 T3899 T3892 prep by,induces
R2740 T3842 T3843 compound cell,death
R2741 T3900 T3899 pobj inhibition,by
R2742 T3901 T3900 prep of,inhibition
R2743 T3902 T3906 nummod CCR5,]
R2744 T3843 T3839 dobj death,affecting
R2745 T3903 T3904 compound expression,[
R2746 T3844 T3828 punct ",",targeted
R2747 T3845 T3846 punct (,2
R2748 T3846 T3848 meta 2,stimulating
R2749 T3904 T3904 ROOT [,[
R2750 T3905 T3906 nummod 32,]
R2751 T3906 T3901 pobj ],of
R2752 T3847 T3846 punct ),2
R2753 T3907 T3882 punct .,reported
R2754 T3908 T3912 nsubj Activation,increases
R2755 T3909 T3908 prep of,Activation
R2756 T3848 T3828 advcl stimulating,targeted
R2757 T3910 T3909 pobj NF-κB,of
R2758 T3911 T3912 advmod also,increases
R2759 T3912 T3912 ROOT increases,increases
R2760 T3913 T3916 amod CCL5-mediated,motility
R2761 T3914 T3916 amod oral,motility
R2762 T3915 T3916 compound cancer,motility
R2763 T3916 T3912 dobj motility,increases
R2764 T3849 T3850 npadvmod tumor,killing
R2765 T3917 T3916 punct (,motility
R2766 T3918 T3916 appos 5,motility
R2767 T3919 T3916 punct ),motility
R2768 T3850 T3852 amod killing,infiltration
R2769 T3920 T3916 cc and,motility
R2770 T3921 T3922 compound lung,metastasis
R2771 T3922 T3923 compound metastasis,[
R2772 T3851 T3852 compound lymphocytes,infiltration
R2773 T3923 T3912 npadvmod [,increases
R2774 T3924 T3925 nummod 33,]
R2775 T3925 T3923 appos ],[
R2776 T3852 T3848 dobj infiltration,stimulating
R2777 T3926 T3912 punct .,increases
R2778 T3927 T3930 advmod Thus,is
R2779 T3959 T3956 pobj genes,of
R2780 T3928 T3930 punct ",",is
R2781 T3929 T3930 nsubj it,is
R2782 T3930 T3930 ROOT is,is
R2783 T3931 T3930 acomp possible,is
R2784 T3960 T3959 punct ",",genes
R2785 T3932 T3938 mark that,involved
R2786 T3933 T3938 nsubjpass inhibition,involved
R2787 T3934 T3933 prep of,inhibition
R2788 T3961 T3962 amod such,as
R2789 T3935 T3934 pobj NF-κB,of
R2790 T3936 T3938 aux could,involved
R2791 T3937 T3938 auxpass be,involved
R2792 T3962 T3959 prep as,genes
R2793 T3938 T3930 ccomp involved,is
R2794 T3939 T3938 prep in,involved
R2795 T3940 T3939 pobj CCR5,in
R2796 T3963 T3962 pobj IL-1alpha,as
R2797 T3941 T3930 advcl mediated,is
R2798 T3942 T3943 compound tumor,development
R2799 T3943 T3941 dobj development,mediated
R2800 T3964 T3963 punct ",",IL-1alpha
R2801 T3944 T3930 punct .,is
R2802 T3945 T3947 amod NF-κB,factor
R2803 T3946 T3947 compound transcription,factor
R2804 T3965 T3963 conj IL-6,IL-1alpha
R2805 T3947 T3947 ROOT factor,factor
R2806 T3948 T3949 amod binding,sites
R2807 T3949 T3950 nsubj sites,are
R2808 T3950 T3947 acl are,factor
R2809 T3951 T3950 acomp present,are
R2810 T3966 T3965 punct ",",IL-6
R2811 T3967 T3965 conj GM-CSF,IL-6
R2812 T3952 T3951 prep in,present
R2813 T3953 T3955 det the,region
R2814 T3954 T3955 compound promoter,region
R2815 T3968 T3967 punct ",",GM-CSF
R2816 T3955 T3952 pobj region,in
R2817 T3956 T3955 prep of,region
R2818 T3957 T3959 amod proinflammatory,genes
R2819 T3969 T3967 cc and,GM-CSF
R2820 T3958 T3959 compound cytokine,genes
R2821 T3970 T3971 compound KC,[
R2822 T3971 T3967 conj [,GM-CSF
R2823 T3972 T3973 nummod 34,]
R2824 T3973 T3971 appos ],[
R2825 T3974 T3947 punct .,factor
R2826 T4006 T3994 punct .,demonstrated
R2827 T4007 T4009 compound Smith,al.
