The morphological abnormalities in the brain of Zic2kd/ include a reduction in the septal mass, thinning of the cerebral cortex and corpus callosum, narrowing of the fimbria hippocampi, and a regional reduction of amygdalar nuclei. These abnormalities have a pathophysiological resemblance to neuropsychiatric disorders in humans. In particular, enlarged lateral ventricles and decrease in whole brain volume are a symptom of the first episode of schizophrenia161718, and have been observed in some genetically-engineered mouse models of schizophrenia1537384041. These finding add further support for the genetic involvement of ZIC2 in the pathogenesis of schizophrenia.