Ideally, the probability categories should be based on clinically relevant cutoffs. However, no well-established clinically relevant probability threshold exists. The probability of CAD is commonly defined as low (<30%), intermediate (≥30–70%) and high (≥70%) [26]. In our view the intermediate category is rather wide, which is why we divided this category into low–intermediate (≥30–50%) and intermediate–high (≥50–70%). It should be noted that the overall percentage of reclassification is highly dependent on the choice and number of probability categories.