Consistent with the decreased number of excitatory projection neurons in PFC in conditional knockouts for fgfr2 driven by the hgfap-Cre transgene, glutamatergic synapses in the bed nuclei of the stria terminalis (BST), an area that receives projections from the PFC and in turn projects to the hypothalamus, were also reduced in these mice. A decreased number of GABAergic neurons in the BST was also noted in these animals, which is likely to be secondary to decreased glutamate input, as FGFR2 was not targeted in this region (Stevens et al., 2010). These changes may have important consequences for the correct functioning of limbic circuitry.