R2828 T3975 T3982 prep On,is
R2829 T4008 T4009 compound et,al.
R2830 T4009 T4010 nsubj al.,suggested
R2831 T4010 T4010 ROOT suggested,suggested
R2832 T3976 T3978 det the,hand
R2833 T4011 T4018 mark that,is
R2834 T4012 T4013 det the,regulation
R2835 T3977 T3978 amod other,hand
R2836 T4013 T4018 nsubj regulation,is
R2837 T4014 T4013 prep of,regulation
R2838 T4015 T4017 amod IL-1Ra,expression
R2839 T3978 T3975 pobj hand,On
R2840 T4016 T4017 compound gene,expression
R2841 T4017 T4014 pobj expression,of
R2842 T4018 T4010 ccomp is,suggested
R2843 T3979 T3982 punct ",",is
R2844 T4019 T4021 det a,event
R2845 T4020 T4021 amod complex,event
R2846 T4021 T4018 attr event,is
R2847 T3980 T3981 det the,IL-1Ra
R2848 T4022 T4021 acl involving,event
R2849 T4023 T4024 det the,interactions
R2850 T4024 T4022 dobj interactions,involving
R2851 T3981 T3982 nsubj IL-1Ra,is
R2852 T4025 T4024 prep of,interactions
R2853 T4026 T4029 nummod three,factors
R2854 T3982 T3982 ROOT is,is
R2855 T4027 T4029 amod different,factors
R2856 T4028 T4029 compound transcription,factors
R2857 T4029 T4025 pobj factors,of
R2858 T4030 T4024 punct ;,interactions
R2859 T3983 T3985 det a,regulator
R2860 T4031 T4033 compound NF-κB,PU
R2861 T3984 T3985 amod negative,regulator
R2862 T4032 T4033 compound /,PU
R2863 T4033 T4035 neg PU,/
R2864 T4034 T4035 compound .1,/
R2865 T3985 T3982 attr regulator,is
R2866 T4035 T4021 appos /,event
R2867 T4036 T4039 amod GA-binding,site
R2868 T4037 T4039 nmod protein,site
R2869 T3986 T3985 prep of,regulator
R2870 T4038 T4039 amod binding,site
R2871 T4039 T4021 appos site,event
R2872 T4040 T4042 nmod [,]
R2873 T3987 T3989 det the,response
R2874 T4041 T4042 nummod 35,]
R2875 T3988 T3989 amod inflammatory,response
R2876 T3989 T3986 pobj response,of
R2877 T4042 T4039 appos ],site
R2878 T4043 T4010 punct .,suggested
R2879 T3990 T3982 punct .,is
R2880 T4044 T4045 compound Nuclear,translocation
R2881 T4045 T4053 nsubjpass translocation,enhanced
R2882 T4046 T4045 prep of,translocation
R2883 T3991 T3992 amod Several,studies
R2884 T4047 T4046 pobj NF-κB,of
R2885 T4048 T4049 punct (,p65
R2886 T3992 T3994 nsubj studies,demonstrated
R2887 T4049 T4047 appos p65,NF-κB
R2888 T4050 T4049 punct ),p65
R2889 T4051 T4053 auxpass was,enhanced
R2890 T3993 T3994 aux have,demonstrated
R2891 T4052 T4053 advmod significantly,enhanced
R2892 T4053 T4053 ROOT enhanced,enhanced
R2893 T4054 T4053 cc and,enhanced
R2894 T3994 T3994 ROOT demonstrated,demonstrated
R2895 T4055 T4053 conj prolonged,enhanced
R2896 T4056 T4055 prep in,prolonged
R2897 T4057 T4058 amod IL-1Ra-deficient,mice
R2898 T4058 T4056 pobj mice,in
R2899 T3995 T3996 det the,ability
R2900 T4059 T4055 punct ",",prolonged
