Data were recorded with a Powerlab 2/25 signal conditioner and Chart 6 analysis software (AD Instruments, Sydney). ECoG activity was acquired continuously for the duration of the experiment at 2 kHz, with receivers set to 0.1 Hz high pass and 1000 Hz low pass filters. Fast Fourier transformation was used to quantify the following frequency bands: delta (1.25–4.50 Hz), theta (4.75–6.75 Hz), alpha (7.00–12.50 Hz), beta (12.75–35 Hz), and gamma (35.5–100 Hz). Simultaneous ECG recording allowed the removal of high frequency/high amplitude movement artifacts which invariably occurred during (WDS). ECoG recordings were examined in 10-min periods. These sampling periods were analyzed by dividing them into half overlapping half-second epochs, using a weighted Cosine bell window. Power spectral density (PSD) for each period was calculated as the sum of all epochs. Baseline PSD for each animal was determined as the mean of the three 10-min periods during acclimatization. PSD values for subsequent periods were expressed as a percentage of baseline and averaged within treatment groups. High frequency/high amplitude (HF/HA) spiking was also quantified as a measure of seizure activity. These were defined as spikes of at least three times the average spike amplitude during baseline.