Appendix
Studies were included if they met all of the following criteria: (1) Study population were patients with chest pain suggestive of stable angina pectoris, (2) study reported a new multivariate prediction rule that included clinical variables, (3) outcome was the presence of significant CAD defined as ≥50% stenosis in at least one vessel. Studies were excluded if they met one of the following criteria: (1) Article was a review, guideline, or cost-effectiveness analysis, or (2) study did not report a prediction model, or (3) the outcome of interest was prognostic (e.g. event rate after treatment) or the authors did not use ≥50% stenosis in at least one vessel as their outcome, or (4) study population consisted of unstable patients, asymptomatic patients, patients with known CAD or patients with a specific co-morbidity, or (5) main topic was a diagnostic (imaging) test, or (6) a reference standard other than conventional coronary angiography was used, or (7) authors did not use the traditional classification of typical and atypical chest pain, or (8) the study focused on the association between one particular risk factor and CAD. Articles not accessible were excluded from the analysis.

Search strategy
Coronary artery disease [MeSH]
Coronary heart disease [MeSH]
Coronary stenosis [MeSH]
Coronary disease
#1 OR #2 OR 3# OR 4
Chest pain [MeSH]
Angina pectoris [MeSH]
Suspected [title/abstract]
#6 OR #7 OR #8
Logistic models [MeSH]
Probability [MeSH]
Risk [MeSH]
Models, statistical [MeSH]
ROC curve [MeSH]
#10 OR #11 OR #12 OR #13 OR #14
Medical history taking [MeSH]
Physical examination [MeSH]
Clinical [title/abstract]
#16 OR #17 OR #18
#5 AND #9 AND #15 AND #19
Animals [MeSH] NOT humans [MeSH]
Editorial [publication type]
Comment [publication type]
Letter [publication type]
Meta-analysis [publication type]
Case reports [publication type])
#22 OR #23 OR #24 OR #25 OR #26
Acute [title/abstract]
#20 NOT #21 NOT #27 NOT #28