R2901 T4060 T4053 prep compared,enhanced
R2902 T3996 T3994 dobj ability,demonstrated
R2903 T4061 T4060 prep to,compared
R2904 T3997 T3996 prep of,ability
R2905 T4062 T4061 pobj that,to
R2906 T3998 T3997 pobj IL-1Ra,of
R2907 T4063 T4062 prep in,that
R2908 T4064 T4066 amod wild,mice
R2909 T4065 T4066 compound type,mice
R2910 T4066 T4063 pobj mice,in
R2911 T4067 T4069 nmod [,]
R2912 T3999 T4000 aux to,abrogate
R2913 T4068 T4069 nummod 36,]
R2914 T4069 T4066 appos ],mice
R2915 T4070 T4053 punct .,enhanced
R2916 T4000 T3996 acl abrogate,ability
R2917 T4071 T4072 amod Intracellular,IL-1Ra
R2918 T4072 T4077 nsubjpass IL-1Ra,found
R2919 T4073 T4074 punct (,icIL-1Ra
R2920 T4074 T4072 appos icIL-1Ra,IL-1Ra
R2921 T4001 T4003 det the,effects
R2922 T4075 T4074 punct ),icIL-1Ra
R2923 T4076 T4077 auxpass was,found
R2924 T4077 T4077 ROOT found,found
R2925 T4002 T4003 amod proinflammatory,effects
R2926 T4078 T4079 aux to,inhibit
R2927 T4079 T4077 advcl inhibit,found
R2928 T4080 T4079 dobj IL-1,inhibit
R2929 T4003 T4000 dobj effects,abrogate
R2930 T4081 T4079 prep by,inhibit
R2931 T4082 T4081 pcomp blocking,by
R2932 T4083 T4086 amod NF-κB,pathways
R2933 T4004 T4003 prep of,effects
R2934 T4084 T4086 nmod signal,pathways
R2935 T4085 T4086 compound transduction,pathways
R2936 T4086 T4082 dobj pathways,blocking
R2937 T4005 T4004 pobj IL-1,of
R2938 T4103 T4102 prep of,inducer
R2939 T4087 T4086 prep in,pathways
R2940 T4088 T4089 amod inflammatory,responses
R2941 T4089 T4087 pobj responses,in
R2942 T4090 T4092 nmod [,]
R2943 T4104 T4105 amod NF-κB,activation
R2944 T4091 T4092 nummod 37,]
R2945 T4092 T4086 conj ],pathways
R2946 T4093 T4077 punct .,found
R2947 T4105 T4103 pobj activation,of
R2948 T4094 T4098 mark Because,shown
R2949 T4095 T4098 nsubjpass IL-1,shown
R2950 T4096 T4098 aux has,shown
R2951 T4097 T4098 auxpass been,shown
R2952 T4106 T4108 nmod [,]
R2953 T4098 T4111 advcl shown,hypothesized
R2954 T4099 T4100 aux to,be
R2955 T4100 T4098 xcomp be,shown
R2956 T4107 T4108 nummod 38,]
R2957 T4101 T4102 det an,inducer
R2958 T4102 T4100 attr inducer,be
R2959 T4108 T4102 appos ],inducer
R2960 T4109 T4111 punct ",",hypothesized
R2961 T4110 T4111 nsubj we,hypothesized
R2962 T4111 T4111 ROOT hypothesized,hypothesized
R2963 T4112 T4118 mark that,play
R2964 T4113 T4114 det the,expression
R2965 T4114 T4118 nsubj expression,play
R2966 T4115 T4114 prep of,expression
R2969 T4116 T4115 pobj IL-1Ra,of
R2973 T4117 T4118 aux could,play
R2976 T4118 T4111 ccomp play,hypothesized
R2977 T4119 T4121 det an,role
R2978 T4120 T4121 amod important,role
R2979 T4121 T4118 dobj role,play
R2980 T4122 T4118 prep in,play
R2981 T4123 T4125 det the,activation
