In spite of the feasible advantages of PCT over PWI, the relative limitations of PCT and consequently of our study are the radiation dose involved with the procedure and also the limited coverage area of the cerebral parenchyma compared with PWI. The latter limitation could be overcome in the future with the new volume PCT technique, which enables the measurement of the whole brain and three-dimensional qualitative and quantitative imaging. Thus, whole-brain PCT could lead to even more precise grading of intra-axial brain tumours. Potential limitations also include the different contrast agent protocols applied. However, we statistically demonstrated no methodological heterogeneity regarding the perfusion parameters generated.