Fig. 5 A 72-year-old woman with histopathological diagnosis of primary cerebral lymphoma. In comparison with the contralateral normal cerebral parenchyma, the lesion depicted in the right lentiform nucleus demonstrates the typical perfusion characteristics of lymphoma: enhancement (a), no significant increase in CBF (b) or CBV values (c), though intensely increased regional permeability (K Trans, d), indicating a massive disturbance of the blood-brain barrier