Previous studies have shown that MVO infarcts show a lack of regional and global functional recovery compared with non-MVO infarcts; however, it remains unclear whether MVO provides independent prognostic information [11, 12]. Despite the strong relation of MVO with IS, some studies indicated that MVO is an important determinant of LV recovery and prognosis, even after controlling for IS, whereas others have reported that MVO loses its predictive power after adjusting for IS [13, 14, 20, 21]. Persistence of MVO, but not MVO that disappeared at 1 week after infarction, was associated with attenuated infarct healing and subsequent adverse remodelling, indicating that the timing of MVO imaging is important [22]. In that study and similar to our findings, IS remained the major determinant of LV remodelling in a multivariate model.