R2984 T4124 T4125 compound autocrine,activation
R2985 T4125 T4122 pobj activation,in
R2997 T4126 T4125 prep of,activation
R3001 T4127 T4128 compound transcription,factors
R3002 T4128 T4126 pobj factors,of
R3003 T4129 T4118 conj NF-κB,play
R3004 T4130 T4129 cc or,NF-κB
R3005 T4131 T4132 advmod vice,versa
R3006 T4132 T4129 conj versa,NF-κB
R3009 T4133 T4111 punct .,hypothesized
R3012 T4134 T4141 advmod Thus,was
R3013 T4135 T4141 punct ",",was
R3014 T4136 T4137 det the,aim
R3015 T4137 T4141 nsubj aim,was
R3017 T4138 T4137 prep of,aim
R3021 T4139 T4140 det this,study
R3024 T4140 T4138 pobj study,of
R3026 T4141 T4141 ROOT was,was
R3027 T4142 T4143 aux to,evaluate
R3028 T4143 T4141 xcomp evaluate,was
R3029 T4144 T4145 det the,roles
R3030 T4145 T4143 dobj roles,evaluate
R3031 T4146 T4145 prep of,roles
R3032 T4147 T4146 pobj NF-κB,of
R3034 T4148 T4147 cc and,NF-κB
R3035 T4149 T4147 conj IL-1Ra,NF-κB
R3037 T4150 T4145 prep in,roles
R3039 T4151 T4155 det the,suppression
R3040 T4152 T4155 nmod chemokine,suppression
R3042 T4153 T4155 nmod receptor,suppression
R3043 T4154 T4155 amod CCR5-mediated,suppression
R3046 T4155 T4150 pobj suppression,in
R3047 T4156 T4155 prep of,suppression
R3048 T4157 T4158 compound tumor,development
R3049 T4158 T4156 pobj development,of
R3050 T4159 T4141 punct .,was

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T3064 5463-5469 Protein denotes IL-1Ra
T3063 5453-5458 Protein denotes NF-κB
T3062 5213-5220 Positive_regulation denotes inducer
T3061 5339-5349 Positive_regulation denotes activation
T3060 5272-5282 Gene_expression denotes expression
T3059 5230-5240 Positive_regulation denotes activation
T3058 5353-5380 Protein denotes transcription factors NF-κB
T3057 5286-5292 Protein denotes IL-1Ra
T3056 5224-5229 Protein denotes NF-κB
T3055 5184-5188 Protein denotes IL-1
T3054 5084-5091 Negative_regulation denotes inhibit
T3053 5084-5091 Negative_regulation denotes inhibit
T3052 5084-5091 Negative_regulation denotes inhibit
T3051 5100-5108 Negative_regulation denotes blocking
T3050 5109-5114 Protein denotes NF-κB
T3049 5092-5096 Protein denotes IL-1
T3048 5061-5069 Protein denotes icIL-1Ra
T3047 5053-5059 Protein denotes IL-1Ra
T3046 4982-4991 Negative_regulation denotes deficient
T3045 4949-4957 Positive_regulation denotes enhanced
T3044 4949-4957 Positive_regulation denotes enhanced
T3043 4902-4915 Localization denotes translocation
T3042 4902-4915 Localization denotes translocation
T3041 4894-4901 Entity denotes Nuclear
T3040 4975-4981 Protein denotes IL-1Ra
T3039 4926-4929 Protein denotes p65
T3038 4919-4924 Protein denotes NF-κB
T3037 4720-4730 Regulation denotes regulation
T3036 4746-4756 Gene_expression denotes expression
