Other polymorphisms in the IL-22 promoter region that reduce the susceptibility of TB in stage II and pooled data
Among the other five SNPs we genotyped in stage II of the experimental cohort, four of them showed significant association with TB susceptibility (Table 2). The locations of the four SNPs to the IL-22 TSS are rs2227472 (-1851bp), rs2227478 (-1340bp), rs2227483 (-894bp), and rs2227485 (-431bp). SNP rs2227472 is 95 bp upstream of our major SNP, rs2227473. Its A allele is a major allele in controls, but a minor allele in cases in both stage II and pooled data. Similar patterns were observed for two other SNPs, rs2227478 and rs2227485, which are 416 bp, and 1325 bp downstream of rs2227473, respectively. All the four SNPs have p-values in the range of 0.021–0.044, with OR range from 0.74–0.80 (Table 2) for the stage II data. Similar results were observed for the pooled data.