The standard user interface of a personal computer is powerful and flexible, but this flexibility is often a barrier to accessibility for many people with disabilities: many small icons, multiple open windows on a complex desktop, drag-and-drop, and so on. This kind of interface makes using a PC difficult and confusing for many people, like people with physical disabilities or first time users such as elderly people. A common approach to assisting people in using ICT is to add some assistive technology on top of the standard interface, such as text-to-speech or screen magnifiers. This approach has provided considerable benefit to specific user groups, but it does not remove the main limitation of standard user interfaces. The solution is then to design simpler user interfaces from scratch whose interaction principles and graphical appearance is uniform across applications. One of the few commercial state-of-the-art AT ICT products is “QualiWORLD” by QualiLife Inc. (Paradiso-Lugano, Switzerland).