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Subscriptions A subscription to Nucleic Acids Research comprises 22 issues. All prices include postage, and for subscribers outside the UK delivery is by Standard Air. Nucleic Acids Research operates a model of continuous online publication, more details of which can be found at www.nar.oxfordjournals.org Annual Subscription Rate (Volume 40, 22 issues, 2012) Institutional Print only: £2300.00/$4388.00/€3292.00 Institutional membership online only: £2396.00/$4793.00/€3596.00 Personal Print: £550.00/$1101.00/€826.00 Please note: US$ rate applies to US and Canada, Euros applies to Europe, UK£ applies to UK and Rest of World. Online access will be completely free of charge from 2005. An institutional membership provides discounted publication charges for corresponding authors based at the member institution. The print subscription does not entitle authors to discounted publication charges. See www.nar.oxfordjournals.org/openaccess. 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Printed by C.O.S. Printers Pte Ltd, Singapore. Cover: “Turn”-ing on cellular uptake. Pyrrole-imidazole hairpin polyamides (upper right) are a class of sequence-specific DNA binding oligomers capable of disrupting protein-DNA interfaces and modulating gene expression in living cells (lower left). For this to occur, these molecules must be efficiently delivered to the cell nucleus (center, blue). In this issue, it is shown that synthetic modifications to the hairpin turn unit of a Py-Im polyamide targeted to a nuclear receptor (NR) response element can potentiate its gene regulatory activity 100-fold in living cells. Quantitative fluorescence analysis suggests this gain in activity is a direct result of increased cellular uptake. This effect extends to a number of different hairpin polyamide oligomers, some of whose cellular penetration is otherwise problematic. For further information, please see the article by J.L. Meier et al., Nucleic Acids Res., 2012, 40, 2345–2356.