Table 3 Complication of letrozole in step-up protocol. Dosage AUB Ovarian cyct Letrozole 2.5 mg 2.08% — Letrozole 5 mg 2.63% 2.63% Letrozole 7.5 mg 14.61% 3.7% χ 2 for linear trend: 6.38, P < 0.011.