The association of rs2227473 was confirmed in the stage II experimental dataset with 431 cases and 310 controls. As shown in Table 1, the association is significant at a p-value of 0.0343, with OR = 0.694 (95% CI = 0.494–0.975). Analysis on the pooled data (479 cases and 358 controls) showed even more significant association at a p-value of 0.0086, with OR = 0.653 (95% CI = 0.449–0.896). This SNP was predicted to alter the protein-DNA interactions among several transcription factors (TFs), including three TFs from the UniPROBE database, and two TFs from the Jaspar database (Supplementary Table S2).