PMC:2944646 / 10350-11049 JSONTXT

{"project":"TEST0","denotations":[{"id":"20877425-110-118-198911","span":{"begin":428,"end":432},"obj":"[\"15353369\"]"},{"id":"20877425-131-139-198912","span":{"begin":449,"end":453},"obj":"[\"18391487\"]"}],"text":"The close association and common basis of oxidative stress and mitochondrial dysfunction in brain aging and age-related neurodegenerative disorders like AD (see the previous chapters) explains that several antioxidants have a long history as possible treatments for AD and even have been and are used in this context. Initially mainly Vitamin E or Vitamin C or the combination of both was investigated (Bastianetto and Quirion, 2004; Farlow et al., 2008; Lee et al., 2009). While both at high concentrations definitively show antioxidant properties in vitro and in vivo, their therapeutical benefit to improve or even prevent cognitive impairment in the elderly is at present seen rather critically."}

{"project":"0_colil","denotations":[{"id":"20877425-15353369-198911","span":{"begin":428,"end":432},"obj":"15353369"},{"id":"20877425-18391487-198912","span":{"begin":449,"end":453},"obj":"18391487"}],"text":"The close association and common basis of oxidative stress and mitochondrial dysfunction in brain aging and age-related neurodegenerative disorders like AD (see the previous chapters) explains that several antioxidants have a long history as possible treatments for AD and even have been and are used in this context. Initially mainly Vitamin E or Vitamin C or the combination of both was investigated (Bastianetto and Quirion, 2004; Farlow et al., 2008; Lee et al., 2009). While both at high concentrations definitively show antioxidant properties in vitro and in vivo, their therapeutical benefit to improve or even prevent cognitive impairment in the elderly is at present seen rather critically."}

{"project":"2_test","denotations":[{"id":"20877425-15353369-38148004","span":{"begin":428,"end":432},"obj":"15353369"},{"id":"20877425-18391487-38148005","span":{"begin":449,"end":453},"obj":"18391487"}],"text":"The close association and common basis of oxidative stress and mitochondrial dysfunction in brain aging and age-related neurodegenerative disorders like AD (see the previous chapters) explains that several antioxidants have a long history as possible treatments for AD and even have been and are used in this context. Initially mainly Vitamin E or Vitamin C or the combination of both was investigated (Bastianetto and Quirion, 2004; Farlow et al., 2008; Lee et al., 2009). While both at high concentrations definitively show antioxidant properties in vitro and in vivo, their therapeutical benefit to improve or even prevent cognitive impairment in the elderly is at present seen rather critically."}