Emerging evidence indicates that memory tasks involving detection and processing of context are most sensitive to changes in neurogenesis and should be good indicators of deteriorating memory performance at old age (Wojtowicz et al., 2008). Thus, a working hypothesis suggests that aging animals can adapt to low levels of neurogenesis, but fundamental dependence of memory on new neurons persists in old age. It is therefore of interest to test whether rate of neurogenesis can be manipulated in old animals. Studies by Kempermann et al. (1998, 2002) have shown that neurogenesis in middle-aged mice is responsive to stimulation by enriched environment and the increases are correlated with modest improvements in learning. In addition, other forms of physiological and pathological stimulation can enhance neurogenesis in aging animals albeit often to a limited extent (Cameron and McKay, 1999; van Praag et al., 2005; Hattiangady et al., 2008).