Borovicka et al. studied the effect of orally administrated cisapride on gastric emptying and motility in eight diabetic patients with previously demonstrated delayed gastric emptying. MRI studies were also performed in seven diabetic patients with normal emptying who served as disease controls. Gastric emptying was slower in the gastroparetic patients compared to patients with normal emptying. Cisapride accelerated gastric emptying in patients with gastroparesis. The contraction amplitudes in the proximal stomach of gastroparetic patients were increased during cisapride treatment, whereas antral contraction frequency, amplitude and velocity were unchanged. It was concluded that cisapride-induced acceleration of liquid gastric emptying in diabetic gastroparesis does not appear to result from changes in antral contractility, but may be related to changes in proximal gastric tone or gastric outlet resistance [10].