For radiographically dense-breasted women, whole-breast ultrasound as an adjunct to screening mammography has shown promise. Berg et al. increased cancer discovery 42% by adding handheld whole-breast ultrasound performed by radiologists [8]. Kelly et al. used an automated whole-breast ultrasound (AWBU) device capturing a ciné loop of 2D breast images [9]. This blinded study of mostly dense-breasted women showed a 100% increase in cancer detection, and a 200% increase in discovery of invasive cancers 1 cm or less, compared with mammograms alone. These ciné loops were recorded and are available for reader trials similar to those performed for comparison of screening mammography with and without computer-aided detection (CAD) [10].