DNA interstrand cross-links (ICLs) represent lethal DNA damage because they block transcription, replication, and segregation of DNA. Unlike the animals, SNM1A-deficient Arabidopsis plants were not found to be hypersensitive to the ICL forming agents like cisplatin and MMC, while displayed a moderate sensitivity to the bleomycin and H2O2 [23]. In Atsnm1, the frequency of somatic HR (HRF) was also not found to be enhanced as compared with the wild-type plants, suggested the existence of an SNM1-dependent recombinational repair process of oxidatively induced DNA damage in plants [24]. Yeast cells deficient for Ku70 have been shown to possess short-ended telomeres [25], while Arabidopsis plants lacking Ku70 or Ku80 found to have longer telomeres than wild-type [26,27]. These results clearly indicated the different mechanisms of telomere maintenance in plants. Beside the above mentioned difference, plants lack many important genes like RAD52, RAD55 and RAD57 which play key role in different DRR pathways in other organisms. Although several complexes that are reported to be involved in DRR other than plants were also well conserved in plant but few members like DNA polymerase β and DNA ligase 3 were absent in plants suggested towards the specificity of plant DRR machinery (Figure 2). Presence of some novel genes and unconventional behaviour of DRR mutant plant lines suggests occurrence of some novel process to cope up with different types of DNA damages in plants.