Our success at suppression of epileptiform activity in cultures using closed-loop multi-electrode stimulation (Wagenaar et al., 2005b) led us to investigate whether similar protocols might suppress seizures in intact, freely moving, epileptic animals (Schachter et al., 2009). Many commercially available systems exist for conducting freely moving multi-electrode recording (for example, Plexon, Neuralynx, Multichannel Systems, Tucker-Davis Technologies, and others). Unfortunately, none was designed for closed-loop stimulation and they are all closed source. Therefore, we set out to adapt our RACS hardware to in vivo use, and to replace MeaBench with a more user-friendly software suite, called NeuroRighter, described below and in more detail in Frontiers in Neuroengineering (Rolston et al., 2009a,c). Both the hardware and software will continually improve because they are free and open-source (available at the Google Group, “NeuroRighter Users”), in an effort to make closed-loop multi-electrode electrophysiology easier to implement and more prevalent.