Authors' contributions JMT carried out the macroarrays, the molecular genetic studies, and participated to the genome assembly. CB-E carried out the major part of the manual annotation of the genome together with PL, HDR, and IB. CB and LM carried out to the genome sequencing and assembly. CM, ZR and AL were involved in the automatic annotation, comparative genomics, and administration of the MaGe system. JYC, MAD and SC participated to the home made DNA arrays preparation, and the statistical analyses. CB, AR-F, AC-M, DL, FM and JCD collected the clinical isolates. AL designed the study, analysed the results, and drafted the manuscript. JR analysed the results, and drafted the manuscript. All authors read and approved the final manuscript.