T3035 4851-4853 Protein denotes PU
T3034 4845-4850 Protein denotes NF-κB
T3033 4734-4745 Protein denotes IL-1Ra gene
T3032 4642-4650 Negative_regulation denotes abrogate
T3031 4682-4686 Protein denotes IL-1
T3030 4632-4638 Protein denotes IL-1Ra
T3029 4522-4528 Protein denotes IL-1Ra
T3028 4478-4484 Protein denotes GM-CSF
T3027 4472-4476 Protein denotes IL-6
T3026 4461-4470 Protein denotes IL-1alpha
T3025 4342-4368 Protein denotes NF-κB transcription factor
T3024 4268-4278 Negative_regulation denotes inhibition
T3023 4309-4313 Protein denotes CCR5
T3022 4282-4287 Protein denotes NF-κB
T3021 4142-4152 Positive_regulation denotes Activation
T3020 4177-4181 Protein denotes CCL5
T3019 4156-4161 Protein denotes NF-κB
T3018 4106-4116 Negative_regulation denotes inhibition
T3017 4125-4135 Gene_expression denotes expression
T3016 3992-4002 Binding denotes inhibition
T3015 4120-4124 Protein denotes CCR5
T3014 4006-4011 Protein denotes NF-κB
T3013 3875-3885 Positive_regulation denotes Activation
T3012 3889-3894 Protein denotes NF-κB
T3011 3640-3645 Protein denotes NF-κB
T3010 3356-3365 Positive_regulation denotes essential
T3009 3356-3365 Positive_regulation denotes essential
T3008 3356-3365 Positive_regulation denotes essential
T3007 3399-3409 Gene_expression denotes expression
T3006 3399-3409 Gene_expression denotes expression
T3005 3399-3409 Gene_expression denotes expression
T3004 3394-3398 Protein denotes IFNγ
T3003 3382-3388 Protein denotes GM-CSF
T3002 3370-3380 Protein denotes IL-2, IL-3
T3001 3204-3209 Protein denotes NF-κB
T3000 2963-2973 Positive_regulation denotes activation
T2999 2977-2982 Protein denotes NF-κB
T2998 2769-2774 Protein denotes NF-κB
T2997 2709-2715 Protein denotes IL-1Ra
T2996 2531-2537 Protein denotes IL-1Ra
T2995 2274-2280 Protein denotes IL-1Ra
T2994 2184-2192 Negative_regulation denotes blockade
T2993 2178-2183 Protein denotes IL-1R
T2992 2113-2124 Protein denotes IL-1Ra gene
T2991 1852-1859 Negative_regulation denotes reduced
T2990 1837-1847 Gene_expression denotes expression
T2989 1830-1836 Protein denotes IL-1Ra
T2988 1795-1801 Protein denotes IL-1Ra
T2987 1611-1617 Protein denotes IL-1Ra
T2986 1572-1578 Negative_regulation denotes blocks
T2985 1572-1578 Negative_regulation denotes blocks
T2984 1583-1596 Protein denotes IL-1 receptor
T2983 1506-1517 Protein denotes IL-1 family
T2982 1481-1487 Protein denotes IL-1Ra
T2981 1446-1479 Protein denotes Interleukin-1 receptor antagonist
T2980 1390-1400 Negative_regulation denotes deficiency
T2979 1385-1389 Protein denotes CCR5
T2978 1221-1231 Negative_regulation denotes deficiency
T2977 1267-1271 Protein denotes CCR5
T2976 1065-1075 Negative_regulation denotes inhibitors
