pQCT permits in vivo assessment of bone morphology and BMD at appendicular bones such as the distal radius and tibia. pQCT can be used simply for BMD and bone geometry, or in HR to provide information on trabecular bone structure. A recently developed device (Scanco, Bruttisellen, Switzerland) has an isotropic voxel size in the order of 80 μm, which allows direct or indirect evaluation of cortical and trabecular bone architecture. Specifically, assessment of parameters such as trabecular number, cortical thickness, trabecular thickness and porosity, and trabecular separation is possible with this technique. Recent studies have focused on HR pQCT imaging of bone microstructure in both adults and adolescents [13, 14].