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physiological relevance of Tat cross talk with NF-κB was demonstrated in the HIV-1 infection of human monocytes, where HIV-1-encoded Tat protein counteracted post-activation turn off of NF-κB, as shown by: (i) sustained NF-κB activity by Tat in presence of newly synthesized IκB-α; (ii) coimmunoprecipitation of Tat with IκB-α and p65; (iii) induction of MIP-1α expression dependent on Tat and p65; (iv) Tat occupancy of the MIP-1α NF-κB enhancer associated with increased recruitment of p65."}

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    bionlp-st-ge-2016-reference-tees

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    bionlp-st-ge-2016-reference

    {"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T19818","span":{"begin":31,"end":34},"obj":"Protein"},{"id":"T19819","span":{"begin":35,"end":45},"obj":"Regulation"},{"id":"T19820","span":{"begin":137,"end":140},"obj":"Protein"},{"id":"T19821","span":{"begin":242,"end":245},"obj":"Protein"},{"id":"T19822","span":{"begin":279,"end":284},"obj":"Protein"},{"id":"T19823","span":{"begin":291,"end":312},"obj":"Binding"},{"id":"T19824","span":{"begin":316,"end":319},"obj":"Protein"},{"id":"T19825","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T19826","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T19827","span":{"begin":346,"end":355},"obj":"Positive_regulation"},{"id":"T19828","span":{"begin":359,"end":365},"obj":"Protein"},{"id":"T19829","span":{"begin":366,"end":376},"obj":"Gene_expression"},{"id":"T19830","span":{"begin":377,"end":386},"obj":"Positive_regulation"},{"id":"T19831","span":{"begin":377,"end":386},"obj":"Positive_regulation"},{"id":"T19832","span":{"begin":390,"end":393},"obj":"Protein"},{"id":"T19833","span":{"begin":398,"end":401},"obj":"Protein"},{"id":"T19834","span":{"begin":408,"end":411},"obj":"Protein"},{"id":"T19835","span":{"begin":412,"end":421},"obj":"Binding"},{"id":"T19836","span":{"begin":429,"end":435},"obj":"Protein"},{"id":"T19837","span":{"begin":436,"end":450},"obj":"Entity"},{"id":"T19838","span":{"begin":467,"end":476},"obj":"Positive_regulation"},{"id":"T19839","span":{"begin":477,"end":488},"obj":"Binding"},{"id":"T19840","span":{"begin":492,"end":495},"obj":"Protein"}],"relations":[{"id":"R15814","pred":"themeOf","subj":"T19818","obj":"T19819"},{"id":"R15815","pred":"causeOf","subj":"T19818","obj":"T19819"},{"id":"R15816","pred":"themeOf","subj":"T19824","obj":"T19823"},{"id":"R15817","pred":"themeOf","subj":"T19825","obj":"T19823"},{"id":"R15818","pred":"themeOf","subj":"T19827","obj":"T19830"},{"id":"R15819","pred":"themeOf","subj":"T19827","obj":"T19831"},{"id":"R15820","pred":"themeOf","subj":"T19828","obj":"T19829"},{"id":"R15821","pred":"themeOf","subj":"T19829","obj":"T19827"},{"id":"R15822","pred":"causeOf","subj":"T19832","obj":"T19830"},{"id":"R15823","pred":"causeOf","subj":"T19833","obj":"T19831"},{"id":"R15824","pred":"themeOf","subj":"T19834","obj":"T19835"},{"id":"R15825","pred":"themeOf","subj":"T19837","obj":"T19835"},{"id":"R15826","pred":"partOf","subj":"T19837","obj":"T19836"},{"id":"R15827","pred":"themeOf","subj":"T19837","obj":"T19839"},{"id":"R15828","pred":"themeOf","subj":"T19839","obj":"T19838"},{"id":"R15829","pred":"themeOf","subj":"T19840","obj":"T19839"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The physiological relevance of Tat cross talk with NF-κB was demonstrated in the HIV-1 infection of human monocytes, where HIV-1-encoded Tat protein counteracted post-activation turn off of NF-κB, as shown by: (i) sustained NF-κB activity by Tat in presence of newly synthesized IκB-α; (ii) coimmunoprecipitation of Tat with IκB-α and p65; (iii) induction of MIP-1α expression dependent on Tat and p65; (iv) Tat occupancy of the MIP-1α NF-κB enhancer associated with increased recruitment of p65."}

    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T21132","span":{"begin":31,"end":34},"obj":"P04608"},{"id":"T21133","span":{"begin":31,"end":34},"obj":"P04610"},{"id":"T21134","span":{"begin":31,"end":34},"obj":"P04605"},{"id":"T21135","span":{"begin":31,"end":34},"obj":"Q8UMQ1"},{"id":"T21136","span":{"begin":137,"end":140},"obj":"P04605"},{"id":"T21137","span":{"begin":137,"end":140},"obj":"Q8UMQ1"},{"id":"T21138","span":{"begin":137,"end":140},"obj":"P04610"},{"id":"T21139","span":{"begin":137,"end":140},"obj":"P04608"},{"id":"T21140","span":{"begin":242,"end":245},"obj":"Q8UMQ1"},{"id":"T21141","span":{"begin":242,"end":245},"obj":"P04610"},{"id":"T21142","span":{"begin":242,"end":245},"obj":"P04608"},{"id":"T21143","span":{"begin":242,"end":245},"obj":"P04605"},{"id":"T21144","span":{"begin":316,"end":319},"obj":"P04605"},{"id":"T21145","span":{"begin":316,"end":319},"obj":"P04608"},{"id":"T21146","span":{"begin":316,"end":319},"obj":"Q8UMQ1"},{"id":"T21147","span":{"begin":316,"end":319},"obj":"P04610"},{"id":"T21148","span":{"begin":335,"end":338},"obj":"P21579"},{"id":"T21149","span":{"begin":335,"end":338},"obj":"Q04206"},{"id":"T21150","span":{"begin":359,"end":365},"obj":"P10147"},{"id":"T21151","span":{"begin":390,"end":393},"obj":"P04608"},{"id":"T21152","span":{"begin":390,"end":393},"obj":"P04610"},{"id":"T21153","span":{"begin":390,"end":393},"obj":"Q8UMQ1"},{"id":"T21154","span":{"begin":390,"end":393},"obj":"P04605"},{"id":"T21155","span":{"begin":398,"end":401},"obj":"P21579"},{"id":"T21156","span":{"begin":398,"end":401},"obj":"Q04206"},{"id":"T21157","span":{"begin":408,"end":411},"obj":"P04610"},{"id":"T21158","span":{"begin":408,"end":411},"obj":"Q8UMQ1"},{"id":"T21159","span":{"begin":408,"end":411},"obj":"P04608"},{"id":"T21160","span":{"begin":408,"end":411},"obj":"P04605"},{"id":"T21161","span":{"begin":429,"end":435},"obj":"P10147"},{"id":"T21162","span":{"begin":492,"end":495},"obj":"P21579"},{"id":"T21163","span":{"begin":492,"end":495},"obj":"Q04206"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"The physiological relevance of Tat cross talk with NF-κB was demonstrated in the HIV-1 infection of human monocytes, where HIV-1-encoded Tat protein counteracted post-activation turn off of NF-κB, as shown by: (i) sustained NF-κB activity by Tat in presence of newly synthesized IκB-α; (ii) coimmunoprecipitation of Tat with IκB-α and p65; (iii) induction of MIP-1α expression dependent on Tat and p65; (iv) Tat occupancy of the MIP-1α NF-κB enhancer associated with increased recruitment of p65."}