Clinical trial reg. no. ISRCTN76920690, www.isrctn.org.
This article contains Supplementary Data online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc11-0685/-/DC1.

Acknowledgments
This research was supported by the Center for Translational Molecular Medicine, project PREDICCt (Grant 01C-104), by the Netherlands Heart Foundation (Grant 2007B081), and by Roba Metals B.V., IJsselstein, the Netherlands. P.C.N.R. is an established investigator of the Netherlands Heart Foundation (Grant 2009T038). No other potential conflicts of interest relevant to this article were reported.
Y.W. researched data, contributed to the discussion, and wrote the manuscript. M.S., J.T.J., S.H., and H.J.L. researched data, contributed to the discussion, and reviewed and edited the manuscript. A.d.R., A.E.M., H.P., J.A.R., J.W.A.S., and I.M.J. contributed to the discussion and reviewed and edited the manuscript. P.C.N.R. contributed to the discussion and wrote the manuscript.