Likewise, endocardial and epicardial contours were manually traced on the LGE and T2 images, which were viewed as separate sets. The T2W images of the first CMR examination were used to determine the presence or absence of IMH, defined as a central hypoenhanced area within the hyperintense oedematous area, indicative of the area at risk (AAR). The AAR was quantified by semiautomatic detection using a signal intensity (SI) threshold of >2 SD above a remote non-infarcted region and expressed as a percentage of LV mass. Subendocardial ‘slow flow’ artefacts were carefully excluded, and areas of IMH were included in the AAR analysis by manual adjustment of contours. IMH was manually traced and expressed as a percentage of LV mass.