In line with our previous observations in 12 patients (11), a subset of the 27 patients who were included in the current study, the VLCD profoundly reduced bodyweight from 113.1 ± 3.7 to 87.7 ± 2.9 kg (P < 0.05) and decreased BMI from 37.2 ± 0.9 to 28.9 ± 0.8 kg/m2 (P < 0.05). In addition, in the 12 patients from whom 1H-MRS scans could be obtained, hepatic TG content reduced considerably from 21.2 ± 4.2 to 3.0 ± 0.9% (n = 12; P < 0.001) as reported previously (11).