A variety of imaging techniques has been described for the assessment of cerebral perfusion. These techniques have been primarily used to assess cerebral ischaemia [1, 2]; however, the range of perfusion applications is being expanded, including the diagnostic field of cerebral tumours. Perfusion-weighted magnetic resonance imaging (PWI) has been proven to provide additional valuable information about intra-axial brain tumours [3–6]. A correlation among perfusion parameters, tumour grade and treatment response has already been demonstrated through the non-invasive measurement of regional cerebral blood volume (CBV), regional cerebral blood flow (CBF) and permeability (PMB) as a measure of blood-brain barrier disruption by PWI techniques [3–6]. Furthermore, perfusion imaging has shown promising results for distinguishing recurrence from radionecrosis, but also for differentiating cerebral tumour lesions, such as lymphomas and gliomas [3].