T2975 996-1003 Negative_regulation denotes absence
T2974 1060-1064 Protein denotes CCR5
T2973 1007-1011 Protein denotes CCR5
T2972 862-866 Protein denotes CCR5
T2971 724-734 Gene_expression denotes production
T2970 742-746 Protein denotes CCL5
T2969 511-521 Gene_expression denotes expression
T2968 506-510 Protein denotes CCR5
T2967 328-332 Protein denotes CCR5
T2966 304-326 Protein denotes C-C chemokine receptor
R1897 T2968 T2969 themeOf CCR5,expression
R1898 T2970 T2971 themeOf CCL5,production
R1900 T2973 T2975 themeOf CCR5,absence
R1903 T2974 T2976 themeOf CCR5,inhibitors
R1905 T2977 T2978 themeOf CCR5,deficiency
R1906 T2979 T2980 themeOf CCR5,deficiency
R1909 T2981 T2985 themeOf Interleukin-1 receptor antagonist,blocks
R1910 T2982 T2985 causeOf IL-1Ra,blocks
R1911 T2982 T2986 causeOf IL-1Ra,blocks
R1912 T2984 T2986 themeOf IL-1 receptor,blocks
R1916 T2989 T2990 themeOf IL-1Ra,expression
R1918 T2990 T2991 themeOf expression,reduced
R1920 T2993 T2994 themeOf IL-1R,blockade
R1921 T2999 T3000 themeOf NF-κB,activation
R1922 T3002 T3005 themeOf "IL-2, IL-3",expression
R1924 T3003 T3006 themeOf GM-CSF,expression
R1925 T3004 T3007 themeOf IFNγ,expression
R1926 T3005 T3008 themeOf expression,essential
R1927 T3006 T3009 themeOf expression,essential
R1928 T3007 T3010 themeOf expression,essential
R1931 T3012 T3013 themeOf NF-κB,Activation
R1932 T3014 T3016 themeOf NF-κB,inhibition
R1933 T3015 T3017 themeOf CCR5,expression
R1935 T3016 T3018 causeOf inhibition,inhibition
R1936 T3017 T3018 themeOf expression,inhibition
R1937 T3019 T3021 themeOf NF-κB,Activation
R1938 T3022 T3024 themeOf NF-κB,inhibition
R1940 T3030 T3032 causeOf IL-1Ra,abrogate
R1941 T3031 T3032 themeOf IL-1,abrogate
R1942 T3033 T3036 themeOf IL-1Ra gene,expression
R1945 T3036 T3037 themeOf expression,regulation
R1946 T3038 T3042 themeOf NF-κB,translocation
R1948 T3039 T3043 themeOf p65,translocation
R1949 T3040 T3046 themeOf IL-1Ra,deficient
R1950 T3041 T3042 locationOf Nuclear,translocation
R1951 T3041 T3043 locationOf Nuclear,translocation
R1952 T3042 T3044 themeOf translocation,enhanced
R1953 T3043 T3045 themeOf translocation,enhanced
R1954 T3047 T3052 themeOf IL-1Ra,inhibit
R1955 T3048 T3053 themeOf icIL-1Ra,inhibit
R1957 T3049 T3054 themeOf IL-1,inhibit
R1958 T3050 T3051 themeOf NF-κB,blocking
R1959 T3051 T3052 causeOf blocking,inhibit
R1960 T3051 T3053 causeOf blocking,inhibit
R1961 T3051 T3054 causeOf blocking,inhibit
R1962 T3055 T3062 causeOf IL-1,inducer
R1963 T3056 T3059 themeOf NF-κB,activation
R1965 T3057 T3060 themeOf IL-1Ra,expression
R1966 T3058 T3061 themeOf transcription factors NF-κB,activation
R1967 T3059 T3062 themeOf activation,inducer